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Here we show that in HPV-transformed cervical cancer cells, MYPOP induces alterations in cell morphology, silences viral and cellular oncogenes including\n                    <jats:italic>E6<\/jats:italic>\n                    and\n                    <jats:italic>MYC<\/jats:italic>\n                    , and stimulates the release of the cancer-killing cytokine interleukin-24. Transcriptomic and live-cell analyses reveal a rapid G1\/S-phase arrest followed by loss of viable cervical cancer cells and induction of apoptosis. Moreover, MYPOP expression is broadly diminished across multiple human cancers, and its re-expression by both DNA- and mRNA-gene transfer markedly suppresses tumor cell proliferation while sparing normal epidermal keratinocytes. Similarly, murine Mypop inhibits mouse cancer cell growth. Collectively, our findings identify MYPOP as a selective suppressor of tumor cell proliferation across species in vitro and point to its potential relevance for future therapeutic investigation.\n                  <\/jats:p>","DOI":"10.1038\/s42003-026-10272-2","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T21:15:13Z","timestamp":1779225313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell 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