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B.H. has an advisory role at ABX, AAA\/Novartis, Astellas, AstraZeneca, Bayer, BMS, Janssen R&D, Lightpoint Medical and Pfizer; receives research funding from Astellas, BMS, AAA\/Novartis, German Research Foundation, Janssen R&D and Pfizer; and receives travel funding from Astellas, AstraZeneca, Bayer and Janssen. D.S. receives personal fees for advisory boards of BMS, Immunocore, MSD, Neracare, Novartis, Pfizer, Philogen, Pierre Fabre, Sanofi and Regeneron; personal fees as an invited speaker from BMS, Merck Serono, MSD, Novartis, Roche and Sanofi; personal fees (financial interest) for steering committee membership from BMS and MSD; personal support (no financial interest) for steering committee membership from Novartis; institutional support as a coordinating principal investigator (no financial interest) from BMS, MSD, Novartis and Pierre Fabre; institutional support as a local principal investigator (no financial interest) from Philogen and Sanofi; institutional research grant support (financial interest) from BMS and MSD; and is an EORTC-MG Member of the Board of Directors (no financial interest). J.T.S. receives honoraria as consultant or for continuing medical education presentations from AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Immunocore, MSD Sharp Dohme, Novartis, Roche\/Genentech and Servier; his institution receives research funding from Abalos Therapeutics, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eisbach Bio and Roche\/Genentech; and he holds ownership and serves on the Board of Directors of Pharma15, all outside the submitted work. M.T. receives speaker fees and personal support from AstraZeneca, Daiichi Sankyo, Novartis, Bayer, Asklepios and Edwards LifeSciences. M.W. receives honoraria and has an advisory role: Amgen, AstraZeneca, Daiichi Sankyo, GlaxoSmithKline, Janssen, Novartis, Pfizer, Roche, Takeda. Research funding: Bristol-Myers Squibb, Takeda. M.S. is a consultant (compensated) for Amgen, AstraZeneca, Blueprint Medicines, Boehringer Ingelheim, Bristol-Myers Squibb, GlaxoSmithKline, Janssen, Merck Serono, Novartis, Roche, Sanofi and Takeda; receives honoraria for CME presentations from Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Janssen, MSD, Novartis, Roche and Sanofi; and receives research funding (institutional) from AstraZeneca and Bristol-Myers Squibb. K.-R.M., F.K. and G.M. hold patents related to this work (9558550; 20180018553) and are co-founders of the computational pathology start-up Aignostics, Berlin. The remaining authors declare no competing interests related to this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}