{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:25:08Z","timestamp":1787703908467,"version":"build-2784847793"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":103,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20251307"],"award-info":[{"award-number":["GZC20251307"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10288-8","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:55:00Z","timestamp":1778874900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["scRNA-seq analysis shows neutrophil extracellular traps as drivers of obstruction-induced intestinal damage in rats"],"prefix":"10.1038","volume":"9","author":[{"given":"Zhanchuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunri","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-0912","authenticated-orcid":false,"given":"Changwei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-2065","authenticated-orcid":false,"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-3397","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"10288_CR1","first-page":"177","volume":"17","author":"D Coco","year":"2022","unstructured":"Coco, D., Leanza, S. & Fiume, I. Small bowel obstruction: a prognostic score index for surgery\u2014a review. Prz. Gastroenterol. 17, 177\u2013182 (2022).","journal-title":"Prz. Gastroenterol."},{"key":"10288_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jemermed.2018.10.024","volume":"56","author":"B Long","year":"2019","unstructured":"Long, B., Robertson, J. & Koyfman, A. Emergency medicine evaluation and management of small bowel obstruction: evidence-based recommendations. J. Emerg. Med. 56, 166\u2013176 (2019).","journal-title":"J. Emerg. Med."},{"key":"10288_CR3","unstructured":"Beach, E. C. & De Jesus, O. Ileus. in StatPearls (StatPearls Publishing, 2023)."},{"key":"10288_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1136\/gut.2005.089615","volume":"56","author":"S Wehner","year":"2007","unstructured":"Wehner, S. et al. Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents. Gut. 56, 176\u2013185 (2007).","journal-title":"Gut"},{"key":"10288_CR5","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1136\/gutjnl-2017-313856","volume":"66","author":"JM Pohl","year":"2017","unstructured":"Pohl, J. M. et al. Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus. Gut. 66, 2110\u20132120 (2017).","journal-title":"Gut"},{"key":"10288_CR6","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532\u20131535 (2004).","journal-title":"Science"},{"key":"10288_CR7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"V Papayannopoulos","year":"2018","unstructured":"Papayannopoulos, V. Neutrophil extracellular traps in immunity and disease. Nat. Rev. Immunol. 18, 134\u2013147 (2018).","journal-title":"Nat. Rev. Immunol."},{"key":"10288_CR8","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.4049\/jimmunol.1201719","volume":"189","author":"MJ Kaplan","year":"2012","unstructured":"Kaplan, M. J. & Radic, M. Neutrophil extracellular traps: double-edged swords of innate immunity. J. Immunol. 189, 2689\u20132695 (2012).","journal-title":"J. Immunol."},{"key":"10288_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639","volume":"5","author":"CF Urban","year":"2009","unstructured":"Urban, C. F. et al. Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog. 5, e1000639 (2009).","journal-title":"PLoS Pathog."},{"key":"10288_CR10","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nm.4294","volume":"23","author":"SK Jorch","year":"2017","unstructured":"Jorch, S. K. & Kubes, P. An emerging role for neutrophil extracellular traps in noninfectious disease. Nat. Med. 23, 279\u2013287 (2017).","journal-title":"Nat. Med."},{"key":"10288_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01785-6","volume":"22","author":"J Singh","year":"2024","unstructured":"Singh, J. et al. Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps. Cell Commun. Signal. 22, 435 (2024).","journal-title":"Cell Commun. Signal."},{"key":"10288_CR12","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","volume":"133","author":"FVS Castanheira","year":"2019","unstructured":"Castanheira, F. V. S. & Kubes, P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood 133, 2178\u20132185 (2019).","journal-title":"Blood"},{"key":"10288_CR13","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","volume":"122","author":"BG Yipp","year":"2013","unstructured":"Yipp, B. G. & Kubes, P. NETosis: how vital is it? Blood 122, 2784\u20132794 (2013).","journal-title":"Blood"},{"key":"10288_CR14","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3389\/fimmu.2019.01037","volume":"10","author":"Y Ma","year":"2019","unstructured":"Ma, Y. et al. Role of Neutrophil Extracellular Traps and Vesicles in Regulating Vascular Endothelial Permeability. Front. Immunol. 10, 1037 (2019).","journal-title":"Front. Immunol."},{"key":"10288_CR15","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/joim.12016","volume":"273","author":"F Polet","year":"2013","unstructured":"Polet, F. & Feron, O. Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force. J. Intern. Med. 273, 156\u2013165 (2013).","journal-title":"J. Intern. Med."},{"key":"10288_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1170","volume":"13","author":"H Zhang","year":"2023","unstructured":"Zhang, H. et al. Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis. Clin. Transl. Med. 13, e1170 (2023).","journal-title":"Clin. Transl. Med."},{"key":"10288_CR17","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","volume":"10","author":"A Brill","year":"2012","unstructured":"Brill, A. et al. Neutrophil extracellular traps promote deep vein thrombosis in mice. J. Thromb. Haemost. 10, 136\u2013144 (2012).","journal-title":"J. Thromb. Haemost."},{"key":"10288_CR18","doi-asserted-by":"publisher","first-page":"15880","DOI":"10.1073\/pnas.1005743107","volume":"107","author":"TA Fuchs","year":"2010","unstructured":"Fuchs, T. A. et al. Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. Usa. 107, 15880\u201315885 (2010).","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"key":"10288_CR19","first-page":"365","volume":"9","author":"M Ravindran","year":"2019","unstructured":"Ravindran, M., Khan, M. A. & Palaniyar, N. Neutrophil Extracellular Trap Formation. Physiol. Pathol. Pharmacol. Biomolecules 9, 365 (2019).","journal-title":"Physiol. Pathol. Pharmacol. Biomolecules"},{"key":"10288_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108289","volume":"26","author":"J Elrod","year":"2023","unstructured":"Elrod, J. et al. Neutrophil extracellular traps and DNases orchestrate formation of peritoneal adhesions. iScience 26, 108289 (2023).","journal-title":"iScience"},{"key":"10288_CR21","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","volume":"9","author":"S Wang","year":"2018","unstructured":"Wang, S. et al. S100A8\/A9 in Inflammation. Front. Immunol. 9, 1298 (2018).","journal-title":"Front. Immunol."},{"key":"10288_CR22","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.chom.2020.12.016","volume":"29","author":"Q Guo","year":"2021","unstructured":"Guo, Q. et al. Induction of alarmin S100A8\/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe 29, 222\u2013235.e4 (2021).","journal-title":"Cell Host Microbe"},{"key":"10288_CR23","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/CIRCULATIONAHA.119.043833","volume":"141","author":"G Sreejit","year":"2020","unstructured":"Sreejit, G. et al. Neutrophil-derived S100A8\/A9 amplify granulopoiesis after myocardial infarction. Circulation 141, 1080\u20131094 (2020).","journal-title":"Circulation"},{"key":"10288_CR24","doi-asserted-by":"publisher","first-page":"103532","DOI":"10.1016\/j.redox.2025.103532","volume":"81","author":"G Shi","year":"2025","unstructured":"Shi, G. et al. Inhibition of S100A8\/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury. Redox Biol. 81, 103532 (2025).","journal-title":"Redox Biol."},{"key":"10288_CR25","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1136\/gutjnl-2021-324855","volume":"70","author":"A Jukic","year":"2021","unstructured":"Jukic, A. et al. Calprotectin: from biomarker to biological function. Gut. 70, 1978\u20131988 (2021).","journal-title":"Gut"},{"key":"10288_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156791","volume":"142","author":"BX Zheng","year":"2025","unstructured":"Zheng, B. X. et al. Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8\/S100A9\/NF-\u03baB, and promoting TGR5 inhibition of NLRP3 inflammasome. Phytomedicine 142, 156791 (2025).","journal-title":"Phytomedicine"},{"key":"10288_CR27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jconrel.2024.06.050","volume":"372","author":"S Rui","year":"2024","unstructured":"Rui, S. et al. Exosomal miRNA-26b-5p from PRP suppresses NETs by targeting MMP-8 to promote diabetic wound healing. J. Control. Release 372, 221\u2013233 (2024).","journal-title":"J. Control. Release"},{"key":"10288_CR28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.cytogfr.2006.04.001","volume":"17","author":"P Van Lint","year":"2006","unstructured":"Van Lint, P. & Libert, C. Matrix metalloproteinase-8: cleavage can be decisive. Cytokine Growth Factor Rev. 17, 217\u2013223 (2006).","journal-title":"Cytokine Growth Factor Rev."},{"key":"10288_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/exmp.2002.2439","volume":"73","author":"SS Cheng","year":"2002","unstructured":"Cheng, S. S., Lukacs, N. W. & Kunkel, S. L. Eotaxin\/CCL11 is a negative regulator of neutrophil recruitment in a murine model of endotoxemia. Exp. Mol. Pathol. 73, 1\u20138 (2002).","journal-title":"Exp. Mol. Pathol."},{"key":"10288_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000598","volume":"4","author":"ML Burke","year":"2010","unstructured":"Burke, M. L. et al. Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis. PLoS Negl. Trop. Dis. 4, e598 (2010).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10288_CR31","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jare.2025.02.018","volume":"71","author":"J Li","year":"2025","unstructured":"Li, J. et al. Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury. J. Adv. Res. 71, 457\u2013470 (2025).","journal-title":"J. Adv. Res."},{"key":"10288_CR32","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00423-012-0915-y","volume":"397","author":"S Wehner","year":"2012","unstructured":"Wehner, S., Vilz, T. O., Stoffels, B. & Kalff, J. C. Immune mediators of postoperative ileus. Langenbecks Arch. Surg. 397, 591\u2013601 (2012).","journal-title":"Langenbecks Arch. Surg."},{"key":"10288_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70136","volume":"15","author":"P Archontakis-Barakakis","year":"2025","unstructured":"Archontakis-Barakakis, P. et al. Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury. Clin. Transl. Med. 15, e70136 (2025).","journal-title":"Clin. Transl. Med"},{"key":"10288_CR34","first-page":"2006","volume":"7","author":"Y Yang","year":"2014","unstructured":"Yang, Y. et al. Adenosine A2B receptor modulates intestinal barrier function under hypoxic and ischemia\/reperfusion conditions. Int. J. Clin. Exp. Pathol. 7, 2006\u20132018 (2014).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10288_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaa042","volume":"9","author":"X Liu","year":"2021","unstructured":"Liu, X. et al. Molecular mechanism mediating enteric bacterial translocation after severe burn: the role of cystic fibrosis transmembrane conductance regulator. Burns Trauma 9, tkaa042 (2021).","journal-title":"Burns Trauma"},{"key":"10288_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70043","volume":"69","author":"B Xu","year":"2025","unstructured":"Xu, B. et al. Apigenin alleviates intestinal ischemia\/reperfusion injury via upregulating Nrf2-mediated tight junction integrity. Mol. Nutr. Food Res 69, e70043 (2025).","journal-title":"Mol. Nutr. Food Res"},{"key":"10288_CR37","doi-asserted-by":"publisher","first-page":"7098","DOI":"10.3390\/ijms26157098","volume":"26","author":"M Ortega-Zapero","year":"2025","unstructured":"Ortega-Zapero, M. et al. Neutrophils and NETs in pathophysiology and treatment of inflammatory bowel disease. Int J. Mol. Sci. 26, 7098 (2025).","journal-title":"Int J. Mol. Sci."},{"key":"10288_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13538","volume":"57","author":"C Chu","year":"2024","unstructured":"Chu, C. et al. Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4\/RIPK3\/FUNDC1-required mitophagy. Cell Prolif. 57, e13538 (2024).","journal-title":"Cell Prolif."},{"key":"10288_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102906","volume":"67","author":"C Chu","year":"2023","unstructured":"Chu, C. et al. Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy. Redox Biol. 67, 102906 (2023).","journal-title":"Redox Biol."},{"key":"10288_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-022-00497-x","volume":"14","author":"F Chen","year":"2022","unstructured":"Chen, F. et al. The emerging role of neutrophilic extracellular traps in intestinal disease. Gut. Pathog. 14, 27 (2022).","journal-title":"Gut. Pathog."},{"key":"10288_CR41","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4049\/jimmunol.2200154","volume":"209","author":"G Wigerblad","year":"2022","unstructured":"Wigerblad, G. et al. Single-cell analysis reveals the range of transcriptional states of circulating human neutrophils. J. Immunol. 209, 772\u2013782 (2022).","journal-title":"J. Immunol."},{"key":"10288_CR42","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-pathmechdis-051222-015009","volume":"19","author":"A Aroca-Crevill\u00e9n","year":"2024","unstructured":"Aroca-Crevill\u00e9n, A., Vicanolo, T., Ovadia, S. & Hidalgo, A. Neutrophils in physiology and pathology. Annu Rev. Pathol. 19, 227\u2013259 (2024).","journal-title":"Annu Rev. Pathol."},{"key":"10288_CR43","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","volume":"99","author":"PX Liew","year":"2019","unstructured":"Liew, P. X. & Kubes, P. The neutrophil\u2019s role during health and disease. Physiol. Rev. 99, 1223\u20131248 (2019).","journal-title":"Physiol. Rev."},{"key":"10288_CR44","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.5010","volume":"14","author":"S Bansal","year":"2024","unstructured":"Bansal, S. et al. A new approach for assessment of neutrophil extracellular traps through immunofluorescence staining in whole blood smears. Bio Protoc. 14, e5010 (2024).","journal-title":"Bio Protoc."},{"key":"10288_CR45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/08941930390194415","volume":"16","author":"AE Demirkiran","year":"2003","unstructured":"Demirkiran, A. E. et al. Strangulated ventral hernia model in rats. J. Invest. Surg. 16, 93\u201397 (2003).","journal-title":"J. Invest. Surg."},{"key":"10288_CR46","first-page":"14","volume":"27","author":"Y Bai","year":"2010","unstructured":"Bai, Y. et al. Establishment of a rat model simulating the progression of strangulated intestinal obstruction. Lab. Anim. Sci. 27, 14\u201318 (2010).","journal-title":"Lab. Anim. Sci."},{"key":"10288_CR47","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","volume":"101","author":"CJ Chiu","year":"1970","unstructured":"Chiu, C. J. et al. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch. Surg. 101, 478\u2013483 (1970).","journal-title":"Arch. Surg."},{"key":"10288_CR48","first-page":"676","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676\u2013682 (2012).","journal-title":"Methods"},{"key":"10288_CR49","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3324\/haematol.2019.217083","volume":"105","author":"Y Hisada","year":"2020","unstructured":"Hisada, Y. et al. Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors. Haematologica 105, 218\u2013225 (2020).","journal-title":"Haematologica"},{"key":"10288_CR50","doi-asserted-by":"publisher","unstructured":"The GSA Family. The GSA family in 2025: a broadened sharing platform for multi-omics and multimodal data. Genomics Proteomics Bioinformatics https:\/\/doi.org\/10.1093\/gpbjnl\/qzaf072 (2025).","DOI":"10.1093\/gpbjnl\/qzaf072"},{"key":"10288_CR51","doi-asserted-by":"publisher","unstructured":"National Genomics Data Center, China National Center for Bioinformation. Database resources of the National Genomics Data Center, China National Center for Bioinformation in 2025. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkae978 (2025).","DOI":"10.1093\/nar\/gkae978"},{"key":"10288_CR52","doi-asserted-by":"publisher","unstructured":"Zhang, Y..Article Data [Dataset]. Zenodo https:\/\/doi.org\/10.5281\/zenodo.18668338 (2026).","DOI":"10.5281\/zenodo.18668338"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10288-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10288-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10288-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:02:27Z","timestamp":1787702547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10288-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10288"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10288-8","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"10 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"1143"}}