{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:54:25Z","timestamp":1792295665468,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG053991"],"award-info":[{"award-number":["AG053991"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Aging"],"DOI":"10.1038\/s43587-022-00181-4","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T17:03:48Z","timestamp":1646672628000},"page":"214-223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries"],"prefix":"10.1038","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-5041","authenticated-orcid":false,"given":"Xinan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Koundal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-3399","authenticated-orcid":false,"given":"Rena","family":"Elkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-5145","authenticated-orcid":false,"given":"Brittany","family":"Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysam","family":"Pedram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-517X","authenticated-orcid":false,"given":"Jonathan","family":"Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-5256","authenticated-orcid":false,"given":"Allen","family":"Tannenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Van Nostrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-6667","authenticated-orcid":false,"given":"Helene","family":"Benveniste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"181_CR1","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1212\/WNL.58.11.1629","volume":"58","author":"LA Pfeifer","year":"2002","unstructured":"Pfeifer, L. A., White, L. R., Ross, G. W., Petrovitch, H. & Launer, L. J. Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 58, 1629\u20131634 (2002).","journal-title":"Neurology"},{"key":"181_CR2","doi-asserted-by":"publisher","first-page":"e1000180","DOI":"10.1371\/journal.pmed.1000180","volume":"6","author":"FE Matthews","year":"2009","unstructured":"Matthews, F. E. et al. Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med. 6, e1000180 (2009).","journal-title":"PLoS Med."},{"key":"181_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1161\/STROKEAHA.117.019409","volume":"49","author":"G Banerjee","year":"2018","unstructured":"Banerjee, G. et al. Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy. Stroke 49, 40\u201345 (2018).","journal-title":"Stroke"},{"key":"181_CR4","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/jnen\/61.3.282","volume":"61","author":"DR Thal","year":"2002","unstructured":"Thal, D. R. et al. Two types of sporadic cerebral amyloid angiopathy. J. Neuropathol. Exp. Neurol. 61, 282\u2013293 (2002).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"181_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1365-2990.2010.01137.x","volume":"37","author":"J Attems","year":"2011","unstructured":"Attems, J., Jellinger, K., Thal, D. R. & Van Nostrand, W. Review: sporadic cerebral amyloid angiopathy. Neuropathol. Appl. Neurobiol. 37, 75\u201393 (2011).","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"181_CR6","first-page":"844","volume":"11070","author":"R Elkin","year":"2018","unstructured":"Elkin, R. et al. GlymphVIS: visualizing glymphatic transport pathways using regularized optimal transport. Med. Image Comput. Comput. Assist. Inter. 11070, 844\u2013852 (2018).","journal-title":"Med. Image Comput. Comput. Assist. Inter."},{"key":"181_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59045-9","volume":"10","author":"S Koundal","year":"2020","unstructured":"Koundal, S. et al. Optimal mass transport with Lagrangian workflow reveals advective and diffusion driven solute transport in the lymphatic system. Sci. Rep. 10, 1990 (2020).","journal-title":"Sci. Rep."},{"key":"181_CR8","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","volume":"184","author":"J Rustenhoven","year":"2021","unstructured":"Rustenhoven, J. et al. Functional characterization of the dural sinuses as a neuroimmune interface. Cell 184, 1000\u20131016 (2021).","journal-title":"Cell"},{"key":"181_CR9","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1146\/annurev-immunol-102319-103410","volume":"38","author":"K Alves de Lima","year":"2020","unstructured":"Alves de Lima, K., Rustenhoven, J. & Kipnis, J. Meningeal immunity and its function in maintenance of the central nervous system in health and disease. Annu. Rev. Immunol. 38, 597\u2013620 (2020).","journal-title":"Annu. Rev. Immunol."},{"key":"181_CR10","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ana.24271","volume":"76","author":"BT Kress","year":"2014","unstructured":"Kress, B. T. et al. Impairment of paravascular clearance pathways in the aging brain. Ann. Neurol. 76, 845\u2013861 (2014).","journal-title":"Ann. Neurol."},{"key":"181_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01484-6","volume":"8","author":"Q Ma","year":"2017","unstructured":"Ma, Q., Ineichen, B. V., Detmar, M. & Proulx, S. T. Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice. Nat. Commun. 8, 1434 (2017).","journal-title":"Nat. Commun."},{"key":"181_CR12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","volume":"560","author":"S Da Mesquita","year":"2018","unstructured":"Da Mesquita, S. et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer\u2019s disease. Nature 560, 185\u2013191 (2018).","journal-title":"Nature"},{"key":"181_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.nbd.2016.05.015","volume":"93","author":"W Peng","year":"2016","unstructured":"Peng, W. et al. Suppression of glymphatic fluid transport in a mouse model of Alzheimer\u2019s disease. Neurobiol. Dis. 93, 215\u2013225 (2016).","journal-title":"Neurobiol. Dis."},{"key":"181_CR14","doi-asserted-by":"crossref","unstructured":"Ding, X. B. et al. Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson\u2019s disease. Nat. Med. 27, 411\u2013418 (2021).","DOI":"10.1038\/s41591-020-01198-1"},{"key":"181_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","volume":"7","author":"A Biffi","year":"2011","unstructured":"Biffi, A. & Greenberg, S. M. Cerebral amyloid angiopathy: a systematic review. J. Clin. Neurol. 7, 1\u20139 (2011).","journal-title":"J. Clin. Neurol."},{"key":"181_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/WCO.0000000000000510","volume":"31","author":"MJH Wermer","year":"2018","unstructured":"Wermer, M. J. H. & Greenberg, S. M. The growing clinical spectrum of cerebral amyloid angiopathy. Curr. Opin. Neurol. 31, 28\u201335 (2018).","journal-title":"Curr. Opin. Neurol."},{"key":"181_CR17","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1212\/WNL.51.3.690","volume":"51","author":"SM Greenberg","year":"1998","unstructured":"Greenberg, S. M. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology 51, 690\u2013694 (1998).","journal-title":"Neurology"},{"key":"181_CR18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00401-018-1862-7","volume":"136","author":"NJ Albargothy","year":"2018","unstructured":"Albargothy, N. J. et al. Convective influx\/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways. Acta Neuropathol. 136, 139\u2013152 (2018).","journal-title":"Acta Neuropathol."},{"key":"181_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1365-2990.2007.00926.x","volume":"34","author":"RO Carare","year":"2008","unstructured":"Carare, R. O. et al. Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol. Appl. Neurobiol. 34, 131\u2013144 (2008).","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"181_CR20","doi-asserted-by":"crossref","unstructured":"Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci. Transl. Med. 4, 147ra111 (2012).","DOI":"10.1126\/scitranslmed.3003748"},{"key":"181_CR21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/scientificamerican0316-44","volume":"314","author":"M Nedergaard","year":"2016","unstructured":"Nedergaard, M. & Goldman, S. A. Brain drain. Sci. Am. 314, 44\u201349 (2016).","journal-title":"Sci. Am."},{"key":"181_CR22","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1016\/j.ajpath.2018.07.030","volume":"188","author":"J Davis","year":"2018","unstructured":"Davis, J. et al. A novel transgenic rat model of robust cerebral microvascular amyloid with prominent vasculopathy. Am. J. Pathol. 188, 2877\u20132889 (2018).","journal-title":"Am. J. Pathol."},{"key":"181_CR23","doi-asserted-by":"crossref","unstructured":"Lee, H. et al. Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy. J. Cereb. Blood Flow Metab. 41, 1103\u20131118 (2020).","DOI":"10.1177\/0271678X20944226"},{"key":"181_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01755-y","volume":"17","author":"X Zhu","year":"2020","unstructured":"Zhu, X., Hatfield, J., Sullivan, J. K., Xu, F. & Van Nostrand, W. E. Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy. J. Neuroinflammation 17, 78 (2020).","journal-title":"J. Neuroinflammation"},{"key":"181_CR25","doi-asserted-by":"publisher","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","volume":"33","author":"JJ Iliff","year":"2013","unstructured":"Iliff, J. J. et al. Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J. Neurosci. 33, 18190\u201318199 (2013).","journal-title":"J. Neurosci."},{"key":"181_CR26","first-page":"431","volume":"52","author":"ML Rennels","year":"1990","unstructured":"Rennels, M. L., Blaumanis, O. R. & Grady, P. A. Rapid solute transport throughout the brain via paravascular fluid pathways. Adv. Neurol. 52, 431\u2013439 (1990).","journal-title":"Adv. Neurol."},{"key":"181_CR27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1001\/jamaneurol.2016.4370","volume":"74","author":"DM Zeppenfeld","year":"2017","unstructured":"Zeppenfeld, D. M. et al. Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains. JAMA Neurol. 74, 91\u201399 (2017).","journal-title":"JAMA Neurol."},{"key":"181_CR28","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI67677","volume":"123","author":"JJ Iliff","year":"2013","unstructured":"Iliff, J. J. et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J. Clin. Invest. 123, 1299\u20131309 (2013).","journal-title":"J. Clin. Invest."},{"key":"181_CR29","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1212\/WNL.0000000000002175","volume":"85","author":"PA Boyle","year":"2015","unstructured":"Boyle, P. A. et al. Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology 85, 1930\u20131936 (2015).","journal-title":"Neurology"},{"key":"181_CR30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/bpa.12221","volume":"25","author":"M Esiri","year":"2015","unstructured":"Esiri, M. et al. Cerebral amyloid angiopathy, subcortical white matter disease and dementia: literature review and study in OPTIMA. Brain Pathol. 25, 51\u201362 (2015).","journal-title":"Brain Pathol."},{"key":"181_CR31","doi-asserted-by":"publisher","first-page":"e1248","DOI":"10.1212\/WNL.0000000000005259","volume":"90","author":"TM Hughes","year":"2018","unstructured":"Hughes, T. M. et al. Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study. Neurology 90, e1248\u2013e1256 (2018).","journal-title":"Neurology"},{"key":"181_CR32","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1161\/STROKEAHA.118.020163","volume":"49","author":"I Riba-Llena","year":"2018","unstructured":"Riba-Llena, I. et al. Arterial stiffness is associated with basal ganglia enlarged perivascular spaces and cerebral small vessel disease load. Stroke 49, 1279\u20131281 (2018).","journal-title":"Stroke"},{"key":"181_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.conb.2021.07.006","volume":"72","author":"H Benveniste","year":"2021","unstructured":"Benveniste, H. & Nedergaard, M. Cerebral small vessel disease: a glymphopathy? Curr. Opin. Neurobiol. 72, 15\u201321 (2021).","journal-title":"Curr. Opin. Neurobiol."},{"key":"181_CR34","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","volume":"43","author":"R Deane","year":"2004","unstructured":"Deane, R. et al. LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43, 333\u2013344 (2004).","journal-title":"Neuron"},{"key":"181_CR35","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"JM Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway, J. M. et al. Clearance systems in the brain-implications for Alzheimer disease. Nat. Rev. Neurol. 11, 457\u2013470 (2015).","journal-title":"Nat. Rev. Neurol."},{"key":"181_CR36","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1097\/ALN.0000000000001888","volume":"127","author":"H Benveniste","year":"2017","unstructured":"Benveniste, H. et al. Anesthesia with dexmedetomidine and low-dose isoflurane increases solute transport via the glymphatic pathway in rat brain when compared with high-dose isoflurane. Anesthesiology 127, 976\u2013988 (2017).","journal-title":"Anesthesiology"},{"key":"181_CR37","doi-asserted-by":"publisher","first-page":"eaav5447","DOI":"10.1126\/sciadv.aav5447","volume":"5","author":"LM Hablitz","year":"2019","unstructured":"Hablitz, L. M. et al. Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia. Sci. Adv. 5, eaav5447 (2019).","journal-title":"Sci. Adv."},{"key":"181_CR38","doi-asserted-by":"publisher","first-page":"11034","DOI":"10.1523\/JNEUROSCI.1625-15.2015","volume":"35","author":"H Lee","year":"2015","unstructured":"Lee, H. et al. The effect of body posture on brain glymphatic transport. J. Neurosci. 35, 11034\u201311044 (2015).","journal-title":"J. Neurosci."},{"key":"181_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18115-2","volume":"11","author":"LM Hablitz","year":"2020","unstructured":"Hablitz, L. M. et al. Circadian control of brain glymphatic and lymphatic fluid flow. Nat. Commun. 11, 4411 (2020).","journal-title":"Nat. Commun."},{"key":"181_CR40","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/glia.23923","volume":"69","author":"MX Wang","year":"2021","unstructured":"Wang, M. X., Ray, L., Tanaka, K. F., Iliff, J. J. & Heys, J. Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular-interstitial flux through the cortical mantle. Glia 69, 715\u2013728 (2021).","journal-title":"Glia"},{"key":"181_CR41","first-page":"F835","volume":"246","author":"I Szentistvanyi","year":"1984","unstructured":"Szentistvanyi, I., Patlak, C. S., Ellis, R. A. & Cserr, H. F. Drainage of interstitial fluid from different regions of rat brain. Am. J. Physiol. 246, F835\u2013F844 (1984).","journal-title":"Am. J. Physiol."},{"key":"181_CR42","doi-asserted-by":"crossref","unstructured":"Yeo, K. P. et al. Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe. Sci. Adv. 6, eabc2697 (2020).","DOI":"10.1126\/sciadv.abc2697"},{"key":"181_CR43","doi-asserted-by":"crossref","unstructured":"Yagmurlu, K. et al. Anatomical features of the deep cervical lymphatic system and intrajugular lymphatic vessels in humans. Brain Sci. 10, 953 (2020).","DOI":"10.3390\/brainsci10120953"},{"key":"181_CR44","first-page":"861","volume":"31","author":"MJ Kim","year":"2017","unstructured":"Kim, M. J. et al. Comparing the organs and vasculature of the head and neck in five murine species. Vivo 31, 861\u2013871 (2017).","journal-title":"Vivo"},{"key":"181_CR45","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0940-9602(11)80371-7","volume":"177","author":"K Szabo","year":"1995","unstructured":"Szabo, K. The cranial venous system in the rat: anatomical pattern and ontogenetic development. II. Dorsal drainage. Ann. Anat. 177, 313\u2013322 (1995).","journal-title":"Ann. Anat."},{"key":"181_CR46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","volume":"18","author":"RO Weller","year":"2008","unstructured":"Weller, R. O., Subash, M., Preston, S. D., Mazanti, I. & Carare, R. O. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease. Brain Pathol. 18, 253\u2013266 (2008).","journal-title":"Brain Pathol."},{"key":"181_CR47","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.20142290","volume":"212","author":"A Aspelund","year":"2015","unstructured":"Aspelund, A. et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J. Exp. Med. 212, 991\u2013999 (2015).","journal-title":"J. Exp. Med."},{"key":"181_CR48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","volume":"523","author":"A Louveau","year":"2015","unstructured":"Louveau, A. et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337\u2013341 (2015).","journal-title":"Nature"},{"key":"181_CR49","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1084\/jem.20170391","volume":"214","author":"S Antila","year":"2017","unstructured":"Antila, S. et al. Development and plasticity of meningeal lymphatic vessels. J. Exp. Med. 214, 3645\u20133667 (2017).","journal-title":"J. Exp. Med."},{"key":"181_CR50","doi-asserted-by":"crossref","unstructured":"Benveniste, H. et al. Glymphatic cerebrospinal fluid and solute transport quantified by MRI and PET imaging. Neuroscience 474, 63\u201379 (2021).","DOI":"10.1016\/j.neuroscience.2020.11.014"},{"key":"181_CR51","first-page":"162","volume":"81","author":"L Bolinger","year":"1989","unstructured":"Bolinger, L., Prammer, M. G. & Leigh, J. S. A multiple-frequency coil with a highly uniform B1 field. J. Magn. Reson. 81, 162\u2013166 (1989).","journal-title":"J. Magn. Reson."},{"key":"181_CR52","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","volume":"29","author":"NJ Tustison","year":"2010","unstructured":"Tustison, N. J. et al. N4ITK: improved N3 bias correction. IEEE Trans. Med. Imaging 29, 1310\u20131320 (2010).","journal-title":"IEEE Trans. Med. Imaging"},{"key":"181_CR53","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuroscience.2019.01.030","volume":"404","author":"S Koundal","year":"2019","unstructured":"Koundal, S. et al. Brain morphometry and longitudinal relaxation time of spontaneously hypertensive rats (SHRs) in early and intermediate stages of hypertension investigated by 3D VFA-SPGR MRI. Neuroscience 404, 14\u201326 (2019).","journal-title":"Neuroscience"},{"key":"181_CR54","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.neuroimage.2014.04.001","volume":"97","author":"EA Papp","year":"2014","unstructured":"Papp, E. A., Leergaard, T. B., Calabrese, E., Johnson, G. A. & Bjaalie, J. G. Waxholm space atlas of the Sprague Dawley rat brain. Neuroimage 97, 374\u2013386 (2014).","journal-title":"Neuroimage"},{"key":"181_CR55","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1523\/JNEUROSCI.1974-18.2019","volume":"39","author":"KN Mortensen","year":"2019","unstructured":"Mortensen, K. N. et al. Impaired glymphatic transport in spontaneously hypertensive rats. J. Neurosci. 39, 6365\u20136377 (2019).","journal-title":"J. Neurosci."}],"updated-by":[{"DOI":"10.1038\/s43587-023-00544-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000}},{"DOI":"10.1038\/s43587-022-00223-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000}}],"container-title":["Nature Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43587-022-00181-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-022-00181-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-022-00181-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T08:03:40Z","timestamp":1700899420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43587-022-00181-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["181"],"URL":"https:\/\/doi.org\/10.1038\/s43587-022-00181-4","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s43587-023-00544-5","asserted-by":"object"},{"id-type":"doi","id":"10.1038\/s43587-022-00223-x","asserted-by":"object"}]},"ISSN":["2662-8465"],"issn-type":[{"value":"2662-8465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,7]]},"assertion":[{"value":"5 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s43587-022-00223-x","URL":"https:\/\/doi.org\/10.1038\/s43587-022-00223-x","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2023","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s43587-023-00544-5","URL":"https:\/\/doi.org\/10.1038\/s43587-023-00544-5","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"H.B. received research support from PureTech. J.K. is a member of the scientific advisory group for PureTech. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}