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Herein, a benziodazole-type O<jats:sub>2<\/jats:sub>NO-I(III) compound was prepared and its reaction with \u03b2-monosubstituted enamines in the presence of CuI could trigger a radical nitration\/cyclization\/dehydration cascade to provide a series of less explored but biologically interesting furazan heterocycles. Mechanistically, the benziodazole-type O<jats:sub>2<\/jats:sub>NO-I(III) compound acts as a nitrating reagent and incorporates its NO moiety into the final furazan product in a fully-<jats:italic>endo<\/jats:italic> model, a process of which was proposed to involve nitration, cyclization and dehydration.<\/jats:p>","DOI":"10.1038\/s42004-024-01238-8","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T19:03:08Z","timestamp":1720551788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preparation of a benziodazole-type iodine(III) compound and its application as a nitrating reagent for synthesis of furazans via a copper-catalyzed cascade process"],"prefix":"10.1038","volume":"7","author":[{"given":"Zhifang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-2854","authenticated-orcid":false,"given":"Yunfei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"1238_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0065-2725(03)86004-X","volume":"86","author":"GF Koser","year":"2003","unstructured":"Koser, G. 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