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A.L., A.-C.A., G.P., C. Dix, M.C. and D.L. are AstraZeneca employees. Y.W., S.K., M.P. and R.G.L. are Ionis Pharmaceuticals employees. S.R. has served as a consultant for AstraZeneca, Celgene, Sanofi, Amgen, Akcea Therapeutics, Camp4, Medacorp and Pfizer in the last 5 years. S.R. has received research grants from AstraZeneca, Sanofi and Amgen. L.V. reports having received speaking fees from MSD, Gilead, AlfaSigma, and AbbVie, having served as a consultant for Gilead, Pfizer, Astra Zeneca, Novo Nordisk, and having received research grants from Gilead. PKL was supported by the Novo Nordisk, Sigrid Jus\u00e9lius and Instrumentarium Science Foundations. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}