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These elements can be found in the active site of certain alcohol dehydrogenase (ADH) enzymes, which are used by methylotrophic bacteria to metabolize simple alcohols such as methanol and ethanol. The 5\u2009\n                    <jats:italic>f<\/jats:italic>\n                    elements, known as the actinides, often show similar chemical behaviour to the lanthanides and recent reports demonstrated that americium (Am) and curium (Cm) can replace lanthanides in certain ADHs to yield a catalytically competent enzyme and support bacterial life. In this work, we expand on these results to show the trivalent ions actinium (Ac\n                    <jats:sup>3+<\/jats:sup>\n                    ), americium (Am\n                    <jats:sup>3+<\/jats:sup>\n                    ), curium (Cm\n                    <jats:sup>3+<\/jats:sup>\n                    ), berkelium (Bk\n                    <jats:sup>3+<\/jats:sup>\n                    ), and californium (Cf\n                    <jats:sup>3+<\/jats:sup>\n                    ) all support growth of an evolved strain of the model methylotroph\n                    <jats:italic>Methylobacterium extorquens<\/jats:italic>\n                    AM1. Further in vitro experiments using a reconstituted ethanol dehydrogenase enzyme confirm the ability of this enzyme to utilize trivalent actinide ions.\n                  <\/jats:p>","DOI":"10.1038\/s42004-025-01749-y","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:18:14Z","timestamp":1763745494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expanding on the ability of trivalent actinides to support microbial alcohol metabolism in evolved methylotrophic bacterium"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6213-4093","authenticated-orcid":false,"given":"Joshua J.","family":"Woods","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan M.","family":"Good","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia G.","family":"Cosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirty","family":"Wadhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"Wacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa N.","family":"Gaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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