{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:41:03Z","timestamp":1792453263332,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":113,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Huntington\u2019s disease research has focused on either loss of normal huntingtin function or toxic gain-of-function of the mutant huntingtin protein as a key driver of pathology. The role of mutant\n                    <jats:italic>HTT<\/jats:italic>\n                    mRNA in vivo has been only partially studied and remains largely unexplored. Recently, we discovered that full-length human\n                    <jats:italic>HTT<\/jats:italic>\n                    mRNA is retained, together with the alternatively processed\n                    <jats:italic>HTT1a<\/jats:italic>\n                    transcript, in RNA nuclear clusters in YAC128 mouse brains. Here, we demonstrate that these clusters were present at the prenatal stage, indicating early developmental effects. Moreover, these clusters were confined to neurons, implying a neuron-specific mechanism of accumulation, and were colocalised with core spliceosomal proteins, suggesting an impact on nuclear homeostasis.\n                    <jats:italic>HTT<\/jats:italic>\n                    nuclear RNA clusters showed remarkable dynamics, rapidly dissolving when ionic interactions were disrupted or transcription and splicing were inhibited. This malleability underscores the importance of\n                    <jats:italic>HTT<\/jats:italic>\n                    mRNA accessibility to therapeutic interventions and may guide future design of\n                    <jats:italic>HTT<\/jats:italic>\n                    -targeting therapies.\n                  <\/jats:p>","DOI":"10.1038\/s42003-026-10419-1","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:16:10Z","timestamp":1782746170000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nuclear RNA clusters are dynamic structural entities in Huntington\u2019s disease"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-7003","authenticated-orcid":false,"given":"Sandra","family":"Fienko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia M.","family":"Nita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Munoz-Munoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-6305","authenticated-orcid":false,"given":"Gillian P.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"10419_CR1","doi-asserted-by":"crossref","unstructured":"The Huntington\u2019s Disease Collaborative Research Group comprises. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 72, 971\u2013983 (1993).","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"10419_CR2","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1073\/pnas.1221891110","volume":"110","author":"K Sathasivam","year":"2013","unstructured":"Sathasivam, K. et al. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc. Natl. Acad. Sci. USA 110, 2366\u20132370 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10419_CR3","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae410","volume":"6","author":"C Landles","year":"2024","unstructured":"Landles, C. et al. Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays. Brain Commun. 6, fcae410 (2024).","journal-title":"Brain Commun."},{"key":"10419_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01510-z","volume":"7","author":"A Neueder","year":"2017","unstructured":"Neueder, A. et al. The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington\u2019s disease patients. Sci. Rep. 7, 1307 (2017).","journal-title":"Sci. Rep."},{"key":"10419_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s10020-024-00801-2","volume":"30","author":"F Hoschek","year":"2024","unstructured":"Hoschek, F. et al. Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues. Mol. Med. 30, 36 (2024).","journal-title":"Mol. Med."},{"key":"10419_CR6","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini, L. et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493\u2013506 (1996).","journal-title":"Cell"},{"key":"10419_CR7","first-page":"668984","volume":"2025","author":"Y Deng","year":"2025","unstructured":"Deng, Y., Joni, M., Wang, H., Cox, R. & Reiner, A. Localization of mutant Huntingtin with HTT exon1 P90 C-terminal neoepitope antibodies in relation to regional and neuronal vulnerability in forebrain in Q175 mice and human Huntington\u2019s disease. J. Huntingtons Dis. 2025, 668984 (2025).","journal-title":"J. Huntingtons Dis."},{"key":"10419_CR8","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1093\/brain\/awac241","volume":"145","author":"S Fienko","year":"2022","unstructured":"Fienko, S. et al. Alternative processing of human HTT mRNA with implications for Huntington\u2019s disease therapeutics. Brain 145, 4409\u20134424 (2022).","journal-title":"Brain"},{"key":"10419_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac248","volume":"4","author":"S Ly","year":"2022","unstructured":"Ly, S. et al. Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains. Brain Commun. 4, fcac248 (2022).","journal-title":"Brain Commun."},{"key":"10419_CR10","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1093\/hmg\/ddr299","volume":"20","author":"M Wojciechowska","year":"2011","unstructured":"Wojciechowska, M. & Krzyzosiak, W. J. Cellular toxicity of expanded RNA repeats: focus on RNA foci. Hum. Mol. Genet. 20, 3811\u20133821 (2011).","journal-title":"Hum. Mol. Genet."},{"key":"10419_CR11","doi-asserted-by":"crossref","unstructured":"Heinz, A., Nabariya, D. K. & Krauss, S. Huntingtin and its role in mechanisms of RNA-mediated toxicity. Toxins 13, 487 (2021).","DOI":"10.3390\/toxins13070487"},{"key":"10419_CR12","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00109-013-1016-2","volume":"91","author":"A Fiszer","year":"2013","unstructured":"Fiszer, A. & Krzyzosiak, W. J. RNA toxicity in polyglutamine disorders: concepts, models, and progress of research. J. Mol. Med. 91, 683\u2013691 (2013).","journal-title":"J. Mol. Med."},{"key":"10419_CR13","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401465R","volume":"38","author":"M Wozna-Wysocka","year":"2024","unstructured":"Wozna-Wysocka, M. et al. Insights into RNA-mediated pathology in new mouse models of Huntington\u2019s disease. FASEB J. 38, e70182 (2024).","journal-title":"FASEB J."},{"key":"10419_CR14","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature22386","volume":"546","author":"A Jain","year":"2017","unstructured":"Jain, A. & Vale, R. D. RNA phase transitions in repeat expansion disorders. Nature 546, 243\u2013247 (2017).","journal-title":"Nature"},{"key":"10419_CR15","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.bbadis.2016.05.015","volume":"1862","author":"MO Urbanek","year":"2016","unstructured":"Urbanek, M. O., Jazurek, M., Switonski, P. M., Figura, G. & Krzyzosiak, W. J. Nuclear speckles are detention centers for transcripts containing expanded CAG repeats. Biochim. Biophys. Acta 1862, 1513\u20131520 (2016).","journal-title":"Biochim. Biophys. Acta"},{"key":"10419_CR16","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676\u2013682 (2012).","journal-title":"Nat. Methods"},{"key":"10419_CR17","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.semcdb.2018.07.001","volume":"90","author":"IA Sawyer","year":"2019","unstructured":"Sawyer, I. A., Bartek, J. & Dundr, M. Phase separated microenvironments inside the cell nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing. Semin. Cell Dev. Biol. 90, 94\u2013103 (2019).","journal-title":"Semin. Cell Dev. Biol."},{"key":"10419_CR18","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/j.jmb.2019.01.034","volume":"431","author":"J Schilling","year":"2019","unstructured":"Schilling, J. et al. Deregulated splicing is a major mechanism of RNA-induced toxicity in Huntington\u2019s disease. J. Mol. Biol. 431, 1869\u20131877 (2019).","journal-title":"J. Mol. Biol."},{"key":"10419_CR19","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s12021-020-09465-9","volume":"18","author":"A Gorlewicz","year":"2020","unstructured":"Gorlewicz, A. et al. Colocalization colormap\u2014an ImageJ plugin for the quantification and visualization of colocalized signals. Neuroinformatics 18, 661\u2013664 (2020).","journal-title":"Neuroinformatics"},{"key":"10419_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-39","volume":"8","author":"JN Hutchinson","year":"2007","unstructured":"Hutchinson, J. N. et al. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genom. 8, 39 (2007).","journal-title":"BMC Genom."},{"key":"10419_CR21","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.molcel.2010.08.011","volume":"39","author":"V Tripathi","year":"2010","unstructured":"Tripathi, V. et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol. Cell 39, 925\u2013938 (2010).","journal-title":"Mol. Cell"},{"key":"10419_CR22","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.molcel.2009.01.026","volume":"33","author":"CM Clemson","year":"2009","unstructured":"Clemson, C. M. et al. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol. Cell 33, 717\u2013726 (2009).","journal-title":"Mol. Cell"},{"key":"10419_CR23","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1365-2818.1993.tb03313.x","volume":"169","author":"EMM Manders","year":"1993","unstructured":"Manders, E. M. M., Verbeek, F. J. & Aten, J. A. Measurement of co-localization of objects in dual-colour confocal images. J. Microsc. 169, 375\u2013382 (1993).","journal-title":"J. Microsc."},{"key":"10419_CR24","doi-asserted-by":"publisher","first-page":"C723","DOI":"10.1152\/ajpcell.00462.2010","volume":"300","author":"KW Dunn","year":"2011","unstructured":"Dunn, K. W., Kamocka, M. M. & McDonald, J. H. A practical guide to evaluating colocalization in biological microscopy. Am. J. Physiol. Cell Physiol. 300, C723\u2013C742 (2011).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10419_CR25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1247\/csf.22.387","volume":"22","author":"MS Hamaguchi","year":"1997","unstructured":"Hamaguchi, M. S., Watanabe, K. & Hamaguchi, Y. Regulation of intracellular pH in sea urchin eggs by medium containing both weak acid and base. Cell Struct. Funct. 22, 387\u2013398 (1997).","journal-title":"Cell Struct. Funct."},{"key":"10419_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-11-13","volume":"11","author":"E Latorre","year":"2012","unstructured":"Latorre, E. et al. Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol. Cancer 11, 13 (2012).","journal-title":"Mol. Cancer"},{"key":"10419_CR27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nchembio.2538","volume":"14","author":"CM Olson","year":"2018","unstructured":"Olson, C. M. et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat. Chem. Biol. 14, 163\u2013170 (2018).","journal-title":"Nat. Chem. Biol."},{"key":"10419_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111106","volume":"40","author":"L Duan","year":"2022","unstructured":"Duan, L. et al. Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export. Cell Rep. 40, 111106 (2022).","journal-title":"Cell Rep."},{"key":"10419_CR29","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41592-023-02128-y","volume":"21","author":"J Wang","year":"2024","unstructured":"Wang, J. et al. RNA structure profiling at single-cell resolution reveals new determinants of cell identity. Nat. Methods 21, 411\u2013422 (2024).","journal-title":"Nat. Methods"},{"key":"10419_CR30","doi-asserted-by":"publisher","first-page":"4942","DOI":"10.1016\/j.molcel.2021.09.027","volume":"81","author":"J Wang","year":"2021","unstructured":"Wang, J. et al. Genome-wide RNA structure changes during human neurogenesis modulate gene regulatory networks. Mol. Cell 81, 4942\u20134953 (2021).","journal-title":"Mol. Cell"},{"key":"10419_CR31","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.cell.2018.07.023","volume":"174","author":"B Van Treeck","year":"2018","unstructured":"Van Treeck, B. & Parker, R. Emerging roles for intermolecular RNA-RNA interactions in RNP assemblies. Cell 174, 791\u2013802 (2018).","journal-title":"Cell"},{"key":"10419_CR32","doi-asserted-by":"publisher","first-page":"621779","DOI":"10.3389\/fcell.2021.621779","volume":"9","author":"D Campos-Melo","year":"2021","unstructured":"Campos-Melo, D., Hawley, Z. C. E., Droppelmann, C. A. & Strong, M. J. The integral role of RNA in stress granule formation and function. Front. Cell Dev. Biol. 9, 621779 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"10419_CR33","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1073\/pnas.1819020116","volume":"116","author":"M Mayerle","year":"2019","unstructured":"Mayerle, M. et al. Prp8 impacts cryptic but not alternative splicing frequency. Proc. Natl. Acad. Sci. USA 116, 2193\u20132199 (2019).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10419_CR34","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/s41590-019-0464-4","volume":"20","author":"D Zhang","year":"2019","unstructured":"Zhang, D. et al. Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40. Nat. Immunol. 20, 1322\u20131334 (2019).","journal-title":"Nat. Immunol."},{"key":"10419_CR35","doi-asserted-by":"crossref","unstructured":"Ratovitski, T. et al. Huntingtin (HTT) interactome in regulation of DNA repair\/remodeling and RNA processing pathways. Life Sci. Alliance 9, e202503424 (2026).","DOI":"10.26508\/lsa.202503424"},{"key":"10419_CR36","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1091\/mbc.E18-09-0590","volume":"29","author":"CL Hung","year":"2018","unstructured":"Hung, C. L. et al. A patient-derived cellular model for Huntington\u2019s disease reveals phenotypes at clinically relevant CAG lengths. Mol. Biol. Cell 29, 2809\u20132820 (2018).","journal-title":"Mol. Biol. Cell"},{"key":"10419_CR37","doi-asserted-by":"publisher","first-page":"e47452","DOI":"10.1371\/journal.pone.0047452","volume":"7","author":"SH Vo","year":"2012","unstructured":"Vo, S. H. et al. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. PLoS ONE 7, e47452 (2012).","journal-title":"PLoS ONE"},{"key":"10419_CR38","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41392-021-00678-1","volume":"6","author":"B Wang","year":"2021","unstructured":"Wang, B. et al. Liquid-liquid phase separation in human health and diseases. Signal Transduct. Target. Ther. 6, 290 (2021).","journal-title":"Signal Transduct. Target. Ther."},{"key":"10419_CR39","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.molcel.2018.04.007","volume":"70","author":"TR Peskett","year":"2018","unstructured":"Peskett, T. R. et al. A liquid to solid phase transition underlying pathological huntingtin exon1 aggregation. Mol. Cell 70, 588\u2013601 (2018).","journal-title":"Mol. Cell"},{"key":"10419_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02455-3","volume":"22","author":"X Liu","year":"2021","unstructured":"Liu, X. et al. Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization. Genome Biol. 22, 230 (2021).","journal-title":"Genome Biol."},{"key":"10419_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52764-x","volume":"15","author":"BM O\u2019Brien","year":"2024","unstructured":"O\u2019Brien, B. M. et al. Stick-slip unfolding favors self-association of expanded HTT mRNA. Nat. Commun. 15, 8738 (2024).","journal-title":"Nat. Commun."},{"key":"10419_CR42","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1261\/rna.5205404","volume":"10","author":"DE Draper","year":"2004","unstructured":"Draper, D. E. A guide to ions and RNA structure. RNA 10, 335\u2013343 (2004).","journal-title":"RNA"},{"key":"10419_CR43","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41420-023-01352-x","volume":"9","author":"Y Cen","year":"2023","unstructured":"Cen, Y. et al. Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics. Cell Death Discov. 9, 52 (2023).","journal-title":"Cell Death Discov."},{"key":"10419_CR44","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1093\/nar\/gkz1213","volume":"48","author":"I Tanaka","year":"2020","unstructured":"Tanaka, I. et al. ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin. Nucleic Acids Res. 48, 2676\u20132693 (2020).","journal-title":"Nucleic Acids Res."},{"key":"10419_CR45","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0026-895X(25)10149-1","volume":"45","author":"FA Fornari","year":"1994","unstructured":"Fornari, F. A., Randolph, J. K., Yalowich, J. C., Ritke, M. K. & Gewirtz, D. A. Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Mol. Pharmacol. 45, 649\u2013656 (1994).","journal-title":"Mol. Pharmacol."},{"key":"10419_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31939-9","volume":"8","author":"H Taymaz-Nikerel","year":"2018","unstructured":"Taymaz-Nikerel, H., Karabekmez, M. E., Eraslan, S. & Kirdar, B. Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells. Sci. Rep. 8, 13672 (2018).","journal-title":"Sci. Rep."},{"key":"10419_CR47","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41586-019-1464-0","volume":"572","author":"YE Guo","year":"2019","unstructured":"Guo, Y. E. et al. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates. Nature 572, 543\u2013548 (2019).","journal-title":"Nature"},{"key":"10419_CR48","doi-asserted-by":"publisher","first-page":"4439","DOI":"10.1093\/emboj\/19.17.4439","volume":"19","author":"JW Miller","year":"2000","unstructured":"Miller, J. W. et al. Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. EMBO J. 19, 4439\u20134448 (2000).","journal-title":"EMBO J."},{"key":"10419_CR49","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1093\/nar\/gkm601","volume":"35","author":"Y Yuan","year":"2007","unstructured":"Yuan, Y. et al. Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs. Nucleic Acids Res. 35, 5474\u20135486 (2007).","journal-title":"Nucleic Acids Res."},{"key":"10419_CR50","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1126\/science.280.5364.737","volume":"280","author":"AV Philips","year":"1998","unstructured":"Philips, A. V., Timchenko, L. T. & Cooper, T. A. Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280, 737\u2013741 (1998).","journal-title":"Science"},{"key":"10419_CR51","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa231","volume":"3","author":"C Landles","year":"2021","unstructured":"Landles, C. et al. Development of novel bioassays to detect soluble and aggregated huntingtin proteins on three technology platforms. Brain Commun. 3, fcaa231 (2021).","journal-title":"Brain Commun."},{"key":"10419_CR52","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1093\/hmg\/dds037","volume":"21","author":"MA Pouladi","year":"2012","unstructured":"Pouladi, M. A. et al. Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice. Hum. Mol. Genet. 21, 2219\u20132232 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"10419_CR53","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","volume":"224","author":"S Bolte","year":"2006","unstructured":"Bolte, S. & Cordelieres, F. P. A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc. 224, 213\u2013232 (2006).","journal-title":"J. Microsc."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10419-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10419-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10419-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:02:28Z","timestamp":1792450948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10419-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10419"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10419-1","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"17 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"1370"}}