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However, the mechanisms underlying chromatin remodeling remain elusive. Here, we investigated the role of CHRAC17, a component of the chromatin assembly complex (CHRAC), in maintaining genome stability. In response to DSBs, the ISWI-family ATPase complex SNF2H-ACF1 is immediately recruited to DSBs through the H2B-type histone-fold protein CHRAC17, forming CHRAC, which promotes nucleosome assembly and recruits BRCA1 and RAD51 to the DSB site. CHRAC promotes later RAD51-mediated HR steps through additional nucleosome-remodeling activity, including nucleosome sliding activity. CHRAC17, also known as POLE3, is a subunit of DNA polymerase \u03b5 (Pol\u03b5). Pol\u03b5 is recruited to DSBs via CHRAC17, facilitating RAD51-mediated homologous recombination (HR) and conferring resistance to PARP inhibitors. These findings define a mechanism of homologous recombination driven by coordinated regulation of nucleosome dynamics by CHRAC and Pol\u03b5, thereby ensuring genome stability.<\/jats:p>","DOI":"10.1038\/s42003-026-10862-0","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:04:11Z","timestamp":1789463051000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ISWI\/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase \u03b5 for homologous recombination"],"prefix":"10.1038","volume":"9","author":[{"given":"Jianghao","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-2858","authenticated-orcid":false,"given":"Kozo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-7168","authenticated-orcid":false,"given":"Ayako","family":"Ui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"10862_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nrm.2017.26","volume":"18","author":"CR Clapier","year":"2017","unstructured":"Clapier, C. 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