{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:14:38Z","timestamp":1784859278790,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31700144"],"award-info":[{"award-number":["31700144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Metab"],"DOI":"10.1038\/s42255-020-0227-4","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T16:04:22Z","timestamp":1594656262000},"page":"717-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease"],"prefix":"10.1038","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-801X","authenticated-orcid":false,"given":"Zeyun","family":"Mi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-5699","authenticated-orcid":false,"given":"Meijuan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxue","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-9547","authenticated-orcid":false,"given":"Yupeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"227_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","volume":"4","author":"C Bergmann","year":"2018","unstructured":"Bergmann, C. et al. Polycystic kidney disease. Nat. Rev. Dis. Primers 4, 50 (2018).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"227_CR2","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","volume":"393","author":"E Cornec-Le Gall","year":"2019","unstructured":"Cornec-Le Gall, E., Alam, A. & Perrone, R. D. Autosomal dominant polycystic kidney disease. Lancet 393, 919\u2013935 (2019).","journal-title":"Lancet"},{"key":"227_CR3","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41581-018-0051-1","volume":"14","author":"V Padovano","year":"2018","unstructured":"Padovano, V., Podrini, C., Boletta, A. & Caplan, M. J. Metabolism and mitochondria in polycystic kidney disease research and therapy. Nat. Rev. Nephrol. 14, 678\u2013687 (2018).","journal-title":"Nat. Rev. Nephrol."},{"key":"227_CR4","doi-asserted-by":"crossref","unstructured":"Menezes, L. F. & Germino, G. G. The pathobiology of polycystic kidney disease from a metabolic viewpoint. Nat. Rev. Nephrol. 15, 735\u2013749 (2019).","DOI":"10.1038\/s41581-019-0183-y"},{"key":"227_CR5","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1093\/ndt\/gft521","volume":"29","author":"I Rowe","year":"2014","unstructured":"Rowe, I. & Boletta, A. Defective metabolism in polycystic kidney disease: potential for therapy and open questions. Nephrol. Dial. Transplant. 29, 1480\u20131486 (2014).","journal-title":"Nephrol. Dial. Transplant."},{"key":"227_CR6","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nm.3092","volume":"19","author":"I Rowe","year":"2013","unstructured":"Rowe, I. et al. Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nat. Med. 19, 488\u2013493 (2013).","journal-title":"Nat. Med."},{"key":"227_CR7","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1681\/ASN.2015030231","volume":"27","author":"M Chiaravalli","year":"2016","unstructured":"Chiaravalli, M. et al. 2-Deoxy-d-glucose ameliorates PKD progression. J. Am. Soc. Nephrol. 27, 1958\u20131969 (2016).","journal-title":"J. Am. Soc. Nephrol."},{"key":"227_CR8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ebiom.2016.01.027","volume":"5","author":"LF Menezes","year":"2016","unstructured":"Menezes, L. F., Lin, C. C., Zhou, F. & Germino, G. G. Fatty acid oxidation is impaired in an orthologous mouse model of autosomal dominant polycystic kidney disease. EBioMedicine 5, 183\u2013192 (2016).","journal-title":"EBioMedicine"},{"key":"227_CR9","doi-asserted-by":"publisher","first-page":"F122","DOI":"10.1152\/ajprenal.00352.2017","volume":"314","author":"R Lakhia","year":"2018","unstructured":"Lakhia, R. et al. PPAR\u03b1 agonist fenofibrate enhances fatty acid beta-oxidation and attenuates polycystic kidney and liver disease in mice. Am. J. Physiol. Renal Physiol. 314, F122\u2013F131 (2018).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"227_CR10","doi-asserted-by":"publisher","first-page":"F492","DOI":"10.1152\/ajprenal.00238.2015","volume":"309","author":"VJ Hwang","year":"2015","unstructured":"Hwang, V. J. et al. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am. J. Physiol. Renal Physiol. 309, F492\u2013F498 (2015).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"227_CR11","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1093\/ndt\/gfx349","volume":"33","author":"I Soomro","year":"2018","unstructured":"Soomro, I. et al. Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease. Nephrol. Dial. Transplant. 33, 1343\u20131353 (2018).","journal-title":"Nephrol. Dial. Transplant."},{"key":"227_CR12","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s42003-018-0200-x","volume":"1","author":"C Podrini","year":"2018","unstructured":"Podrini, C. et al. Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways. Commun. Biol. 1, 194 (2018).","journal-title":"Commun. Biol."},{"key":"227_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20856-6","volume":"8","author":"CC Lin","year":"2018","unstructured":"Lin, C. C. et al. A cleavage product of polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci. Rep. 8, 2743 (2018).","journal-title":"Sci. Rep."},{"key":"227_CR14","doi-asserted-by":"crossref","unstructured":"Kuo, I. Y. et al. Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2. Sci. Signal 12, eaat7397 (2019).","DOI":"10.1126\/scisignal.aat7397"},{"key":"227_CR15","doi-asserted-by":"crossref","unstructured":"Ishimoto, Y. et al. Mitochondrial abnormality facilitates cyst formation in autosomal dominant polycystic kidney disease. Mol. Cell. Biol. 37, e00337-17 (2017).","DOI":"10.1128\/MCB.00337-17"},{"key":"227_CR16","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1172\/JCI72272","volume":"124","author":"PC Harris","year":"2014","unstructured":"Harris, P. C. & Torres, V. E. Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease. J. Clin. Invest. 124, 2315\u20132324 (2014).","journal-title":"J. Clin. Invest."},{"key":"227_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1091\/mbc.e16-08-0597","volume":"28","author":"V Padovano","year":"2017","unstructured":"Padovano, V. et al. The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Mol. Biol. Cell 28, 261\u2013269 (2017).","journal-title":"Mol. Biol. Cell"},{"key":"227_CR18","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1159\/000500458","volume":"44","author":"D Liu","year":"2019","unstructured":"Liu, D. et al. Identification of key genes and candidated pathways in human autosomal dominant polycystic kidney disease by bioinformatics analysis. Kidney Blood Press. Res. 44, 533\u2013552 (2019).","journal-title":"Kidney Blood Press. Res."},{"key":"227_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-016-0095-x","volume":"10","author":"RM de Almeida","year":"2016","unstructured":"de Almeida, R. M. et al. Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD. Hum. Genomics 10, 37 (2016).","journal-title":"Hum. Genomics"},{"key":"227_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","volume":"153","author":"WA Whyte","year":"2013","unstructured":"Whyte, W. A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307\u2013319 (2013).","journal-title":"Cell"},{"key":"227_CR21","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.trecan.2017.03.006","volume":"3","author":"S Sengupta","year":"2017","unstructured":"Sengupta, S. & George, R. E. Super-enhancer-driven transcriptional dependencies in cancer. Trends Cancer 3, 269\u2013281 (2017).","journal-title":"Trends Cancer"},{"key":"227_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev-biochem-060815-014857","volume":"85","author":"E Compe","year":"2016","unstructured":"Compe, E. & Egly, J. M. Nucleotide excision repair and transcriptional regulation: TFIIH and Beyond. Annu. Rev. Biochem. 85, 265\u2013290 (2016).","journal-title":"Annu. Rev. Biochem."},{"key":"227_CR23","first-page":"506","volume":"41","author":"HY Shin","year":"2018","unstructured":"Shin, H. Y. Targeting super-enhancers for disease treatment and diagnosis. Mol. Cells 41, 506\u2013514 (2018).","journal-title":"Mol. Cells"},{"key":"227_CR24","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3390\/genes6041183","volume":"6","author":"AR Niederriter","year":"2015","unstructured":"Niederriter, A. R., Varshney, A., Parker, S. C. & Martin, D. M. Super enhancers in cancers, complex disease, and developmental disorders. Genes (Basel) 6, 1183\u20131200 (2015).","journal-title":"Genes (Basel)"},{"key":"227_CR25","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1083\/jcb.201006173","volume":"191","author":"HC Chapin","year":"2010","unstructured":"Chapin, H. C. & Caplan, M. J. The cell biology of polycystic kidney disease. J. Cell Biol. 191, 701\u2013710 (2010).","journal-title":"J. Cell Biol."},{"key":"227_CR26","doi-asserted-by":"publisher","first-page":"109495","DOI":"10.1016\/j.cellsig.2019.109495","volume":"67","author":"C Podrini","year":"2019","unstructured":"Podrini, C., Cassina, L. & Boletta, A. Metabolic reprogramming and the role of mitochondria in polycystic kidney disease. Cell. Signal. 67, 109495 (2019).","journal-title":"Cell. Signal."},{"key":"227_CR27","doi-asserted-by":"publisher","first-page":"8699","DOI":"10.1016\/S0021-9258(19)68900-3","volume":"256","author":"E Bustamante","year":"1981","unstructured":"Bustamante, E., Morris, H. P. & Pedersen, P. L. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J. Biol. Chem. 256, 8699\u20138704 (1981).","journal-title":"J. Biol. Chem."},{"key":"227_CR28","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1074\/jbc.274.1.471","volume":"274","author":"HP Cho","year":"1999","unstructured":"Cho, H. P., Nakamura, M. T. & Clarke, S. D. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J. Biol. Chem. 274, 471\u2013477 (1999).","journal-title":"J. Biol. Chem."},{"key":"227_CR29","doi-asserted-by":"publisher","first-page":"14493","DOI":"10.1074\/jbc.M808952200","volume":"284","author":"H Kaur","year":"2009","unstructured":"Kaur, H., Kumar, C., Junot, C., Toledano, M. B. & Bachhawat, A. K. Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases. J. Biol. Chem. 284, 14493\u201314502 (2009).","journal-title":"J. Biol. Chem."},{"key":"227_CR30","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.chembiol.2019.09.009","volume":"26","author":"JT Kim","year":"2019","unstructured":"Kim, J. T., Li, V. L., Terrell, S. M., Fischer, C. R. & Long, J. Z. Family-wide annotation of enzymatic pathways by parallel in vivo metabolomics. Cell Chem. Biol. 26, 1623\u20131629 (2019). e1623.","journal-title":"Cell Chem. Biol."},{"key":"227_CR31","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1021\/bi3014104","volume":"52","author":"S Ahmad","year":"2013","unstructured":"Ahmad, S. et al. Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. Biochemistry 52, 1755\u20131764 (2013).","journal-title":"Biochemistry"},{"key":"227_CR32","doi-asserted-by":"publisher","first-page":"11482","DOI":"10.1016\/S0021-9258(19)38422-4","volume":"265","author":"T Morisaki","year":"1990","unstructured":"Morisaki, T., Sabina, R. L. & Holmes, E. W. Adenylate deaminase. A multigene family in humans and rats. J. Biol. Chem. 265, 11482\u201311486 (1990).","journal-title":"J. Biol. Chem."},{"key":"227_CR33","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1046\/j.1471-4159.2001.00016.x","volume":"76","author":"SL Patterson","year":"2001","unstructured":"Patterson, S. L., Sluka, K. A. & Arnold, M. A. A novel transverse push-pull microprobe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn. J. Neurochem. 76, 234\u2013246 (2001).","journal-title":"J. Neurochem."},{"key":"227_CR34","doi-asserted-by":"publisher","first-page":"20866","DOI":"10.1016\/S0021-9258(19)36768-7","volume":"267","author":"DK Mahnke-Zizelman","year":"1992","unstructured":"Mahnke-Zizelman, D. K. & Sabina, R.L. Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5\u2032-exons. J. Biol. Chem. 267, 20866\u201320877 (1992).","journal-title":"J. Biol. Chem."},{"key":"227_CR35","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","volume":"18","author":"X Song","year":"2009","unstructured":"Song, X. et al. Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks. Hum. Mol. Genet. 18, 2328\u20132343 (2009).","journal-title":"Hum. Mol. Genet."},{"key":"227_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","volume":"19","author":"S Herzig","year":"2018","unstructured":"Herzig, S. & Shaw, R. J. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat. Rev. Mol. Cell Biol. 19, 121\u2013135 (2018).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"227_CR37","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1172\/JCI80467","volume":"125","author":"L Chen","year":"2015","unstructured":"Chen, L. et al. Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J. Clin. Invest. 125, 2399\u20132412 (2015).","journal-title":"J. Clin. Invest."},{"key":"227_CR38","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/ki.1993.17","volume":"43","author":"JP Calvet","year":"1993","unstructured":"Calvet, J. P. Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation? Kidney Int. 43, 101\u2013108 (1993).","journal-title":"Kidney Int."},{"key":"227_CR39","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","volume":"155","author":"D Hnisz","year":"2013","unstructured":"Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934\u2013947 (2013).","journal-title":"Cell"},{"key":"227_CR40","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1101\/gr.197590.115","volume":"26","author":"V Saint-Andre","year":"2016","unstructured":"Saint-Andre, V. et al. Models of human core transcriptional regulatory circuitries. Genome Res. 26, 385\u2013396 (2016).","journal-title":"Genome Res."},{"key":"227_CR41","first-page":"11481","volume":"47","author":"X Wang","year":"2019","unstructured":"Wang, X., Cairns, M. J. & Yan, J. Super-enhancers in transcriptional regulation and genome organization. Nucleic Acids Res. 47, 11481\u201311496 (2019).","journal-title":"Nucleic Acids Res."},{"key":"227_CR42","doi-asserted-by":"publisher","first-page":"eaaw3593","DOI":"10.1126\/sciadv.aaw3593","volume":"5","author":"Y Sun","year":"2019","unstructured":"Sun, Y. et al. Activation of P-TEFb by cAMP\u2013PKA signaling in autosomal dominant polycystic kidney disease. Sci. Adv. 5, eaaw3593 (2019).","journal-title":"Sci. Adv."},{"key":"227_CR43","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.cell.2009.07.031","volume":"138","author":"A Zippo","year":"2009","unstructured":"Zippo, A. et al. Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell 138, 1122\u20131136 (2009).","journal-title":"Cell"},{"key":"227_CR44","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/nsmb.2912","volume":"21","author":"T Kanno","year":"2014","unstructured":"Kanno, T. et al. BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Nat. Struct. Mol. Biol. 21, 1047\u20131057 (2014).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"227_CR45","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1093\/hmg\/ddv136","volume":"24","author":"X Zhou","year":"2015","unstructured":"Zhou, X. et al. Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. Hum. Mol. Genet. 24, 3982\u20133993 (2015).","journal-title":"Hum. Mol. Genet."},{"key":"227_CR46","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/nrneph.2015.46","volume":"11","author":"T Seeger-Nukpezah","year":"2015","unstructured":"Seeger-Nukpezah, T., Geynisman, D. M., Nikonova, A. S., Benzing, T. & Golemis, E. A. The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat. Rev. Nephrol. 11, 515\u2013534 (2015).","journal-title":"Nat. Rev. Nephrol."},{"key":"227_CR47","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1111\/bph.14558","volume":"176","author":"X Lian","year":"2019","unstructured":"Lian, X. et al. The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease. Br. J. Pharmacol. 176, 711\u2013724 (2019).","journal-title":"Br. J. Pharmacol."},{"key":"227_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14395","volume":"8","author":"S Hajarnis","year":"2017","unstructured":"Hajarnis, S. et al. microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism. Nat. Commun. 8, 14395 (2017).","journal-title":"Nat. Commun."},{"key":"227_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11918-y","volume":"10","author":"EC Lee","year":"2019","unstructured":"Lee, E. C. et al. Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease. Nat. Commun. 10, 4148 (2019).","journal-title":"Nat. Commun."},{"key":"227_CR50","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1073\/pnas.1011498108","volume":"108","author":"V Takiar","year":"2011","unstructured":"Takiar, V. et al. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc. Natl Acad. Sci. USA 108, 2462\u20132467 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"227_CR51","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ebiom.2019.08.041","volume":"47","author":"WN Leonhard","year":"2019","unstructured":"Leonhard, W. N. et al. Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease. EBioMedicine 47, 436\u2013445 (2019).","journal-title":"EBioMedicine"},{"key":"227_CR52","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1159\/000488807","volume":"47","author":"SL Seliger","year":"2018","unstructured":"Seliger, S. L. et al. A randomized clinical trial of metformin to treat autosomal dominant polycystic kidney disease. Am. J. Nephrol. 47, 352\u2013360 (2018).","journal-title":"Am. J. Nephrol."},{"key":"227_CR53","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12882-018-1090-3","volume":"19","author":"A Pisani","year":"2018","unstructured":"Pisani, A., Riccio, E., Bruzzese, D. & Sabbatini, M. Metformin in autosomal dominant polycystic kidney disease: experimental hypothesis or clinical fact? BMC Nephrol. 19, 282 (2018).","journal-title":"BMC Nephrol."},{"key":"227_CR54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1001\/jamaoncol.2015.4134","volume":"2","author":"A Sarvaria","year":"2016","unstructured":"Sarvaria, A., Topp, Z. & Saven, A. Current therapy and new directions in the treatment of hairy cell leukemia: a review. JAMA Oncol. 2, 123\u2013129 (2016).","journal-title":"JAMA Oncol."},{"key":"227_CR55","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/00313020123290","volume":"33","author":"AA Thike","year":"2001","unstructured":"Thike, A. A., Chng, M. J., Fook-Chong, S. & Tan, P. H. Immunohistochemical expression of hormone receptors in invasive breast carcinoma: correlation of results of H-score with pathological parameters. Pathology 33, 21\u201325 (2001).","journal-title":"Pathology"},{"key":"227_CR56","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1093\/hmg\/ddn039","volume":"17","author":"S Shibazaki","year":"2008","unstructured":"Shibazaki, S. et al. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum. Mol. Genet. 17, 1505\u20131516 (2008).","journal-title":"Hum. Mol. Genet."},{"key":"227_CR57","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1681\/ASN.2018010074","volume":"29","author":"Y Yang","year":"2018","unstructured":"Yang, Y. et al. Interactions between macrophages and cyst-lining epithelial cells promote kidney cyst growth in Pkd1-deficient mice. J. Am. Soc. Nephrol. 29, 2310\u20132325 (2018).","journal-title":"J. Am. Soc. Nephrol."},{"key":"227_CR58","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1089\/thy.2018.0550","volume":"29","author":"X Cao","year":"2019","unstructured":"Cao, X. et al. Targeting super-enhancer-driven oncogenic transcription by CDK7 inhibition in anaplastic thyroid carcinoma. Thyroid 29, 809\u2013823 (2019).","journal-title":"Thyroid"}],"container-title":["Nature Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42255-020-0227-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42255-020-0227-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42255-020-0227-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T04:12:46Z","timestamp":1670386366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42255-020-0227-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["227"],"URL":"https:\/\/doi.org\/10.1038\/s42255-020-0227-4","relation":{},"ISSN":["2522-5812"],"issn-type":[{"value":"2522-5812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]},"assertion":[{"value":"21 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}