{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:10:25Z","timestamp":1744863025192,"version":"3.40.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA BC 011806"],"award-info":[{"award-number":["ZIA BC 011806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Aging"],"DOI":"10.1038\/s43587-025-00814-4","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:02:43Z","timestamp":1739959363000},"page":"534-535","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FGF21 keeps the thymus young"],"prefix":"10.1038","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-9174","authenticated-orcid":false,"given":"Yousuke","family":"Takahama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"814_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s42000-018-0026-4","volume":"17","author":"K Laios","year":"2018","unstructured":"Laios, K. Hormones (Athens) 17, 285\u2013286 (2018).","journal-title":"Hormones (Athens)"},{"key":"814_CR2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/nri2318","volume":"8","author":"J Nikolich-\u017dugich","year":"2008","unstructured":"Nikolich-\u017dugich, J. Nat. Rev. Immunol. 8, 512\u2013522 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"814_CR3","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41590-021-00927-z","volume":"22","author":"M Mittelbrunn","year":"2021","unstructured":"Mittelbrunn, M. & Kroemer, G. Nat. Immunol. 22, 687\u2013698 (2021).","journal-title":"Nat. Immunol."},{"key":"814_CR4","doi-asserted-by":"publisher","first-page":"101837","DOI":"10.1016\/j.smim.2023.101837","volume":"70","author":"YR Li","year":"2023","unstructured":"Li, Y. R. & Z\u00fa\u00f1iga-Pfl\u00fccker, J. C. Semin. Immunol. 70, 101837 (2023).","journal-title":"Semin. Immunol."},{"key":"814_CR5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3389\/fimmu.2020.00897","volume":"11","author":"JE Cowan","year":"2020","unstructured":"Cowan, J. E., Takahama, Y., Bhandoola, A. & Ohigashi, I. Front. Immunol. 11, 897 (2020).","journal-title":"Front. Immunol."},{"key":"814_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00813-5","author":"Y-H Youm","year":"2025","unstructured":"Youm, Y.-H. et al. Nat. Aging https:\/\/doi.org\/10.1038\/s43587-025-00813-5 (2025).","journal-title":"Nat. Aging"},{"key":"814_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00801-1","author":"SA Wedemeyer","year":"2025","unstructured":"Wedemeyer, S. A. et al. Nat. Aging https:\/\/doi.org\/10.1038\/s43587-024-00801-1 (2025).","journal-title":"Nat. Aging"},{"key":"814_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0167-4781(00)00067-1","volume":"1492","author":"T Nishimura","year":"2000","unstructured":"Nishimura, T., Nakatake, Y., Konishi, M. & Itoh, N. Biochim. Biophys. Acta 1492, 203\u2013206 (2000).","journal-title":"Biochim. Biophys. Acta"},{"key":"814_CR9","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI23606","volume":"115","author":"A Kharitonenkov","year":"2005","unstructured":"Kharitonenkov, A. et al. J. Clin. Invest. 115, 1627\u20131635 (2005).","journal-title":"J. Clin. Invest."},{"key":"814_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","volume":"78","author":"FM Fisher","year":"2016","unstructured":"Fisher, F. M. & Maratos-Flier, E. Annu. Rev. Physiol. 78, 223\u2013241 (2016).","journal-title":"Annu. Rev. Physiol."},{"key":"814_CR11","doi-asserted-by":"publisher","first-page":"e00065","DOI":"10.7554\/eLife.00065","volume":"1","author":"Y Zhang","year":"2012","unstructured":"Zhang, Y. et al. eLife 1, e00065 (2012).","journal-title":"eLife"},{"key":"814_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41580-021-00411-4","volume":"23","author":"CL Green","year":"2022","unstructured":"Green, C. L., Lamming, D. W. & Fontana, L. Nat. Rev. Mol. Cell Biol. 23, 56\u201373 (2022).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"814_CR13","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1073\/pnas.1514511113","volume":"113","author":"YH Youm","year":"2016","unstructured":"Youm, Y. H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A. & Dixit, V. D. Proc. Natl Acad. Sci. USA 113, 1026\u20131031 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"814_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11879-2","volume":"10","author":"T Venables","year":"2019","unstructured":"Venables, T. et al. Nat. Commun. 10, 4402 (2019).","journal-title":"Nat. Commun."},{"key":"814_CR15","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s43587-021-00082-y","volume":"1","author":"N Sayed","year":"2021","unstructured":"Sayed, N. et al. Nat. Aging 1, 598\u2013615 (2021).","journal-title":"Nat. Aging"}],"container-title":["Nature Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43587-025-00814-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-025-00814-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-025-00814-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:10:37Z","timestamp":1744809037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43587-025-00814-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["814"],"URL":"https:\/\/doi.org\/10.1038\/s43587-025-00814-4","relation":{},"ISSN":["2662-8465"],"issn-type":[{"type":"electronic","value":"2662-8465"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"assertion":[{"value":"19 February 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}