{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:55:03Z","timestamp":1790776503712,"version":"4.1.0"},"reference-count":234,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10263-3","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:24:10Z","timestamp":1779362650000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of the gut microbiota in radiation enteritis: from mechanistic insights to therapeutic applications"],"prefix":"10.1038","volume":"9","author":[{"given":"Mingyang","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4777-1442","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-5907","authenticated-orcid":false,"given":"Xuebing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-5696","authenticated-orcid":false,"given":"Yefei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"10263_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229\u2013263 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"10263_CR2","doi-asserted-by":"publisher","first-page":"e2443198","DOI":"10.1001\/jamanetworkopen.2024.43198","volume":"7","author":"HM Bizuayehu","year":"2024","unstructured":"Bizuayehu, H. M. et al. Global disparities of cancer and its projected burden in 2050. JAMA Netw. Open 7, e2443198 (2024).","journal-title":"JAMA Netw. Open"},{"key":"10263_CR3","doi-asserted-by":"publisher","first-page":"205031212110343","DOI":"10.1177\/20503121211034366","volume":"9","author":"DT Debela","year":"2021","unstructured":"Debela, D. T. et al. New approaches and procedures for cancer treatment: Current perspectives. SAGE Open Med 9, 20503121211034366 (2021).","journal-title":"SAGE Open Med"},{"key":"10263_CR4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/pcmedi\/pbaa038","volume":"3","author":"X Peng","year":"2020","unstructured":"Peng, X., Wei, Z. & Gerweck, L. E. Making radiation therapy more effective in the era of precision medicine. Precis Clin. Med 3, 272\u2013283 (2020).","journal-title":"Precis Clin. Med"},{"key":"10263_CR5","doi-asserted-by":"publisher","first-page":"e4103","DOI":"10.1002\/cbf.4103","volume":"42","author":"D Srinivasan","year":"2024","unstructured":"Srinivasan, D. et al. A comprehensive overview of radiation therapy impacts of various cancer treatments and pivotal role in the immune system. Cell Biochem Funct. 42, e4103 (2024).","journal-title":"Cell Biochem Funct."},{"key":"10263_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.7150\/ijms.3635","volume":"9","author":"R Baskar","year":"2012","unstructured":"Baskar, R., Lee, K. A., Yeo, R. & Yeoh, K. W. Cancer and radiation therapy: current advances and future directions. Int. J. Med Sci. 9, 193\u2013199 (2012).","journal-title":"Int. J. Med Sci."},{"key":"10263_CR7","doi-asserted-by":"publisher","first-page":"1622060","DOI":"10.3389\/fonc.2025.1622060","volume":"15","author":"C Ma","year":"2025","unstructured":"Ma, C. et al. Recent technical advancements and clinical applications of MR-guided radiotherapy in lung cancer treatment. Front Oncol. 15, 1622060 (2025).","journal-title":"Front Oncol."},{"key":"10263_CR8","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1056\/NEJMoa2402614","volume":"391","author":"S Lu","year":"2024","unstructured":"Lu, S. et al. Osimertinib after chemoradiotherapy in stage III EGFR-mutated NSCLC. N. Engl. J. Med 391, 585\u2013597 (2024).","journal-title":"N. Engl. J. Med"},{"key":"10263_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1056\/NEJMoa2409408","volume":"392","author":"J Hoeppner","year":"2025","unstructured":"Hoeppner, J. et al. Perioperative chemotherapy or preoperative chemoradiotherapy in esophageal cancer. N. Engl. J. Med 392, 323\u2013335 (2025).","journal-title":"N. Engl. J. Med"},{"key":"10263_CR10","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/S1470-2045(25)00286-4","volume":"26","author":"F Tian","year":"2025","unstructured":"Tian, F. et al. Total neoadjuvant treatment with short-course radiotherapy followed by sintilimab plus capecitabine-oxaliplatin versus short-course radiotherapy followed by capecitabine-oxaliplatin in patients with locally advanced rectal cancer (SPRING-01): a single-centre, open-label, phase 2, randomised controlled trial. Lancet Oncol. 26, 1043\u20131054 (2025).","journal-title":"Lancet Oncol."},{"key":"10263_CR11","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/S0140-6736(24)00317-9","volume":"403","author":"D Lorusso","year":"2024","unstructured":"Lorusso, D. et al. Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11\/GOG-3047\/KEYNOTE-A18): a randomised, double-blind, phase 3 clinical trial. Lancet 403, 1341\u20131350 (2024).","journal-title":"Lancet"},{"key":"10263_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.trecan.2021.10.003","volume":"8","author":"KB Pointer","year":"2022","unstructured":"Pointer, K. B., Pitroda, S. P. & Weichselbaum, R. R. Radiotherapy and immunotherapy: open questions and future strategies. Trends Cancer 8, 9\u201320 (2022).","journal-title":"Trends Cancer"},{"key":"10263_CR13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3747\/co.27.6233","volume":"27","author":"V Dilalla","year":"2020","unstructured":"Dilalla, V., Chaput, G., Williams, T. & Sultanem, K. Radiotherapy side effects: integrating a survivorship clinical lens to better serve patients. Curr. Oncol. 27, 107\u2013112 (2020).","journal-title":"Curr. Oncol."},{"key":"10263_CR14","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.tem.2023.05.006","volume":"34","author":"I Moraitis","year":"2023","unstructured":"Moraitis, I., Guiu, J. & Rubert, J. Gut microbiota controlling radiation-induced enteritis and intestinal regeneration. Trends Endocrinol. Metab. 34, 489\u2013501 (2023).","journal-title":"Trends Endocrinol. Metab."},{"key":"10263_CR15","doi-asserted-by":"publisher","first-page":"888962","DOI":"10.3389\/fonc.2022.888962","volume":"12","author":"J Fan","year":"2022","unstructured":"Fan, J. et al. Research progress on the mechanism of radiation enteritis. Front Oncol. 12, 888962 (2022).","journal-title":"Front Oncol."},{"key":"10263_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3857\/roj.2023.00346","volume":"41","author":"H Ren","year":"2023","unstructured":"Ren, H. et al. Research progress and treatment of radiation enteritis and gut microbiota. Radiat. Oncol. J. 41, 61\u201368 (2023).","journal-title":"Radiat. Oncol. J."},{"key":"10263_CR17","doi-asserted-by":"publisher","first-page":"189381","DOI":"10.1016\/j.bbcan.2025.189381","volume":"1880","author":"W Dan","year":"2025","unstructured":"Dan, W., Xiong, C., Zhou, G., Chen, J. & Pan, F. Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma. Biochim Biophys. Acta Rev. Cancer 1880, 189381 (2025).","journal-title":"Biochim Biophys. Acta Rev. Cancer"},{"key":"10263_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-025-01034-0","volume":"9","author":"D B\u00f6hm","year":"2025","unstructured":"B\u00f6hm, D. et al. The role of the gut microbiota in chemotherapy response, efficacy and toxicity: a systematic review. NPJ Precis. Oncol. 9, 265 (2025).","journal-title":"NPJ Precis. Oncol."},{"key":"10263_CR19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41571-025-01026-w","volume":"22","author":"YQ Gao","year":"2025","unstructured":"Gao, Y. Q., Tan, Y. J. & Fang, J. Y. Roles of the gut microbiota in immune-related adverse events: mechanisms and therapeutic intervention. Nat. Rev. Clin. Oncol. 22, 499\u2013516 (2025).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10263_CR20","doi-asserted-by":"publisher","first-page":"2353399","DOI":"10.1080\/19490976.2024.2353399","volume":"16","author":"H Wu","year":"2024","unstructured":"Wu, H. et al. Host-microbiota interaction in intestinal stem cell homeostasis. Gut Microbes 16, 2353399 (2024).","journal-title":"Gut Microbes"},{"key":"10263_CR21","doi-asserted-by":"publisher","first-page":"e39456","DOI":"10.1097\/MD.0000000000039456","volume":"103","author":"NL Faizo","year":"2024","unstructured":"Faizo, N. L. The intestinal stem cell as a target: a review. Med. (Baltim.) 103, e39456 (2024).","journal-title":"Med. (Baltim.)"},{"key":"10263_CR22","doi-asserted-by":"publisher","first-page":"122452","DOI":"10.1016\/j.lfs.2024.122452","volume":"344","author":"X Hu","year":"2024","unstructured":"Hu, X. et al. The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis. Life Sci. 344, 122452 (2024).","journal-title":"Life Sci."},{"key":"10263_CR23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jcmgh.2024.02.003","volume":"17","author":"HE Abud","year":"2024","unstructured":"Abud, H. E., Amarasinghe, S. L., Micati, D. & Jard\u00e9, T. Stromal Niche Signals That Orchestrate Intestinal Regeneration. Cell Mol. Gastroenterol. Hepatol. 17, 679\u2013685 (2024).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10263_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.stem.2023.12.006","volume":"31","author":"J Beumer","year":"2024","unstructured":"Beumer, J. & Clevers, H. Hallmarks of stemness in mammalian tissues. Cell Stem Cell 31, 7\u201324 (2024).","journal-title":"Cell Stem Cell"},{"key":"10263_CR25","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.stem.2024.05.009","volume":"31","author":"S Viragova","year":"2024","unstructured":"Viragova, S., Li, D. & Klein, O. D. Activation of fetal-like molecular programs during regeneration in the intestine and beyond. Cell Stem Cell 31, 949\u2013960 (2024).","journal-title":"Cell Stem Cell"},{"key":"10263_CR26","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1016\/j.devcel.2025.03.014","volume":"60","author":"NR Smith","year":"2025","unstructured":"Smith, N. R. et al. Dual states of murine Bmi1-expressing intestinal stem cells drive epithelial development utilizing non-canonical Wnt signaling. Dev. Cell 60, 2177\u20132191.e2175 (2025).","journal-title":"Dev. Cell"},{"key":"10263_CR27","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s10020-025-01399-9","volume":"31","author":"S Yamaga","year":"2025","unstructured":"Yamaga, S. et al. Ghrelin mitigates partial body irradiation-induced gastrointestinal acute radiation syndrome by promoting intestinal stem cell regeneration. Mol. Med 31, 337 (2025).","journal-title":"Mol. Med"},{"key":"10263_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60364-6","volume":"16","author":"EJ Mulholland","year":"2025","unstructured":"Mulholland, E. J. et al. Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a Wnt-dependent ectopic stem cell niche through stromal remodelling. Nat. Commun. 16, 5167 (2025).","journal-title":"Nat. Commun."},{"key":"10263_CR29","doi-asserted-by":"publisher","first-page":"102942","DOI":"10.1016\/j.redox.2023.102942","volume":"68","author":"T Yuan","year":"2023","unstructured":"Yuan, T., Zhang, J., Zhao, Y., Guo, Y. & Fan, S. Single-cell RNA sequencing of intestinal crypts reveals vital events in damage repair and the double-edged sword effect of the Wnt3\/\u03b2-catenin pathway in irradiated mice. Redox Biol. 68, 102942 (2023).","journal-title":"Redox Biol."},{"key":"10263_CR30","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3390\/ijms21062032","volume":"21","author":"T Takahashi","year":"2020","unstructured":"Takahashi, T. & Shiraishi, A. Stem cell signaling pathways in the small intestine. Int. J. Mol. Sci. 21, 2032 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"10263_CR31","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41573-024-00979-4","volume":"23","author":"C Glorieux","year":"2024","unstructured":"Glorieux, C., Liu, S., Trachootham, D. & Huang, P. Targeting ROS in cancer: rationale and strategies. Nat. Rev. Drug Discov. 23, 583\u2013606 (2024).","journal-title":"Nat. Rev. Drug Discov."},{"key":"10263_CR32","doi-asserted-by":"publisher","first-page":"153424","DOI":"10.1016\/j.phymed.2020.153424","volume":"81","author":"SY Kwak","year":"2021","unstructured":"Kwak, S. Y. et al. Ghrelin reverts intestinal stem cell loss associated with radiation-induced enteropathy by activating Notch signaling. Phytomedicine 81, 153424 (2021).","journal-title":"Phytomedicine"},{"key":"10263_CR33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s43018-022-00336-7","volume":"3","author":"E Nolan","year":"2022","unstructured":"Nolan, E. et al. Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization. Nat. Cancer 3, 173\u2013187 (2022).","journal-title":"Nat. Cancer"},{"key":"10263_CR34","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/s42255-023-00828-5","volume":"5","author":"G Pontarollo","year":"2023","unstructured":"Pontarollo, G. et al. Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling. Nat. Metab. 5, 1174\u20131187 (2023).","journal-title":"Nat. Metab."},{"key":"10263_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40993-5","volume":"14","author":"M Calafiore","year":"2023","unstructured":"Calafiore, M. et al. A tissue-intrinsic IL-33\/EGF circuit promotes epithelial regeneration after intestinal injury. Nat. Commun. 14, 5411 (2023).","journal-title":"Nat. Commun."},{"key":"10263_CR36","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s43556-024-00211-0","volume":"5","author":"SM Chen","year":"2024","unstructured":"Chen, S. M. et al. Pathways regulating intestinal stem cells and potential therapeutic targets for radiation enteropathy. Mol. Biomed. 5, 46 (2024).","journal-title":"Mol. Biomed."},{"key":"10263_CR37","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.trecan.2022.06.002","volume":"8","author":"SV Kozin","year":"2022","unstructured":"Kozin, S. V. Vascular damage in tumors: a key player in stereotactic radiation therapy? Trends Cancer 8, 806\u2013819 (2022).","journal-title":"Trends Cancer"},{"key":"10263_CR38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S0140-6736(24)02319-5","volume":"405","author":"II Verginadis","year":"2025","unstructured":"Verginadis, I. I. et al. Radiotherapy toxicities: mechanisms, management, and future directions. Lancet 405, 338\u2013352 (2025).","journal-title":"Lancet"},{"key":"10263_CR39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41556-024-01565-x","volume":"27","author":"S Herv\u00e9","year":"2025","unstructured":"Herv\u00e9, S. et al. Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint. Nat. Cell Biol. 27, 73\u201386 (2025).","journal-title":"Nat. Cell Biol."},{"key":"10263_CR40","doi-asserted-by":"publisher","unstructured":"Leong, K. X., Yang, W., Sharma, D., Liu, S. & Czarnota, G. J. Ultrasound-stimulated microbubbles enhanced vascular disruption in fractionated radiotherapy-treated tumours via ASMase activation. Dis. Model Mech. 16 (2023). https:\/\/doi.org\/10.1242\/dmm.049531","DOI":"10.1242\/dmm.049531"},{"key":"10263_CR41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo, Q. et al. NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct. Target Ther. 9, 53 (2024).","journal-title":"Signal Transduct. Target Ther."},{"key":"10263_CR42","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.3390\/ijms23073645","volume":"23","author":"JL Wautier","year":"2022","unstructured":"Wautier, J. L. & Wautier, M. P. Vascular permeability in diseases. Int J. Mol. Sci. 23, 3645 (2022).","journal-title":"Int J. Mol. Sci."},{"key":"10263_CR43","doi-asserted-by":"publisher","first-page":"105089","DOI":"10.1016\/j.ebiom.2024.105089","volume":"103","author":"M Fijardo","year":"2024","unstructured":"Fijardo, M. et al. The clinical manifestations and molecular pathogenesis of radiation fibrosis. EBioMedicine 103, 105089 (2024).","journal-title":"EBioMedicine"},{"key":"10263_CR44","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/s12276-020-0439-4","volume":"52","author":"KJ Choi","year":"2020","unstructured":"Choi, K. J., Nam, J. K., Kim, J. H., Choi, S. H. & Lee, Y. J. Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage. Exp. Mol. Med 52, 781\u2013792 (2020).","journal-title":"Exp. Mol. Med"},{"key":"10263_CR45","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.cell.2020.12.016","volume":"184","author":"D Fawkner-Corbett","year":"2021","unstructured":"Fawkner-Corbett, D. et al. Spatiotemporal analysis of human intestinal development at single-cell resolution. Cell 184, 810\u2013826.e823 (2021).","journal-title":"Cell"},{"key":"10263_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04446-3","volume":"21","author":"J Ni","year":"2023","unstructured":"Ni, J. et al. STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury. J. Transl. Med 21, 590 (2023).","journal-title":"J. Transl. Med"},{"key":"10263_CR47","doi-asserted-by":"publisher","first-page":"115009","DOI":"10.1016\/j.intimp.2025.115009","volume":"161","author":"J Xu","year":"2025","unstructured":"Xu, J. et al. Tumor-associated macrophages in radiotherapy: Mechanisms of polarization, immune regulation and therapeutic strategies. Int. Immunopharmacol. 161, 115009 (2025).","journal-title":"Int. Immunopharmacol."},{"key":"10263_CR48","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","volume":"20","author":"P Broz","year":"2020","unstructured":"Broz, P., Pelegr\u00edn, P. & Shao, F. The gasdermins, a protein family executing cell death and inflammation. Nat. Rev. Immunol. 20, 143\u2013157 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"10263_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2021.12.034","volume":"529","author":"G Tan","year":"2022","unstructured":"Tan, G. et al. Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E. Cancer Lett. 529, 1\u201310 (2022).","journal-title":"Cancer Lett."},{"key":"10263_CR50","doi-asserted-by":"publisher","unstructured":"Adams, S. et al. Topical TLR7 agonist and radiotherapy in patients with metastatic breast cancer. J. Immunother. Cancer 13 (2025). https:\/\/doi.org\/10.1136\/jitc-2024-011173","DOI":"10.1136\/jitc-2024-011173"},{"key":"10263_CR51","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41392-025-02476-5","volume":"10","author":"JC Fischer","year":"2025","unstructured":"Fischer, J. C. et al. Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury. Signal Transduct. Target Ther. 10, 384 (2025).","journal-title":"Signal Transduct. Target Ther."},{"key":"10263_CR52","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12026-020-09142-8","volume":"68","author":"X Gong","year":"2020","unstructured":"Gong, X. et al. Patients with radiation enteritis present regulatory T cell impairment associated with CTLA-4. Immunol. Res. 68, 179\u2013188 (2020).","journal-title":"Immunol. Res."},{"key":"10263_CR53","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/s42003-023-05645-w","volume":"6","author":"H Lu","year":"2023","unstructured":"Lu, H. et al. Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury. Commun. Biol. 6, 1248 (2023).","journal-title":"Commun. Biol."},{"key":"10263_CR54","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ijrobp.2021.08.037","volume":"112","author":"I Franiak-Pietryga","year":"2022","unstructured":"Franiak-Pietryga, I. et al. Activated B cells and plasma cells are resistant to radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 112, 514\u2013528 (2022).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10263_CR55","doi-asserted-by":"publisher","first-page":"eadk0642","DOI":"10.1126\/scitranslmed.adk0642","volume":"16","author":"JC Jagodinsky","year":"2024","unstructured":"Jagodinsky, J. C. et al. Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade. Sci. Transl. Med 16, eadk0642 (2024).","journal-title":"Sci. Transl. Med"},{"key":"10263_CR56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1053\/j.gastro.2025.01.252","volume":"169","author":"I Moraitis","year":"2025","unstructured":"Moraitis, I. et al. Mucosal macrophages govern intestinal regeneration in response to injury. Gastroenterology 169, 119\u2013135.e126 (2025).","journal-title":"Gastroenterology"},{"key":"10263_CR57","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41575-022-00675-x","volume":"19","author":"JK Gustafsson","year":"2022","unstructured":"Gustafsson, J. K. & Johansson, M. E. V. The role of goblet cells and mucus in intestinal homeostasis. Nat. Rev. Gastroenterol. Hepatol. 19, 785\u2013803 (2022).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10263_CR58","first-page":"e2305893","volume":"11","author":"J Li","year":"2024","unstructured":"Li, J. et al. TSP50 attenuates DSS-induced colitis by regulating TGF-\u03b2 signaling mediated maintenance of intestinal mucosal barrier integrity. Adv. Sci. (Weinh.) 11, e2305893 (2024).","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10263_CR59","doi-asserted-by":"publisher","first-page":"114021","DOI":"10.1016\/j.addr.2021.114021","volume":"179","author":"Y Lee","year":"2021","unstructured":"Lee, Y., Kamada, N. & Moon, J. J. Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome. Adv. Drug Deliv. Rev. 179, 114021 (2021).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10263_CR60","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/ibd\/izae232","volume":"31","author":"P Arumugam","year":"2025","unstructured":"Arumugam, P., Saha, K. & Nighot, P. Intestinal epithelial tight junction barrier regulation by novel pathways. Inflamm. Bowel Dis. 31, 259\u2013271 (2025).","journal-title":"Inflamm. Bowel Dis."},{"key":"10263_CR61","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","volume":"10","author":"MF Neurath","year":"2025","unstructured":"Neurath, M. F., Artis, D. & Becker, C. The intestinal barrier: a pivotal role in health, inflammation, and cancer. Lancet Gastroenterol. Hepatol. 10, 573\u2013592 (2025).","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10263_CR62","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.3390\/ijms24021753","volume":"24","author":"AA Livanova","year":"2023","unstructured":"Livanova, A. A., Fedorova, A. A., Zavirsky, A. V., Krivoi, I. I. & Markov, A. G. Dose- and segment-dependent disturbance of rat gut by ionizing radiation: impact of tight junction proteins. Int. J. Mol. Sci. 24, 1753 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"10263_CR63","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ijrobp.2022.01.006","volume":"113","author":"Z Wang","year":"2022","unstructured":"Wang, Z. et al. The NF-\u03baB-regulated miR-221\/222\/Syndecan-1 axis and intestinal mucosal barrier function in radiation enteritis. Int. J. Radiat. Oncol. Biol. Phys. 113, 166\u2013176 (2022).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10263_CR64","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1007\/s10620-025-09131-7","volume":"70","author":"R Sevim","year":"2025","unstructured":"Sevim, R., Erhan, S. & Matur, E. MicroRNAs as key modulators of intestinal barrier function: pattern recognition receptors, epithelial junctional complexes, and therapeutic approaches. Dig. Dis. Sci. 70, 3206\u20133228 (2025).","journal-title":"Dig. Dis. Sci."},{"key":"10263_CR65","doi-asserted-by":"publisher","first-page":"5929","DOI":"10.3390\/ijms23115929","volume":"23","author":"H Jang","year":"2022","unstructured":"Jang, H. et al. Metformin protects the intestinal barrier by activating goblet cell maturation and epithelial proliferation in radiation-induced enteropathy. Int. J. Mol. Sci. 23, 5929 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"10263_CR66","doi-asserted-by":"publisher","first-page":"106517","DOI":"10.1016\/j.intimp.2020.106517","volume":"84","author":"X Qiu","year":"2020","unstructured":"Qiu, X., Dong, K., Guan, J. & He, J. Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and inflammatory response. Int. Immunopharmacol. 84, 106517 (2020).","journal-title":"Int. Immunopharmacol."},{"key":"10263_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02065-7","volume":"23","author":"RM Chugh","year":"2025","unstructured":"Chugh, R. M. et al. Modulation of \u03b2-Catenin promotes WNT expression in macrophages and mitigates intestinal injury. Cell Commun. Signal 23, 78 (2025).","journal-title":"Cell Commun. Signal"},{"key":"10263_CR68","doi-asserted-by":"publisher","first-page":"1675155","DOI":"10.3389\/fmicb.2025.1675155","volume":"16","author":"S Liu","year":"2025","unstructured":"Liu, S. Mechanisms of gut microbiota in host fat deposition: metabolites, signaling pathways, and translational applications. Front Microbiol. 16, 1675155 (2025).","journal-title":"Front Microbiol."},{"key":"10263_CR69","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1007\/s11605-023-05654-4","volume":"27","author":"Q Li","year":"2023","unstructured":"Li, Q. et al. Gut barrier dysfunction and bacterial lipopolysaccharides in colorectal cancer. J. Gastrointest. Surg. 27, 1466\u20131472 (2023).","journal-title":"J. Gastrointest. Surg."},{"key":"10263_CR70","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.tim.2024.02.013","volume":"32","author":"S Yersin","year":"2024","unstructured":"Yersin, S. & Vonaesch, P. Small intestinal microbiota: from taxonomic composition to metabolism. Trends Microbiol 32, 970\u2013983 (2024).","journal-title":"Trends Microbiol"},{"key":"10263_CR71","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/procel\/pwad044","volume":"15","author":"W Wang","year":"2024","unstructured":"Wang, W., Cui, B., Nie, Y., Sun, L. & Zhang, F. Radiation injury and gut microbiota-based treatment. Protein Cell 15, 83\u201397 (2024).","journal-title":"Protein Cell"},{"key":"10263_CR72","doi-asserted-by":"publisher","first-page":"114341","DOI":"10.1016\/j.ecoenv.2022.114341","volume":"248","author":"JY Xin","year":"2022","unstructured":"Xin, J. Y. et al. Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage. Ecotoxicol. Environ. Saf. 248, 114341 (2022).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10263_CR73","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.3390\/nu13093025","volume":"13","author":"A Fernandes","year":"2021","unstructured":"Fernandes, A., Oliveira, A., Soares, R. & Barata, P. The effects of ionizing radiation on gut microbiota: a systematic review. Nutrients 13, 3025 (2021).","journal-title":"Nutrients"},{"key":"10263_CR74","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-021-01899-y","volume":"16","author":"L Wang","year":"2021","unstructured":"Wang, L. et al. The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review. Radiat. Oncol. 16, 187 (2021).","journal-title":"Radiat. Oncol."},{"key":"10263_CR75","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill, C. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506\u2013514 (2014).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10263_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42788-0","volume":"14","author":"L Ning","year":"2023","unstructured":"Ning, L. et al. Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts. Nat. Commun. 14, 7135 (2023).","journal-title":"Nat. Commun."},{"key":"10263_CR77","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s42003-023-05714-0","volume":"7","author":"X Zhu","year":"2024","unstructured":"Zhu, X. et al. Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis. Commun. Biol. 7, 24 (2024).","journal-title":"Commun. Biol."},{"key":"10263_CR78","doi-asserted-by":"publisher","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.122.320184","volume":"131","author":"HB Li","year":"2022","unstructured":"Li, H. B. et al. Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis. Circ. Res. 131, e120\u2013e134 (2022).","journal-title":"Circ. Res"},{"key":"10263_CR79","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1158\/0008-5472.CAN-23-0605","volume":"83","author":"Y Gao","year":"2023","unstructured":"Gao, Y. et al. Faecalibacterium prausnitzii abrogates intestinal toxicity and promotes tumor immunity to increase the efficacy of dual CTLA4 and PD-1 checkpoint blockade. Cancer Res. 83, 3710\u20133725 (2023).","journal-title":"Cancer Res."},{"key":"10263_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1812867","volume":"12","author":"A Lapiere","year":"2020","unstructured":"Lapiere, A. et al. Prophylactic Faecalibacterium prausnitzii treatment prevents the acute breakdown of colonic epithelial barrier in a preclinical model of pelvic radiation disease. Gut Microbes 12, 1\u201315 (2020).","journal-title":"Gut Microbes"},{"key":"10263_CR81","doi-asserted-by":"publisher","first-page":"e154722","DOI":"10.1172\/jci.insight.154722","volume":"7","author":"S Touch","year":"2022","unstructured":"Touch, S. et al. Human CD4+CD8\u03b1+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation. JCI Insight 7, e154722 (2022).","journal-title":"JCI Insight"},{"key":"10263_CR82","doi-asserted-by":"publisher","first-page":"115568","DOI":"10.1016\/j.biopha.2023.115568","volume":"167","author":"N Mohebali","year":"2023","unstructured":"Mohebali, N. et al. Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg\/Th17 cell balance and intestinal barrier integrity. Biomed. Pharmacother. 167, 115568 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"10263_CR83","doi-asserted-by":"publisher","first-page":"eado6828","DOI":"10.1126\/science.ado6828","volume":"386","author":"J Cheng","year":"2024","unstructured":"Cheng, J., Venkatesh, S., Ke, K., Barratt, M. J. & Gordon, J. I. A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase. Science 386, eado6828 (2024).","journal-title":"Science"},{"key":"10263_CR84","doi-asserted-by":"publisher","first-page":"107277","DOI":"10.1016\/j.phrs.2024.107277","volume":"206","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. Faecalibacterium prausnitzii-derived extracellular vesicles alleviate chronic colitis-related intestinal fibrosis by macrophage metabolic reprogramming. Pharm. Res. 206, 107277 (2024).","journal-title":"Pharm. Res."},{"key":"10263_CR85","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jconrel.2023.05.041","volume":"359","author":"H Hu","year":"2023","unstructured":"Hu, H. et al. Sonodynamic therapy combined with phototherapy: Novel synergistic strategy with superior efficacy for antitumor and antiinfection therapy. J. Control Release 359, 188\u2013205 (2023).","journal-title":"J. Control Release"},{"key":"10263_CR86","doi-asserted-by":"publisher","first-page":"2528429","DOI":"10.1080\/19490976.2025.2528429","volume":"17","author":"L Li","year":"2025","unstructured":"Li, L., Yang, Z., Yi, Y., Song, Y. & Zhang, W. Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies. Gut microbes 17, 2528429 (2025).","journal-title":"Gut microbes"},{"key":"10263_CR87","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.ajog.2025.09.042","volume":"234","author":"J Chalif","year":"2026","unstructured":"Chalif, J. et al. Assessment of probiotic and prebiotic use in gynecologic cancer patients: a systematic review. Am. J. Obstet. Gynecol. 234, 893\u2013918 (2025).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10263_CR88","doi-asserted-by":"publisher","first-page":"1626169","DOI":"10.3389\/fnut.2025.1626169","volume":"12","author":"Y Yang","year":"2025","unstructured":"Yang, Y. et al. A phase II clinical trial of Bifidobacterium longum subsp. longum BL21 for preventing acute radiation enteritis among pelvic radiotherapy patients. Front Nutr. 12, 1626169 (2025).","journal-title":"Front Nutr."},{"key":"10263_CR89","doi-asserted-by":"publisher","first-page":"2291164","DOI":"10.1080\/19490976.2023.2291164","volume":"15","author":"SJ Gavzy","year":"2023","unstructured":"Gavzy, S. J. et al. Bifidobacterium mechanisms of immune modulation and tolerance. Gut Microbes 15, 2291164 (2023).","journal-title":"Gut Microbes"},{"key":"10263_CR90","doi-asserted-by":"publisher","first-page":"1671152","DOI":"10.3389\/fcell.2025.1671152","volume":"13","author":"MM Ferris","year":"2025","unstructured":"Ferris, M. M., Subitoni Antonio, L. & Al-Sadi, R. Probiotics and the intestinal tight junction barrier function. Front Cell Dev. Biol. 13, 1671152 (2025).","journal-title":"Front Cell Dev. Biol."},{"key":"10263_CR91","doi-asserted-by":"publisher","first-page":"122921","DOI":"10.1016\/j.lfs.2024.122921","volume":"353","author":"M Acharya","year":"2024","unstructured":"Acharya, M., Venkidesh, B. S. & Mumbrekar, K. D. Bacterial supplementation in mitigation of radiation-induced gastrointestinal damage. Life Sci. 353, 122921 (2024).","journal-title":"Life Sci."},{"key":"10263_CR92","doi-asserted-by":"publisher","first-page":"2431643","DOI":"10.1080\/19490976.2024.2431643","volume":"16","author":"AB Shah","year":"2024","unstructured":"Shah, A. B. et al. Probiotic significance of Lactobacillus strains: a comprehensive review on health impacts, research gaps, and future prospects. Gut microbes 16, 2431643 (2024).","journal-title":"Gut microbes"},{"key":"10263_CR93","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1099\/ijsem.0.004107","volume":"70","author":"J Zheng","year":"2020","unstructured":"Zheng, J. et al. A taxonomic note on the genus Lactobacillus: description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. Int J. Syst. Evol. Microbiol 70, 2782\u20132858 (2020).","journal-title":"Int J. Syst. Evol. Microbiol"},{"key":"10263_CR94","doi-asserted-by":"publisher","first-page":"2451088","DOI":"10.1080\/19490976.2025.2451088","volume":"17","author":"AH Lee","year":"2025","unstructured":"Lee, A. H., Rodriguez Jimenez, D. M. & Meisel, M. Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity. Gut Microbes 17, 2451088 (2025).","journal-title":"Gut Microbes"},{"key":"10263_CR95","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/19490976.2020.1734423","volume":"11","author":"H Wu","year":"2020","unstructured":"Wu, H. et al. Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa. Gut Microbes 11, 997\u20131014 (2020).","journal-title":"Gut Microbes"},{"key":"10263_CR96","first-page":"e2309725","volume":"11","author":"Y Chen","year":"2024","unstructured":"Chen, Y. et al. Lactobacillus reuteri vesicles regulate mitochondrial function of macrophages to promote mucosal and cutaneous wound healing. Adv. Sci. (Weinh.) 11, e2309725 (2024).","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10263_CR97","doi-asserted-by":"publisher","first-page":"2377576","DOI":"10.1080\/19490976.2024.2377576","volume":"16","author":"M Li","year":"2024","unstructured":"Li, M. et al. Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation. Gut Microbes 16, 2377576 (2024).","journal-title":"Gut Microbes"},{"key":"10263_CR98","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02506-4","volume":"22","author":"N Li","year":"2024","unstructured":"Li, N. et al. Taking SCFAs produced by Lactobacillus reuteri orally reshapes gut microbiota and elicits antitumor responses. J. Nanobiotechnol. 22, 241 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"10263_CR99","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s12602-023-10071-9","volume":"16","author":"SU Lee","year":"2024","unstructured":"Lee, S. U. et al. Effect of Lactobacillus rhamnosus GG for regulation of inflammatory response in radiation-induced enteritis. Probiot. Antimicrob. Proteins 16, 636\u2013648 (2024).","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"10263_CR100","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/microorganisms12040794","volume":"12","author":"T Leser","year":"2024","unstructured":"Leser, T. & Baker, A. Molecular mechanisms of Lacticaseibacillus rhamnosus, LGG(\u00ae) probiotic function. Microorganisms 12, 794 (2024).","journal-title":"Microorganisms"},{"key":"10263_CR101","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02893-8","volume":"22","author":"J Wang","year":"2024","unstructured":"Wang, J. et al. Lactobacillus rhamnosus GG-derived extracellular vesicles promote wound healing via miR-21-5p-mediated re-epithelization and angiogenesis. J. Nanobiotechnol. 22, 644 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"10263_CR102","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.semcancer.2021.12.013","volume":"86","author":"K Garbacz","year":"2022","unstructured":"Garbacz, K. Anticancer activity of lactic acid bacteria. Semin Cancer Biol. 86, 356\u2013366 (2022).","journal-title":"Semin Cancer Biol."},{"key":"10263_CR103","doi-asserted-by":"publisher","first-page":"106916","DOI":"10.1016\/j.phrs.2023.106916","volume":"196","author":"X Zhao","year":"2023","unstructured":"Zhao, X. et al. Akkermansia muciniphila: a potential target and pending issues for oncotherapy. Pharm. Res. 196, 106916 (2023).","journal-title":"Pharm. Res"},{"key":"10263_CR104","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52683-x","volume":"15","author":"P Garcia-Vello","year":"2024","unstructured":"Garcia-Vello, P. et al. The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity. Nat. Commun. 15, 8411 (2024).","journal-title":"Nat. Commun."},{"key":"10263_CR105","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","volume":"24","author":"ER Mann","year":"2024","unstructured":"Mann, E. R., Lam, Y. K. & Uhlig, H. H. Short-chain fatty acids: linking diet, the microbiome and immunity. Nat. Rev. Immunol. 24, 577\u2013595 (2024).","journal-title":"Nat. Rev. Immunol."},{"key":"10263_CR106","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47275-8","volume":"15","author":"EJ Kang","year":"2024","unstructured":"Kang, E. J. et al. The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation. Nat. Commun. 15, 2983 (2024).","journal-title":"Nat. Commun."},{"key":"10263_CR107","doi-asserted-by":"publisher","first-page":"2293312","DOI":"10.1080\/19490976.2023.2293312","volume":"15","author":"KY He","year":"2023","unstructured":"He, K. Y. et al. Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid. Gut Microbes 15, 2293312 (2023).","journal-title":"Gut Microbes"},{"key":"10263_CR108","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-02001-w","volume":"13","author":"Z Wang","year":"2025","unstructured":"Wang, Z. et al. Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer\u2019s disease pathologic process via GPR41 and GPR43. Microbiome 13, 16 (2025).","journal-title":"Microbiome"},{"key":"10263_CR109","doi-asserted-by":"publisher","first-page":"e72171","DOI":"10.7554\/eLife.72171","volume":"10","author":"SP Thomas","year":"2021","unstructured":"Thomas, S. P. & Denu, J. M. Short-chain fatty acids activate acetyltransferase p300. Elife 10, e72171 (2021).","journal-title":"Elife"},{"key":"10263_CR110","first-page":"e2306217","volume":"11","author":"Z Ge","year":"2024","unstructured":"Ge, Z. et al. Gut microbiota-derived 3-hydroxybutyrate blocks GPR43-mediated IL6 signaling to ameliorate radiation proctopathy. Adv. Sci. (Weinh.) 11, e2306217 (2024).","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10263_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1892441","volume":"13","author":"S Kim","year":"2021","unstructured":"Kim, S. et al. Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development. Gut Microbes 13, 1\u201320 (2021).","journal-title":"Gut Microbes"},{"key":"10263_CR112","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41591-021-01655-5","volume":"28","author":"L Derosa","year":"2022","unstructured":"Derosa, L. et al. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer. Nat. Med 28, 315\u2013324 (2022).","journal-title":"Nat. Med"},{"key":"10263_CR113","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.tins.2025.04.004","volume":"48","author":"X Ma","year":"2025","unstructured":"Ma, X., Liu, Q. & Yang, G. The multifaceted roles of Akkermansia muciniphila in neurological disorders. Trends Neurosci. 48, 403\u2013415 (2025).","journal-title":"Trends Neurosci."},{"key":"10263_CR114","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.chom.2024.05.002","volume":"32","author":"S Woelfel","year":"2024","unstructured":"Woelfel, S., Silva, M. S. & Stecher, B. Intestinal colonization resistance in the context of environmental, host, and microbial determinants. Cell Host Microbe 32, 820\u2013836 (2024).","journal-title":"Cell Host Microbe"},{"key":"10263_CR115","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1186\/s12866-024-03620-x","volume":"24","author":"C Ma","year":"2024","unstructured":"Ma, C., Xu, X., Qin, S. & Zhou, J. Screening of biomarkers in acute radiation enteritis based on microbiome and clustering methods. BMC Microbiol. 24, 463 (2024).","journal-title":"BMC Microbiol."},{"key":"10263_CR116","doi-asserted-by":"publisher","first-page":"541178","DOI":"10.3389\/fcimb.2020.541178","volume":"10","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Alterations of the gut microbiome composition and lipid metabolic profile in radiation enteritis. Front Cell Infect. Microbiol 10, 541178 (2020).","journal-title":"Front Cell Infect. Microbiol"},{"key":"10263_CR117","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3390\/nu16091368","volume":"16","author":"YF Tang","year":"2024","unstructured":"Tang, Y. F. et al. Huaier polysaccharide alleviates dextran sulphate sodium salt-induced colitis by inhibiting inflammation and oxidative stress, maintaining the intestinal barrier, and modulating gut microbiota. Nutrients 16, 1368 (2024).","journal-title":"Nutrients"},{"key":"10263_CR118","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00848-x","volume":"11","author":"L Hu","year":"2025","unstructured":"Hu, L. et al. The association of proton pump inhibitors and inflammatory bowel disease from the perspective of gut microbiota perturbation. NPJ Biofilms Microbiomes 11, 218 (2025).","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10263_CR119","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3892\/ol.2024.14390","volume":"27","author":"Z Wang","year":"2024","unstructured":"Wang, Z., Chang, Y., Sun, H., Li, Y. & Tang, T. Advances in molecular mechanisms of inflammatory bowel disease\u2011associated colorectal cancer (Review). Oncol. Lett. 27, 257 (2024).","journal-title":"Oncol. Lett."},{"key":"10263_CR120","doi-asserted-by":"publisher","unstructured":"Lu, Q. et al. Radiation-induced intestinal injury: injury mechanism and potential treatment strategies. Toxics 11 (2023). https:\/\/doi.org\/10.3390\/toxics11121011","DOI":"10.3390\/toxics11121011"},{"key":"10263_CR121","doi-asserted-by":"publisher","first-page":"2185028","DOI":"10.1080\/19490976.2023.2185028","volume":"15","author":"MW Dougherty","year":"2023","unstructured":"Dougherty, M. W. & Jobin, C. Intestinal bacteria and colorectal cancer: etiology and treatment. Gut Microbes 15, 2185028 (2023).","journal-title":"Gut Microbes"},{"key":"10263_CR122","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1053\/j.gastro.2021.08.003","volume":"161","author":"Y Cao","year":"2021","unstructured":"Cao, Y. et al. Enterotoxigenic bacteroides fragilis promotes intestinal inflammation and malignancy by inhibiting exosome-packaged miR-149-3p. Gastroenterology 161, 1552\u20131566.e1512 (2021).","journal-title":"Gastroenterology"},{"key":"10263_CR123","doi-asserted-by":"publisher","first-page":"2399215","DOI":"10.1080\/19490976.2024.2399215","volume":"16","author":"J Ma","year":"2024","unstructured":"Ma, J. et al. Enterotoxigenic Escherichia coli heat labile enterotoxin affects neutrophil effector functions via cAMP\/PKA\/ERK signaling. Gut Microbes 16, 2399215 (2024).","journal-title":"Gut Microbes"},{"key":"10263_CR124","doi-asserted-by":"publisher","first-page":"2055943","DOI":"10.1080\/19490976.2022.2055943","volume":"14","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y., Tan, P., Zhao, Y. & Ma, X. Enterotoxigenic Escherichia coli: intestinal pathogenesis mechanisms and colonization resistance by gut microbiota. Gut Microbes 14, 2055943 (2022).","journal-title":"Gut Microbes"},{"key":"10263_CR125","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34687-7","volume":"13","author":"A Sheikh","year":"2022","unstructured":"Sheikh, A. et al. Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small intestinal epithelia. Nat. Commun. 13, 6886 (2022).","journal-title":"Nat. Commun."},{"key":"10263_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1891852","volume":"13","author":"J Brubaker","year":"2021","unstructured":"Brubaker, J. et al. Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic E. coli infection and impact on intestinal colonization and ETEC specific immune responses in an experimental human challenge model. Gut Microbes 13, 1\u201313 (2021).","journal-title":"Gut Microbes"},{"key":"10263_CR127","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-022-00344-6","volume":"8","author":"T Sauvaitre","year":"2022","unstructured":"Sauvaitre, T. et al. Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome. NPJ Biofilms Microbiomes 8, 86 (2022).","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10263_CR128","doi-asserted-by":"publisher","first-page":"e0006924","DOI":"10.1128\/mmbr.00069-24","volume":"88","author":"C Archambaud","year":"2024","unstructured":"Archambaud, C., Nunez, N., da Silva, R. A. G., Kline, K. A. & Serror, P. Enterococcus faecalis: an overlooked cell invader. Microbiol Mol. Biol. Rev. 88, e0006924 (2024).","journal-title":"Microbiol Mol. Biol. Rev."},{"key":"10263_CR129","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1136\/gutjnl-2024-334604","volume":"74","author":"Y Sun","year":"2025","unstructured":"Sun, Y. et al. Enterococcus faecalis hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn\u2019s disease by inducing gut dysbiosis. Gut 74, 1962\u20131976 (2025).","journal-title":"Gut"},{"key":"10263_CR130","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.17305\/bb.2025.11835","volume":"25","author":"Q Ding","year":"2025","unstructured":"Ding, Q., Xue, J., Li, N., Hu, Z. & Song, J. Fecal microbiota transplantation alleviates radiation enteritis by modulating gut microbiota and metabolite profiles. Biomol. Biomed. 25, 1992\u20132003 (2025).","journal-title":"Biomol. Biomed."},{"key":"10263_CR131","doi-asserted-by":"publisher","first-page":"616045","DOI":"10.3389\/fmicb.2021.616045","volume":"12","author":"BM Woodall","year":"2021","unstructured":"Woodall, B. M. et al. Enterococcus faecalis readily adapts membrane phospholipid composition to environmental and genetic perturbation. Front Microbiol 12, 616045 (2021).","journal-title":"Front Microbiol"},{"key":"10263_CR132","doi-asserted-by":"publisher","first-page":"xtae027","DOI":"10.1093\/femsmc\/xtae027","volume":"5","author":"WAM Madani","year":"2024","unstructured":"Madani, W. A. M., Ramos, Y., Cubillos-Ruiz, J. R. & Morales, D. K. Enterococcal-host interactions in the gastrointestinal tract and beyond. FEMS Microbes 5, xtae027 (2024).","journal-title":"FEMS Microbes"},{"key":"10263_CR133","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41579-024-01058-6","volume":"22","author":"Y Wei","year":"2024","unstructured":"Wei, Y., Palacios Araya, D. & Palmer, K. L. Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics. Nat. Rev. Microbiol 22, 705\u2013721 (2024).","journal-title":"Nat. Rev. Microbiol"},{"key":"10263_CR134","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/jrr\/rrad084","volume":"65","author":"YF Chen","year":"2024","unstructured":"Chen, Y. F., Li, S. C. & Huang, E. Y. Role of microbiota in radiation-induced small-bowel damage. J. Radiat. Res. 65, 55\u201362 (2024).","journal-title":"J. Radiat. Res."},{"key":"10263_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-024-03210-6","volume":"11","author":"RO Jensen","year":"2024","unstructured":"Jensen, R. O. et al. Phylogenomics and genetic analysis of solvent-producing Clostridium species. Sci. Data 11, 432 (2024).","journal-title":"Sci. Data"},{"key":"10263_CR136","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.3390\/nu15112507","volume":"15","author":"L Li","year":"2023","unstructured":"Li, L. et al. Physalis alkekengi L. Calyx extract alleviates glycolipid metabolic disturbance and inflammation by modulating gut microbiota, fecal metabolites, and glycolipid metabolism gene expression in obese mice. Nutrients 15, 2507 (2023).","journal-title":"Nutrients"},{"key":"10263_CR137","doi-asserted-by":"publisher","first-page":"1064462","DOI":"10.3389\/fcimb.2022.1064462","volume":"12","author":"XL Yan","year":"2022","unstructured":"Yan, X. L. et al. Succinate aggravates intestinal injury in mice with necrotizing enterocolitis. Front Cell Infect. Microbiol 12, 1064462 (2022).","journal-title":"Front Cell Infect. Microbiol"},{"key":"10263_CR138","doi-asserted-by":"publisher","first-page":"6259381","DOI":"10.1155\/2021\/6259381","volume":"2021","author":"Q Sun","year":"2021","unstructured":"Sun, Q. et al. Sodium butyrate alleviates intestinal inflammation in mice with necrotizing enterocolitis. Mediators Inflamm. 2021, 6259381 (2021).","journal-title":"Mediators Inflamm."},{"key":"10263_CR139","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.3748\/wjg.v27.i21.2834","volume":"27","author":"X Wen","year":"2021","unstructured":"Wen, X. et al. Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation. World J. Gastroenterol. 27, 2834\u20132849 (2021).","journal-title":"World J. Gastroenterol."},{"key":"10263_CR140","doi-asserted-by":"publisher","first-page":"802823","DOI":"10.3389\/fmicb.2022.802823","volume":"13","author":"J Wan","year":"2022","unstructured":"Wan, J. et al. Gut microbiota and metabolite changes in patients with ulcerative colitis and Clostridioides difficile infection. Front Microbiol 13, 802823 (2022).","journal-title":"Front Microbiol"},{"key":"10263_CR141","doi-asserted-by":"publisher","first-page":"e0032223","DOI":"10.1128\/spectrum.00322-23","volume":"11","author":"OS Akinsuyi","year":"2023","unstructured":"Akinsuyi, O. S. & Roesch, L. F. W. Meta-analysis reveals compositional and functional microbial changes associated with osteoporosis. Microbiol Spectr. 11, e0032223 (2023).","journal-title":"Microbiol Spectr."},{"key":"10263_CR142","doi-asserted-by":"publisher","first-page":"1126808","DOI":"10.3389\/fmicb.2023.1126808","volume":"14","author":"H Yu","year":"2023","unstructured":"Yu, H. et al. Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses. Front Microbiol 14, 1126808 (2023).","journal-title":"Front Microbiol"},{"key":"10263_CR143","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41586-020-2047-9","volume":"579","author":"RA Quinn","year":"2020","unstructured":"Quinn, R. A. et al. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 579, 123\u2013129 (2020).","journal-title":"Nature"},{"key":"10263_CR144","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.chom.2022.02.004","volume":"30","author":"J Cai","year":"2022","unstructured":"Cai, J., Sun, L. & Gonzalez, F. J. Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis. Cell Host Microbe 30, 289\u2013300 (2022).","journal-title":"Cell Host Microbe"},{"key":"10263_CR145","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","volume":"71","author":"WM de Vos","year":"2022","unstructured":"de Vos, W. M., Tilg, H., Van Hul, M. & Cani, P. D. Gut microbiome and health: mechanistic insights. Gut 71, 1020\u20131032 (2022).","journal-title":"Gut"},{"key":"10263_CR146","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41575-024-00896-2","volume":"21","author":"JM Ridlon","year":"2024","unstructured":"Ridlon, J. M. & Gaskins, H. R. Another renaissance for bile acid gastrointestinal microbiology. Nat. Rev. Gastroenterol. Hepatol. 21, 348\u2013364 (2024).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10263_CR147","doi-asserted-by":"publisher","first-page":"105767","DOI":"10.1016\/j.phrs.2021.105767","volume":"171","author":"S Dong","year":"2021","unstructured":"Dong, S. et al. Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism. Pharm. Res. 171, 105767 (2021).","journal-title":"Pharm. Res"},{"key":"10263_CR148","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","volume":"9","author":"JS Fleishman","year":"2024","unstructured":"Fleishman, J. S. & Kumar, S. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets. Signal Transduct. Target Ther. 9, 97 (2024).","journal-title":"Signal Transduct. Target Ther."},{"key":"10263_CR149","doi-asserted-by":"publisher","first-page":"108238","DOI":"10.1016\/j.pharmthera.2022.108238","volume":"237","author":"J Cai","year":"2022","unstructured":"Cai, J., Rimal, B., Jiang, C., Chiang, J. Y. L. & Patterson, A. D. Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharm. Ther. 237, 108238 (2022).","journal-title":"Pharm. Ther."},{"key":"10263_CR150","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.ijrobp.2022.08.007","volume":"115","author":"L Guo","year":"2023","unstructured":"Guo, L. et al. Irradiation-induced intestinal injury is associated with disorders of bile acids metabolism. Int. J. Radiat. Oncol. Biol. Phys. 115, 490\u2013500 (2023).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10263_CR151","first-page":"e2406917","volume":"11","author":"K Zhang","year":"2024","unstructured":"Zhang, K. et al. Bifidobacterium pseudolongum-derived bile acid from dietary carvacrol and thymol supplementation attenuates colitis via cGMP-PKG-mTORC1 Pathway. Adv. Sci. (Weinh.) 11, e2406917 (2024).","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10263_CR152","doi-asserted-by":"publisher","first-page":"108605","DOI":"10.1016\/j.pharmthera.2024.108605","volume":"256","author":"LM Williams","year":"2024","unstructured":"Williams, L. M. & Cao, S. Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches. Pharm. Ther. 256, 108605 (2024).","journal-title":"Pharm. Ther."},{"key":"10263_CR153","doi-asserted-by":"publisher","first-page":"1993582","DOI":"10.1080\/19490976.2021.1993582","volume":"13","author":"RR Fagundes","year":"2021","unstructured":"Fagundes, R. R. et al. Inulin-grown Faecalibacterium prausnitzii cross-feeds fructose to the human intestinal epithelium. Gut Microbes 13, 1993582 (2021).","journal-title":"Gut Microbes"},{"key":"10263_CR154","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40164-023-00410-5","volume":"12","author":"Y Yi","year":"2023","unstructured":"Yi, Y., Lu, W., Shen, L., Wu, Y. & Zhang, Z. The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury. Exp. Hematol. Oncol. 12, 48 (2023).","journal-title":"Exp. Hematol. Oncol."},{"key":"10263_CR155","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","volume":"39","author":"T Zelante","year":"2013","unstructured":"Zelante, T. et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39, 372\u2013385 (2013).","journal-title":"Immunity"},{"key":"10263_CR156","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/gutjnl-2024-333530","volume":"74","author":"Z Shi","year":"2025","unstructured":"Shi, Z. et al. Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer\/T-cell lymphoma by dampening the JAK-STAT pathway. Gut 74, 557\u2013570 (2025).","journal-title":"Gut"},{"key":"10263_CR157","doi-asserted-by":"publisher","unstructured":"Kullberg, R. F. J. et al. Butyrate-producing gut bacterium Faecalibacterium prausnitzii protects against bacterial pneumonia. Eur. Respir. J. 66 (2025). https:\/\/doi.org\/10.1183\/13993003.02208-2024","DOI":"10.1183\/13993003.02208-2024"},{"key":"10263_CR158","doi-asserted-by":"publisher","first-page":"2483780","DOI":"10.1080\/19490976.2025.2483780","volume":"17","author":"B Thulasinathan","year":"2025","unstructured":"Thulasinathan, B. et al. The impact of gut microbial short-chain fatty acids on colorectal cancer development and prevention. Gut Microbes 17, 2483780 (2025).","journal-title":"Gut Microbes"},{"key":"10263_CR159","doi-asserted-by":"publisher","unstructured":"Mart\u00edn, R. et al. Faecalibacterium: a bacterial genus with promising human health applications. FEMS Microbiol. Rev. 47 (2023). https:\/\/doi.org\/10.1093\/femsre\/fuad039","DOI":"10.1093\/femsre\/fuad039"},{"key":"10263_CR160","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","volume":"70","author":"A Agus","year":"2021","unstructured":"Agus, A., Cl\u00e9ment, K. & Sokol, H. Gut microbiota-derived metabolites as central regulators in metabolic disorders. Gut 70, 1174\u20131182 (2021).","journal-title":"Gut"},{"key":"10263_CR161","doi-asserted-by":"publisher","first-page":"105420","DOI":"10.1016\/j.phrs.2021.105420","volume":"165","author":"P Liu","year":"2021","unstructured":"Liu, P. et al. The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis. Pharm. Res. 165, 105420 (2021).","journal-title":"Pharm. Res."},{"key":"10263_CR162","doi-asserted-by":"publisher","first-page":"eaay9097","DOI":"10.1126\/science.aay9097","volume":"370","author":"H Guo","year":"2020","unstructured":"Guo, H. et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science 370, eaay9097 (2020).","journal-title":"Science"},{"key":"10263_CR163","doi-asserted-by":"publisher","first-page":"24400","DOI":"10.1021\/acs.jafc.4c04456","volume":"72","author":"K Peng","year":"2024","unstructured":"Peng, K. et al. Butyrate inhibits the HDAC8\/NF-\u03baB pathway to enhance Slc26a3 expression and improve the intestinal epithelial barrier to relieve colitis. J. Agric Food Chem. 72, 24400\u201324416 (2024).","journal-title":"J. Agric Food Chem."},{"key":"10263_CR164","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.chom.2021.01.009","volume":"29","author":"N Benech","year":"2021","unstructured":"Benech, N., Rolhion, N. & Sokol, H. Tryptophan metabolites get the gut moving. Cell Host Microbe 29, 145\u2013147 (2021).","journal-title":"Cell Host Microbe"},{"key":"10263_CR165","doi-asserted-by":"crossref","unstructured":"Wang, G. et al. Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding. Microbiome 12, 59 (2024).","DOI":"10.1186\/s40168-024-01750-y"},{"key":"10263_CR166","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.chembiol.2024.12.005","volume":"32","author":"K Jones","year":"2025","unstructured":"Jones, K., de Brito, C. B. & Byndloss, M. X. Metabolic tug-of-war: microbial metabolism shapes colonization resistance against enteric pathogens. Cell Chem. Biol. 32, 46\u201360 (2025).","journal-title":"Cell Chem. Biol."},{"key":"10263_CR167","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/s12276-023-01028-7","volume":"55","author":"SK Seo","year":"2023","unstructured":"Seo, S. K. & Kwon, B. Immune regulation through tryptophan metabolism. Exp. Mol. Med 55, 1371\u20131379 (2023).","journal-title":"Exp. Mol. Med"},{"key":"10263_CR168","doi-asserted-by":"publisher","first-page":"19376","DOI":"10.1073\/pnas.2000047117","volume":"117","author":"SA Scott","year":"2020","unstructured":"Scott, S. A., Fu, J. & Chang, P. V. Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. USA. 117, 19376\u201319387 (2020).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10263_CR169","doi-asserted-by":"publisher","first-page":"wrae166","DOI":"10.1093\/ismejo\/wrae166","volume":"18","author":"L Jiang","year":"2024","unstructured":"Jiang, L. et al. Gut microbiota dysbiosis deteriorates immunoregulatory effects of tryptophan via colonic indole and LBP\/HTR2B-mediated macrophage function. ISME J. 18, wrae166 (2024).","journal-title":"ISME J."},{"key":"10263_CR170","doi-asserted-by":"publisher","first-page":"100174","DOI":"10.1016\/j.esmogo.2025.100174","volume":"9","author":"L Twhigg","year":"2025","unstructured":"Twhigg, L., Ng, H. M., Glyn, T., Wall, C. & Purcell, R. Fibre, microbes and radiotherapy: unravelling the gut\u2019s impact on radiotherapy in cancer. ESMO Gastrointest. Oncol. 9, 100174 (2025).","journal-title":"ESMO Gastrointest. Oncol."},{"key":"10263_CR171","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1097\/DCR.0b013e318265720a","volume":"55","author":"C Sahakitrungruang","year":"2012","unstructured":"Sahakitrungruang, C., Patiwongpaisarn, A., Kanjanasilp, P., Malakorn, S. & Atittharnsakul, P. A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4% formalin application for treatment of hemorrhagic radiation proctitis. Dis. Colon Rectum 55, 1053\u20131058 (2012).","journal-title":"Dis. Colon Rectum"},{"key":"10263_CR172","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1136\/gut.32.10.1180","volume":"32","author":"A Danielsson","year":"1991","unstructured":"Danielsson, A. et al. Chronic diarrhoea after radiotherapy for gynaecological cancer: occurrence and aetiology. Gut 32, 1180\u20131187 (1991).","journal-title":"Gut"},{"key":"10263_CR173","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1136\/gutjnl-2024-333812","volume":"74","author":"J Andreyev","year":"2025","unstructured":"Andreyev, J. et al. British Society of Gastroenterology practice guidance on the management of acute and chronic gastrointestinal symptoms and complications as a result of treatment for cancer. Gut 74, 1040\u20131067 (2025).","journal-title":"Gut"},{"key":"10263_CR174","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1021\/acsomega.9b03906","volume":"5","author":"Z Zhao","year":"2020","unstructured":"Zhao, Z., Cheng, W., Qu, W., Shao, G. & Liu, S. Antibiotic alleviates radiation-induced intestinal injury by remodeling microbiota, reducing inflammation, and inhibiting fibrosis. ACS Omega 5, 2967\u20132977 (2020).","journal-title":"ACS Omega"},{"key":"10263_CR175","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s41579-023-00933-y","volume":"21","author":"SRS Fishbein","year":"2023","unstructured":"Fishbein, S. R. S., Mahmud, B. & Dantas, G. Antibiotic perturbations to the gut microbiome. Nat. Rev. Microbiol 21, 772\u2013788 (2023).","journal-title":"Nat. Rev. Microbiol"},{"key":"10263_CR176","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1136\/gutjnl-2016-313017","volume":"66","author":"G Cammarota","year":"2017","unstructured":"Cammarota, G. et al. European consensus conference on faecal microbiota transplantation in clinical practice. Gut 66, 569\u2013580 (2017).","journal-title":"Gut"},{"key":"10263_CR177","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.scib.2025.01.029","volume":"70","author":"X Wang","year":"2025","unstructured":"Wang, X. et al. Fecal microbiota transplantation: transitioning from chaos and controversial realm to scientific precision era. Sci. Bull. (Beijing) 70, 970\u2013985 (2025).","journal-title":"Sci. Bull. (Beijing)"},{"key":"10263_CR178","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.radonc.2020.01.011","volume":"143","author":"X Ding","year":"2020","unstructured":"Ding, X. et al. Fecal microbiota transplantation: A promising treatment for radiation enteritis? Radiother. Oncol. 143, 12\u201318 (2020).","journal-title":"Radiother. Oncol."},{"key":"10263_CR179","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.3748\/wjg.v30.i19.2603","volume":"30","author":"L Wang","year":"2024","unstructured":"Wang, L., Li, Y., Zhang, Y. J. & Peng, L. H. Intestinal microecological transplantation for a patient with chronic radiation enteritis: a case report. World J. Gastroenterol. 30, 2603\u20132611 (2024).","journal-title":"World J. Gastroenterol."},{"key":"10263_CR180","doi-asserted-by":"publisher","unstructured":"Bustamante, J. M. et al. Impact of fecal microbiota transplantation on gut bacterial bile acid metabolism in humans. Nutrients 14 (2022). https:\/\/doi.org\/10.3390\/nu14245200","DOI":"10.3390\/nu14245200"},{"key":"10263_CR181","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41586-020-2396-4","volume":"582","author":"M Funabashi","year":"2020","unstructured":"Funabashi, M. et al. A metabolic pathway for bile acid dehydroxylation by the gut microbiome. Nature 582, 566\u2013570 (2020).","journal-title":"Nature"},{"key":"10263_CR182","doi-asserted-by":"publisher","first-page":"1702694","DOI":"10.3389\/fmicb.2025.1702694","volume":"16","author":"L Lu","year":"2025","unstructured":"Lu, L. et al. Effects of total abdominal irradiation on gut microbiota and metabolome during acute tissue injury. Front Microbiol 16, 1702694 (2025).","journal-title":"Front Microbiol"},{"key":"10263_CR183","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1056\/NEJMoa2106516","volume":"386","author":"P Feuerstadt","year":"2022","unstructured":"Feuerstadt, P. et al. SER-109, an oral microbiome therapy for recurrent Clostridioides difficile infection. N. Engl. J. Med 386, 220\u2013229 (2022).","journal-title":"N. Engl. J. Med"},{"key":"10263_CR184","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1053\/j.gastro.2021.02.013","volume":"160","author":"K Fujimoto","year":"2021","unstructured":"Fujimoto, K. et al. Functional restoration of bacteriomes and viromes by fecal microbiota transplantation. Gastroenterology 160, 2089\u20132102.e2012 (2021).","journal-title":"Gastroenterology"},{"key":"10263_CR185","doi-asserted-by":"publisher","first-page":"2100197","DOI":"10.1080\/19490976.2022.2100197","volume":"14","author":"R He","year":"2022","unstructured":"He, R. et al. The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation. Gut Microbes 14, 2100197 (2022).","journal-title":"Gut Microbes"},{"key":"10263_CR186","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.chom.2024.01.013","volume":"32","author":"Q Chen","year":"2024","unstructured":"Chen, Q. et al. Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome. Cell Host Microbe 32, 349\u2013365.e344 (2024).","journal-title":"Cell Host Microbe"},{"key":"10263_CR187","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41575-021-00441-5","volume":"18","author":"C Danne","year":"2021","unstructured":"Danne, C., Rolhion, N. & Sokol, H. Recipient factors in faecal microbiota transplantation: one stool does not fit all. Nat. Rev. Gastroenterol. Hepatol. 18, 503\u2013513 (2021).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10263_CR188","doi-asserted-by":"publisher","first-page":"135280","DOI":"10.1016\/j.foodchem.2022.135280","volume":"409","author":"Q Fang","year":"2023","unstructured":"Fang, Q. et al. Effects of dietary irritants on intestinal homeostasis and the intervention strategies. Food Chem. 409, 135280 (2023).","journal-title":"Food Chem."},{"key":"10263_CR189","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1136\/gutjnl-2020-322670","volume":"70","author":"LA Bolte","year":"2021","unstructured":"Bolte, L. A. et al. Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut 70, 1287\u20131298 (2021).","journal-title":"Gut"},{"key":"10263_CR190","doi-asserted-by":"publisher","first-page":"2489072","DOI":"10.1080\/19490976.2025.2489072","volume":"17","author":"Y He","year":"2025","unstructured":"He, Y. et al. Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding. Gut Microbes 17, 2489072 (2025).","journal-title":"Gut Microbes"},{"key":"10263_CR191","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1038\/s41416-022-01980-7","volume":"127","author":"SE Eaton","year":"2022","unstructured":"Eaton, S. E. et al. Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients. Br. J. Cancer 127, 2087\u20132098 (2022).","journal-title":"Br. J. Cancer"},{"key":"10263_CR192","doi-asserted-by":"publisher","unstructured":"Malipatlolla, D. K. et al. A fiber-rich diet and radiation-induced injury in the murine intestinal mucosa. Int. J. Mol. Sci. 23 (2021). https:\/\/doi.org\/10.3390\/ijms23010439","DOI":"10.3390\/ijms23010439"},{"key":"10263_CR193","doi-asserted-by":"publisher","first-page":"175628482513473","DOI":"10.1177\/17562848251347347","volume":"18","author":"Q Wang","year":"2025","unstructured":"Wang, Q., Xu, G., Yan, O., Wang, S. & Wang, X. Radiation-induced injury and the gut microbiota: insights from a microbial perspective. Ther. Adv. Gastroenterol. 18, 17562848251347347 (2025).","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10263_CR194","doi-asserted-by":"publisher","first-page":"e21787","DOI":"10.1096\/fj.202100351RR","volume":"35","author":"Y Li","year":"2021","unstructured":"Li, Y. et al. Caloric restriction alleviates radiation injuries in a sex-dependent fashion. FASEB J. 35, e21787 (2021).","journal-title":"FASEB J."},{"key":"10263_CR195","doi-asserted-by":"publisher","first-page":"109707","DOI":"10.1016\/j.jnutbio.2024.109707","volume":"133","author":"LL Zhang","year":"2024","unstructured":"Zhang, L. L. et al. Dietary restriction and fasting alleviate radiation-induced intestinal injury by inhibiting cGAS\/STING activation. J. Nutr. Biochem 133, 109707 (2024).","journal-title":"J. Nutr. Biochem"},{"key":"10263_CR196","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41392-021-00831-w","volume":"7","author":"H Zhu","year":"2022","unstructured":"Zhu, H. et al. Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations. Signal Transduct. Target Ther. 7, 11 (2022).","journal-title":"Signal Transduct. Target Ther."},{"key":"10263_CR197","first-page":"e04249","volume":"12","author":"C Mu","year":"2025","unstructured":"Mu, C., Rho, J. M. & Shearer, J. The interplay between the gut and ketogenic diets in health and disease. Adv. Sci. (Weinh.) 12, e04249 (2025).","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10263_CR198","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41392-021-00549-9","volume":"6","author":"C Kong","year":"2021","unstructured":"Kong, C. et al. Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome. Signal Transduct. Target Ther. 6, 154 (2021).","journal-title":"Signal Transduct. Target Ther."},{"key":"10263_CR199","doi-asserted-by":"publisher","first-page":"101667","DOI":"10.1016\/j.xcrm.2024.101667","volume":"5","author":"A Hengist","year":"2024","unstructured":"Hengist, A. et al. Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT. Cell Rep. Med 5, 101667 (2024).","journal-title":"Cell Rep. Med"},{"key":"10263_CR200","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1053\/j.gastro.2021.08.041","volume":"162","author":"J Yang","year":"2022","unstructured":"Yang, J. et al. High-fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites. Gastroenterology 162, 135\u2013149.e132 (2022).","journal-title":"Gastroenterology"},{"key":"10263_CR201","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.immuni.2025.03.017","volume":"58","author":"L Xiong","year":"2025","unstructured":"Xiong, L. et al. Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis. Immunity 58, 1185\u20131200.e1188 (2025).","journal-title":"Immunity"},{"key":"10263_CR202","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.2147\/DMSO.S456173","volume":"17","author":"J Hong","year":"2024","unstructured":"Hong, J. et al. An update on the role and potential molecules in relation to ruminococcus gnavus in inflammatory bowel disease, obesity and diabetes mellitus. Diab. Metab. Syndr. Obes. 17, 1235\u20131248 (2024).","journal-title":"Diab. Metab. Syndr. Obes."},{"key":"10263_CR203","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41392-024-01771-x","volume":"9","author":"YL Xiao","year":"2024","unstructured":"Xiao, Y. L., Gong, Y., Qi, Y. J., Shao, Z. M. & Jiang, Y. Z. Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential. Signal Transduct. Target Ther. 9, 59 (2024).","journal-title":"Signal Transduct. Target Ther."},{"key":"10263_CR204","doi-asserted-by":"publisher","unstructured":"Wu, P. et al. Puerariae lobatae Radix ameliorates chronic kidney disease by reshaping gut microbiota and downregulating Wnt\/\u03b2\u2011catenin signaling. Mol. Med. Rep. 30 (2024). https:\/\/doi.org\/10.3892\/mmr.2024.13241","DOI":"10.3892\/mmr.2024.13241"},{"key":"10263_CR205","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1875774","volume":"13","author":"VT Pham","year":"2021","unstructured":"Pham, V. T. et al. Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome- a pilot study. Gut Microbes 13, 1\u201320 (2021).","journal-title":"Gut Microbes"},{"key":"10263_CR206","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03322-0","volume":"23","author":"S Xian","year":"2025","unstructured":"Xian, S., Meng, F., Chen, X., Zhu, L. & Wang, H. Reduction of colitis in mice by chemically programmed supramolecular nanoassemblies of vitamin-lipid conjugates. J. Nanobiotechnol. 23, 247 (2025).","journal-title":"J. Nanobiotechnol."},{"key":"10263_CR207","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","volume":"40","author":"M Muscaritoli","year":"2021","unstructured":"Muscaritoli, M. et al. ESPEN practical guideline: clinical nutrition in cancer. Clin. Nutr. 40, 2898\u20132913 (2021).","journal-title":"Clin. Nutr."},{"key":"10263_CR208","doi-asserted-by":"publisher","first-page":"6294","DOI":"10.3390\/nu7085288","volume":"7","author":"X Wan","year":"2015","unstructured":"Wan, X. et al. Partial enteral nutrition preserves elements of gut barrier function, including innate immunity, intestinal alkaline phosphatase (IAP) level, and intestinal microbiota in mice. Nutrients 7, 6294\u20136312 (2015).","journal-title":"Nutrients"},{"key":"10263_CR209","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/jnci\/djae051","volume":"116","author":"NP Ilerhunmwuwa","year":"2024","unstructured":"Ilerhunmwuwa, N. P. et al. Dietary interventions in cancer: a systematic review of all randomized controlled trials. J. Natl. Cancer Inst. 116, 1026\u20131034 (2024).","journal-title":"J. Natl. Cancer Inst."},{"key":"10263_CR210","doi-asserted-by":"publisher","first-page":"e75633","DOI":"10.2196\/75633","volume":"11","author":"J Huang","year":"2025","unstructured":"Huang, J. et al. Effectiveness and adherence of nutritional management via electronic patient-reported outcomes platform in patients with cancer: multicenter prospective longitudinal cohort study. JMIR Cancer 11, e75633 (2025).","journal-title":"JMIR Cancer"},{"key":"10263_CR211","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s00394-024-03561-1","volume":"64","author":"A William","year":"2025","unstructured":"William, A. et al. Delphi survey to gather feedback on a CONSORT extension proposal for nutrition intervention trials. Eur. J. Nutr. 64, 76 (2025).","journal-title":"Eur. J. Nutr."},{"key":"10263_CR212","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bbi.2025.03.032","volume":"128","author":"M Sim","year":"2025","unstructured":"Sim, M. et al. Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitamin C status: A randomized, double-blind, placebo-controlled trial. Brain Behav. Immun. 128, 179\u2013191 (2025).","journal-title":"Brain Behav. Immun."},{"key":"10263_CR213","doi-asserted-by":"publisher","first-page":"2473524","DOI":"10.1080\/19490976.2025.2473524","volume":"17","author":"M Jimenez-Sanchez","year":"2025","unstructured":"Jimenez-Sanchez, M., Celiberto, L. S., Yang, H., Sham, H. P. & Vallance, B. A. The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential. Gut Microbes 17, 2473524 (2025).","journal-title":"Gut Microbes"},{"key":"10263_CR214","doi-asserted-by":"publisher","first-page":"103964","DOI":"10.1016\/j.numecd.2025.103964","volume":"35","author":"B Chen","year":"2025","unstructured":"Chen, B. et al. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: a randomized controlled trial. Nutr. Metab. Cardiovasc Dis. 35, 103964 (2025).","journal-title":"Nutr. Metab. Cardiovasc Dis."},{"key":"10263_CR215","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.clnu.2013.02.004","volume":"32","author":"A Hamad","year":"2013","unstructured":"Hamad, A., Fragkos, K. C. & Forbes, A. A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease. Clin. Nutr. 32, 353\u2013360 (2013).","journal-title":"Clin. Nutr."},{"key":"10263_CR216","doi-asserted-by":"publisher","first-page":"912","DOI":"10.3748\/wjg.v13.i6.912","volume":"13","author":"P Delia","year":"2007","unstructured":"Delia, P. et al. Use of probiotics for prevention of radiation-induced diarrhea. World J. Gastroenterol. 13, 912\u2013915 (2007).","journal-title":"World J. Gastroenterol."},{"key":"10263_CR217","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.ijrobp.2007.11.009","volume":"71","author":"J Giralt","year":"2008","unstructured":"Giralt, J. et al. Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial. Int. J. Radiat. Oncol. Biol. Phys. 71, 1213\u20131219 (2008).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10263_CR218","doi-asserted-by":"publisher","first-page":"e0103924","DOI":"10.1128\/jvi.01039-24","volume":"98","author":"J Wang","year":"2024","unstructured":"Wang, J. et al. AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection. J. Virol. 98, e0103924 (2024).","journal-title":"J. Virol."},{"key":"10263_CR219","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41575-020-0344-2","volume":"17","author":"KS Swanson","year":"2020","unstructured":"Swanson, K. S. et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat. Rev. Gastroenterol. Hepatol. 17, 687\u2013701 (2020).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10263_CR220","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ijrobp.2014.05.049","volume":"90","author":"M Nascimento","year":"2014","unstructured":"Nascimento, M., Aguilar-Nascimento, J. E., Caporossi, C., Castro-Barcellos, H. M. & Motta, R. T. Efficacy of synbiotics to reduce acute radiation proctitis symptoms and improve quality of life: a randomized, double-blind, placebo-controlled pilot trial. Int J. Radiat. Oncol. Biol. Phys. 90, 289\u2013295 (2014).","journal-title":"Int J. Radiat. Oncol. Biol. Phys."},{"key":"10263_CR221","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.clnu.2025.03.025","volume":"49","author":"C Stene","year":"2025","unstructured":"Stene, C. et al. Synbiotics protected radiation-induced tissue damage in rectal cancer patients: a controlled trial. Clin. Nutr. 49, 33\u201341 (2025).","journal-title":"Clin. Nutr."},{"key":"10263_CR222","first-page":"e2417283","volume":"12","author":"W Chen","year":"2025","unstructured":"Chen, W. et al. Engineered probiotics mitigate gut barrier dysfunction induced by nanoplastics. Adv. Sci. (Weinh.) 12, e2417283 (2025).","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10263_CR223","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jconrel.2024.08.036","volume":"374","author":"P Peng","year":"2024","unstructured":"Peng, P. et al. Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease. J. Control Release 374, 538\u2013549 (2024).","journal-title":"J. Control Release"},{"key":"10263_CR224","doi-asserted-by":"publisher","first-page":"155527","DOI":"10.1016\/j.cej.2024.155527","volume":"499","author":"Y Chang","year":"2024","unstructured":"Chang, Y. et al. Bioencapsulation of probiotics with self-assembled DNA capsules for the treatment of inflammatory bowel diseases. Chem. Eng. J. 499, 155527 (2024).","journal-title":"Chem. Eng. J."},{"key":"10263_CR225","doi-asserted-by":"publisher","first-page":"101876","DOI":"10.1016\/j.nantod.2023.101876","volume":"50","author":"K Wang","year":"2023","unstructured":"Wang, K. et al. Mucoadhesive probiotic-based oral microcarriers with prolonged intestinal retention for inflammatory bowel disease therapy. Nano Today 50, 101876 (2023).","journal-title":"Nano Today"},{"key":"10263_CR226","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48560-2","volume":"15","author":"J Wu","year":"2024","unstructured":"Wu, J. et al. Bacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence. Nat. Commun. 15, 4764 (2024).","journal-title":"Nat. Commun."},{"key":"10263_CR227","doi-asserted-by":"publisher","first-page":"109930","DOI":"10.1016\/j.celrep.2021.109930","volume":"37","author":"KN Lam","year":"2021","unstructured":"Lam, K. N. et al. Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome. Cell Rep. 37, 109930 (2021).","journal-title":"Cell Rep."},{"key":"10263_CR228","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-01833-w","volume":"12","author":"M Zuppi","year":"2024","unstructured":"Zuppi, M. et al. Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity. Microbiome 12, 122 (2024).","journal-title":"Microbiome"},{"key":"10263_CR229","doi-asserted-by":"publisher","first-page":"117003","DOI":"10.1016\/j.foodres.2025.117003","volume":"219","author":"MS Islam","year":"2025","unstructured":"Islam, M. S., Wei, P., Zhang, K., Nime, I. & Pan, F. Phage therapy modulates the gut microbiome and immune responses in non-typhoidal Salmonella-induced colitis. Food Res. Int. 219, 117003 (2025).","journal-title":"Food Res. Int."},{"key":"10263_CR230","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/bs.pmbts.2023.04.005","volume":"201","author":"X Chen","year":"2023","unstructured":"Chen, X., Mendes, B. G., Alves, B. S. & Duan, Y. Phage therapy in gut microbiome. Prog. Mol. Biol. Transl. Sci. 201, 93\u2013118 (2023).","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10263_CR231","doi-asserted-by":"publisher","first-page":"8048","DOI":"10.1080\/10408398.2022.2054934","volume":"63","author":"BL He","year":"2023","unstructured":"He, B. L., Xiong, Y., Hu, T. G., Zong, M. H. & Wu, H. Bifidobacterium spp. as functional foods: a review of current status, challenges, and strategies. Crit. Rev. Food Sci. Nutr. 63, 8048\u20138065 (2023).","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10263_CR232","doi-asserted-by":"publisher","first-page":"112010","DOI":"10.1016\/j.foodres.2022.112010","volume":"162","author":"S Chen","year":"2022","unstructured":"Chen, S. et al. Targeting the gut microbiota to investigate the mechanism of Lactiplantibacillus plantarum 1201 in negating colitis aggravated by a high-salt diet. Food Res Int 162, 112010 (2022).","journal-title":"Food Res Int"},{"key":"10263_CR233","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s12276-022-00911-z","volume":"55","author":"B Wang","year":"2023","unstructured":"Wang, B. et al. Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases. Exp. Mol. Med 55, 55\u201368 (2023).","journal-title":"Exp. Mol. Med"},{"key":"10263_CR234","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1039\/D4FO06377E","volume":"16","author":"Y Chen","year":"2025","unstructured":"Chen, Y. et al. Alleviation effects of Lactobacillus plantarum in colitis aggravated by a high-salt diet depend on intestinal barrier protection, NF-\u03baB pathway regulation, and oxidative stress improvement. Food Funct. 16, 2718\u20132736 (2025).","journal-title":"Food Funct."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10263-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10263-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10263-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:02:51Z","timestamp":1779368571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10263-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":234,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10263"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10263-3","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"13 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"692"}}