{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:56:08Z","timestamp":1787003768224,"version":"build-2736575974"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007053","name":"Ministry of Knowledge Economy | Korea Institute of Energy Technology Evaluation and Planning","doi-asserted-by":"publisher","award":["NRF-2022M3C1A3092056"],"award-info":[{"award-number":["NRF-2022M3C1A3092056"]}],"id":[{"id":"10.13039\/501100007053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Chem"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The direct oxidation of methane to methanol has been spotlighted research for decades, but has never been commercialized. This study introduces cost-effective process for co-producing methanol and sulfuric acid through a direct oxidation of methane. In the initial phase, methane oxidation forms methyl bisulfate (CH\n                    <jats:sub>3<\/jats:sub>\n                    OSO\n                    <jats:sub>3<\/jats:sub>\n                    H), then transformed into methyl trifluoroacetate (CF\n                    <jats:sub>3<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    CH\n                    <jats:sub>3<\/jats:sub>\n                    ) via esterification, and hydrolyzed into methanol. This approach eliminates the need for energy-intensive separation of methyl bisulfate from sulfuric acid by replacing the former with methyl trifluoroacetate. Through the superstructure optimization, our sequential process reduces the levelized cost of methanol to nearly two-fold reduction from the current market price. Importantly, this process demonstrates adaptability to smaller gas fields, assuring its economical operation across a broad range of gas fields. The broader application of this process could substantially mitigate global warming by utilizing methane, leading to a significantly more sustainable and economically beneficial methanol industry.\n                  <\/jats:p>","DOI":"10.1038\/s42004-023-01080-4","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T06:02:11Z","timestamp":1703052131000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Economically viable co-production of methanol and sulfuric acid via direct methane oxidation"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-4754","authenticated-orcid":false,"given":"Jaehyung","family":"Im","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hyeon","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyen Tran","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4187-9344","authenticated-orcid":false,"given":"Nak-Kyoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Bong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-7605","authenticated-orcid":false,"given":"Kyeongsu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-5309","authenticated-orcid":false,"given":"Ung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"1080_CR1","doi-asserted-by":"publisher","first-page":"16464","DOI":"10.1002\/anie.201702550","volume":"56","author":"M Ravi","year":"2017","unstructured":"Ravi, M., Ranocchiari, M. & van Bokhoven, J. A. The direct catalytic oxidation of methane to methanol\u2014a critical assessment. Angew. Chem. Int. Ed. 56, 16464\u201316483 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1080_CR2","doi-asserted-by":"publisher","first-page":"123153","DOI":"10.1016\/j.jclepro.2020.123153","volume":"274","author":"W Li","year":"2020","unstructured":"Li, W., Zhuang, Y., Liu, L., Zhang, L. & Du, J. Process evaluation and optimization of methanol production from shale gas based on kinetics modeling. J. Clean. Prod. 274, 123153 (2020).","journal-title":"J. Clean. Prod."},{"key":"1080_CR3","doi-asserted-by":"publisher","first-page":"136259","DOI":"10.1016\/j.jclepro.2023.136259","volume":"393","author":"R Rinaldi","year":"2023","unstructured":"Rinaldi, R., Lombardelli, G., Gatti, M., Visconti, C. G. & Romano, M. C. Techno-economic analysis of a biogas-to-methanol process: study of different process configurations and conditions. J. Clean. Prod. 393, 136259 (2023).","journal-title":"J. Clean. Prod."},{"key":"1080_CR4","doi-asserted-by":"publisher","first-page":"135976","DOI":"10.1016\/j.jclepro.2023.135976","volume":"389","author":"H Wei","year":"2023","unstructured":"Wei, H. et al. Towards a sustainable, and economic production future: proposing a new process for methanol production based on renewable hydrogen. J. Clean. Prod. 389, 135976 (2023).","journal-title":"J. Clean. Prod."},{"key":"1080_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/en9010014","volume":"9","author":"CD Elvidge","year":"2016","unstructured":"Elvidge, C. D., Zhizhin, M., Baugh, K., Hsu, F.-C. & Ghosh, T. Methods for global survey of natural gas flaring from visible infrared imaging radiometer suite data. Energies 9, 14 (2016).","journal-title":"Energies"},{"key":"1080_CR6","doi-asserted-by":"publisher","first-page":"111298","DOI":"10.1016\/j.rse.2019.111298","volume":"232","author":"D Fisher","year":"2019","unstructured":"Fisher, D. & Wooster, M. J. Multi-decade global gas flaring change inventoried using the ATSR-1, ATSR-2, AATSR and SLSTR data records. Remote Sens. Environ. 232, 111298 (2019).","journal-title":"Remote Sens. Environ."},{"key":"1080_CR7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.cej.2007.03.044","volume":"134","author":"CG Dallos","year":"2007","unstructured":"Dallos, C. G. & Kafarov, V. & Maciel Filho, R. A two dimensional steady-state model of the gas\u2013solid\u2013solid reactor: example of the partial oxidation of methane to methanol. Chem. Eng. J. 134, 209\u2013217 (2007).","journal-title":"Chem. Eng. J."},{"key":"1080_CR8","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1126\/science.aam9035","volume":"356","author":"VL Sushkevich","year":"2017","unstructured":"Sushkevich, V. L., Palagin, D., Ranocchiari, M. & Van Bokhoven, J. A. Selective anaerobic oxidation of methane enables direct synthesis of methanol. Science 356, 523\u2013527 (2017).","journal-title":"Science"},{"key":"1080_CR9","doi-asserted-by":"publisher","first-page":"9044","DOI":"10.1002\/ange.201802922","volume":"130","author":"VL Sushkevich","year":"2018","unstructured":"Sushkevich, V. L., Palagin, D. & van Bokhoven, J. A. The effect of the active\u2010site structure on the activity of copper mordenite in the aerobic and anaerobic conversion of methane into methanol. Angew. Chem. 130, 9044\u20139048 (2018).","journal-title":"Angew. Chem."},{"key":"1080_CR10","doi-asserted-by":"publisher","first-page":"15270","DOI":"10.1021\/jacs.8b08071","volume":"140","author":"DK Pappas","year":"2018","unstructured":"Pappas, D. K. et al. The nuclearity of the active site for methane to methanol conversion in Cu-mordenite: a quantitative assessment. J. Am. Chem. Soc. 140, 15270\u201315278 (2018).","journal-title":"J. Am. Chem. Soc."},{"key":"1080_CR11","doi-asserted-by":"publisher","first-page":"14961","DOI":"10.1021\/jacs.7b06472","volume":"139","author":"DK Pappas","year":"2017","unstructured":"Pappas, D. K. et al. Methane to methanol: structure\u2013activity relationships for Cu-CHA. J. Am. Chem. Soc. 139, 14961\u201314975 (2017).","journal-title":"J. Am. Chem. Soc."},{"key":"1080_CR12","doi-asserted-by":"publisher","first-page":"4973","DOI":"10.1021\/acscatal.1c00543","volume":"11","author":"G Brezicki","year":"2021","unstructured":"Brezicki, G., Zheng, J., Paolucci, C., Schl\u00f6gl, R. & Davis, R. J. Effect of the Co-cation on Cu speciation in Cu-exchanged mordenite and ZSM-5 catalysts for the oxidation of methane to methanol. ACS Catal. 11, 4973\u20134987 (2021).","journal-title":"ACS Catal."},{"key":"1080_CR13","doi-asserted-by":"publisher","first-page":"122178","DOI":"10.1016\/j.fuel.2021.122178","volume":"309","author":"C Zhou","year":"2022","unstructured":"Zhou, C. et al. Methane-selective oxidation to methanol and ammonia selective catalytic reduction of NOx over monolithic Cu\/SSZ-13 catalysts: are hydrothermal stability and active sites same? Fuel 309, 122178 (2022).","journal-title":"Fuel"},{"key":"1080_CR14","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1021\/jacsau.1c00196","volume":"1","author":"I Lee","year":"2021","unstructured":"Lee, I. et al. Activity of Cu\u2013Al\u2013Oxo extra-framework clusters for selective methane oxidation on Cu-exchanged zeolites. JACS Au 1, 1412\u20131421 (2021).","journal-title":"JACS Au"},{"key":"1080_CR15","doi-asserted-by":"publisher","first-page":"4897","DOI":"10.1002\/cctc.202101244","volume":"13","author":"L Fu","year":"2021","unstructured":"Fu, L. et al. The influence of UiO\u2010bpy skeleton for the direct methane\u2010to\u2010methanol conversion on Cu@ UiO\u2010bpy: importance of the encapsulation effect. ChemCatChem. 13, 4897\u20134902 (2021).","journal-title":"ChemCatChem."},{"key":"1080_CR16","doi-asserted-by":"publisher","first-page":"125483","DOI":"10.1016\/j.fuel.2022.125483","volume":"329","author":"C Zhou","year":"2022","unstructured":"Zhou, C. et al. Temperature-dependant active sites for methane continuous conversion to methanol over Cu-zeolite catalysts using water as the oxidant. Fuel 329, 125483 (2022).","journal-title":"Fuel"},{"key":"1080_CR17","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.cej.2010.08.001","volume":"166","author":"T Nozaki","year":"2011","unstructured":"Nozaki, T., A\u011f\u0131ral, A., Yuzawa, S., Gardeniers, J. H. & Okazaki, K. A single step methane conversion into synthetic fuels using microplasma reactor. Chem. Eng. J. 166, 288\u2013293 (2011).","journal-title":"Chem. Eng. J."},{"key":"1080_CR18","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cej.2010.10.050","volume":"167","author":"A A\u011f\u0131ral","year":"2011","unstructured":"A\u011f\u0131ral, A. et al. Gas-to-liquids process using multi-phase flow, non-thermal plasma microreactor. Chem. Eng. J. 167, 560\u2013566 (2011).","journal-title":"Chem. Eng. J."},{"key":"1080_CR19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1126\/science.aaw1108","volume":"367","author":"Z Jin","year":"2020","unstructured":"Jin, Z. et al. Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol. Science 367, 193\u2013197 (2020).","journal-title":"Science"},{"key":"1080_CR20","doi-asserted-by":"crossref","unstructured":"Wang, S. et al. H2-reduced phosphomolybdate promotes room-temperature aerobic oxidation of methane to methanol. Nat. Catal. 1-11 (2023).","DOI":"10.21203\/rs.3.rs-2307433\/v1"},{"key":"1080_CR21","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/anie.201207717","volume":"52","author":"MH Ab Rahim","year":"2013","unstructured":"Ab Rahim, M. H. et al. Oxidation of methane to methanol with hydrogen peroxide using supported gold\u2013palladium alloy nanoparticles. Angew. Chem. Int. Ed. 52, 1280\u20131284 (2013).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1080_CR22","doi-asserted-by":"publisher","first-page":"e202201630","DOI":"10.1002\/cctc.202201630","volume":"15","author":"GS Yang","year":"2023","unstructured":"Yang, G. S., Kang, J. & Park, E. D. Aqueous\u2010Phase Partial Oxidation of Methane over Pd\u2212 Fe\/ZSM\u20105 with O2 in the Presence of H2. ChemCatChem. 15, e202201630 (2023).","journal-title":"ChemCatChem."},{"key":"1080_CR23","doi-asserted-by":"publisher","first-page":"e202201540","DOI":"10.1002\/anie.202201540","volume":"61","author":"F Gu","year":"2022","unstructured":"Gu, F. et al. Selective catalytic oxidation of methane to methanol in aqueous medium over copper cations promoted by atomically dispersed rhodium on TiO2. Angew. Chem. Int. Ed. 61, e202201540 (2022).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1080_CR24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1006\/jcat.1995.1208","volume":"155","author":"Y Wang","year":"1995","unstructured":"Wang, Y. & Otsuka, K. Catalytic oxidation of methane to methanol with H2-O2 gas mixture at atmospheric pressure. J. Catal. 155, 256\u2013267 (1995).","journal-title":"J. Catal."},{"key":"1080_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S2095-4956(13)60002-9","volume":"22","author":"JN Armor","year":"2013","unstructured":"Armor, J. N. Emerging importance of shale gas to both the energy & chemicals landscape. J. Energy Chem. 22, 21\u201326 (2013).","journal-title":"J. Energy Chem."},{"key":"1080_CR26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jechem.2015.08.005","volume":"24","author":"S Abate","year":"2015","unstructured":"Abate, S., Centi, G., Lanzafame, P. & Perathoner, S. The energy-chemistry nexus: a vision of the future from sustainability perspective. J. Energy Chem. 24, 535\u2013547 (2015).","journal-title":"J. Energy Chem."},{"key":"1080_CR27","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1126\/science.aav0177","volume":"363","author":"C D\u00edaz-Urrutia","year":"2019","unstructured":"D\u00edaz-Urrutia, C. & Ott, T. Activation of methane: a selective industrial route to methanesulfonic acid. Science 363, 1326\u20131329 (2019).","journal-title":"Science"},{"key":"1080_CR28","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1021\/jacsau.2c00176","volume":"2","author":"A Nandy","year":"2022","unstructured":"Nandy, A., Duan, C., Goffinet, C. & Kulik, H. J. New strategies for direct methane-to-methanol conversion from active learning exploration of 16 million catalysts. JACS Au 2, 1200\u20131213 (2022).","journal-title":"JACS Au"},{"key":"1080_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12639-x","volume":"12","author":"TK Kapuge","year":"2022","unstructured":"Kapuge, T. K. et al. Partial oxidation of methane to methanol on boron nitride at near critical acetonitrile. Sci. Rep. 12, 8577 (2022).","journal-title":"Sci. Rep."},{"key":"1080_CR30","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.gee.2021.05.004","volume":"7","author":"K Sun","year":"2022","unstructured":"Sun, K., Zhang, Z., Shen, C., Rui, N. & Liu, C.-J. The feasibility study of the indium oxide supported silver catalyst for selective hydrogenation of CO2 to methanol. Green. Energy Environ. 7, 807\u2013817 (2022).","journal-title":"Green. Energy Environ."},{"key":"1080_CR31","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1021\/acscatal.8b01878","volume":"8","author":"T Zimmermann","year":"2018","unstructured":"Zimmermann, T., Bilke, M., Soorholtz, M. & Sch\u00fcth, F. Influence of catalyst concentration on activity and selectivity in selective methane oxidation with platinum compounds in sulfuric acid and oleum. ACS Catal. 8, 9262\u20139268 (2018).","journal-title":"ACS Catal."},{"key":"1080_CR32","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1126\/science.259.5093.340","volume":"259","author":"RA Periana","year":"1993","unstructured":"Periana, R. A. et al. A mercury-catalyzed, high-yield system for the oxidation of methane to methanol. Science 259, 340\u2013343 (1993).","journal-title":"Science"},{"key":"1080_CR33","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1126\/science.280.5363.560","volume":"280","author":"RA Periana","year":"1998","unstructured":"Periana, R. A. et al. Platinum catalysts for the high-yield oxidation of methane to a methanol derivative. Science 280, 560\u2013564 (1998).","journal-title":"Science"},{"key":"1080_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cej.2009.03.046","volume":"154","author":"B Michalkiewicz","year":"2009","unstructured":"Michalkiewicz, B., Jarosi\u0144ska, M. & \u0141ukasiewicz, I. Kinetic study on catalytic methane esterification in oleum catalyzed by iodine. Chem. Eng. J. 154, 156\u2013161 (2009).","journal-title":"Chem. Eng. J."},{"key":"1080_CR35","doi-asserted-by":"publisher","first-page":"12395","DOI":"10.1021\/jacs.6b05167","volume":"138","author":"T Zimmermann","year":"2016","unstructured":"Zimmermann, T., Soorholtz, M., Bilke, M. & Sch\u00fcth, F. Selective methane oxidation catalyzed by platinum salts in oleum at turnover frequencies of large-scale industrial processes. J. Am. Chem. Soc. 138, 12395\u201312400 (2016).","journal-title":"J. Am. Chem. Soc."},{"key":"1080_CR36","doi-asserted-by":"crossref","unstructured":"Olah, G. A. & Prakash, G. S. Across Conventional Lines: Selected Papers of George A Olah (In 2 Volumes). Vol. 11 (World Scientific, 2003).","DOI":"10.1142\/9789812791405"},{"key":"1080_CR37","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1002\/cctc.201800412","volume":"10","author":"M Ravi","year":"2018","unstructured":"Ravi, M. & van Bokhoven, J. A. Homogeneous copper\u2010catalyzed conversion of methane to methyl trifluoroacetate in high yield at low pressure. ChemCatChem. 10, 2383\u20132386 (2018).","journal-title":"ChemCatChem."},{"key":"1080_CR38","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1021\/acscatal.0c05205","volume":"11","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y. et al. Atmosphere-pressure methane oxidation to methyl trifluoroacetate enabled by a porous organic polymer-supported single-site palladium catalyst. ACS Catal. 11, 1008\u20131013 (2021).","journal-title":"ACS Catal."},{"key":"1080_CR39","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.apcata.2011.03.028","volume":"398","author":"T Li","year":"2011","unstructured":"Li, T. et al. Direct conversion of methane to methanol over nano-[Au\/SiO2] in [Bmim] Cl ionic liquid. Appl. Catal. A Gen. 398, 150\u2013154 (2011).","journal-title":"Appl. Catal. A Gen."},{"key":"1080_CR40","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.jcat.2022.07.031","volume":"413","author":"S-H Cheong","year":"2022","unstructured":"Cheong, S.-H. et al. Methane oxidation to methyl trifluoroacetate by simple anionic palladium catalyst: comprehensive understanding of K2S2O8-based methane oxidation in CF3CO2H. J. Catal. 413, 803\u2013811 (2022).","journal-title":"J. Catal."},{"key":"1080_CR41","doi-asserted-by":"publisher","first-page":"11854","DOI":"10.1021\/acscatal.8b04101","volume":"8","author":"HT Dang","year":"2018","unstructured":"Dang, H. T. et al. Enhanced catalytic activity of (DMSO) 2PtCl2 for the methane oxidation in the SO3\u2013H2SO4 system. ACS Catal. 8, 11854\u201311862 (2018).","journal-title":"ACS Catal."},{"key":"1080_CR42","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jcat.2019.04.042","volume":"374","author":"HW Lee","year":"2019","unstructured":"Lee, H. W. et al. Pt black catalyzed methane oxidation to methyl bisulfate in H2SO4-SO3. J. Catal. 374, 230\u2013236 (2019).","journal-title":"J. Catal."},{"key":"1080_CR43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.memsci.2006.09.039","volume":"286","author":"B Michalkiewicz","year":"2006","unstructured":"Michalkiewicz, B., Ziebro, J. & Tomaszewska, M. Preliminary investigation of low pressure membrane distillation of methyl bisulphate from its solutions in fuming sulphuric acid combined with hydrolysis to methanol. J. Membr. Sci. 286, 223\u2013227 (2006).","journal-title":"J. Membr. Sci."},{"key":"1080_CR44","doi-asserted-by":"publisher","first-page":"17110","DOI":"10.1021\/ja903930e","volume":"131","author":"M Ahlquist","year":"2009","unstructured":"Ahlquist, M., Nielsen, R. J., Periana, R. A. & Goddard, W. A. III. Product protection, the key to developing high performance methane selective oxidation catalysts. J. Am. Chem. Soc. 131, 17110\u201317115 (2009).","journal-title":"J. Am. Chem. Soc."},{"key":"1080_CR45","doi-asserted-by":"publisher","first-page":"8781","DOI":"10.1002\/er.5573","volume":"44","author":"HW Lee","year":"2020","unstructured":"Lee, H. W. et al. Toward the practical application of direct CO2 hydrogenation technology for methanol production. Int. J. Energy Res. 44, 8781\u20138798 (2020).","journal-title":"Int. J. Energy Res."},{"key":"1080_CR46","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1002\/adsc.200404394","volume":"347","author":"S Mukhopadhyay","year":"2005","unstructured":"Mukhopadhyay, S., Zerella, M. & Bell, A. T. A high\u2010yield, liquid\u2010phase approach for the partial oxidation of methane to methanol using SO3 as the oxidant. Adv. Synth. Catal. 347, 1203\u20131206 (2005).","journal-title":"Adv. Synth. Catal."},{"key":"1080_CR47","unstructured":"Periana, R. et al. High-efficiency mercury-catalyzed oxidative process to convert methane into methanol. Suigin wo shokubai to shita methane sanka ni yoru methanol no koshuritsu seizo hoshiki. Mitsubishi sekiyu Gijutsu Shiryo;(Japan) 81, 72\u201378 (1994)."},{"key":"1080_CR48","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1021\/ja00002a063","volume":"113","author":"LC Kao","year":"1991","unstructured":"Kao, L. C., Hutson, A. C. & Sen, A. Low-temperature, palladium (II)-catalyzed, solution-phase oxidation of methane to methanol derivative. J. Am. Chem. Soc. 113, 700\u2013701 (1991).","journal-title":"J. Am. Chem. Soc."},{"key":"1080_CR49","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0920-5861(96)00213-1","volume":"35","author":"CE Taylor","year":"1997","unstructured":"Taylor, C. E., Anderson, R. R. & Noceti, R. P. Activation of methane with organopalladium complexes. Catal. Today 35, 407\u2013413 (1997).","journal-title":"Catal. Today"},{"key":"1080_CR50","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.apenergy.2019.04.135","volume":"248","author":"J Hwang","year":"2019","unstructured":"Hwang, J. et al. An experimental based optimization of a novel water lean amine solvent for post combustion CO2 capture process. Appl. Energy 248, 174\u2013184 (2019).","journal-title":"Appl. Energy"},{"key":"1080_CR51","doi-asserted-by":"publisher","first-page":"16943","DOI":"10.1039\/D0TA05607C","volume":"8","author":"K Kim","year":"2020","unstructured":"Kim, K. et al. Data-driven pilot optimization for electrochemical CO mass production. J. Mater. Chem. A 8, 16943\u201316950 (2020).","journal-title":"J. Mater. Chem. A"},{"key":"1080_CR52","doi-asserted-by":"publisher","first-page":"7186","DOI":"10.1021\/acscatal.5b01911","volume":"5","author":"W Alharbi","year":"2015","unstructured":"Alharbi, W., Kozhevnikova, E. F. & Kozhevnikov, I. V. Dehydration of methanol to dimethyl ether over heteropoly acid catalysts: the relationship between reaction rate and catalyst acid strength. ACS Catal. 5, 7186\u20137193 (2015).","journal-title":"ACS Catal."},{"key":"1080_CR53","doi-asserted-by":"crossref","unstructured":"Goldberg D. E., H. J. Genetic Algorithms And Machine Learning. Mach Learn 3, 95\u201399 (1988).","DOI":"10.1007\/BF00113892"},{"key":"1080_CR54","unstructured":"George, E., Hunter, W. G. & Hunter, J. S. Statistics for Experimenters: Design, Innovation, And Discovery (Wiley, 2005)."},{"key":"1080_CR55","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10898-018-0609-2","volume":"71","author":"E Bradford","year":"2018","unstructured":"Bradford, E., Schweidtmann, A. M. & Lapkin, A. Efficient multiobjective optimization employing Gaussian processes, spectral sampling and a genetic algorithm. J. Glob. Optim. 71, 407\u2013438 (2018).","journal-title":"J. Glob. Optim."},{"key":"1080_CR56","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1021\/acs.iecr.8b04825","volume":"58","author":"K Kim","year":"2019","unstructured":"Kim, K., Kim, J., Kim, C., Lee, Y. & Lee, W. B. Robust design of multicomponent working fluid for organic rankine cycle. Ind. Eng. Chem. Res. 58, 4154\u20134167 (2019).","journal-title":"Ind. Eng. Chem. Res."},{"key":"1080_CR57","unstructured":"Hinton, G. & van der Maaten, L. Visualizing data using t-SNE. J. Mach. Learn. Res. 9, 2579\u20132605 (2008)."},{"key":"1080_CR58","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cageo.2012.03.008","volume":"44","author":"F Cannav\u00f3","year":"2012","unstructured":"Cannav\u00f3, F. Sensitivity analysis for volcanic source modeling quality assessment and model selection. Comput. Geosci. 44, 52\u201359 (2012).","journal-title":"Comput. Geosci."},{"key":"1080_CR59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0098-1354(82)80003-3","volume":"6","author":"GJ McRae","year":"1982","unstructured":"McRae, G. J., Tilden, J. W. & Seinfeld, J. H. Global sensitivity analysis\u2014a computational implementation of the Fourier amplitude sensitivity test (FAST). Comput. Chem. Eng. 6, 15\u201325 (1982).","journal-title":"Comput. Chem. Eng."},{"key":"1080_CR60","doi-asserted-by":"publisher","first-page":"14857","DOI":"10.1016\/j.ijhydene.2021.01.160","volume":"46","author":"Y Lee","year":"2021","unstructured":"Lee, Y., Lee, U. & Kim, K. A comparative techno-economic and quantitative risk analysis of hydrogen delivery infrastructure options. Int. J. Hydrog. Energy 46, 14857\u201314870 (2021).","journal-title":"Int. J. Hydrog. Energy"},{"key":"1080_CR61","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1007\/s11367-016-1087-8","volume":"21","author":"G Wernet","year":"2016","unstructured":"Wernet, G. et al. The ecoinvent database version 3 (part I): overview and methodology. Int. J. Life Cycle Assess. 21, 1218\u20131230 (2016).","journal-title":"Int. J. Life Cycle Assess."},{"key":"1080_CR62","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jclepro.2019.03.015","volume":"225","author":"M Rumayor","year":"2019","unstructured":"Rumayor, M., Dominguez-Ramos, A. & Irabien, A. Innovative alternatives to methanol manufacture: Carbon footprint assessment. J. Clean. Prod. 225, 426\u2013434 (2019).","journal-title":"J. Clean. Prod."},{"key":"1080_CR63","doi-asserted-by":"crossref","unstructured":"Cho, S., Do, T. N. & Kim, J. Advanced Design and Comparative Analysis of Methanol Production Routes from CO 2 and Renewable H 2: via Syngas vs. Direct Hydrogenation Processes. Int. J. Energy Res. 2023 (2023).","DOI":"10.1155\/2023\/6270858"}],"container-title":["Communications Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42004-023-01080-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42004-023-01080-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42004-023-01080-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T07:17:01Z","timestamp":1703056621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42004-023-01080-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1080"],"URL":"https:\/\/doi.org\/10.1038\/s42004-023-01080-4","relation":{},"ISSN":["2399-3669"],"issn-type":[{"value":"2399-3669","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,20]]},"assertion":[{"value":"21 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"282"}}