{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:55:25Z","timestamp":1785293725747,"version":"3.55.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":65,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM131877"],"award-info":[{"award-number":["R35GM131877"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011929","name":"Foundation for Food and Agriculture Research","doi-asserted-by":"publisher","award":["FFAR G-20011-01"],"award-info":[{"award-number":["FFAR G-20011-01"]}],"id":[{"id":"10.13039\/100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"United States Department of Agriculture | Agricultural Research Service","doi-asserted-by":"publisher","award":["ARS 8062-22000-023-000D"],"award-info":[{"award-number":["ARS 8062-22000-023-000D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"United States Department of Agriculture | Agricultural Research Service","doi-asserted-by":"publisher","award":["AFRI 2011- 68004- 30154"],"award-info":[{"award-number":["AFRI 2011- 68004- 30154"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["271511104"],"award-info":[{"award-number":["271511104"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Plants sense a diverse array of small molecules and macromolecules derived from their natural environment, including diverse microbe-associated molecular patterns (MAMPs) that can trigger defense responses. Several MAMPs have been shown to prime plants for enhanced defense, providing extended protection against pathogens with minimal fitness costs. However, the extent to which conserved small molecule signatures of other phyla contribute to priming of plant defenses is unclear. Here, we demonstrate that exposure of seeds or plants to the ascaroside ascr#18, a pheromone secreted by plant-parasitic and free-living soil nematodes, primes immune genes for enhanced expression upon pathogen challenge, thereby increasing resistance to diverse microbial pathogens. We further show that ascr#18-induced priming is associated with the formation of open chromatin in the regulatory regions of defense genes. Defense priming and disease protection by ascr#18 is compromised in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    mutants defective in the receptor of ascr#18, the leucine-rich repeat receptor-like kinase NILR1. Defense priming by ascr#18 is retained under field conditions, demonstrating potential of ascaroside treatment as a crop protection strategy to reduce pesticide usage. Our findings provide insight into the molecular basis of defense priming by ascr#18 and demonstrate how evolutionarily conserved small molecule signatures of plant-associated macrobiota modulate immunity.\n                  <\/jats:p>","DOI":"10.1038\/s42003-026-10211-1","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:28:28Z","timestamp":1778027308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The conserved nematode pheromone ascr#18 primes plant immunity"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-0369","authenticated-orcid":false,"given":"Murli","family":"Manohar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-5248","authenticated-orcid":false,"given":"Andrea","family":"Sistenich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoashuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shine","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3869-2228","authenticated-orcid":false,"given":"Wim","family":"Dejonghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-1193","authenticated-orcid":false,"given":"Sophie","family":"Levecque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-6521","authenticated-orcid":false,"given":"Patricia M.","family":"Manosalva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-4397","authenticated-orcid":false,"given":"Jan E.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aardra","family":"Kachroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-003X","authenticated-orcid":false,"given":"Karl-Heinz","family":"Kogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-1943","authenticated-orcid":false,"given":"Uwe","family":"Conrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-0237","authenticated-orcid":false,"given":"Frank C.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-5920","authenticated-orcid":false,"given":"Daniel F.","family":"Klessig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"10211_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-phyto-080614-120132","volume":"53","author":"U Conrath","year":"2015","unstructured":"Conrath, U., Beckers, G. J., Langenbach, C. J. & Jaskiewicz, M. R. Priming for enhanced defense. Annu. Rev. Phytopathol. 53, 97\u2013119 (2015).","journal-title":"Annu. Rev. Phytopathol."},{"key":"10211_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1146577","volume":"14","author":"M H\u00f6nig","year":"2023","unstructured":"H\u00f6nig, M., Roeber, V. M., Schm\u00fclling, T. & Cortleven, A. Chemical priming of plant defense responses to pathogen attacks. Front. Plant Sci. 14, 1146577 (2023).","journal-title":"Front. Plant Sci."},{"key":"10211_CR3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.chom.2012.06.006","volume":"12","author":"J Quintin","year":"2012","unstructured":"Quintin, J. et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe 12, 223\u2013232 (2012).","journal-title":"Cell Host Microbe"},{"key":"10211_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.coi.2007.11.003","volume":"20","author":"C Zipfel","year":"2008","unstructured":"Zipfel, C. Pattern-recognition receptors in plant innate immunity. Curr. Opin. Immunol. 20, 10\u201316 (2008).","journal-title":"Curr. Opin. Immunol."},{"key":"10211_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-phyto-080614-120106","volume":"55","author":"F Boutrot","year":"2017","unstructured":"Boutrot, F. & Zipfel, C. Function, discovery, and exploitation of plant pattern recognition receptors for broad-spectrum disease resistance. Annu. Rev. Phytopathol. 55, 257\u2013286 (2017).","journal-title":"Annu. Rev. Phytopathol."},{"key":"10211_CR6","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1104\/pp.107.113027","volume":"146","author":"CJ Frost","year":"2008","unstructured":"Frost, C. J., Mescher, M. C., Carlson, J. E. & De Moraes, C. M. Plant defense priming against herbivores: getting ready for a different battle. Plant Physiol. 146, 818\u2013824 (2008).","journal-title":"Plant Physiol."},{"key":"10211_CR7","doi-asserted-by":"crossref","unstructured":"Abdul Malik, N. A., Kumar, I. S. & Nadarajah, K. Elicitor and receptor molecules: orchestrators of plant defense and immunity. Int. J. Mol. Sci. 21, 963 (2020).","DOI":"10.3390\/ijms21030963"},{"key":"10211_CR8","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1073\/pnas.84.15.5202","volume":"84","author":"JR Ecker","year":"1987","unstructured":"Ecker, J. R. & Davis, R. W. Plant defense genes are regulated by ethylene. Proc. Natl. Acad. Sci. USA 84, 5202\u20135206 (1987).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10211_CR9","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/tpj.13388","volume":"89","author":"C Yang","year":"2017","unstructured":"Yang, C. et al. Activation of ethylene signaling pathways enhances disease resistance by regulating ROS and phytoalexin production in rice. Plant J. 89, 338\u2013353 (2017).","journal-title":"Plant J."},{"key":"10211_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1217771","volume":"14","author":"M L\u00f6we","year":"2023","unstructured":"L\u00f6we, M. et al. N-hydroxypipecolic acid primes plants for enhanced microbial pattern-induced responses. Front. Plant Sci. 14, 1217771 (2023).","journal-title":"Front. Plant Sci."},{"key":"10211_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42629-0","volume":"14","author":"Q Li","year":"2023","unstructured":"Li, Q. et al. N-hydroxypipecolic acid triggers systemic acquired resistance through extracellular NAD(P). Nat. Commun. 14, 6848 (2023).","journal-title":"Nat. Commun."},{"key":"10211_CR12","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1093\/aob\/mcm079","volume":"100","author":"C Wasternack","year":"2007","unstructured":"Wasternack, C. Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development. Ann. Bot. 100, 681\u2013697 (2007).","journal-title":"Ann. Bot."},{"key":"10211_CR13","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1093\/mp\/ssu049","volume":"7","author":"B Huot","year":"2014","unstructured":"Huot, B., Yao, J., Montgomery, B. L. & He, S. Y. Growth-defense tradeoffs in plants: a balancing act to optimize fitness. Mol. Plant 7, 1267\u20131287 (2014).","journal-title":"Mol. Plant"},{"key":"10211_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.pmpp.2016.02.004","volume":"95","author":"DJ Kliebenstein","year":"2016","unstructured":"Kliebenstein, D. J. False idolatry of the mythical growth versus immunity tradeoff in molecular systems plant pathology. Physiol. Mol. Plant Pathol. 95, 55\u201359 (2016).","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"10211_CR15","doi-asserted-by":"publisher","first-page":"12920","DOI":"10.1073\/pnas.230416897","volume":"97","author":"L Zimmerli","year":"2000","unstructured":"Zimmerli, L., Jakab, G., M\u00e9traux, J.-P. & Mauch-Mani, B. Potentiation of pathogen-specific defense mechanisms in Arabidopsis by \u03b2-aminobutyric acid. Proc. Natl. Acad. Sci. USA 97, 12920\u201312925 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10211_CR16","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1094\/MPMI-19-1062","volume":"19","author":"U Conrath","year":"2006","unstructured":"Conrath, U. et al. Priming: getting ready for battle. Mol. Plant Microbe Interact. 19, 1062\u20131071 (2006).","journal-title":"Mol. Plant Microbe Interact."},{"key":"10211_CR17","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1146\/annurev.arplant.57.032905.105346","volume":"60","author":"T Boller","year":"2009","unstructured":"Boller, T. & Felix, G. A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors. Annu. Rev. Plant Biol. 60, 379\u2013406 (2009).","journal-title":"Annu. Rev. Plant Biol."},{"key":"10211_CR18","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.tplants.2016.07.009","volume":"21","author":"A Martinez-Medina","year":"2016","unstructured":"Martinez-Medina, A. et al. Recognizing plant defense priming. Trends Plant Sci. 21, 818\u2013822 (2016).","journal-title":"Trends Plant Sci."},{"key":"10211_CR19","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.1073\/pnas.0510213103","volume":"103","author":"M van Hulten","year":"2006","unstructured":"van Hulten, M., Pelser, M., van Loon, L. C., Pieterse, C. M. & Ton, J. Costs and benefits of priming for defense in Arabidopsis. Proc. Natl. Acad. Sci. USA 103, 5602\u20135607 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10211_CR20","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1104\/pp.19.00673","volume":"181","author":"S Baum","year":"2019","unstructured":"Baum, S. et al. Isolation of open chromatin identifies regulators of systemic acquired resistance. Plant Physiol. 181, 817\u2013833 (2019).","journal-title":"Plant Physiol."},{"key":"10211_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.pbi.2007.06.002","volume":"10","author":"GJ Beckers","year":"2007","unstructured":"Beckers, G. J. & Conrath, U. Priming for stress resistance: from the lab to the field. Curr. Opin. Plant Biol. 10, 425\u2013431 (2007).","journal-title":"Curr. Opin. Plant Biol."},{"key":"10211_CR22","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1104\/pp.17.00124","volume":"176","author":"B Schillheim","year":"2018","unstructured":"Schillheim, B. et al. Sulforaphane modifies histone H3, unpacks chromatin, and primes defense. Plant Physiol. 176, 2395\u20132405 (2018).","journal-title":"Plant Physiol."},{"key":"10211_CR23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/embor.2010.186","volume":"12","author":"M Jaskiewicz","year":"2011","unstructured":"Jaskiewicz, M., Conrath, U. & Peterh\u00e4nsel, C. Chromatin modification acts as a memory for systemic acquired resistance in the plant stress response. EMBO Rep. 12, 50\u201355 (2011).","journal-title":"EMBO Rep."},{"key":"10211_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.986940","volume":"13","author":"H Kang","year":"2022","unstructured":"Kang, H., Fan, T., Wu, J., Zhu, Y. & Shen, W. H. Histone modification and chromatin remodeling in plant response to pathogens. Front. Plant Sci. 13, 986940 (2022).","journal-title":"Front. Plant Sci."},{"key":"10211_CR25","doi-asserted-by":"crossref","unstructured":"Ding, B. & Wang, G.-L. Chromatin versus pathogens: the function of epigenetics in plant immunity. Front. Plant Sci. 6, 675 (2015).","DOI":"10.3389\/fpls.2015.00675"},{"key":"10211_CR26","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41596-019-0277-9","volume":"15","author":"S Baum","year":"2020","unstructured":"Baum, S., Reimer-Michalski, E. M., Jaskiewicz, M. R. & Conrath, U. Formaldehyde-assisted isolation of regulatory DNA elements from Arabidopsis leaves. Nat. Protoc. 15, 713\u2013733 (2020).","journal-title":"Nat. Protoc."},{"key":"10211_CR27","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1101\/gad.927301","volume":"15","author":"Y Zhang","year":"2001","unstructured":"Zhang, Y. & Reinberg, D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 15, 2343\u20132360 (2001).","journal-title":"Genes Dev."},{"key":"10211_CR28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6\u201321 (2002).","journal-title":"Genes Dev."},{"key":"10211_CR29","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tplants.2014.01.014","volume":"19","author":"MY Kim","year":"2014","unstructured":"Kim, M. Y. & Zilberman, D. DNA methylation as a system of plant genomic immunity. Trends Plant Sci. 19, 320\u2013326 (2014).","journal-title":"Trends Plant Sci."},{"key":"10211_CR30","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/embo-reports\/kvf053","volume":"3","author":"A Eberharter","year":"2002","unstructured":"Eberharter, A. & Becker, P. B. Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep. 3, 224\u2013229 (2002).","journal-title":"EMBO Rep."},{"key":"10211_CR31","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1105\/tpc.114.131938","volume":"26","author":"C Tateda","year":"2014","unstructured":"Tateda, C. et al. Salicylic acid regulates Arabidopsis microbial pattern receptor kinase levels and signaling. Plant Cell 26, 4171\u20134187 (2014).","journal-title":"Plant Cell"},{"key":"10211_CR32","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/nature07168","volume":"454","author":"J Srinivasan","year":"2008","unstructured":"Srinivasan, J. et al. A blend of small molecules regulates both mating and development in Caenorhabditis elegans. Nature 454, 1115\u20131118 (2008).","journal-title":"Nature"},{"key":"10211_CR33","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1039\/C5NP00042D","volume":"32","author":"SH von Reuss","year":"2015","unstructured":"von Reuss, S. H. & Schroeder, F. C. Combinatorial chemistry in nematodes: modular assembly of primary metabolism-derived building blocks. Nat. Prod. Rep. 32, 994\u20131006 (2015).","journal-title":"Nat. Prod. Rep."},{"key":"10211_CR34","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2533\/chimia.2022.945","volume":"76","author":"RAR Machado","year":"2022","unstructured":"Machado, R. A. R. & Von Reuss, S. H. Chemical ecology of nematodes. Chimia 76, 945\u2013953 (2022).","journal-title":"Chimia"},{"key":"10211_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/jph.12795","volume":"167","author":"DF Klessig","year":"2019","unstructured":"Klessig, D. F. et al. Nematode ascaroside enhances resistance in a broad spectrum of plant\u2013pathogen systems. J. Phytopathol. 167, 265\u2013272 (2019).","journal-title":"J. Phytopathol."},{"key":"10211_CR36","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1007\/s41348-024-00950-w","volume":"131","author":"A Kamboj","year":"2024","unstructured":"Kamboj, A. et al. The nematode signaling molecule ascr#18 induces prepenetration defenses in wheat against a leaf rust fungus. J. Plant Dis. Prot. 131, 2053\u20132062 (2024).","journal-title":"J. Plant Dis. Prot."},{"key":"10211_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8795","volume":"6","author":"P Manosalva","year":"2015","unstructured":"Manosalva, P. et al. Conserved nematode signalling molecules elicit plant defenses and pathogen resistance. Nat. Commun. 6, 7795 (2015).","journal-title":"Nat. Commun."},{"key":"10211_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14104-2","volume":"11","author":"M Manohar","year":"2020","unstructured":"Manohar, M. et al. Plant metabolism of nematode pheromones mediates plant-nematode interactions. Nat. Commun. 11, 208 (2020).","journal-title":"Nat. Commun."},{"key":"10211_CR39","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.1016\/j.cub.2023.08.017","volume":"33","author":"L Huang","year":"2023","unstructured":"Huang, L. et al. NILR1 perceives a nematode ascaroside triggering immune signaling and resistance. Curr. Biol. 33, 3992\u20133997 (2023).","journal-title":"Curr. Biol."},{"key":"10211_CR40","doi-asserted-by":"crossref","unstructured":"Shinoda, K. et al. Nematode ascarosides attenuate mammalian type 2 inflammatory responses. Proc. Natl. Acad. Sci. USA 119, e2108686119 (2022).","DOI":"10.1073\/pnas.2108686119"},{"key":"10211_CR41","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-phyto-073009-114447","volume":"49","author":"A Robert-Seilaniantz","year":"2011","unstructured":"Robert-Seilaniantz, A., Grant, M. & Jones, J. D. Hormone crosstalk in plant disease and defense: more than just jasmonate-salicylate antagonism. Annu. Rev. Phytopathol. 49, 317\u2013343 (2011).","journal-title":"Annu. Rev. Phytopathol."},{"key":"10211_CR42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1046\/j.1365-313X.1998.00093.x","volume":"14","author":"O Thulke","year":"1998","unstructured":"Thulke, O. & Conrath, U. Salicylic acid has a dual role in the activation of defence-related genes in parsley. Plant J. 14, 35\u201342 (1998).","journal-title":"Plant J."},{"key":"10211_CR43","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1104\/pp.117.4.1333","volume":"117","author":"VA Katz","year":"1998","unstructured":"Katz, V. A., Thulke, O. U. & Conrath, U. A benzothiadiazole primes parsley cells for augmented elicitation of defense responses. Plant Physiol. 117, 1333\u20131339 (1998).","journal-title":"Plant Physiol."},{"key":"10211_CR44","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.4200","volume":"11","author":"K Schmitz","year":"2021","unstructured":"Schmitz, K., Werner, L. & Conrath, U. High-throughput screening for defense priming-inducing compounds in parsley cell cultures. Bio Protoc. 11, e4200 (2021).","journal-title":"Bio Protoc."},{"key":"10211_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-023-04043-y","volume":"23","author":"K Hoffmann","year":"2023","unstructured":"Hoffmann, K. et al. Spotting priming-active compounds using parsley cell cultures in microtiter plates. BMC Plant Biol. 23, 72 (2023).","journal-title":"BMC Plant Biol."},{"key":"10211_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-015-0666-3","volume":"15","author":"JV Schilling","year":"2015","unstructured":"Schilling, J. V. et al. Oxygen transfer rate identifies priming compounds in parsley cells. BMC Plant Biol. 15, 282 (2015).","journal-title":"BMC Plant Biol."},{"key":"10211_CR47","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0014-5793(02)02759-X","volume":"520","author":"V Katz","year":"2002","unstructured":"Katz, V., Fuchs, A. & Conrath, U. Pretreatment with salicylic acid primes parsley cells for enhanced ion transport following elicitation. FEBS Lett. 520, 53\u201357 (2002).","journal-title":"FEBS Lett."},{"key":"10211_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53982-5","volume":"14","author":"AJ Sistenich","year":"2024","unstructured":"Sistenich, A. J., F\u00fcrtauer, L., Scheele, F. & Conrath, U. Marker and readout genes for defense priming in Pseudomonas cannabina pv. alisalensis interaction aid understanding systemic immunity in Arabidopsis. Sci. Rep. 14, 3489 (2024).","journal-title":"Sci. Rep."},{"key":"10211_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40406-7","volume":"14","author":"Y-L Chen","year":"2023","unstructured":"Chen, Y.-L. et al. XCP1 cleaves pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis. Nat. Commun. 14, 4697 (2023).","journal-title":"Nat. Commun."},{"key":"10211_CR50","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1111\/nph.18562","volume":"237","author":"Y Wang","year":"2023","unstructured":"Wang, Y. et al. Coordinated regulation of plant defense and autoimmunity by paired trihelix transcription factors ASR3\/AITF1 in Arabidopsis. New Phytol. 237, 914\u2013929 (2023).","journal-title":"New Phytol."},{"key":"10211_CR51","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.tig.2023.07.001","volume":"39","author":"T Javed","year":"2023","unstructured":"Javed, T. & Gao, S. J. WRKY transcription factors in plant defense. Trends Genet. 39, 787\u2013801 (2023).","journal-title":"Trends Genet."},{"key":"10211_CR52","volume":"1","author":"F Katagiri","year":"2002","unstructured":"Katagiri, F., Thilmony, R. & He, S. Y. The Arabidopsis thaliana-Pseudomonas syringae interaction. Arab. Book Am. Soc. Plant Biol. 1, e0039 (2002).","journal-title":"Arab. Book Am. Soc. Plant Biol."},{"key":"10211_CR53","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/82521","volume":"26","author":"K Maleck","year":"2000","unstructured":"Maleck, K. et al. The transcriptome of Arabidopsis thaliana during systemic acquired resistance. Nat. Genet. 26, 403\u2013410 (2000).","journal-title":"Nat. Genet."},{"key":"10211_CR54","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1094\/PHYTO-98-11-1226","volume":"98","author":"MA Herman","year":"2008","unstructured":"Herman, M. A., Davidson, J. K. & Smart, C. D. Induction of plant defense gene expression by plant activators and Pseudomonas syringae pv. tomato in greenhouse-grown tomatoes. Phytopathology 98, 1226\u20131232 (2008).","journal-title":"Phytopathology"},{"key":"10211_CR55","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1042\/EBC20210082","volume":"66","author":"A Cooper","year":"2022","unstructured":"Cooper, A. & Ton, J. Immune priming in plants: from the onset to transgenerational maintenance. Essays Biochem. 66, 635\u2013646 (2022).","journal-title":"Essays Biochem."},{"key":"10211_CR56","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.envexpbot.2012.02.013","volume":"94","author":"V Pastor","year":"2013","unstructured":"Pastor, V., Luna, E., Mauch-Mani, B., Ton, J. & Flors, V. Primed plants do not forget. Environ. Exp. Bot. 94, 46\u201356 (2013).","journal-title":"Environ. Exp. Bot."},{"key":"10211_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.836326","volume":"13","author":"M Catoni","year":"2022","unstructured":"Catoni, M. et al. Long-lasting defence priming by \u03b2-aminobutyric acid in tomato is marked by genome-wide changes in DNA methylation. Front. Plant Sci. 13, 836326 (2022).","journal-title":"Front. Plant Sci."},{"key":"10211_CR58","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/j.1469-8137.2011.03987.x","volume":"193","author":"D Worrall","year":"2012","unstructured":"Worrall, D. et al. Treating seeds with activators of plant defence generates long-lasting priming of resistance to pests and pathogens. New Phytol. 193, 770\u2013778 (2012).","journal-title":"New Phytol."},{"key":"10211_CR59","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1021\/acschembio.1c00217","volume":"16","author":"Y Yu","year":"2021","unstructured":"Yu, Y. et al. Nematode signaling molecules are extensively metabolized by animals, plants, and microorganisms. ACS Chem. Biol. 16, 1050\u20131058 (2021).","journal-title":"ACS Chem. Biol."},{"key":"10211_CR60","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1046\/j.1365-313X.1999.00265.x","volume":"18","author":"G Felix","year":"1999","unstructured":"Felix, G., Duran, J. D., Volko, S. & Boller, T. Plants have a sensitive perception system for the most conserved domain of bacterial flagellin.  Plant J. 18, 265\u2013276 (1999).","journal-title":"Plant J."},{"key":"10211_CR61","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1105\/tpc.105.036574","volume":"18","author":"D Chinchilla","year":"2006","unstructured":"Chinchilla, D., Bauer, Z., Regenass, M., Boller, T. & Felix, G. The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception.  Plant Cell 18, 465\u2013476 (2006).","journal-title":"Plant Cell"},{"key":"10211_CR62","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.it.2014.05.004","volume":"35","author":"C Zipfel","year":"2014","unstructured":"Zipfel, C. Plant pattern-recognition receptors. Trends Immunol. 35, 345\u2013351 (2014).","journal-title":"Trends Immunol."},{"key":"10211_CR63","doi-asserted-by":"publisher","first-page":"e1006284","DOI":"10.1371\/journal.ppat.1006284","volume":"13","author":"B Mendy","year":"2017","unstructured":"Mendy, B. et al. Arabidopsis leucine-rich repeat receptor-like kinase NILR1 is required for induction of innate immunity to parasitic nematodes. PLoS Pathog. 13, e1006284 (2017).","journal-title":"PLoS Pathog."},{"key":"10211_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.692328","volume":"12","author":"P Zhi","year":"2021","unstructured":"Zhi, P. & Chang, C. Exploiting epigenetic variations for crop disease resistance improvement. Front. Plant Sci. 12, 692328 (2021).","journal-title":"Front. Plant Sci."},{"key":"10211_CR65","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1101\/gr.5533506","volume":"17","author":"PG Giresi","year":"2007","unstructured":"Giresi, P. G., Kim, J., McDaniell, R. M., Iyer, V. R. & Lieb, J. D. FAIRE (formaldehyde-assisted isolation of regulatory elements) isolates active regulatory elements from human chromatin. Genome Res. 17, 877\u2013885 (2007).","journal-title":"Genome Res."},{"key":"10211_CR66","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nprot.2011.444","volume":"7","author":"JM Simon","year":"2012","unstructured":"Simon, J. M., Giresi, P. G., Davis, I. J. & Lieb, J. D. Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA. Nat. Protoc. 7, 256\u2013267 (2012).","journal-title":"Nat. Protoc."},{"key":"10211_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2022.101889","volume":"121","author":"B Kumar","year":"2022","unstructured":"Kumar, B. et al. Maydis leaf blight of maize: update on status, sustainable management and genetic architecture of its resistance. Physiol. Mol. Plant Pathol. 121, 101889 (2022).","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"10211_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47611-y","volume":"15","author":"Q Hao","year":"2024","unstructured":"Hao, Q. et al. An pair of an atypical NLR encoding genes confer Asian soybean rust resistance in soybean. Nat. Commun. 15, 3310 (2024).","journal-title":"Nat. Commun."},{"key":"10211_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37551-4","volume":"14","author":"YK Gupta","year":"2023","unstructured":"Gupta, Y. K. et al. Major proliferation of transposable elements shaped the genome of the soybean rust pathogen Phakopsora pachyrhizi. Nat. Commun. 14, 1835 (2023).","journal-title":"Nat. Commun."},{"key":"10211_CR70","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11284-008-0522-0","volume":"24","author":"A Kaliszewicz","year":"2009","unstructured":"Kaliszewicz, A. & Uchma\u0144ski, J. A cross-phyla response to Daphnia chemical alarm substances by an aquatic oligochaete. Ecol. Res. 24, 461\u2013466 (2009).","journal-title":"Ecol. Res."},{"key":"10211_CR71","doi-asserted-by":"publisher","first-page":"13971","DOI":"10.1073\/pnas.95.23.13971","volume":"95","author":"PW Pare","year":"1998","unstructured":"Pare, P. W., Alborn, H. T. & Tumlinson, J. H. Concerted biosynthesis of an insect elicitor of plant volatiles. Proc. Natl. Acad. Sci. USA 95, 13971\u201313975 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10211_CR72","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fpls.2013.00139","volume":"4","author":"MA Newman","year":"2013","unstructured":"Newman, M. A., Sundelin, T., Nielsen, J. T. & Erbs, G. MAMP (microbe-associated molecular pattern) triggered immunity in plants. Front. Plant Sci. 4, 139 (2013).","journal-title":"Front. Plant Sci."},{"key":"10211_CR73","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cropro.2009.01.009","volume":"28","author":"DR Walters","year":"2009","unstructured":"Walters, D. R. Are plants in the field already induced? Implications for practical disease control. Crop Prot. 28, 459\u2013465 (2009).","journal-title":"Crop Prot."},{"key":"10211_CR74","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1094\/PDIS-03-16-0331-RE","volume":"101","author":"S Kunwar","year":"2017","unstructured":"Kunwar, S. et al. Foliar applications of acibenzolar-S-methyl negatively affect the yield of grafted tomatoes in fields infested with Ralstonia solanacearum. Plant Dis. 101, 890\u2013894 (2017).","journal-title":"Plant Dis."},{"key":"10211_CR75","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nrg2206","volume":"9","author":"S Henikoff","year":"2008","unstructured":"Henikoff, S. Nucleosome destabilization in the epigenetic regulation of gene expression. Nat. Rev. Genet. 9, 15\u201326 (2008).","journal-title":"Nat. Rev. Genet."},{"key":"10211_CR76","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1104\/pp.111.187468","volume":"158","author":"E Luna","year":"2012","unstructured":"Luna, E., Bruce, T. J. A., Roberts, M. R., Flors, V. & Ton, J. Next-generation systemic acquired resistance. Plant Physiol. 158, 844\u2013853 (2012).","journal-title":"Plant Physiol."},{"key":"10211_CR77","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1002\/dvg.22877","volume":"53","author":"TZ Berardini","year":"2015","unstructured":"Berardini, T. Z. et al. The Arabidopsis information resource: making and mining the \u201cgold standard\u201d annotated reference plant genome. Genesis 53, 474\u2013485 (2015).","journal-title":"Genesis"},{"key":"10211_CR78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2412016121","volume":"121","author":"L Huang","year":"2024","unstructured":"Huang, L. et al. A receptor for dual ligands governs plant immunity and hormone response and is targeted by a nematode effector. Proc. Natl. Acad. Sci. USA 121, e2412016121 (2024).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10211_CR79","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1105\/tpc.114.126763","volume":"26","author":"ST Schenk","year":"2014","unstructured":"Schenk, S. T. et al. N-acyl-homoserine lactone primes plants for cell wall reinforcement and induces resistance to bacterial pathogens via the salicylic acid\/oxylipin pathway. Plant Cell 26, 2708\u20132723 (2014).","journal-title":"Plant Cell"},{"key":"10211_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21307\/jofnem-2019-009","volume":"51","author":"BD Waldo","year":"2019","unstructured":"Waldo, B. D., Grabau, Z. J., Mengistu, T. M. & Crow, W. T. Nematicide effects on non-target nematodes in bermudagrass. J. Nematol. 51, 1\u201312 (2019).","journal-title":"J. Nematol."},{"key":"10211_CR81","doi-asserted-by":"crossref","unstructured":"Carpio, M. J., Garc\u00eda-Delgado, C., Mar\u00edn-Benito, J. M., S\u00e1nchez-Mart\u00edn, M. J. & Rodr\u00edguez-Cruz, M. S. Soil microbial community changes in a field treatment with chlorotoluron, flufenacet and diflufenican and two organic amendments. Agronomy 10, 1166 (2020).","DOI":"10.3390\/agronomy10081166"},{"key":"10211_CR82","doi-asserted-by":"publisher","first-page":"072007","DOI":"10.1088\/1742-6596\/1294\/7\/072007","volume":"1294","author":"MAM Al-Ani","year":"2019","unstructured":"Al-Ani, M. A. M., Hmoshi, R. M., Kanaan, I. A. & Thanoon, A. A. Effect of pesticides on soil microorganisms. J. Phys. Conf. Ser. 1294, 072007 (2019).","journal-title":"J. Phys. Conf. Ser."},{"key":"10211_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164149","volume":"888","author":"Z Yu","year":"2023","unstructured":"Yu, Z., Lu, T. & Qian, H. Pesticide interference and additional effects on plant microbiomes.  Sci. Total Environ. 888, 164149 (2023).","journal-title":"Sci. Total Environ."},{"key":"10211_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.118020","volume":"245","author":"A Jeyaseelan","year":"2024","unstructured":"Jeyaseelan, A., Murugesan, K., Thayanithi, S. & Palanisamy, S. B. A review of the impact of herbicides and insecticides on the microbial communities. Environ. Res. 245, 118020 (2024).","journal-title":"Environ. Res."},{"key":"10211_CR85","doi-asserted-by":"crossref","unstructured":"Curtis, B. J. et al. Identification of uric acid gluconucleoside-ascaroside conjugates in Caenorhabditis elegans by combining synthesis and MicroED. Org. Lett. 22, 6724\u20136728 (2020).","DOI":"10.1021\/acs.orglett.0c02038"},{"key":"10211_CR86","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0092-8674(94)90423-5","volume":"78","author":"T N\u00fcrnberger","year":"1994","unstructured":"N\u00fcrnberger, T. et al. High affinity binding of a fungal oligopeptide elicitor to parsley plasma membranes triggers multiple defense responses. Cell 78, 449\u2013460 (1994).","journal-title":"Cell"},{"key":"10211_CR87","first-page":"301","volume":"44","author":"EO King","year":"1954","unstructured":"King, E. O., Ward, M. K. & Raney, D. E. Two simple media for the demonstration of pyocyanin and fluorescin. J. Lab Clin. Med. 44, 301\u2013307 (1954).","journal-title":"J. Lab Clin. Med."},{"key":"10211_CR88","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski, P. & Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156\u2013159 (1987).","journal-title":"Anal. Biochem."},{"key":"10211_CR89","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25, 402\u2013408 (2001).","journal-title":"Methods"},{"key":"10211_CR90","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1104\/pp.109.137604","volume":"150","author":"M Tian","year":"2009","unstructured":"Tian, M. et al. Arabidopsis actin-depolymerizing factor AtADF4 mediates defense signal transduction triggered by the Pseudomonas syringae effector AvrPphB. Plant Physiol. 150, 815\u2013824 (2009).","journal-title":"Plant Physiol."},{"key":"10211_CR91","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1094\/MPMI-23-9-1151","volume":"23","author":"PM Manosalva","year":"2010","unstructured":"Manosalva, P. M. et al. Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato. Mol. Plant Microbe Interact. 23, 1151\u20131163 (2010).","journal-title":"Mol. Plant Microbe Interact."},{"key":"10211_CR92","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1094\/Phyto-73-992","volume":"73","author":"L Calvert","year":"1983","unstructured":"Calvert, L. & Ghabrial, S. Enhancement by soybean mosaic virus of bean pod mottle virus titer in doubly infected soybean. Phytopathology 73, 992\u2013997 (1983).","journal-title":"Phytopathology"},{"key":"10211_CR93","doi-asserted-by":"crossref","unstructured":"Jeffers, S. Laboratory Protocols for Phytophthora Species Protocols (ed. Jeffers, S.) 1\u20132 (The American Phytopathological Society, 2015).","DOI":"10.1094\/9780890544969.07.12.1"},{"key":"10211_CR94","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1094\/MPMI-21-5-0564","volume":"21","author":"A Kachroo","year":"2008","unstructured":"Kachroo, A. et al. An oleic acid-mediated pathway induces constitutive defense signaling and enhanced resistance to multiple pathogens in soybean. Mol. Plant Microbe Interact. 21, 564\u2013575 (2008).","journal-title":"Mol. Plant Microbe Interact."},{"key":"10211_CR95","first-page":"537","volume":"57","author":"HE Kauffman","year":"1973","unstructured":"Kauffman, H. E., Reddy, A. P. K., Hsieh, S. P. Y. & Merca, S. D. An improved technique for evaluating resistance of rice varieties to Xanthomonas oryzae. Plant Dis. Rep. 57, 537\u2013541 (1973).","journal-title":"Plant Dis. Rep."},{"key":"10211_CR96","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1094\/PD-70-70","volume":"70","author":"DM Weller","year":"1986","unstructured":"Weller, D. M. et al. Rhizoctonia root rot of small grains favored by reduced tillage in the Pacific Northwest. Plant Dis. 70, 70\u201373 (1986).","journal-title":"Plant Dis."},{"key":"10211_CR97","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1094\/PDIS-05-15-0611-SR","volume":"100","author":"PA Okubara","year":"2016","unstructured":"Okubara, P. A., Leston, N., Micknass, U., Kogel, K. H. & Imani, J. Rapid quantitative assessment of Rhizoctonia resistance in roots of selected wheat and barley genotypes. Plant Dis. 100, 640\u2013644 (2016).","journal-title":"Plant Dis."},{"key":"10211_CR98","doi-asserted-by":"publisher","first-page":"e0289619","DOI":"10.1371\/journal.pone.0289619","volume":"18","author":"K Hristova","year":"2023","unstructured":"Hristova, K. & Wimley, W. C. Determining the statistical significance of the difference between arbitrary curves: a spreadsheet method. PLoS ONE 18, e0289619 (2023).","journal-title":"PLoS ONE"},{"key":"10211_CR99","doi-asserted-by":"publisher","first-page":"e1685","DOI":"10.21769\/BioProtoc.1685","volume":"5","author":"NG Bisceglia","year":"2015","unstructured":"Bisceglia, N. G., Gravino, M. & Savatin, D. V. Luminol-based assay for detection of immunity elicitor-induced hydrogen peroxide production in Arabidopsis thaliana leaves. Bio Protoc. 5, e1685 (2015).","journal-title":"Bio Protoc."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10211-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10211-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10211-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:02:38Z","timestamp":1783645358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10211-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":99,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10211"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10211-1","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.F.K., M.M., and F.C.S. are founders of Ascribe Bioscience Inc., a company developing crop protection products based on nematode-derived metabolites. F.C.S. is a member of the Board of Directors of Ascribe Bioscience and serves on the Scientific Advisory Board of Hexagon Bio. M.M. is a founder of CryoBio, Inc., a company developing frost protection products based on natural antifreeze molecules. U.C. is a founder of AgPrime, a contract research organization for agricultural companies that develops crop protection products based on defense priming activation. U.C. is also a member of the Scientific Advisory Board of AgPrime and Ascribe Bioscience and a scientific advisor to S\u00fcdzucker. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"936"}}