{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:51:00Z","timestamp":1787755860436,"version":"build-2784847793"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Flowering in day-neutral tobacco (\n                    <jats:italic>Nicotiana tabacum<\/jats:italic>\n                    ) cultivars requires the photoperiod-dependent expression of FLOWERING LOCUS T (FT)-like floral activators, which compete with FT-like inhibitors to interact with FD proteins and induce the switch from vegetative to reproductive growth. In the short-day (SD) cultivar Maryland Mammoth (MM), vegetative growth persists under long-day (LD) conditions, generating unusually tall plants. We found that overexpression of the major LD floral inducer (NtFT5) from the day-neutral cultivar Hicks induces flowering in MM plants under LD conditions. However, a 2-bp deletion near the end of the endogenous\n                    <jats:italic>NtFT5<\/jats:italic>\n                    <jats:sub>MM<\/jats:sub>\n                    gene generates a truncated NtFT5\n                    <jats:sub>MM<\/jats:sub>\n                    protein that still interacts with FD proteins but acts as a weaker floral inducer than NtFT5. The truncation does not impair NtFT5\n                    <jats:sub>MM<\/jats:sub>\n                    protein stability but may affect its binding to NtFD1, weakening the expression of target genes. Our results provide a potential explanation for the MM gigantism phenotype first observed more than 100 years ago.\n                  <\/jats:p>","DOI":"10.1038\/s42003-026-10729-4","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T01:06:06Z","timestamp":1787706366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A mutant allele of the long-day floral activator NtFT5 is associated with the short-day-specific flowering of tobacco cultivar Maryland Mammoth"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-3990","authenticated-orcid":false,"given":"Lena","family":"Grundmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius M.","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Iordanidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-562X","authenticated-orcid":false,"given":"Andrea","family":"K\u00e4nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schwarze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Wiedmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost","family":"Muth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-3003","authenticated-orcid":false,"given":"Richard M.","family":"Twyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-7702","authenticated-orcid":false,"given":"Dirk","family":"Pr\u00fcfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-9891","authenticated-orcid":false,"given":"Gundula A.","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"10729_CR1","first-page":"553","volume":"18","author":"WW Garner","year":"1920","unstructured":"Garner, W. W. & Allard, H. A. Effect of the relative length of day and night and other factors of the environment on growth and reproduction in plants. J. Agric. Res. 18, 553\u2013606 (1920).","journal-title":"J. Agric. Res."},{"key":"10729_CR2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.molp.2015.01.007","volume":"8","author":"DP Wickland","year":"2015","unstructured":"Wickland, D. P. & Hanzawa, Y. The FLOWERING LOCUS T\/TERMINAL FLOWER 1 gene family: functional evolution and molecular mechanisms. Mol. Plant 8, 983\u2013997 (2015).","journal-title":"Mol. Plant"},{"key":"10729_CR3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1146\/annurev.arplant.59.032607.092755","volume":"59","author":"F Turck","year":"2008","unstructured":"Turck, F., Fornara, F. & Coupland, G. Regulation and identity of florigen: FLOWERING LOCUS T moves center stage. Annu. Rev. Plant Biol. 59, 573\u2013594 (2008).","journal-title":"Annu. Rev. Plant Biol."},{"key":"10729_CR4","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1126\/science.1115983","volume":"309","author":"M Abe","year":"2005","unstructured":"Abe, M. et al. FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex. Science 309, 1052\u20131056 (2005).","journal-title":"Science"},{"key":"10729_CR5","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1126\/science.1114358","volume":"309","author":"PA Wigge","year":"2005","unstructured":"Wigge, P. A. et al. Integration of spatial and temporal information during floral induction in Arabidopsis. Science 309, 1056\u20131059 (2005).","journal-title":"Science"},{"key":"10729_CR6","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1126\/science.1141752","volume":"316","author":"L Corbesier","year":"2007","unstructured":"Corbesier, L., Vincent, C. & Jang, S. FT protein movement contributes to long-distance signaling in floral induction of Arabidopsis. Science 316, 1030\u20131033 (2007).","journal-title":"Science"},{"key":"10729_CR7","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1126\/science.1141753","volume":"316","author":"S Tamaki","year":"2007","unstructured":"Tamaki, S., Matsuo, S., Wong, H. L., Yokoi, S. & Shimamoto, K. Hd3a protein is a mobile flowering signal in rice. Science 316, 1033\u20131036 (2007).","journal-title":"Science"},{"key":"10729_CR8","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.molp.2015.11.001","volume":"9","author":"S-J Kim","year":"2016","unstructured":"Kim, S.-J. et al. Post-translational regulation of FLOWERING LOCUS T protein in Arabidopsis. Mol. Plant 9, 308\u2013311 (2016).","journal-title":"Mol. Plant"},{"key":"10729_CR9","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1093\/pcp\/pcy063","volume":"59","author":"M Endo","year":"2018","unstructured":"Endo, M. et al. Re-evaluation of florigen transport kinetics with separation of functions by mutations that uncouple flowering initiation and long-distance transport. Plant Cell Physiol. 59, 1621\u20131629 (2018).","journal-title":"Plant Cell Physiol."},{"key":"10729_CR10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/0014-5793(95)00376-K","volume":"369","author":"F Schoentgen","year":"1995","unstructured":"Schoentgen, F. & Joll\u00e8s, P. From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site. FEBS Lett. 369, 22\u201326 (1995).","journal-title":"FEBS Lett."},{"key":"10729_CR11","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/379791a0","volume":"379","author":"D Bradley","year":"1996","unstructured":"Bradley, D. et al. Control of inflorescence architecture in Antirrhinum. Nature 379, 791\u2013797 (1996).","journal-title":"Nature"},{"key":"10729_CR12","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0969-2126(98)00125-7","volume":"6","author":"MJ Banfield","year":"1998","unstructured":"Banfield, M. J., Barker, J. J., Perry, C. & Brady, R. L. Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. Structure 6, 1245\u20131254 (1998).","journal-title":"Structure"},{"key":"10729_CR13","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1104\/pp.111.176206","volume":"156","author":"A Karlgren","year":"2011","unstructured":"Karlgren, A. et al. Evolution of the PEBP gene family in plants: functional diversification in seed plant evolution. Plant Physiol. 156, 1967\u20131977 (2011).","journal-title":"Plant Physiol."},{"key":"10729_CR14","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1126\/science.286.5446.1960","volume":"286","author":"Y Kobayashi","year":"1999","unstructured":"Kobayashi, Y., Kaya, H., Goto, K., Iwabuchi, M. & Araki, T. A pair of related genes with antagonistic roles in mediating flowering signals. Science 286, 1960\u20131962 (1999).","journal-title":"Science"},{"key":"10729_CR15","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1126\/science.1197004","volume":"330","author":"PA Pin","year":"2010","unstructured":"Pin, P. A. et al. An antagonistic pair of FT homologs mediates the control of flowering time in sugar beet. Science 330, 1397\u20131400 (2010).","journal-title":"Science"},{"key":"10729_CR16","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/j.1365-313X.2012.05125.x","volume":"72","author":"L Harig","year":"2012","unstructured":"Harig, L. et al. Proteins from the FLOWERING LOCUS T-like subclade of the PEBP family act antagonistically to regulate floral initiation in tobacco. Plant J. 72, 908\u2013921 (2012).","journal-title":"Plant J."},{"key":"10729_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00425-003-1109-1","volume":"218","author":"N Molinero-Rosales","year":"2004","unstructured":"Molinero-Rosales, N., Latorre, A., Jamilena, M. & Lozano, R. SINGLE FLOWER TRUSS regulates the transition and maintenance of flowering in tomato. Planta 218, 427\u2013434 (2004).","journal-title":"Planta"},{"key":"10729_CR18","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1073\/pnas.0601620103","volume":"103","author":"E Lifschitz","year":"2006","unstructured":"Lifschitz, E. et al. The tomato FT ortholog triggers systemic signals that regulate growth and flowering and substitute for diverse environmental stimuli. Proc. Natl. Acad. Sci. USA 103, 6398\u20136403 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10729_CR19","first-page":"1213","volume":"6","author":"K Cao","year":"2015","unstructured":"Cao, K. et al. Four tomato FLOWERING LOCUS T-like proteins act antagonistically to regulate floral initiation. Front. Plant Sci. 6, 1213 (2015).","journal-title":"Front. Plant Sci."},{"key":"10729_CR20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/tpj.14033","volume":"96","author":"FA Beinecke","year":"2018","unstructured":"Beinecke, F. A. et al. The FT\/FD-dependent initiation of flowering under long-day conditions in the day-neutral species Nicotiana tabacum originates from the facultative short-day ancestor Nicotiana tomentosiformis. Plant J. 96, 329\u2013342 (2018).","journal-title":"Plant J."},{"key":"10729_CR21","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.jplph.2018.10.021","volume":"231","author":"G Wang","year":"2018","unstructured":"Wang, G. et al. Isolation and functional characterization of a novel FLOWERING LOCUS T homolog (NtFT5) in Nicotiana tabacum. J. Plant Physiol. 231, 393\u2013401 (2018).","journal-title":"J. Plant Physiol."},{"key":"10729_CR22","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3389\/fpls.2019.01666","volume":"10","author":"FJ Schmidt","year":"2020","unstructured":"Schmidt, F. J. et al. The major floral promoter NtFT5 in tobacco Nicotiana tabacum is a promising target for crop improvement. Front. Plant Sci. 10, 1666 (2020).","journal-title":"Front. Plant Sci."},{"key":"10729_CR23","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/0012-1606(92)90103-N","volume":"153","author":"SM Smith","year":"1992","unstructured":"Smith, S. M. & McDaniel, C. N. The Maryland mammoth allele and rooting both perturb the fate of florally determined apices in Nicotiana tabacum. Dev. Biol. 153, 176\u2013184 (1992).","journal-title":"Dev. Biol."},{"key":"10729_CR24","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.1093\/jxb\/ert083","volume":"64","author":"RM Amasino","year":"2013","unstructured":"Amasino, R. M. My favourite flowering image: Maryland Mammoth tobacco. J. Exp. Bot. 64, 5817\u20135818 (2013).","journal-title":"J. Exp. Bot."},{"key":"10729_CR25","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","volume":"630","author":"J Abramson","year":"2024","unstructured":"Abramson, J. et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630, 493\u2013500 (2024).","journal-title":"Nature"},{"key":"10729_CR26","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1104\/pp.107.106377","volume":"145","author":"JA Lindbo","year":"2007","unstructured":"Lindbo, J. A. TRBO: A high-efficiency tobacco mosaic virus RNA-based overexpression vector. Plant Physiol. 145, 1232\u20131240 (2007).","journal-title":"Plant Physiol."},{"key":"10729_CR27","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1126\/science.286.5446.1962","volume":"286","author":"I Kardailsky","year":"1999","unstructured":"Kardailsky, I. et al. Activation tagging of the floral inducer FT. Science 286, 1962\u20131965 (1999).","journal-title":"Science"},{"key":"10729_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/BF00264213","volume":"229","author":"M Koornneef","year":"1991","unstructured":"Koornneef, M., Hanhart, C. J. & van der Veen, J. H. A genetic and physiological analysis of late flowering mutants in Arabidopsis thaliana. Mol. Gen. Genet. 229, 57\u201366 (1991).","journal-title":"Mol. Gen. Genet."},{"key":"10729_CR29","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature10272","volume":"476","author":"K Taoka","year":"2011","unstructured":"Taoka, K. et al. 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen. Nature 476, 332\u2013335 (2011).","journal-title":"Nature"},{"key":"10729_CR30","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41586-025-09704-6","volume":"648","author":"H Gao","year":"2025","unstructured":"Gao, H. et al. Florigen activation complex forms via multifaceted assembly in Arabidopsis. Nature 648, 686\u2013695 (2025).","journal-title":"Nature"},{"key":"10729_CR31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1105\/tpc.113.115220","volume":"26","author":"WWH Ho","year":"2014","unstructured":"Ho, W. W. H. & Weigel, D. Structural features determining flower-promoting activity of Arabidopsis FLOWERING LOCUS T. Plant Cell 26, 552\u2013564 (2014).","journal-title":"Plant Cell"},{"key":"10729_CR32","doi-asserted-by":"publisher","first-page":"7748","DOI":"10.1073\/pnas.0500932102","volume":"102","author":"Y Hanzawa","year":"2005","unstructured":"Hanzawa, Y., Money, T. & Bradley, D. A single amino acid converts a repressor to an activator of flowering. Proc. Natl. Acad. Sci. USA 102, 7748\u20137753 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10729_CR33","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/sj.emboj.7600950","volume":"25","author":"JH Ahn","year":"2006","unstructured":"Ahn, J. H. et al. A divergent external loop confers antagonistic activity on floral regulators FT and TFL1. EMBO J. 25, 605\u2013614 (2006).","journal-title":"EMBO J."},{"key":"10729_CR34","doi-asserted-by":"publisher","first-page":"100826","DOI":"10.1016\/j.xplc.2024.100826","volume":"5","author":"S M\u00e4ckelmann","year":"2024","unstructured":"M\u00e4ckelmann, S. et al. Gene complementation analysis indicates that parasitic dodder plants do not depend on the host FT protein for flowering. Plant Commun. 5, 100826 (2024).","journal-title":"Plant Commun."},{"key":"10729_CR35","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1126\/science.227.4691.1229","volume":"227","author":"RB Horsch","year":"1985","unstructured":"Horsch, R. B. et al. A simple and general method for transferring genes into plants. Science 227, 1229\u20131231 (1985).","journal-title":"Science"},{"key":"10729_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/303179a0","volume":"303","author":"A Hoekema","year":"1983","unstructured":"Hoekema, A., Hirsch, P. R., Hooykaas, P. J. J. & Schilperoort, R. A. A binary plant vector strategy based on separation of vir- and T-region of the Agrobacterium tumefaciens Ti-plasmid. Nature 303, 179\u2013180 (1983).","journal-title":"Nature"},{"key":"10729_CR37","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1399-3054.1962.tb08052.x","volume":"15","author":"T Murashige","year":"1962","unstructured":"Murashige, T. & Skoog, F. A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiol. Plant. 15, 473\u2013497 (1962).","journal-title":"Physiol. Plant."},{"key":"10729_CR38","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00438-010-0511-1","volume":"283","author":"GW Schmidt","year":"2010","unstructured":"Schmidt, G. W. & Delaney, S. K. Stable internal reference genes for normalization of real-time RT-PCR in tobacco Nicotiana tabacum during development and abiotic stress. Mol. Genet. Genomics 283, 233\u2013241 (2010).","journal-title":"Mol. Genet. Genomics"},{"key":"10729_CR39","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method. Methods 25, 402\u2013408 (2001).","journal-title":"Methods"},{"key":"10729_CR40","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.1093\/nar\/15.14.5890","volume":"15","author":"R T\u00f6pfer","year":"1987","unstructured":"T\u00f6pfer, R., Matzeit, V., Gronenborn, B., Schell, J. & Steinbiss, H.-H. A set of plant expression vectors for transcriptional and translational fusions. Nucleic Acids Res. 15, 5890 (1987).","journal-title":"Nucleic Acids Res."},{"key":"10729_CR41","doi-asserted-by":"publisher","first-page":"8711","DOI":"10.1093\/nar\/12.22.8711","volume":"12","author":"M Bevan","year":"1984","unstructured":"Bevan, M. Binary Agrobacterium vectors for plant transformation. Nucleic Acids Res. 12, 8711\u20138721 (1984).","journal-title":"Nucleic Acids Res."},{"key":"10729_CR42","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00253-010-2771-4","volume":"88","author":"B M\u00fcller","year":"2010","unstructured":"M\u00fcller, B. et al. Recombinant artificial forisomes provide ample quantities of smart biomaterials for use in technical devices. Appl. Microbiol. Biotechnol. 88, 689\u2013698 (2010).","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10729_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.molcatb.2013.07.013","volume":"103","author":"J Post","year":"2014","unstructured":"Post, J. et al. Establishment of an ex vivo laticifer cell suspension culture from Taraxacum brevicorniculatum as a production system for cis-isoprene. J. Mol. Catal. B Enzym. 103, 85\u201393 (2014).","journal-title":"J. Mol. Catal. B Enzym."},{"key":"10729_CR44","doi-asserted-by":"publisher","first-page":"9975","DOI":"10.1073\/pnas.93.18.9975","volume":"93","author":"CM Hamilton","year":"1996","unstructured":"Hamilton, C. M., Frary, A., Lewis, C. & Tanksley, S. D. Stable transfer of intact high molecular weight DNA into plant chromosomes. Proc. Natl. Acad. Sci. USA 93, 9975\u20139979 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10729_CR45","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1365-313X.2004.02219.x","volume":"40","author":"M Walter","year":"2004","unstructured":"Walter, M. et al. Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation. Plant J. 40, 428\u2013438 (2004).","journal-title":"Plant J."},{"key":"10729_CR46","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nbt816","volume":"21","author":"CD Hu","year":"2003","unstructured":"Hu, C. D. & Kerppola, T. K. Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis. Nat. Biotechnol. 21, 539\u2013545 (2003).","journal-title":"Nat. Biotechnol."},{"key":"10729_CR47","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1365-313X.2008.03612.x","volume":"56","author":"R Waadt","year":"2008","unstructured":"Waadt, R. et al. Multicolor bimolecular fluorescence complementation reveals simultaneous formation of alternative CBL\/CIPK complexes in planta. Plant J. 56, 505\u2013516 (2008).","journal-title":"Plant J."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10729-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10729-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10729-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:01:34Z","timestamp":1787752894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10729-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10729"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10729-4","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"11 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Author RMT was employed by the company TRM Ltd. All other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"1144"}}