{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:07:26Z","timestamp":1788908846997,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":97,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10284-y","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:55:15Z","timestamp":1780595715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NR3C1\/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury"],"prefix":"10.1038","volume":"9","author":[{"given":"Guowei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingze","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-7204","authenticated-orcid":false,"given":"Bin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-3188","authenticated-orcid":false,"given":"Weibo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"10284_CR1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1037\/emo0001362","volume":"24","author":"D Colombo","year":"2024","unstructured":"Colombo, D. et al. Daily stress encounters: positive emotion upregulation and depressive symptoms. Emotion 24, 1403\u20131416 (2024).","journal-title":"Emotion"},{"key":"10284_CR2","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1600-0447.2005.00634.x","volume":"112","author":"J Read","year":"2005","unstructured":"Read, J., van Os, J., Morrison, A. P. & Ross, C. A. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr. Scand. 112, 330\u2013350 (2005).","journal-title":"Acta Psychiatr. Scand."},{"key":"10284_CR3","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/wps.21018","volume":"21","author":"M Freeman","year":"2022","unstructured":"Freeman, M. The World Mental Health Report: transforming mental health for all. World Psychiatry 21, 391\u2013392 (2022).","journal-title":"World Psychiatry"},{"key":"10284_CR4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41569-024-01024-y","volume":"21","author":"V Vaccarino","year":"2024","unstructured":"Vaccarino, V. & Bremner, J. D. Stress and cardiovascular disease: an update. Nat. Rev. Cardiol. 21, 603\u2013616 (2024).","journal-title":"Nat. Rev. Cardiol."},{"key":"10284_CR5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41584-023-01037-w","volume":"19","author":"J Brock","year":"2023","unstructured":"Brock, J. et al. Immune mechanisms of depression in rheumatoid arthritis. Nat. Rev. Rheumatol. 19, 790\u2013804 (2023).","journal-title":"Nat. Rev. Rheumatol."},{"key":"10284_CR6","doi-asserted-by":"publisher","unstructured":"Munalisa, R. et al. Restraint stress-induced neutrophil inflammation contributes to concurrent gastrointestinal injury in mice. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms25105261 (2024).","DOI":"10.3390\/ijms25105261"},{"key":"10284_CR7","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1016\/j.immuni.2024.07.011","volume":"57","author":"B Wei","year":"2024","unstructured":"Wei, B. et al. Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension. Immunity 57, 2030\u20132042 e2038 (2024).","journal-title":"Immunity"},{"key":"10284_CR8","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neuron.2012.08.019","volume":"75","author":"JJ Harris","year":"2012","unstructured":"Harris, J. J., Jolivet, R. & Attwell, D. Synaptic energy use and supply. Neuron 75, 762\u2013777 (2012).","journal-title":"Neuron"},{"key":"10284_CR9","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.1219855","volume":"337","author":"RJ Youle","year":"2012","unstructured":"Youle, R. J. & van der Bliek, A. M. Mitochondrial fission, fusion, and stress. Science 337, 1062\u20131065 (2012).","journal-title":"Science"},{"key":"10284_CR10","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","volume":"83","author":"L Uoselis","year":"2023","unstructured":"Uoselis, L., Nguyen, T. N. & Lazarou, M. Mitochondrial degradation: mitophagy and beyond. Mol. Cell 83, 3404\u20133420 (2023).","journal-title":"Mol. Cell"},{"key":"10284_CR11","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1038\/s12276-023-01046-5","volume":"55","author":"TT Nguyen","year":"2023","unstructured":"Nguyen, T. T. et al. Mitochondria-associated programmed cell death as a therapeutic target for age-related disease. Exp. Mol. Med. 55, 1595\u20131619 (2023).","journal-title":"Exp. Mol. Med."},{"key":"10284_CR12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2016.23","volume":"17","author":"PM Quiros","year":"2016","unstructured":"Quiros, P. M., Mottis, A. & Auwerx, J. Mitonuclear communication in homeostasis and stress. Nat. Rev. Mol. Cell Biol. 17, 213\u2013226 (2016).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10284_CR13","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s12640-020-00283-0","volume":"39","author":"T Huang","year":"2021","unstructured":"Huang, T. et al. Involvement of mitophagy in aluminum oxide nanoparticle-induced impairment of learning and memory in mice. Neurotox. Res. 39, 378\u2013391 (2021).","journal-title":"Neurotox. Res."},{"key":"10284_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.brainresbull.2022.01.009","volume":"182","author":"L Guo","year":"2022","unstructured":"Guo, L. et al. Repeated social defeat stress inhibits development of hippocampus neurons through mitophagy and autophagy. Brain Res. Bull. 182, 111\u2013117 (2022).","journal-title":"Brain Res. Bull."},{"key":"10284_CR15","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1016\/j.celrep.2018.01.089","volume":"22","author":"A Iannielli","year":"2018","unstructured":"Iannielli, A. et al. Pharmacological inhibition of necroptosis protects from dopaminergic neuronal cell death in Parkinson\u2019s disease models. Cell Rep. 22, 2066\u20132079 (2018).","journal-title":"Cell Rep."},{"key":"10284_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/j.2040-4603.2016.tb00694.x","volume":"6","author":"JP Herman","year":"2016","unstructured":"Herman, J. P. et al. Regulation of the hypothalamic-pituitary-adrenocortical stress response. Compr. Physiol. 6, 603\u2013621 (2016).","journal-title":"Compr. Physiol."},{"key":"10284_CR17","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1093\/brain\/awad127","volume":"146","author":"F Du","year":"2023","unstructured":"Du, F., Yu, Q., Swerdlow, R. H. & Waites, C. L. Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain 146, 4378\u20134394 (2023).","journal-title":"Brain"},{"key":"10284_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41413-024-00371-3","volume":"12","author":"W Shao","year":"2024","unstructured":"Shao, W. et al. Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head. Bone Res. 12, 64 (2024).","journal-title":"Bone Res."},{"key":"10284_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","volume":"8","author":"W Chen","year":"2023","unstructured":"Chen, W., Zhao, H. & Li, Y. Mitochondrial dynamics in health and disease: mechanisms and potential targets. Signal Transduct. Target Ther. 8, 333 (2023).","journal-title":"Signal Transduct. Target Ther."},{"key":"10284_CR20","doi-asserted-by":"publisher","unstructured":"Zhang, L. et al. Interleukin 6 (IL-6) regulates GABAA receptors in the dorsomedial hypothalamus nucleus (DMH) through activation of the JAK\/STAT pathway to affect heart rate variability in stressed rats. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms241612985 (2023).","DOI":"10.3390\/ijms241612985"},{"key":"10284_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02543-6","volume":"19","author":"Z Peng","year":"2022","unstructured":"Peng, Z. et al. Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain. J. Neuroinflamm. 19, 186 (2022).","journal-title":"J. Neuroinflamm."},{"key":"10284_CR22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.redox.2014.11.006","volume":"4","author":"HM Ni","year":"2015","unstructured":"Ni, H. M., Williams, J. A. & Ding, W. X. Mitochondrial dynamics and mitochondrial quality control. Redox Biol. 4, 6\u201313 (2015).","journal-title":"Redox Biol."},{"key":"10284_CR23","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.apsb.2020.03.004","volume":"10","author":"J Wang","year":"2020","unstructured":"Wang, J. & Zhou, H. Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury. Acta Pharm. Sin. B 10, 1866\u20131879 (2020).","journal-title":"Acta Pharm. Sin. B"},{"key":"10284_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2020.151144","volume":"100","author":"M Cheng","year":"2021","unstructured":"Cheng, M. et al. PGAM5: a crucial role in mitochondrial dynamics and programmed cell death. Eur. J. Cell Biol. 100, 151144 (2021).","journal-title":"Eur. J. Cell Biol."},{"key":"10284_CR25","first-page":"32","volume":"11","author":"BH Liu","year":"2024","unstructured":"Liu, B. H. et al. Mitochondrial quality control in human health and disease. Mil. Med. Res. 11, 32 (2024).","journal-title":"Mil. Med. Res."},{"key":"10284_CR26","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1038\/s42255-023-00924-6","volume":"5","author":"W-T Dong","year":"2023","unstructured":"Dong, W.-T. et al. Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice. Nat. Metab. 5, 2220\u20132236 (2023).","journal-title":"Nat. Metab."},{"key":"10284_CR27","doi-asserted-by":"publisher","first-page":"5916","DOI":"10.1002\/ptr.8004","volume":"37","author":"X Zhu","year":"2023","unstructured":"Zhu, X. et al. Resveratrol prevents Drp1-mediated mitochondrial fission in the diabetic kidney through the PDE4D\/PKA pathway. Phytother. Res. 37, 5916\u20135931 (2023).","journal-title":"Phytother. Res."},{"key":"10284_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","volume":"12","author":"RJ Youle","year":"2011","unstructured":"Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9\u201314 (2011).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10284_CR29","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022113033","volume":"42","author":"Y Cao","year":"2023","unstructured":"Cao, Y. et al. A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. EMBO J. 42, e113033 (2023).","journal-title":"EMBO J."},{"key":"10284_CR30","doi-asserted-by":"publisher","unstructured":"Ding, W. et al. Neuroprotective effects of macrostemonoside T on glutamate-induced injury in HT22 cells. Biochem. Pharmacol. https:\/\/doi.org\/10.1016\/j.bcp.2025.116827 (2025).","DOI":"10.1016\/j.bcp.2025.116827"},{"key":"10284_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20679-y","volume":"12","author":"GE Choi","year":"2021","unstructured":"Choi, G. E. et al. BNIP3L\/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat. Commun. 12, 487 (2021).","journal-title":"Nat. Commun."},{"key":"10284_CR32","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","volume":"18","author":"H Chen","year":"2009","unstructured":"Chen, H. & Chan, D. C. Mitochondrial dynamics\u2013fusion, fission, movement, and mitophagy\u2013in neurodegenerative diseases. Hum. Mol. Genet. 18, R169\u2013R176 (2009).","journal-title":"Hum. Mol. Genet."},{"key":"10284_CR33","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00018-015-2087-8","volume":"73","author":"A Hamacher-Brady","year":"2016","unstructured":"Hamacher-Brady, A. & Brady, N. R. Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. Cell Mol. Life Sci. 73, 775\u2013795 (2016).","journal-title":"Cell Mol. Life Sci."},{"key":"10284_CR34","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","volume":"17","author":"R He","year":"2021","unstructured":"He, R. et al. HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. Autophagy 17, 3338\u20133360 (2021).","journal-title":"Autophagy"},{"key":"10284_CR35","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1007\/s12094-018-1958-5","volume":"21","author":"L Hui","year":"2019","unstructured":"Hui, L. et al. Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1. Clin. Transl. Oncol. 21, 596\u2013606 (2019).","journal-title":"Clin. Transl. Oncol."},{"key":"10284_CR36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","volume":"21","author":"M Giacomello","year":"2020","unstructured":"Giacomello, M., Pyakurel, A., Glytsou, C. & Scorrano, L. The cell biology of mitochondrial membrane dynamics. Nat. Rev. Mol. Cell Biol. 21, 204\u2013224 (2020).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10284_CR37","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","volume":"20","author":"JB Spinelli","year":"2018","unstructured":"Spinelli, J. B. & Haigis, M. C. The multifaceted contributions of mitochondria to cellular metabolism. Nat. Cell Biol. 20, 745\u2013754 (2018).","journal-title":"Nat. Cell Biol."},{"key":"10284_CR38","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/s41590-024-01798-w","volume":"25","author":"HF Bradford","year":"2024","unstructured":"Bradford, H. F. et al. Thioredoxin is a metabolic rheostat controlling regulatory B cells. Nat. Immunol. 25, 873\u2013885 (2024).","journal-title":"Nat. Immunol."},{"key":"10284_CR39","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jbspin.2011.04.011","volume":"79","author":"J Liu","year":"2012","unstructured":"Liu, J., Wang, J. & Zhou, Y. Upregulation of BNIP3 and translocation to mitochondria in nutrition deprivation induced apoptosis in nucleus pulposus cells. Jt. Bone Spine 79, 186\u2013191 (2012).","journal-title":"Jt. Bone Spine"},{"key":"10284_CR40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","volume":"21","author":"FJ Bock","year":"2020","unstructured":"Bock, F. J. & Tait, S. W. G. Mitochondria as multifaceted regulators of cell death. Nat. Rev. Mol. Cell Biol. 21, 85\u2013100 (2020).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10284_CR41","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.apsb.2024.04.020","volume":"14","author":"X Jin","year":"2024","unstructured":"Jin, X. et al. Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer. Acta Pharm. Sin. B. 14, 2815\u20132853 (2024).","journal-title":"Acta Pharm. Sin. B"},{"key":"10284_CR42","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","volume":"187","author":"K Newton","year":"2024","unstructured":"Newton, K., Strasser, A., Kayagaki, N. & Dixit, V. M. Cell death. Cell 187, 235\u2013256 (2024).","journal-title":"Cell"},{"key":"10284_CR43","doi-asserted-by":"publisher","unstructured":"Zhou, B. et al. Necroptosis contributes to LPS-induced activation of the hypothalamic-pituitary-adrenal axis in a piglet model. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms231911218 (2022).","DOI":"10.3390\/ijms231911218"},{"key":"10284_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42780-8","volume":"14","author":"SG Xue","year":"2023","unstructured":"Xue, S. G. et al. Enhanced TARP-gamma8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice. Nat. Commun. 14, 7971 (2023).","journal-title":"Nat. Commun."},{"key":"10284_CR45","doi-asserted-by":"publisher","first-page":"10190","DOI":"10.1073\/pnas.1107402108","volume":"108","author":"AS Rambold","year":"2011","unstructured":"Rambold, A. S., Kostelecky, B., Elia, N. & Lippincott-Schwartz, J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc. Natl. Acad. Sci. USA. 108, 10190\u201310195 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10284_CR46","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.toxlet.2005.02.003","volume":"157","author":"M Cavas","year":"2005","unstructured":"Cavas, M., Beltran, D. & Navarro, J. F. Behavioural effects of dimethyl sulfoxide (DMSO): changes in sleep architecture in rats. Toxicol. Lett. 157, 221\u2013232 (2005).","journal-title":"Toxicol. Lett."},{"key":"10284_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03900-8","volume":"12","author":"H Wen","year":"2021","unstructured":"Wen, H. et al. Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1\/Parkin-induced mitochondrial ubiquitination in adult rats. Cell Death Dis. 12, 630 (2021).","journal-title":"Cell Death Dis."},{"key":"10284_CR48","doi-asserted-by":"publisher","unstructured":"Zaric Kontic, M. et al. Prolonged alprazolam treatment alters components of glutamatergic neurotransmission in the hippocampus of male wistar rats\u2014the neuroadaptive changes following long-term benzodiazepine (mis)use. Pharmaceuticals (Basel) https:\/\/doi.org\/10.3390\/ph16030331 (2023).","DOI":"10.3390\/ph16030331"},{"key":"10284_CR49","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1083\/jcb.11.3.736","volume":"11","author":"G Millonig","year":"1961","unstructured":"Millonig, G. A modified procedure for lead staining of thin sections. J. Biophys. Biochem. Cytol. 11, 736\u2013739 (1961).","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10284_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).","journal-title":"Genome Biol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10284-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10284-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10284-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:28:59Z","timestamp":1788906539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10284-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10284"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10284-y","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"30 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"1182"}}