{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:15:38Z","timestamp":1788218138835,"version":"build-2803163510"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":91,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10320-x","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:27:00Z","timestamp":1780410420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GFPT1 as a cross-ancestry validated target for degenerative spinal disease: genetic association in a Chinese cohort and functional characterization in zebrafish"],"prefix":"10.1038","volume":"9","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6912-7673","authenticated-orcid":false,"given":"Jing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"10320_CR1","unstructured":"Melancia, J. L., Francisco, A. F. & Antunes, J. L. Neurologic Aspects of Systemic Disease Part I Handbook of Clinical Neurology 541\u2013549 (Elsevier, 2014)."},{"key":"10320_CR2","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1055\/s-0036-1585071","volume":"36","author":"T Witham","year":"2016","unstructured":"Witham, T. & Elder, B. Low back pain and spondylosis. Semin. Neurol. 36, 456\u2013461 (2016).","journal-title":"Semin. Neurol."},{"key":"10320_CR3","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00701-022-05118-9","volume":"164","author":"E Aimar","year":"2022","unstructured":"Aimar, E. et al. Complications of degenerative lumbar spondylolisthesis and stenosis surgery in patients over 80 s: comparative study with over 60 s and 70 s. Experience with 678 cases. Acta Neurochir. 164, 923\u2013931 (2022).","journal-title":"Acta Neurochir."},{"key":"10320_CR4","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.31616\/asj.2018.12.6.1060","volume":"12","author":"M Dehnokhalaji","year":"2018","unstructured":"Dehnokhalaji, M. et al. Evaluation of the degenerative changes of the distal intervertebral discs after internal fixation surgery in adolescent idiopathic scoliosis. Asian Spine J. 12, 1060\u20131068 (2018).","journal-title":"Asian Spine J."},{"key":"10320_CR5","doi-asserted-by":"crossref","unstructured":"Zhang, Y. G., Sun, Z., Liu, J. & Guo, X. Advances in susceptibility genetics of intervertebral degenerative disc disease. Int. J. Biol. Sci. 4, 283\u2013290 (2008).","DOI":"10.7150\/ijbs.4.283"},{"key":"10320_CR6","unstructured":"Tom\u00e9-Bermejo, F., Pi\u00f1era, A. R. & Alvarez, L. Osteoporosis and the management of spinal degenerative disease (II). Arch. Bone Jt. Surg. 5, 363\u2013374 (2017)."},{"key":"10320_CR7","doi-asserted-by":"publisher","unstructured":"Song, C. et al. An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration. JOR Spine 5, https:\/\/doi.org\/10.1002\/jsp2.1233 (2022).","DOI":"10.1002\/jsp2.1233"},{"key":"10320_CR8","doi-asserted-by":"publisher","unstructured":"Nica, A. C. & Dermitzakis, E. T. Expression quantitative trait loci: present and future. Philos.Trans. R. Soc. B Biol. Sci. 368, https:\/\/doi.org\/10.1098\/rstb.2012.0362 (2013).","DOI":"10.1098\/rstb.2012.0362"},{"key":"10320_CR9","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/nature18270","volume":"534","author":"JM Chick","year":"2016","unstructured":"Chick, J. M. et al. Defining the consequences of genetic variation on a proteome-wide scale. Nature 534, 500\u2013505 (2016).","journal-title":"Nature"},{"key":"10320_CR10","doi-asserted-by":"publisher","unstructured":"Brlek, P. et al. Implementing whole genome sequencing (WGS) in clinical practice: advantages, challenges, and future perspectives. Cells 13, https:\/\/doi.org\/10.3390\/cells13060504 (2024).","DOI":"10.3390\/cells13060504"},{"key":"10320_CR11","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1093\/hmg\/ddy225","volume":"27","author":"Y Issop","year":"2018","unstructured":"Issop, Y. et al. GFPT1 deficiency in muscle leads to myasthenia and myopathy in mice. Hum. Mol. Genet. 27, 3218\u20133232 (2018).","journal-title":"Hum. Mol. Genet."},{"key":"10320_CR12","doi-asserted-by":"publisher","first-page":"8888","DOI":"10.3390\/ijms22168888","volume":"22","author":"MJ Kim","year":"2021","unstructured":"Kim, M. J. et al. Hexosamine biosynthetic pathway-derived O-GlcNAcylation is critical for RANKL-mediated osteoclast differentiation. Int. J. Mol. Sci. 22, 8888 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"10320_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.joca.2008.06.011","volume":"17","author":"K Zou","year":"2009","unstructured":"Zou, K., Liu, G., Wu, T. & Du, L. Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthr. Cartil. 17, 144\u2013151 (2009).","journal-title":"Osteoarthr. Cartil."},{"key":"10320_CR14","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1093\/abbs\/gmw125","volume":"49","author":"J Yan","year":"2017","unstructured":"Yan, J. et al. GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress. Acta Biochim. Biophys. Sin. 49, 110\u2013118 (2017).","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10320_CR15","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.joca.2010.02.004","volume":"18","author":"YM Xiong","year":"2010","unstructured":"Xiong, Y. M. et al. Association study between polymorphisms in selenoprotein genes and susceptibility to kashin-beck disease. Osteoarthr. Cartil. 18, 817\u2013824 (2010).","journal-title":"Osteoarthr. Cartil."},{"key":"10320_CR16","doi-asserted-by":"publisher","first-page":"e71411","DOI":"10.1371\/journal.pone.0071411","volume":"8","author":"J Long","year":"2013","unstructured":"Long, J. et al. Association study of polymorphisms in selenoprotein genes and kashin\u2013beck disease and serum selenium\/iodine concentration in a Tibetan population. PLoS ONE 8, e71411 (2013).","journal-title":"PLoS ONE"},{"key":"10320_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.trsl.2022.02.006","volume":"245","author":"H Zhong","year":"2022","unstructured":"Zhong, H. et al. SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1\/miR-214-3p axis. Transl. Res. 245, 99\u2013116 (2022).","journal-title":"Transl. Res."},{"key":"10320_CR18","doi-asserted-by":"publisher","first-page":"104333","DOI":"10.1016\/j.ebiom.2022.104333","volume":"86","author":"X Hu","year":"2022","unstructured":"Hu, X. et al. Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. eBioMedicine 86, 104333 (2022).","journal-title":"eBioMedicine"},{"key":"10320_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1158\/1535-7163.MCT-20-0328","volume":"20","author":"RG Hoyle","year":"2021","unstructured":"Hoyle, R. G., Wang, H., Cen, Y., Zhang, Y. & Li, J. IOX1 suppresses Wnt target gene transcription and colorectal cancer tumorigenesis through inhibition of KDM3 histone demethylases. Mol. Cancer Ther. 20, 191\u2013202 (2021).","journal-title":"Mol. Cancer Ther."},{"key":"10320_CR20","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","volume":"53","author":"U V\u00f5sa","year":"2021","unstructured":"V\u00f5sa, U. et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat. Genet. 53, 1300\u20131310 (2021).","journal-title":"Nat. Genet."},{"key":"10320_CR21","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ajhg.2016.12.008","volume":"100","author":"LR Lloyd-Jones","year":"2017","unstructured":"Lloyd-Jones, L. R. et al. The genetic architecture of gene expression in peripheral blood. Am. J. Hum. Genet. 100, 228\u2013237 (2017).","journal-title":"Am. J. Hum. Genet."},{"key":"10320_CR22","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/s41593-021-00886-6","volume":"24","author":"C Yang","year":"2021","unstructured":"Yang, C. et al. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nat. Neurosci. 24, 1302\u20131312 (2021).","journal-title":"Nat. Neurosci."},{"key":"10320_CR23","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki, M. I. et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613, 508\u2013518 (2023).","journal-title":"Nature"},{"key":"10320_CR24","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.ajhg.2023.03.010","volume":"110","author":"W Bi","year":"2023","unstructured":"Bi, W. et al. Scalable mixed model methods for set-based association studies on large-scale categorical data analysis and its application to exome-sequencing data in UK Biobank. Am. J. Hum. Genet. 110, 762\u2013773 (2023).","journal-title":"Am. J. Hum. Genet."},{"key":"10320_CR25","doi-asserted-by":"publisher","first-page":"eaag1166","DOI":"10.1126\/scitranslmed.aag1166","volume":"9","author":"C Finan","year":"2017","unstructured":"Finan, C. et al. The druggable genome and support for target identification and validation in drug development. Sci. Transl. Med. 9, eaag1166 (2017).","journal-title":"Sci. Transl. Med."},{"key":"10320_CR26","doi-asserted-by":"publisher","first-page":"4784","DOI":"10.1016\/j.cell.2021.07.038","volume":"184","author":"CG Boer","year":"2021","unstructured":"Boer, C. G. et al. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell 184, 4784\u20134818 (2021).","journal-title":"Cell"},{"key":"10320_CR27","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"10320_CR28","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.gpb.2020.10.007","volume":"19","author":"L Yin","year":"2021","unstructured":"Yin, L. et al. rMVP: a memory-efficient, visualization-enhanced, and parallel-accelerated tool for genome-wide association study. Genom. Proteom. Bioinform. 19, 619\u2013628 (2021).","journal-title":"Genom. Proteom. Bioinform."},{"key":"10320_CR29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481\u2013487 (2016).","journal-title":"Nat. Genet."},{"key":"10320_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02578-9","volume":"20","author":"P Alipour","year":"2022","unstructured":"Alipour, P. et al. Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study. BMC Med. 20, 382 (2022).","journal-title":"BMC Med."},{"key":"10320_CR31","doi-asserted-by":"publisher","first-page":"e1009440","DOI":"10.1371\/journal.pgen.1009440","volume":"17","author":"HJ Cordell","year":"2021","unstructured":"Cordell, H. J. & Wallace, C. A more accurate method for colocalisation analysis allowing for multiple causal variants. PLOS Genet. 17, e1009440 (2021).","journal-title":"PLOS Genet."},{"key":"10320_CR32","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1089\/bio.2018.29040.zjk","volume":"16","author":"Z Kozlakidis","year":"2018","unstructured":"Kozlakidis, Z., Seiler, C. & Simeon-Dubach, D. ISBER best practices fourth edition: a success story. Biopreservation Biobanking 16, 242\u2013243 (2018).","journal-title":"Biopreservation Biobanking"},{"key":"10320_CR33","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","volume":"26","author":"H Li","year":"2010","unstructured":"Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows\u2013Wheeler transform. Bioinformatics 26, 589\u2013595 (2010).","journal-title":"Bioinformatics"},{"key":"10320_CR34","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297\u20131303 (2010).","journal-title":"Genome Res."},{"key":"10320_CR35","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR36","doi-asserted-by":"publisher","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","volume":"42","author":"MJ Landrum","year":"2014","unstructured":"Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res. 42, D980\u2013D985 (2014).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR37","doi-asserted-by":"publisher","DOI":"10.1093\/gpbjnl\/qzaf072","volume":"23","author":"S Zhang","year":"2025","unstructured":"Zhang, S. et al. The GSA family in 2025: a broadened sharing platform for multi-omics and multimodal data. Genom. Proteom. Bioinform. 23, qzaf072 (2025).","journal-title":"Genom. Proteom. Bioinform."},{"key":"10320_CR38","doi-asserted-by":"publisher","first-page":"D28","DOI":"10.1093\/nar\/gkaf1172","volume":"54","author":"CNCB\u2013NGDC Members and Partners","year":"2026","unstructured":"CNCB\u2013NGDC Members and Partners Database resources of the National Genomics Data Center, China National Center for Bioinformation in 2026. Nucleic Acids Res. 54, D28\u2013D47 (2026).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR39","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","volume":"49","author":"SL Freshour","year":"2021","unstructured":"Freshour, S. L. et al. Integration of the drug\u2013gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 49, D1144\u2013D1151 (2021).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR40","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gky1075","volume":"47","author":"D Mendez","year":"2019","unstructured":"Mendez, D. et al. ChEMBL: towards direct deposition of bioassay data. Nucleic Acids Res. 47, D930\u2013D940 (2019).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR41","doi-asserted-by":"publisher","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","volume":"52","author":"C Knox","year":"2024","unstructured":"Knox, C. et al. DrugBank 6.0: the DrugBank knowledgebase for 2024. Nucleic Acids Res. 52, D1265\u2013D1275 (2024).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR42","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman, H. M. The Protein Data Bank. Nucleic Acids Res. 28, 235\u2013242 (2000).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR43","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris, G. M. et al. AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J. Comput. Chem. 30, 2785\u20132791 (2009).","journal-title":"J. Comput. Chem."},{"key":"10320_CR44","doi-asserted-by":"publisher","first-page":"W530","DOI":"10.1093\/nar\/gkab294","volume":"49","author":"MF Adasme","year":"2021","unstructured":"Adasme, M. F. et al. PLIP 2021: expanding the scope of the protein\u2013ligand interaction profiler to DNA and RNA. Nucleic Acids Res. 49, W530\u2013W534 (2021).","journal-title":"Nucleic Acids Res."},{"key":"10320_CR45","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00018-018-2928-3","volume":"76","author":"J Tian","year":"2018","unstructured":"Tian, J. et al. Deficiency of LRP4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged\u2013Notch signaling in fin and limb development. Cell. Mol. Life Sci. 76, 163\u2013178 (2018).","journal-title":"Cell. Mol. Life Sci."},{"key":"10320_CR46","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jbbm.2003.02.001","volume":"59","author":"F Ye","year":"2004","unstructured":"Ye, F. et al. A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay. J. Biochem. Biophys. Methods 59, 201\u2013208 (2004).","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10320_CR47","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ajhg.2011.01.008","volume":"88","author":"J Senderek","year":"2011","unstructured":"Senderek, J. et al. Hexosamine biosynthetic pathway mutations cause neuromuscular transmission defect. Am. J. Hum. Genet. 88, 162\u2013172 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"10320_CR48","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.7150\/thno.53330","volume":"11","author":"S Lu","year":"2021","unstructured":"Lu, S. et al. Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics 11, 2788\u20132805 (2021).","journal-title":"Theranostics"},{"key":"10320_CR49","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/cmdc.201300428","volume":"9","author":"R Schiller","year":"2014","unstructured":"Schiller, R. et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem 9, 566\u2013571 (2014).","journal-title":"ChemMedChem"},{"key":"10320_CR50","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ccell.2019.03.006","volume":"35","author":"Y Huang","year":"2019","unstructured":"Huang, Y. et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell 35, 677\u2013691 (2019).","journal-title":"Cancer Cell"},{"key":"10320_CR51","doi-asserted-by":"publisher","first-page":"105868","DOI":"10.1016\/j.tiv.2024.105868","volume":"99","author":"V Chantho","year":"2024","unstructured":"Chantho, V. et al. Effects of polystyrene nanoplastic size on zebrafish embryo development. Toxicol. Vitr. 99, 105868 (2024).","journal-title":"Toxicol. Vitr."},{"key":"10320_CR52","doi-asserted-by":"publisher","unstructured":"Zhu, H. et al. Bacterial quorum-sensing signal DSF inhibits LPS-induced inflammations by suppressing toll-like receptor signaling and preventing lysosome-mediated apoptosis in zebrafish. Int. J. Mol. Sci. 23, https:\/\/doi.org\/10.3390\/ijms23137110 (2022).","DOI":"10.3390\/ijms23137110"},{"key":"10320_CR53","doi-asserted-by":"publisher","first-page":"113809","DOI":"10.1016\/j.jep.2021.113809","volume":"270","author":"Z Wang","year":"2021","unstructured":"Wang, Z. et al. Naoxintong restores ischemia injury and inhibits thrombosis via COX2-VEGF\/ NF\u03baB signaling. J. Ethnopharmacol. 270, 113809 (2021).","journal-title":"J. Ethnopharmacol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10320-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10320-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10320-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:37:44Z","timestamp":1788215864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10320-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10320"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10320-x","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"21 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"1158"}}