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WO2013177426-A2). A.J.S. reports being named as an inventor on a patent application not relevant to this work. J.D.L reports being named as a coinventor on pending and issued patents held by the Cleveland Clinic relating to cancer therapies, which are not directly relevant to this work. D.R.W. has consulted for Agios Pharmaceuticals, Admare Pharmaceuticals, Bruker and Innocrin Pharmaceuticals. D.R.W. is listed as an inventor on patents pertaining to the treatment of brain tumors (US provisional patent applications 63\/416,146, 62\/744,342 and 62\/724,337). The other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}