{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:46:39Z","timestamp":1792622799439,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10137-8","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:35:50Z","timestamp":1777548950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mitochondrial protein Mrpl13 regulates zebrafish liver development through the mTORC1-mitochondrial homeostasis pathway"],"prefix":"10.1038","volume":"9","author":[{"given":"Xinkai","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libaijia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-7055","authenticated-orcid":false,"given":"Long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-0043","authenticated-orcid":false,"given":"Ying","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"10137_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.devcel.2010.01.011","volume":"18","author":"K Si-Tayeb","year":"2010","unstructured":"Si-Tayeb, K., Lemaigre, F. P. & Duncan, S. A. Organogenesis and development of the liver. Dev. Cell 18, 175\u2013189 (2010).","journal-title":"Dev. Cell"},{"key":"10137_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","volume":"78","author":"B Fromenty","year":"2023","unstructured":"Fromenty, B. & Roden, M. Mitochondrial alterations in fatty liver diseases. J. Hepatol. 78, 415\u2013429 (2023).","journal-title":"J. Hepatol."},{"key":"10137_CR3","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","volume":"5","author":"AS Monzel","year":"2023","unstructured":"Monzel, A. S., Enr\u00edquez, J. A. & Picard, M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat. Metab. 5, 546\u2013562 (2023).","journal-title":"Nat. Metab."},{"key":"10137_CR4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","volume":"155","author":"A Mansouri","year":"2018","unstructured":"Mansouri, A., Gattolliat, C. H. & Asselah, T. Mitochondrial dysfunction and signaling in chronic liver diseases. Gastroenterology 155, 629\u2013647 (2018).","journal-title":"Gastroenterology"},{"key":"10137_CR5","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1111\/liv.15711","volume":"43","author":"GJ Shami","year":"2023","unstructured":"Shami, G. J. et al. Giant mitochondria in human liver disease. Liver Int. 43, 2365\u20132378 (2023).","journal-title":"Liver Int."},{"key":"10137_CR6","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.7150\/ijbs.107777","volume":"21","author":"J Li","year":"2025","unstructured":"Li, J., Liu, W., Zhang, J. & Sun, C. The role of mitochondrial quality control in liver diseases: dawn of a therapeutic era. Int J. Biol. Sci. 21, 1767\u20131783 (2025).","journal-title":"Int J. Biol. Sci."},{"key":"10137_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04367-1","volume":"21","author":"Y Zheng","year":"2023","unstructured":"Zheng, Y., Wang, S., Wu, J. & Wang, Y. Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy. J. Transl. Med. 21, 510 (2023).","journal-title":"J. Transl. Med."},{"key":"10137_CR8","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/j.2040-4603.2013.tb00516.x","volume":"3","author":"BJ Wilkins","year":"2013","unstructured":"Wilkins, B. J. & Pack, M. Zebrafish models of human liver development and disease. Compr. Physiol. 3, 1213\u20131230 (2013).","journal-title":"Compr. Physiol."},{"key":"10137_CR9","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1053\/j.gastro.2015.08.034","volume":"149","author":"W Goessling","year":"2015","unstructured":"Goessling, W. & Sadler, K. C. Zebrafish: an important tool for liver disease research. Gastroenterology 149, 1361\u20131377 (2015).","journal-title":"Gastroenterology"},{"key":"10137_CR10","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.3390\/cells11203290","volume":"11","author":"Y Gao","year":"2022","unstructured":"Gao, Y. et al. Unraveling differential transcriptomes and cell types in zebrafish larvae intestine and liver. Cells 11, 3290 (2022).","journal-title":"Cells"},{"key":"10137_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0925-4773(02)00327-1","volume":"120","author":"EA Ober","year":"2003","unstructured":"Ober, E. A., Field, H. A. & Stainier, D. Y. From endoderm formation to liver and pancreas development in zebrafish. Mech. Dev. 120, 5\u201318 (2003).","journal-title":"Mech. Dev."},{"key":"10137_CR12","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1002\/1873-3468.12330","volume":"590","author":"K Landgraf","year":"2016","unstructured":"Landgraf, K., Strobach, A., Kiess, W. & K\u00f6rner, A. Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae. FEBS Lett. 590, 2852\u20132861 (2016).","journal-title":"FEBS Lett."},{"key":"10137_CR13","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1242\/dmm.004390","volume":"3","author":"S Curado","year":"2010","unstructured":"Curado, S. et al. The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Dis. Model Mech. 3, 486\u2013495 (2010).","journal-title":"Dis. Model Mech."},{"key":"10137_CR14","doi-asserted-by":"publisher","first-page":"e1003563","DOI":"10.1371\/journal.pgen.1003563","volume":"9","author":"SH Kim","year":"2013","unstructured":"Kim, S. H. et al. Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. PLoS Genet. 9, e1003563 (2013).","journal-title":"PLoS Genet."},{"key":"10137_CR15","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ymgme.2009.10.003","volume":"99","author":"AW El-Hattab","year":"2010","unstructured":"El-Hattab, A. W. et al. MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: new patients and novel mutations. Mol. Genet. Metab. 99, 300\u2013308 (2010).","journal-title":"Mol. Genet. Metab."},{"key":"10137_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41420-021-00630-w","volume":"7","author":"WP Bian","year":"2021","unstructured":"Bian, W. P. et al. Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell Death Discov. 7, 250 (2021).","journal-title":"Cell Death Discov."},{"key":"10137_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1146\/annurev-biochem-060815-014343","volume":"85","author":"BJ Greber","year":"2016","unstructured":"Greber, B. J. & Ban, N. Structure and function of the mitochondrial ribosome. Annu Rev. Biochem. 85, 103\u2013132 (2016).","journal-title":"Annu Rev. Biochem."},{"key":"10137_CR18","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.3390\/ijms22083827","volume":"22","author":"MIG Lopez Sanchez","year":"2021","unstructured":"Lopez Sanchez, M. I. G., Kr\u00fcger, A., Shiriaev, D. I., Liu, Y. & Rorbach, J. Human mitoribosome biogenesis and its emerging links to disease. Int J. Mol. Sci. 22, 3827 (2021).","journal-title":"Int J. Mol. Sci."},{"key":"10137_CR19","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1080\/15384101.2015.1053672","volume":"14","author":"D De Silva","year":"2015","unstructured":"De Silva, D., Tu, Y. T., Amunts, A., Fontanesi, F. & Barrientos, A. Mitochondrial ribosome assembly in health and disease. Cell Cycle 14, 2226\u20132250 (2015).","journal-title":"Cell Cycle"},{"key":"10137_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50011-x","volume":"15","author":"M Cipullo","year":"2024","unstructured":"Cipullo, M. et al. GTPBP8 plays a role in mitoribosome formation in human mitochondria. Nat. Commun. 15, 5664 (2024).","journal-title":"Nat. Commun."},{"key":"10137_CR21","doi-asserted-by":"publisher","first-page":"11797","DOI":"10.1093\/nar\/gkad842","volume":"51","author":"H Zhong","year":"2023","unstructured":"Zhong, H. et al. BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome. Nucleic Acids Res 51, 11797\u201311812 (2023).","journal-title":"Nucleic Acids Res"},{"key":"10137_CR22","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1002\/1873-3468.14024","volume":"595","author":"A Ferrari","year":"2021","unstructured":"Ferrari, A., Del\u2019Olio, S. & Barrientos, A. The diseased mitoribosome. FEBS Lett. 595, 1025\u20131061 (2021).","journal-title":"FEBS Lett."},{"key":"10137_CR23","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.3389\/fonc.2019.01373","volume":"9","author":"KG de la Cruz L\u00f3pez","year":"2019","unstructured":"de la Cruz L\u00f3pez, K. G., Toledo Guzm\u00e1n, M. E., S\u00e1nchez, E. O. & Garc\u00eda Carranc\u00e1, A. mTORC1 as a regulator of mitochondrial functions and a therapeutic target in cancer. Front Oncol. 9, 1373 (2019).","journal-title":"Front Oncol."},{"key":"10137_CR24","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41580-023-00641-8","volume":"24","author":"C Goul","year":"2023","unstructured":"Goul, C., Peruzzo, R. & Zoncu, R. The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease. Nat. Rev. Mol. Cell Biol. 24, 857\u2013875 (2023).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10137_CR25","first-page":"109","volume":"39","author":"L He","year":"2025","unstructured":"He, L., Cho, S. & Blenis, J. Blenis, mTORC1, the maestro of cell metabolism and growth. Genes Dev. 39, 109\u2013131 (2025).","journal-title":"Genes Dev."},{"key":"10137_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26295-8","volume":"12","author":"SZ Peng","year":"2021","unstructured":"Peng, S. Z. et al. Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62\/SQSTM1 condensates. Nat. Commun. 12, 5989 (2021).","journal-title":"Nat. Commun."},{"key":"10137_CR27","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","volume":"137","author":"J Moscat","year":"2009","unstructured":"Moscat, J. & Diaz-Meco, M. T. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137, 1001\u20131004 (2009).","journal-title":"Cell"},{"key":"10137_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54258-2","volume":"15","author":"Z Chen","year":"2024","unstructured":"Chen, Z. et al. Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nat. Commun. 15, 9769 (2024).","journal-title":"Nat. Commun."},{"key":"10137_CR29","doi-asserted-by":"publisher","first-page":"3976","DOI":"10.3390\/ijms19123976","volume":"19","author":"E Verbueken","year":"2018","unstructured":"Verbueken, E. et al. From mRNA expression of drug disposition genes to in vivo assessment of CYP-mediated biotransformation during zebrafish embryonic and larval development. Int J. Mol. Sci. 19, 3976 (2018).","journal-title":"Int J. Mol. Sci."},{"key":"10137_CR30","first-page":"295","volume":"8","author":"JP Otis","year":"2015","unstructured":"Otis, J. P. et al. Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake. Dis. Model Mech. 8, 295\u2013309 (2015).","journal-title":"Dis. Model Mech."},{"key":"10137_CR31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3389\/fendo.2017.00319","volume":"8","author":"VH Quinlivan","year":"2017","unstructured":"Quinlivan, V. H. & Farber, S. A. Lipid uptake, metabolism, and transport in the larval zebrafish. Front Endocrinol. (Lausanne) 8, 319 (2017).","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10137_CR32","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1242\/dev.027565","volume":"136","author":"RP Matthews","year":"2009","unstructured":"Matthews, R. P. et al. TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development 136, 865\u2013875 (2009).","journal-title":"Development"},{"key":"10137_CR33","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.jcmgh.2019.02.002","volume":"7","author":"X Zhang","year":"2019","unstructured":"Zhang, X. et al. Defective phosphatidylglycerol remodeling causes hepatopathy, linking mitochondrial dysfunction to hepatosteatosis. Cell Mol. Gastroenterol. Hepatol. 7, 763\u2013781 (2019).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10137_CR34","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.molcel.2008.10.021","volume":"32","author":"R Acin-Perez","year":"2008","unstructured":"Acin-Perez, R., Fernandez-Silva, P., Peleato, M. L., Perez-Martos, A. & Enriquez, J. A. Respiratory active mitochondrial supercomplexes. Mol. Cell 32, 529\u2013539 (2008).","journal-title":"Mol. Cell"},{"key":"10137_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470942390.mo150182","volume":"6","author":"P Jha","year":"2016","unstructured":"Jha, P., Wang, X. & Auwerx, J. Analysis of mitochondrial respiratory chain supercomplexes using blue native polyacrylamide gel electrophoresis (BN-PAGE). Curr. Protoc. Mouse Biol. 6, 1\u201314 (2016).","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10137_CR36","doi-asserted-by":"publisher","first-page":"e1009980","DOI":"10.1371\/journal.pgen.1009980","volume":"17","author":"W Zhang","year":"2021","unstructured":"Zhang, W. et al. Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genet. 17, e1009980 (2021).","journal-title":"PLoS Genet."},{"key":"10137_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07953-x","volume":"16","author":"O Liu","year":"2025","unstructured":"Liu, O. et al. MRPL13 enhances mitochondrial function and promotes tumor progression in ovarian cancer by inhibiting mPTP opening via SLC25A6. Cell Death Dis. 16, 634 (2025).","journal-title":"Cell Death Dis."},{"key":"10137_CR38","doi-asserted-by":"publisher","first-page":"20208","DOI":"10.1074\/jbc.M117.809012","volume":"292","author":"YK Lee","year":"2017","unstructured":"Lee, Y. K. et al. Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness. J. Biol. Chem. 292, 20208\u201320217 (2017).","journal-title":"J. Biol. Chem."},{"key":"10137_CR39","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.2147\/CMAR.S296038","volume":"13","author":"M Cai","year":"2021","unstructured":"Cai, M., Li, H., Chen, R. & Zhou, X. MRPL13 promotes tumor cell proliferation, migration and EMT process in breast cancer through the PI3K-AKT-mTOR pathway. Cancer Manag. Res. 13, 2009\u20132024 (2021).","journal-title":"Cancer Manag. Res."},{"key":"10137_CR40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/gene.10248","volume":"38","author":"GM Her","year":"2004","unstructured":"Her, G. M., Chiang, C. C. & Wu, J. L. Zebrafish intestinal fatty acid binding protein (I-FABP) gene promoter drives gut-specific expression in stable transgenic fish. Genesis 38, 26\u201331 (2004).","journal-title":"Genesis"},{"key":"10137_CR41","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ydbio.2004.07.001","volume":"274","author":"JW Lin","year":"2004","unstructured":"Lin, J. W. et al. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev. Biol. 274, 491\u2013503 (2004).","journal-title":"Dev. Biol."},{"key":"10137_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23345","volume":"58","author":"G Dong","year":"2020","unstructured":"Dong, G. et al. Mypt1 regulates Bmp signaling to promote embryonic exocrine pancreas growth in zebrafish. Genesis 58, e23345 (2020).","journal-title":"Genesis"},{"key":"10137_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103689","volume":"74","author":"U Lendahl","year":"2021","unstructured":"Lendahl, U., Lui, V. C. H., Chung, P. H. Y. & Tam, P. K. H. Biliary atresia - emerging diagnostic and therapy opportunities. EBioMedicine 74, 103689 (2021).","journal-title":"EBioMedicine"},{"key":"10137_CR44","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3350\/cmh.2015.21.2.175","volume":"21","author":"DH Gu","year":"2015","unstructured":"Gu, D. H. et al. Caroli\u2019s disease misdiagnosed as intraductal papillary neoplasm of the bile duct. Clin. Mol. Hepatol. 21, 175\u2013179 (2015).","journal-title":"Clin. Mol. Hepatol."},{"key":"10137_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/kjm2.12368","volume":"37","author":"D Prasad","year":"2021","unstructured":"Prasad, D. & Nguyen, M. H. Epidemiology, pathogenesis, diagnosis, surveillance, and management of hepatocellular carcinoma associated with vascular liver disease. Kaohsiung J. Med. Sci. 37, 355\u2013360 (2021).","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10137_CR46","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1471-213X-8-84","volume":"8","author":"S Korzh","year":"2008","unstructured":"Korzh, S. et al. Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Dev. Biol. 8, 84 (2008).","journal-title":"BMC Dev. Biol."},{"key":"10137_CR47","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.cub.2008.08.065","volume":"18","author":"TF Sakaguchi","year":"2008","unstructured":"Sakaguchi, T. F., Sadler, K. C., Crosnier, C. & Stainier, D. Y. Endothelial signals modulate hepatocyte apicobasal polarization in zebrafish. Curr. Biol. 18, 1565\u20131571 (2008).","journal-title":"Curr. Biol."},{"key":"10137_CR48","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/dvdy.22220","volume":"239","author":"K Lorent","year":"2010","unstructured":"Lorent, K., Moore, J. C., Siekmann, A. F., Lawson, N. & Pack, M. Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Dev. Dyn. 239, 855\u2013864 (2010).","journal-title":"Dev. Dyn."},{"key":"10137_CR49","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/hep.31679","volume":"74","author":"K Jung","year":"2021","unstructured":"Jung, K. et al. Farnesoid X receptor activation impairs liver progenitor cell-mediated liver regeneration via the PTEN-PI3K-AKT-mTOR axis in zebrafish. Hepatology 74, 397\u2013410 (2021).","journal-title":"Hepatology"},{"key":"10137_CR50","doi-asserted-by":"publisher","first-page":"25353","DOI":"10.1074\/jbc.M112.349126","volume":"287","author":"L Li","year":"2012","unstructured":"Li, L., Yan, B., Shi, Y. Q., Zhang, W. Q. & Wen, Z. L. Live imaging reveals differing roles of macrophages and neutrophils during zebrafish tail fin regeneration. J. Biol. Chem. 287, 25353\u201325360 (2012).","journal-title":"J. Biol. Chem."},{"key":"10137_CR51","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2144\/000112909","volume":"45","author":"MJ Kim","year":"2008","unstructured":"Kim, M. J., Kang, K. H., Kim, C. H. & Choi, S. Y. Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP. Biotechniques 45, 331\u2013334 (2008).","journal-title":"Biotechniques"},{"key":"10137_CR52","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1242\/dev.048785","volume":"137","author":"Y Wang","year":"2010","unstructured":"Wang, Y. et al. Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development 137, 3119\u20133128 (2010).","journal-title":"Development"},{"key":"10137_CR53","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/cr.2013.45","volume":"23","author":"N Chang","year":"2013","unstructured":"Chang, N. et al. Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res. 23, 465\u2013472 (2013).","journal-title":"Cell Res."},{"key":"10137_CR54","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jgg.2016.03.007","volume":"43","author":"J Ear","year":"2016","unstructured":"Ear, J. et al. A zebrafish model of 5q-syndrome using CRISPR\/Cas9 targeting RPS14 reveals a p53-independent and p53-dependent mechanism of erythroid failure. J. Genet. Genomics 43, 307\u2013318 (2016).","journal-title":"J. Genet. Genomics"},{"key":"10137_CR55","doi-asserted-by":"publisher","first-page":"e58858","DOI":"10.1371\/journal.pone.0058858","volume":"8","author":"T Tao","year":"2013","unstructured":"Tao, T., Shi, H., Huang, D. & Peng, J. Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. PLoS ONE 8, e58858 (2013).","journal-title":"PLoS ONE"},{"key":"10137_CR56","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.celrep.2018.12.048","volume":"26","author":"L Zhao","year":"2019","unstructured":"Zhao, L., Ben-Yair, R., Burns, C. E. & Burns, C. G. Endocardial notch signaling promotes cardiomyocyte proliferation in the regenerating Zebrafish heart through Wnt pathway antagonism. Cell Rep. 26, 546\u2013554 e545 (2019).","journal-title":"Cell Rep."},{"key":"10137_CR57","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nprot.2007.514","volume":"3","author":"C Thisse","year":"2008","unstructured":"Thisse, C. & Thisse, B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat. Protoc. 3, 59\u201369 (2008).","journal-title":"Nat. Protoc."},{"key":"10137_CR58","first-page":"89","volume":"326","author":"J Asp","year":"2006","unstructured":"Asp, J., Abramsson, A. & Betsholtz, C. Nonradioactive in situ hybridization on frozen sections and whole mounts. Methods Mol. Biol. 326, 89\u2013102 (2006).","journal-title":"Methods Mol. Biol."},{"key":"10137_CR59","doi-asserted-by":"publisher","unstructured":"Dobrzycki, T., Krecsmarik, M. & Monteiro, R. Genotyping and quantification of in situ hybridization staining in Zebrafish. J. Vis. Exp. https:\/\/doi.org\/10.3791\/59956 (2020).","DOI":"10.3791\/59956"},{"key":"10137_CR60","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1096\/fj.06-6246com","volume":"21","author":"Y Su","year":"2007","unstructured":"Su, Y. et al. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J. 21, 682\u2013690 (2007).","journal-title":"FASEB J."},{"key":"10137_CR61","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1038\/s41596-020-0376-7","volume":"15","author":"J He","year":"2020","unstructured":"He, J., Mo, D., Chen, J. & Luo, L. Combined whole-mount fluorescence in situ hybridization and antibody staining in zebrafish embryos and larvae. Nat. Protoc. 15, 3361\u20133379 (2020).","journal-title":"Nat. Protoc."},{"key":"10137_CR62","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1523\/JNEUROSCI.1316-20.2020","volume":"41","author":"A Mandal","year":"2021","unstructured":"Mandal, A. et al. Retrograde mitochondrial transport is essential for organelle distribution and health in Zebrafish neurons. J. Neurosci. 41, 1371\u20131392 (2021).","journal-title":"J. Neurosci."},{"key":"10137_CR63","doi-asserted-by":"publisher","first-page":"e64744","DOI":"10.7554\/eLife.64744","volume":"10","author":"D Lumaquin","year":"2021","unstructured":"Lumaquin, D. et al. An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. Elife 10, e64744 (2021).","journal-title":"Elife"},{"key":"10137_CR64","doi-asserted-by":"publisher","first-page":"642","DOI":"10.4161\/auto.6.5.12092","volume":"6","author":"C He","year":"2010","unstructured":"He, C. & Klionsky, D. J. Analyzing autophagy in zebrafish. Autophagy 6, 642\u2013644 (2010).","journal-title":"Autophagy"},{"key":"10137_CR65","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/dvdy.21908","volume":"238","author":"YH Chen","year":"2009","unstructured":"Chen, Y. H. et al. Zebrafish cdx1b regulates differentiation of various intestinal cell lineages. Dev. Dyn. 238, 1021\u20131032 (2009).","journal-title":"Dev. Dyn."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10137-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10137-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10137-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:07:58Z","timestamp":1783382878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10137-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10137"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10137-8","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"4 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"909"}}