{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:17:15Z","timestamp":1783682235273,"version":"3.55.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10155-6","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:45:11Z","timestamp":1777992311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toxoplasma gondii hijacks host S100A6 to enhance cell migration and brain cyst formation"],"prefix":"10.1038","volume":"9","author":[{"given":"Lijuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4242-9397","authenticated-orcid":false,"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-8218","authenticated-orcid":false,"given":"Hongjuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"10155_CR1","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"JG Montoya","year":"2004","unstructured":"Montoya, J. G. & Liesenfeld, O. Toxoplasmosis. Lancet 363, 1965\u20131976 (2004).","journal-title":"Lancet"},{"key":"10155_CR2","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.ijpara.2009.04.003","volume":"39","author":"G Pappas","year":"2009","unstructured":"Pappas, G., Roussos, N. & Falagas, M. E. Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J. Parasitol. 39, 1385\u20131394 (2009).","journal-title":"Int J. Parasitol."},{"key":"10155_CR3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1086\/590149","volume":"47","author":"JG Montoya","year":"2008","unstructured":"Montoya, J. G. & Remington, J. S. Management of Toxoplasma gondii infection during pregnancy. Clin. Infect. Dis. 47, 554\u2013566 (2008).","journal-title":"Clin. Infect. Dis."},{"key":"10155_CR4","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/aps.2011.55","volume":"32","author":"P di Carlo","year":"2011","unstructured":"di Carlo, P. et al. Investigation and management of Toxoplasma gondii infection in pregnancy and infancy: a prospective study. Acta Pharm. Sin. 32, 1063\u20131070 (2011).","journal-title":"Acta Pharm. Sin."},{"key":"10155_CR5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/00006454-199007000-00012","volume":"9","author":"CD Mitchell","year":"1990","unstructured":"Mitchell, C. D. et al. Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1. Pediatr. Infect. Dis. J. 9, 512\u2013518 (1990).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10155_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fcimb.2019.00103","volume":"9","author":"TS Lima","year":"2019","unstructured":"Lima, T. S. & Lodoen, M. B. Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii. Front Cell Infect. Microbiol 9, 103 (2019).","journal-title":"Front Cell Infect. Microbiol"},{"key":"10155_CR7","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3389\/fcimb.2019.00460","volume":"9","author":"S-Z Wu","year":"2019","unstructured":"Wu, S.-Z. et al. Genome-wide CRISPR screen identifies host factors required by Toxoplasma gondii infection. Front. Cell Infect. Microbiol. 9, 460 (2019).","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10155_CR8","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1182\/blood-2005-02-0666","volume":"107","author":"N Courret","year":"2006","unstructured":"Courret, N. et al. CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain. Blood 107, 309\u2013316 (2006).","journal-title":"Blood"},{"key":"10155_CR9","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1111\/j.1462-5822.2006.00735.x","volume":"8","author":"H Lambert","year":"2006","unstructured":"Lambert, H., Hitziger, N., Dellacasa, I., Svensson, M. & Barragan, A. Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination. Cell Microbiol. 8, 1611\u20131623 (2006).","journal-title":"Cell Microbiol."},{"key":"10155_CR10","doi-asserted-by":"publisher","unstructured":"Augusto, L. et al. Toxoplasma gondii Co-opts the unfolded protein response to enhance migration and dissemination of infected host cells. mBio 11, https:\/\/doi.org\/10.1128\/mBio.00915-20 (2020).","DOI":"10.1128\/mBio.00915-20"},{"key":"10155_CR11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0014-5793(90)80263-I","volume":"264","author":"A Filipek","year":"1990","unstructured":"Filipek, A., Heizmann, C. W. & Ku\u017anicki, J. Calcyclin is a calcium and zinc binding protein. FEBS Lett. 264, 263\u2013266 (1990).","journal-title":"FEBS Lett."},{"key":"10155_CR12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0014-4827(92)90191-A","volume":"200","author":"J Ku\u017anicki","year":"1992","unstructured":"Ku\u017anicki, J., Kordowska, J., Puzianowska, M. & Wo\u017aniewicz, B. M. Calcyclin as a marker of human epithelial cells and fibroblasts. Exp. Cell Res. 200, 425\u2013430 (1992).","journal-title":"Exp. Cell Res."},{"key":"10155_CR13","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1111\/liv.12151","volume":"33","author":"J Tani","year":"2013","unstructured":"Tani, J. et al. Ca(2+) \/S100 proteins regulate HCV virus NS5A-FKBP8\/FKBP38 interaction and HCV virus RNA replication. Liver Int 33, 1008\u20131018 (2013).","journal-title":"Liver Int"},{"key":"10155_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103525","volume":"70","author":"A Biji","year":"2021","unstructured":"Biji, A. et al. Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. EBioMedicine 70, 103525 (2021).","journal-title":"EBioMedicine"},{"key":"10155_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/0960327111417266","volume":"31","author":"KS Jin","year":"2012","unstructured":"Jin, K. S., Park, C. M. & Lee, Y.-W. Identification of differentially expressed genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human bronchial epithelial cells. Hum. Exp. Toxicol. 31, 107\u2013112 (2012).","journal-title":"Hum. Exp. Toxicol."},{"key":"10155_CR16","doi-asserted-by":"publisher","unstructured":"Le\u015bniak, W. & Filipek, A. S100A6 protein-expression and function in norm and pathology. Int. J. Mol. Sci. 24, https:\/\/doi.org\/10.3390\/ijms24021341 (2023).","DOI":"10.3390\/ijms24021341"},{"key":"10155_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216709","volume":"587","author":"T Chen","year":"2024","unstructured":"Chen, T. et al. S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE\/NF-kB\/VEGF-D pathway. Cancer Lett. 587, 216709 (2024).","journal-title":"Cancer Lett."},{"key":"10155_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103514","volume":"24","author":"L-J Zhou","year":"2021","unstructured":"Zhou, L.-J. et al. Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity. iScience 24, 103514 (2021).","journal-title":"iScience"},{"key":"10155_CR19","doi-asserted-by":"publisher","first-page":"31593","DOI":"10.1074\/jbc.274.44.31593","volume":"274","author":"TB Stradal","year":"1999","unstructured":"Stradal, T. B. & Gimona, M. Ca(2+)-dependent association of S100A6 (Calcyclin) with the plasma membrane and the nuclear envelope. J. Biol. Chem. 274, 31593\u201331596 (1999).","journal-title":"J. Biol. Chem."},{"key":"10155_CR20","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1242\/jcs.00683","volume":"116","author":"RE Molestina","year":"2003","unstructured":"Molestina, R. E., Payne, T. M., Coppens, I. & Sinai, A. P. Activation of NF-kappaB by Toxoplasma gondii correlates with increased expression of antiapoptotic genes and localization of phosphorylated IkappaB to the parasitophorous vacuole membrane. J. Cell Sci. 116, 4359\u20134371 (2003).","journal-title":"J. Cell Sci."},{"key":"10155_CR21","doi-asserted-by":"publisher","first-page":"30174","DOI":"10.1074\/jbc.M805318200","volume":"283","author":"JN Tsoporis","year":"2008","unstructured":"Tsoporis, J. N., Izhar, S. & Parker, T. G. Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha. J. Biol. Chem. 283, 30174\u201330183 (2008).","journal-title":"J. Biol. Chem."},{"key":"10155_CR22","doi-asserted-by":"publisher","first-page":"D433","DOI":"10.1093\/nar\/gki005","volume":"33","author":"C von Mering","year":"2005","unstructured":"von Mering, C. et al. STRING: known and predicted protein-protein associations, integrated and transferred across organisms. Nucleic Acids Res. 33, D433\u2013D437 (2005).","journal-title":"Nucleic Acids Res."},{"key":"10155_CR23","doi-asserted-by":"publisher","unstructured":"Bandaru, S., Ala, C., Zhou, A.-X. & Aky\u00fcrek, L. M. Filamin a regulates cardiovascular remodeling. Int. J. Mol. Sci. 22, https:\/\/doi.org\/10.3390\/ijms22126555 (2021).","DOI":"10.3390\/ijms22126555"},{"key":"10155_CR24","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1126\/science.adq8191","volume":"386","author":"J Liu","year":"2024","unstructured":"Liu, J. et al. The complete telomere-to-telomere sequence of a mouse genome. Science 386, 1141\u20131146 (2024).","journal-title":"Science"},{"key":"10155_CR25","doi-asserted-by":"publisher","unstructured":"Huang, Y.-C. et al. Single-cell transcriptomic profiles of lung pre-metastatic niche reveal neutrophil and lymphatic endothelial cell roles in breast cancer. Cancers 15, https:\/\/doi.org\/10.3390\/cancers15010176 (2022).","DOI":"10.3390\/cancers15010176"},{"key":"10155_CR26","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/(SICI)1096-9861(19990208)404:2<235::AID-CNE8>3.0.CO;2-7","volume":"404","author":"N Yamashita","year":"1999","unstructured":"Yamashita, N., Ilg, E. C., Sch\u00e4fer, B. W., Heizmann, C. W. & Kosaka, T. Distribution of a specific calcium-binding protein of the S100 protein family, S100A6 (calcyclin), in subpopulations of neurons and glial cells of the adult rat nervous system. J. Comp. Neurol. 404, 235\u2013257 (1999).","journal-title":"J. Comp. Neurol."},{"key":"10155_CR27","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1007\/s00018-017-2526-9","volume":"74","author":"R Donato","year":"2017","unstructured":"Donato, R., Sorci, G. & Giambanco, I. S100A6 protein: functional roles. Cell Mol. Life Sci. 74, 2749\u20132760 (2017).","journal-title":"Cell Mol. Life Sci."},{"key":"10155_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-68","volume":"13","author":"Y Wang","year":"2012","unstructured":"Wang, Y. et al. Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis. BMC Genom. 13, 68 (2012).","journal-title":"BMC Genom."},{"key":"10155_CR29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s13353-014-0260-7","volume":"56","author":"X Zhou","year":"2015","unstructured":"Zhou, X. et al. Molecular characterization of the porcine S100A6 gene and analysis of its expression in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). J. Appl. Genet. 56, 355\u2013363 (2015).","journal-title":"J. Appl. Genet."},{"key":"10155_CR30","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1038\/sj.jid.5700879","volume":"127","author":"W Le\u015bniak","year":"2007","unstructured":"Le\u015bniak, W., S\u0142omnicki, P. & Ku\u017anicki, J. Epigenetic control of the S100A6 (calcyclin) gene expression. J. Investig. Dermatol. 127, 2307\u20132314 (2007).","journal-title":"J. Investig. Dermatol."},{"key":"10155_CR31","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00281-020-00779-z","volume":"42","author":"M Villares","year":"2020","unstructured":"Villares, M., Berthelet, J. & Weitzman, J. B. The clever strategies used by intracellular parasites to hijack host gene expression. Semin. Immunopathol. 42, 215\u2013226 (2020).","journal-title":"Semin. Immunopathol."},{"key":"10155_CR32","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2016.06.006","volume":"20","author":"P Olias","year":"2016","unstructured":"Olias, P., Etheridge, R. D., Zhang, Y., Holtzman, M. J. & Sibley, L. D. Toxoplasma effector recruits the Mi-2\/NuRD complex to repress STAT1 transcription and block IFN-\u03b3-dependent gene expression. Cell Host Microbe 20, 72\u201382 (2016).","journal-title":"Cell Host Microbe"},{"key":"10155_CR33","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S0969-2126(02)00740-2","volume":"10","author":"LR Otterbein","year":"2002","unstructured":"Otterbein, L. R., Kordowska, J., Witte-Hoffmann, C., Wang, C. L. A. & Dominguez, R. Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. Structure 10, 557\u2013567 (2002).","journal-title":"Structure"},{"key":"10155_CR34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s004180050381","volume":"111","author":"A Mueller","year":"1999","unstructured":"Mueller, A., B\u00e4chi, T., H\u00f6chli, M., Sch\u00e4fer, B. W. & Heizmann, C. W. Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation. Histochem Cell Biol. 111, 453\u2013459 (1999).","journal-title":"Histochem Cell Biol."},{"key":"10155_CR35","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fcimb.2019.00061","volume":"9","author":"AK Bhandage","year":"2019","unstructured":"Bhandage, A. K. & Barragan, A. Calling in the CaValry-Toxoplasma gondii hijacks GABAergic signaling and voltage-dependent calcium channel signaling for trojan horse-mediated dissemination. Front Cell Infect. Microbiol 9, 61 (2019).","journal-title":"Front Cell Infect. Microbiol"},{"key":"10155_CR36","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","volume":"30","author":"P Viatour","year":"2005","unstructured":"Viatour, P., Merville, M.-P., Bours, V. & Chariot, A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci. 30, 43\u201352 (2005).","journal-title":"Trends Biochem Sci."},{"key":"10155_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1417502","volume":"12","author":"X Sun","year":"2024","unstructured":"Sun, X. et al. Post-translational modifications of p65: state of the art. Front. Cell Dev. Biol. 12, 1417502 (2024).","journal-title":"Front. Cell Dev. Biol."},{"key":"10155_CR38","doi-asserted-by":"publisher","first-page":"e1007923","DOI":"10.1371\/journal.ppat.1007923","volume":"15","author":"WJ Pandori","year":"2019","unstructured":"Pandori, W. J. et al. Toxoplasma gondii activates a Syk-CARD9-NF-\u03baB signaling axis and gasdermin D-independent release of IL-1\u03b2 during infection of primary human monocytes. PLoS Pathog. 15, e1007923 (2019).","journal-title":"PLoS Pathog."},{"key":"10155_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2245496","volume":"2021","author":"K Yan","year":"2021","unstructured":"Yan, K. et al. Inhibitory effects of inonotus obliquus polysaccharide on inflammatory response in Toxoplasma gondii-infected RAW264.7 macrophages. Evid. Based Complement Altern. Med. 2021, 2245496 (2021).","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10155_CR40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cyto.2016.08.035","volume":"101","author":"E Varfolomeev","year":"2018","unstructured":"Varfolomeev, E. & Vucic, D. Intracellular regulation of TNF activity in health and disease. Cytokine 101, 26\u201332 (2018).","journal-title":"Cytokine"},{"key":"10155_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2011.37","volume":"1","author":"H Tamai","year":"2011","unstructured":"Tamai, H. et al. Resistance of MLL-AFF1-positive acute lymphoblastic leukemia to tumor necrosis factor-alpha is mediated by S100A6 upregulation. Blood Cancer J. 1, e38 (2011).","journal-title":"Blood Cancer J."},{"key":"10155_CR42","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4161\/cam.5.2.14401","volume":"5","author":"F Nakamura","year":"2011","unstructured":"Nakamura, F., Stossel, T. P. & Hartwig, J. H. The filamins: organizers of cell structure and function. Cell Adh Migr. 5, 160\u2013169 (2011).","journal-title":"Cell Adh Migr."},{"key":"10155_CR43","doi-asserted-by":"publisher","first-page":"e568","DOI":"10.1111\/j.1365-2893.2011.01487.x","volume":"18","author":"S Ghosh","year":"2011","unstructured":"Ghosh, S. et al. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J. Viral Hepat. 18, e568\u2013e577 (2011).","journal-title":"J. Viral Hepat."},{"key":"10155_CR44","doi-asserted-by":"publisher","first-page":"e1011595","DOI":"10.1371\/journal.ppat.1011595","volume":"19","author":"A Shepley-McTaggart","year":"2023","unstructured":"Shepley-McTaggart, A. et al. Contrasting effects of filamin A and B proteins in modulating filovirus entry. PLoS Pathog. 19, e1011595 (2023).","journal-title":"PLoS Pathog."},{"key":"10155_CR45","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.1074\/jbc.M115.708123","volume":"291","author":"D Dotson","year":"2016","unstructured":"Dotson, D. et al. Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression. J. Biol. Chem. 291, 4236\u20134246 (2016).","journal-title":"J. Biol. Chem."},{"key":"10155_CR46","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1574-6976.2010.00215.x","volume":"34","author":"HM Elsheikha","year":"2010","unstructured":"Elsheikha, H. M. & Khan, N. A. Protozoa traversal of the blood-brain barrier to invade the central nervous system. FEMS Microbiol Rev. 34, 532\u2013553 (2010).","journal-title":"FEMS Microbiol Rev."},{"key":"10155_CR47","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3389\/fgene.2019.01188","volume":"10","author":"M-H Tsai","year":"2019","unstructured":"Tsai, M.-H. et al. S100A6 Promotes B Lymphocyte Penetration Through the Blood-Brain Barrier in Autoimmune Encephalitis. Front Genet 10, 1188 (2019).","journal-title":"Front Genet"},{"key":"10155_CR48","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ijpara.2020.11.010","volume":"51","author":"MM Maia","year":"2021","unstructured":"Maia, M. M. et al. Immunization with extracellular vesicles excreted by Toxoplasma gondii confers protection in murine infection, activating cellular and humoral responses. Int J. Parasitol. 51, 559\u2013569 (2021).","journal-title":"Int J. Parasitol."},{"key":"10155_CR49","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/mmi.14634","volume":"115","author":"L Augusto","year":"2021","unstructured":"Augusto, L., Wek, R. C. & Sullivan, W. J. Host sensing and signal transduction during Toxoplasma stage conversion. Mol. Microbiol. 115, 839\u2013848 (2021).","journal-title":"Mol. Microbiol."},{"key":"10155_CR50","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1590\/S0074-02762009000200005","volume":"104","author":"WJ Sullivan","year":"2009","unstructured":"Sullivan, W. J., Smith, A. T. & Joyce, B. R. Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review. Mem. Inst. Oswaldo Cruz 104, 155\u2013161 (2009).","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10155_CR51","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1084\/jem.20082826","volume":"206","author":"A Bougdour","year":"2009","unstructured":"Bougdour, A. et al. Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites. J. Exp. Med. 206, 953\u2013966 (2009).","journal-title":"J. Exp. Med."},{"key":"10155_CR52","doi-asserted-by":"publisher","first-page":"e1001232","DOI":"10.1371\/journal.ppat.1001232","volume":"6","author":"A Naguleswaran","year":"2010","unstructured":"Naguleswaran, A. et al. Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes. PLoS Pathog. 6, e1001232 (2010).","journal-title":"PLoS Pathog."},{"key":"10155_CR53","doi-asserted-by":"publisher","unstructured":"Waldman, B. S. et al. Identification of a master regulator of differentiation in Toxoplasma. Cell 180, https:\/\/doi.org\/10.1016\/j.cell.2019.12.013 (2020).","DOI":"10.1016\/j.cell.2019.12.013"},{"key":"10155_CR54","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0020-7519(98)00035-6","volume":"28","author":"SK Halonen","year":"1998","unstructured":"Halonen, S. K., Weiss, L. M. & Chiu, F. C. Association of host cell intermediate filaments with Toxoplasma gondii cysts in murine astrocytes in vitro. Int. J. Parasitol. 28, 815\u2013823 (1998).","journal-title":"Int. J. Parasitol."},{"key":"10155_CR55","doi-asserted-by":"publisher","unstructured":"Kannan, G., Thaprawat, P., Schultz, T. L. & Carruthers, V. B. Acquisition of host cytosolic protein by Toxoplasma gondii bradyzoites. mSphere 6, https:\/\/doi.org\/10.1128\/mSphere.00934-20 (2021).","DOI":"10.1128\/mSphere.00934-20"},{"key":"10155_CR56","doi-asserted-by":"publisher","first-page":"4896","DOI":"10.1091\/mbc.e03-06-0387","volume":"14","author":"N Zobiack","year":"2003","unstructured":"Zobiack, N., Rescher, U., Ludwig, C., Zeuschner, D. & Gerke, V. The annexin 2\/S100A10 complex controls the distribution of transferrin receptor-containing recycling endosomes. Mol. Biol. Cell 14, 4896\u20134908 (2003).","journal-title":"Mol. Biol. Cell"},{"key":"10155_CR57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4049\/jimmunol.1303284","volume":"193","author":"E Cekanaviciute","year":"2014","unstructured":"Cekanaviciute, E. et al. Astrocytic TGF-\u03b2 signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J. Immunol. 193, 139\u2013149 (2014).","journal-title":"J. Immunol."},{"key":"10155_CR58","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41579-021-00518-7","volume":"19","author":"SK Matta","year":"2021","unstructured":"Matta, S. K., Rinkenberger, N., Dunay, I. R. & Sibley, L. D. Toxoplasma gondii infection and its implications within the central nervous system. Nat. Rev. Microbiol 19, 467\u2013480 (2021).","journal-title":"Nat. Rev. Microbiol"},{"key":"10155_CR59","doi-asserted-by":"publisher","first-page":"726","DOI":"10.7150\/thno.100638","volume":"15","author":"B C\u00f3mitre-Mariano","year":"2025","unstructured":"C\u00f3mitre-Mariano, B. et al. S100A proteins show a spatial distribution of inflammation associated with the glioblastoma microenvironment architecture. Theranostics 15, 726\u2013744 (2025).","journal-title":"Theranostics"},{"key":"10155_CR60","doi-asserted-by":"publisher","unstructured":"Yamada, J. & Jinno, S. S100A6 (calcyclin) is a novel marker of neural stem cells and astrocyte precursors in the subgranular zone of the adult mouse hippocampus. Hippocampus 24, https:\/\/doi.org\/10.1002\/hipo.22207 (2014).","DOI":"10.1002\/hipo.22207"},{"key":"10155_CR61","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s10753-022-01750-w","volume":"46","author":"H Tong","year":"2022","unstructured":"Tong, H. et al. S100A6 activates Kupffer cells via the p-P38 and p-JNK pathways to induce inflammation, mononuclear\/macrophage infiltration sterile liver injury in mice. Inflammation 46, 534\u2013554 (2022).","journal-title":"Inflammation"},{"key":"10155_CR62","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.ijpara.2006.03.003","volume":"36","author":"C Su","year":"2006","unstructured":"Su, C., Zhang, X. & Dubey, J. P. Genotyping of Toxoplasma gondii by multilocus PCR-RFLP markers: a high resolution and simple method for identification of parasites. Int. J. Parasitol. 36, 841\u2013848 (2006).","journal-title":"Int. J. Parasitol."},{"key":"10155_CR63","doi-asserted-by":"publisher","unstructured":"Long, S., Brown, K. M. & Sibley, L. D. CRISPR-mediated tagging with bira allows proximity labeling in Toxoplasma gondii. Bio Protoc 8, https:\/\/doi.org\/10.21769\/BioProtoc.2768 (2018).","DOI":"10.21769\/BioProtoc.2768"},{"key":"10155_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1173379","volume":"14","author":"M Chen","year":"2023","unstructured":"Chen, M. et al. Toxoplasma gondii gra5 deletion mutant protects hosts against Toxoplasma gondii infection and breast tumors. Front. Immunol. 14, 1173379 (2023).","journal-title":"Front. Immunol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10155-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10155-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10155-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:02:38Z","timestamp":1783681358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10155-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10155"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10155-6","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"22 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"930"}}