{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:03:54Z","timestamp":1784077434509,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10202-2","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:13:50Z","timestamp":1778210030000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3140-2665","authenticated-orcid":false,"given":"Yang","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunwang","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4734-8114","authenticated-orcid":false,"given":"Shengwei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-021X","authenticated-orcid":false,"given":"Jianguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4959-1266","authenticated-orcid":false,"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"10202_CR1","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1007\/s00134-024-07694-z","volume":"50","author":"I Martin-Loeches","year":"2024","unstructured":"Martin-Loeches, I., Singer, M. & Leone, M. Sepsis: key insights, future directions, and immediate goals. A review and expert opinion. Intensive Care Med. 50, 2043\u20132049 (2024).","journal-title":"Intensive Care Med."},{"key":"10202_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41590-023-01660-5","volume":"25","author":"EJ Giamarellos-Bourboulis","year":"2024","unstructured":"Giamarellos-Bourboulis, E. J. et al. The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nat. Immunol. 25, 19\u201328 (2024).","journal-title":"Nat. Immunol."},{"key":"10202_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S2213-2600(21)00157-0","volume":"10","author":"JR Beitler","year":"2022","unstructured":"Beitler, J. R. et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir. Med. 10, 107\u2013120 (2022).","journal-title":"Lancet Respir. Med."},{"key":"10202_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1146\/annurev-med-043021-014005","volume":"74","author":"P Sinha","year":"2023","unstructured":"Sinha, P., Meyer, N. J. & Calfee, C. S. Biological phenotyping in sepsis and acute respiratory distress syndrome. Annu. Rev. Med. 74, 457\u2013471 (2023).","journal-title":"Annu. Rev. Med."},{"key":"10202_CR5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s42003-024-06197-3","volume":"7","author":"Y Fujita","year":"2024","unstructured":"Fujita, Y. et al. Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling. Commun. Biol. 7, 514 (2024).","journal-title":"Commun. Biol."},{"key":"10202_CR6","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.1073\/pnas.1215432110","volume":"110","author":"H Yoshida","year":"2013","unstructured":"Yoshida, H. et al. KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization. Proc. Natl. Acad. Sci. USA 110, 5612\u20135617 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10202_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1222425","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu, Y. et al. Research on the biological mechanism and potential application of CEMIP. Front. Immunol. 14, 1222425 (2023).","journal-title":"Front. Immunol."},{"key":"10202_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112504","volume":"146","author":"Y Chen","year":"2022","unstructured":"Chen, Y. et al. The role of CEMIP in tumors: an update based on cellular and molecular insights. Biomedi. Pharmacother. 146, 112504 (2022).","journal-title":"Biomedi. Pharmacother."},{"key":"10202_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111507","volume":"138","author":"J Liu","year":"2021","unstructured":"Liu, J., Yan, W., Han, P. & Tian, D. The emerging role of KIAA1199 in cancer development and therapy. Biomed. Pharmacother. 138, 111507 (2021).","journal-title":"Biomed. Pharmacother."},{"key":"10202_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6232","volume":"5","author":"K Shostak","year":"2014","unstructured":"Shostak, K. et al. NF-\u03baB-induced KIAA1199 promotes survival through EGFR signalling. Nat. Commun. 5, 5232 (2014).","journal-title":"Nat. Commun."},{"key":"10202_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/s41419-019-1377-8","volume":"10","author":"C Deroyer","year":"2019","unstructured":"Deroyer, C. et al. CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes. Cell Death Dis. 10, 103 (2019).","journal-title":"Cell Death Dis."},{"key":"10202_CR12","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s00018-022-04282-6","volume":"79","author":"C Deroyer","year":"2022","unstructured":"Deroyer, C. et al. CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane. Cell. Mol. Life Sci. 79, 260 (2022).","journal-title":"Cell. Mol. Life Sci."},{"key":"10202_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41419-021-03393-5","volume":"12","author":"W Zhang","year":"2021","unstructured":"Zhang, W. et al. Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner. Cell Death Dis. 12, 102 (2021).","journal-title":"Cell Death Dis."},{"key":"10202_CR14","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13075-015-0637-y","volume":"17","author":"X Yang","year":"2015","unstructured":"Yang, X. et al. KIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis. Arthritis Res. Ther. 17, 140 (2015).","journal-title":"Arthritis Res. Ther."},{"key":"10202_CR15","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1093\/glycob\/cwy064","volume":"28","author":"M Marella","year":"2018","unstructured":"Marella, M. et al. KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions. Glycobiology 28, 958\u2013967 (2018).","journal-title":"Glycobiology"},{"key":"10202_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.celrep.2019.12.001","volume":"30","author":"T Dokoshi","year":"2020","unstructured":"Dokoshi, T. et al. Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection. Cell Rep. 30, 61\u201368.e64 (2020).","journal-title":"Cell Rep."},{"key":"10202_CR17","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1007\/s00018-016-2418-4","volume":"74","author":"R Parente","year":"2017","unstructured":"Parente, R., Clark, S. J., Inforzato, A. & Day, A. J. Complement factor H in host defense and immune evasion. Cell. Mol. Life Sci. 74, 1605\u20131624 (2017).","journal-title":"Cell. Mol. Life Sci."},{"key":"10202_CR18","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1007\/s00134-024-07611-4","volume":"50","author":"E Azoulay","year":"2024","unstructured":"Azoulay, E. et al. Complement system activation: bridging physiology, pathophysiology, and therapy. Intensive Care Med. 50, 1791\u20131803 (2024).","journal-title":"Intensive Care Med."},{"key":"10202_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.418","volume":"4","author":"W Zhang","year":"2023","unstructured":"Zhang, W. et al. The pathogenesis and potential therapeutic targets in sepsis. MedComm 4, e418 (2023).","journal-title":"MedComm"},{"key":"10202_CR20","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.semcdb.2017.12.018","volume":"85","author":"M J\u00f3zsi","year":"2019","unstructured":"J\u00f3zsi, M., Schneider, A. E., K\u00e1rp\u00e1ti, \u00c9 & S\u00e1ndor, N. Complement factor H family proteins in their non-canonical role as modulators of cellular functions. Semin. Cell Dev. Biol. 85, 122\u2013131 (2019).","journal-title":"Semin. Cell Dev. Biol."},{"key":"10202_CR21","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1158\/2326-6066.CIR-20-0787","volume":"9","author":"MV Daugan","year":"2021","unstructured":"Daugan, M. V. et al. Intracellular factor H drives tumor progression independently of the complement cascade. Cancer Immunol. Res. 9, 909\u2013925 (2021).","journal-title":"Cancer Immunol. Res."},{"key":"10202_CR22","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.kint.2021.05.033","volume":"100","author":"S Mahajan","year":"2021","unstructured":"Mahajan, S. et al. Local complement factor H protects kidney endothelial cell structure and function. Kidney Int. 100, 824\u2013836 (2021).","journal-title":"Kidney Int."},{"key":"10202_CR23","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1038\/s41401-024-01342-4","volume":"45","author":"XJ Shen","year":"2024","unstructured":"Shen, X. J. et al. Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module. Acta Pharmacol. Sin. 45, 2657\u20132671 (2024).","journal-title":"Acta Pharmacol. Sin."},{"key":"10202_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41419-023-05644-z","volume":"14","author":"G Xu","year":"2023","unstructured":"Xu, G. et al. CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42\/MAPK pathway. Cell Death Dis. 14, 167 (2023).","journal-title":"Cell Death Dis."},{"key":"10202_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115914","volume":"169","author":"Y Jiang","year":"2023","unstructured":"Jiang, Y. et al. Pyroptosis in septic lung injury: interactions with other types of cell death. Biomed.Pharmacother. 169, 115914 (2023).","journal-title":"Biomed.Pharmacother."},{"key":"10202_CR26","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/s42003-024-07072-x","volume":"7","author":"T Gong","year":"2024","unstructured":"Gong, T. et al. Decoding the multiple functions of ZBP1 in the mechanism of sepsis-induced acute lung injury. Commun. Biol. 7, 1361 (2024).","journal-title":"Commun. Biol."},{"key":"10202_CR27","doi-asserted-by":"crossref","unstructured":"Kwapiszewska, G. et al. Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis. Eur. Respir. J. 52, 1800564 (2018).","DOI":"10.1183\/13993003.00564-2018"},{"key":"10202_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.preteyeres.2017.09.001","volume":"62","author":"CB Toomey","year":"2018","unstructured":"Toomey, C. B., Johnson, L. V. & Bowes Rickman, C. Complement factor H in AMD: bridging genetic associations and pathobiology. Prog. Retin. Eye Res. 62, 38\u201357 (2018).","journal-title":"Prog. Retin. Eye Res."},{"key":"10202_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.625","volume":"8","author":"J Shimizu","year":"2021","unstructured":"Shimizu, J. et al. Association between plasma complement factor H concentration and clinical outcomes in patients with sepsis. Acute Med. Surg. 8, e625 (2021).","journal-title":"Acute Med. Surg."},{"key":"10202_CR30","doi-asserted-by":"crossref","unstructured":"Bain, W. et al. Factor H preserves alternative complement function during ARDS, linked to improved survival. ERJ Open Res. 9, 00702-2022 (2023).","DOI":"10.1183\/23120541.00702-2022"},{"key":"10202_CR31","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/PCC.0b013e3181d900ba","volume":"11","author":"RS Agbeko","year":"2010","unstructured":"Agbeko, R. S. et al. Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children. Pediatr. Crit. Care Med. 11, 561\u2013567 (2010).","journal-title":"Pediatr. Crit. Care Med."},{"key":"10202_CR32","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00011-010-0178-4","volume":"59","author":"R Kurihara","year":"2010","unstructured":"Kurihara, R. et al. C5a promotes migration, proliferation, and vessel formation in endothelial cells. Inflamm. Res. 59, 659\u2013666 (2010).","journal-title":"Inflamm. Res."},{"key":"10202_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1100461","volume":"14","author":"Z Yang","year":"2023","unstructured":"Yang, Z., Nicholson, S. E., Cancio, T. S., Cancio, L. C. & Li, Y. Complement as a vital nexus of the pathobiological connectome for acute respiratory distress syndrome: an emerging therapeutic target. Front. Immunol. 14, 1100461 (2023).","journal-title":"Front. Immunol."},{"key":"10202_CR34","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.kint.2019.03.005","volume":"96","author":"KY Wu","year":"2019","unstructured":"Wu, K. Y. et al. The C3a\/C3aR axis mediates anti-inflammatory activity and protects against uropathogenic E coli-induced kidney injury in mice. Kidney Int. 96, 612\u2013627 (2019).","journal-title":"Kidney Int."},{"key":"10202_CR35","doi-asserted-by":"publisher","first-page":"22414","DOI":"10.1074\/jbc.M702321200","volume":"282","author":"Z Wu","year":"2007","unstructured":"Wu, Z., Lauer, T. W., Sick, A., Hackett, S. F. & Campochiaro, P. A. Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. J. Biol. Chem. 282, 22414\u201322425 (2007).","journal-title":"J. Biol. Chem."},{"key":"10202_CR36","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.molimm.2005.02.009","volume":"43","author":"KK Tim\u00e1r","year":"2006","unstructured":"Tim\u00e1r, K. K. et al. Human keratinocytes produce the complement inhibitor factor H: synthesis is regulated by interferon-gamma. Mol. Immunol. 43, 317\u2013325 (2006).","journal-title":"Mol. Immunol."},{"key":"10202_CR37","doi-asserted-by":"publisher","first-page":"31315","DOI":"10.1074\/jbc.M805371200","volume":"283","author":"WJ Lukiw","year":"2008","unstructured":"Lukiw, W. J., Zhao, Y. & Cui, J. G. An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 283, 31315\u201331322 (2008).","journal-title":"J. Biol. Chem."},{"key":"10202_CR38","doi-asserted-by":"crossref","unstructured":"Yoon, Y. H. et al. Upregulation of complement factor H by SOCS-1\/3\u207bSTAT4 in lung cancer. Cancers 11, 471 (2019).","DOI":"10.3390\/cancers11040471"},{"key":"10202_CR39","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/bjh.18377","volume":"199","author":"J Qi","year":"2022","unstructured":"Qi, J. et al. Upregulation of HIF-1\u03b1 contributes to complement activation in transplantation-associated thrombotic microangiopathy. Br. J. Haematol. 199, 603\u2013615 (2022).","journal-title":"Br. J. Haematol."},{"key":"10202_CR40","doi-asserted-by":"crossref","unstructured":"Zhang, B. et al. Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation. J. Immun. Cancer 11, e005592 (2023).","DOI":"10.1136\/jitc-2022-005592"},{"key":"10202_CR41","doi-asserted-by":"publisher","first-page":"6443","DOI":"10.1038\/s41388-021-02023-w","volume":"40","author":"Q Hua","year":"2021","unstructured":"Hua, Q. et al. CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of \u03b2-catenin. Oncogene 40, 6443\u20136455 (2021).","journal-title":"Oncogene"},{"key":"10202_CR42","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/jama.2017.21907","volume":"319","author":"E Fan","year":"2018","unstructured":"Fan, E., Brodie, D. & Slutsky, A. S. Acute respiratory distress syndrome: advances in diagnosis and treatment. Jama 319, 698\u2013710 (2018).","journal-title":"Jama"},{"key":"10202_CR43","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1001\/jama.2016.0289","volume":"315","author":"M Shankar-Hari","year":"2016","unstructured":"Shankar-Hari, M. et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 775\u2013787 (2016).","journal-title":"JAMA"},{"key":"10202_CR44","doi-asserted-by":"crossref","unstructured":"Wang, J. et al. CircRNA-Cacna1d plays a critical role in sepsis-induced lung injury by sponging miRNA-185-5p. Am. J. Respir. Cell Mol. Biol. 72, 181\u2013194 (2024).","DOI":"10.1165\/rcmb.2024-0067OC"},{"key":"10202_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115072","volume":"165","author":"H Ling","year":"2023","unstructured":"Ling, H. et al. Erythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction. Biomed. Pharmacother. 165, 115072 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"10202_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233","volume":"7","author":"B Shrum","year":"2014","unstructured":"Shrum, B. et al. A robust scoring system to evaluate sepsis severity in an animal model. BMC Res. Notes 7, 233 (2014).","journal-title":"BMC Res. Notes"},{"key":"10202_CR47","doi-asserted-by":"publisher","first-page":"e1013398","DOI":"10.1371\/journal.ppat.1013398","volume":"21","author":"TR Smallman","year":"2025","unstructured":"Smallman, T. R. et al. Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice. PLoS Pathog. 21, e1013398 (2025).","journal-title":"PLoS Pathog."},{"key":"10202_CR48","doi-asserted-by":"publisher","first-page":"e1007308","DOI":"10.1371\/journal.ppat.1007308","volume":"14","author":"L Ghimire","year":"2018","unstructured":"Ghimire, L. et al. NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function. PLoS Pathog. 14, e1007308 (2018).","journal-title":"PLoS Pathog."},{"key":"10202_CR49","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/s41586-023-06287-y","volume":"621","author":"J Major","year":"2023","unstructured":"Major, J. et al. Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature 621, 813\u2013820 (2023).","journal-title":"Nature"},{"key":"10202_CR50","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1007\/s00018-022-04628-0","volume":"79","author":"L Ning","year":"2022","unstructured":"Ning, L. et al. A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. Cell. Mol. Life Sci. 79, 610 (2022).","journal-title":"Cell. Mol. Life Sci."},{"key":"10202_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102464","volume":"112","author":"Y Du","year":"2020","unstructured":"Du, Y. et al. Pirfenidone alleviates lipopolysaccharide-induced lung injury by accentuating BAP31 regulation of ER stress and mitochondrial injury. J. Autoimmun. 112, 102464 (2020).","journal-title":"J. Autoimmun."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10202-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10202-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10202-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:03:59Z","timestamp":1784073839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10202-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10202"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10202-2","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"1 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"962"}}