{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:48:06Z","timestamp":1792129686569,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG065943"],"award-info":[{"award-number":["R21AG065943"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["K01ag088232"],"award-info":[{"award-number":["K01ag088232"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"U.S. Department of Health & Human Services | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG028716"],"award-info":[{"award-number":["P30AG028716"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL007057"],"award-info":[{"award-number":["T32HL007057"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK124723"],"award-info":[{"award-number":["P30DK124723"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK124723"],"award-info":[{"award-number":["P30DK124723"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK132819"],"award-info":[{"award-number":["R01DK132819"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K08DE031029"],"award-info":[{"award-number":["K08DE031029"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["DK046092"],"award-info":[{"award-number":["DK046092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Aging"],"DOI":"10.1038\/s43587-026-01120-3","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:03:39Z","timestamp":1778749419000},"page":"1007-1020","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis"],"prefix":"10.1038","volume":"6","author":[{"given":"David E.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren K.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Bareja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaCheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demitrius A.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihuan","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-5864","authenticated-orcid":false,"given":"Guo-Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-691X","authenticated-orcid":false,"given":"Christopher B.","family":"Newgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-0806","authenticated-orcid":false,"given":"James P.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"1120_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0570-x","volume":"16","author":"BP Martinez","year":"2015","unstructured":"Martinez, B. P. et al. Frequency of sarcopenia and associated factors among hospitalized elderly patients. BMC Musculoskelet. Disord. 16, 108 (2015).","journal-title":"BMC Musculoskelet. Disord."},{"key":"1120_CR2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1532-5415.2004.52014.x","volume":"52","author":"I Janssen","year":"2004","unstructured":"Janssen, I., Shepard, D. S., Katzmarzyk, P. T. & Roubenoff, R. The healthcare costs of sarcopenia in the United States. J. Am. Geriatr. Soc. 52, 80\u201385 (2004).","journal-title":"J. Am. Geriatr. Soc."},{"key":"1120_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-020-00237-2","volume":"10","author":"E Masschelein","year":"2020","unstructured":"Masschelein, E. et al. Exercise promotes satellite cell contribution to myofibers in a load-dependent manner. Skelet. Muscle 10, 21 (2020).","journal-title":"Skelet. Muscle"},{"key":"1120_CR4","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.stem.2012.10.002","volume":"11","author":"CD Folmes","year":"2012","unstructured":"Folmes, C. D., Dzeja, P. P., Nelson, T. J. & Terzic, A. Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell 11, 596\u2013606 (2012).","journal-title":"Cell Stem Cell"},{"key":"1120_CR5","doi-asserted-by":"publisher","first-page":"jcs212977","DOI":"10.1242\/jcs.212977","volume":"131","author":"F Pala","year":"2018","unstructured":"Pala, F. et al. Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis. J. Cell Sci. 131, jcs212977 (2018).","journal-title":"J. Cell Sci."},{"key":"1120_CR6","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.15252\/embj.201488278","volume":"33","author":"AH Tang","year":"2014","unstructured":"Tang, A. H. & Rando, T. A. Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. EMBO J. 33, 2782\u20132797 (2014).","journal-title":"EMBO J."},{"key":"1120_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.stem.2014.12.004","volume":"16","author":"JG Ryall","year":"2015","unstructured":"Ryall, J. G. et al. The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. Cell Stem Cell 16, 171\u2013183 (2015).","journal-title":"Cell Stem Cell"},{"key":"1120_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.stemcr.2018.06.014","volume":"11","author":"JP White","year":"2018","unstructured":"White, J. P. et al. The AMPK\/p27Kip1 axis regulates autophagy\/apoptosis decisions in aged skeletal muscle stem cells. Stem Cell Rep. 11, 425\u2013439 (2018).","journal-title":"Stem Cell Rep."},{"key":"1120_CR9","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.15252\/embj.201695273","volume":"36","author":"M Theret","year":"2017","unstructured":"Theret, M. et al. AMPK\u03b11-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J.36, 1946\u20131962 (2017).","journal-title":"EMBO J."},{"key":"1120_CR10","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s12276-020-00504-8","volume":"52","author":"HC Yoo","year":"2020","unstructured":"Yoo, H. C., Yu, Y. C., Sung, Y. & Han, J. M. Glutamine reliance in cell metabolism. Exp. Mol. Med. 52, 1496\u20131516 (2020).","journal-title":"Exp. Mol. Med."},{"key":"1120_CR11","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.cmet.2019.01.016","volume":"29","author":"Y Yu","year":"2019","unstructured":"Yu, Y. et al. Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells. Cell Metab. 29, 966\u2013978 (2019).","journal-title":"Cell Metab."},{"key":"1120_CR12","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1016\/j.devcel.2024.07.015","volume":"59","author":"I Soro-Arn\u00e1iz","year":"2024","unstructured":"Soro-Arn\u00e1iz, I. et al. GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels. Dev. Cell 59, 2850\u20132865 (2024).","journal-title":"Dev. Cell"},{"key":"1120_CR13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nature10642","volume":"481","author":"AR Mullen","year":"2011","unstructured":"Mullen, A. R. et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481, 385\u2013388 (2011).","journal-title":"Nature"},{"key":"1120_CR14","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s13287-023-03506-1","volume":"14","author":"D Mademtzoglou","year":"2023","unstructured":"Mademtzoglou, D., Geara, P., Mourikis, P. & Relaix, F. Pax7 haploinsufficiency impairs muscle stem cell function in Cre-recombinase mice and underscores the importance of appropriate controls. Stem Cell Res. Ther. 14, 294 (2023).","journal-title":"Stem Cell Res. Ther."},{"key":"1120_CR15","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-024-07348-6","volume":"629","author":"Y Lai","year":"2024","unstructured":"Lai, Y. et al. Multimodal cell atlas of the ageing human skeletal muscle. Nature 629, 154\u2013164 (2024).","journal-title":"Nature"},{"key":"1120_CR16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.cmet.2020.11.020","volume":"33","author":"GF Zhang","year":"2021","unstructured":"Zhang, G. F. et al. Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion. Cell Metab. 33, 804\u2013817 (2021).","journal-title":"Cell Metab."},{"key":"1120_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","volume":"7","author":"TR Koves","year":"2008","unstructured":"Koves, T. R. et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7, 45\u201356 (2008).","journal-title":"Cell Metab."},{"key":"1120_CR18","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1194\/jlr.M043448","volume":"55","author":"SE Seiler","year":"2014","unstructured":"Seiler, S. E. et al. Obesity and lipid stress inhibit carnitine acetyltransferase activity. J. Lipid Res. 55, 635\u2013644 (2014).","journal-title":"J. Lipid Res."},{"key":"1120_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s42255-023-00955-z","volume":"6","author":"J Kang","year":"2024","unstructured":"Kang, J. et al. Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing. Nat Metab. 6, 153\u2013168 (2024).","journal-title":"Nat Metab."},{"key":"1120_CR20","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1101\/gad.351428.123","volume":"38","author":"V Ciuffoli","year":"2024","unstructured":"Ciuffoli, V. et al. Psat1-generated \u03b1-ketoglutarate and glutamine promote muscle stem cell activation and regeneration. Genes Dev. 38, 151\u2013167 (2024).","journal-title":"Genes Dev."},{"key":"1120_CR21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/genes9020108","volume":"9","author":"A Castegna","year":"2018","unstructured":"Castegna, A. & Menga, A. Glutamine synthetase: localization dictates outcome. Genes (Basel) 9, 108 (2018).","journal-title":"Genes (Basel)"},{"key":"1120_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/BF01076071","volume":"152","author":"AL Holleran","year":"1995","unstructured":"Holleran, A. L., Briscoe, D. A., Fiskum, G. & Kelleher, J. K. Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation. Mol. Cell. Biochem. 152, 95\u2013101 (1995).","journal-title":"Mol. Cell. Biochem."},{"key":"1120_CR23","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.stem.2021.01.017","volume":"28","author":"L Machado","year":"2021","unstructured":"Machado, L. et al. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell 28, 1125\u20131135 (2021).","journal-title":"Cell Stem Cell"},{"key":"1120_CR24","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1016\/j.celrep.2017.10.037","volume":"21","author":"CTJ van Velthoven","year":"2017","unstructured":"van Velthoven, C. T. J., de Morree, A., Egner, I. M., Brett, J. O. & Rando, T. A. Transcriptional profiling of quiescent muscle stem cells in vivo. Cell Rep. 21, 1994\u20132004 (2017).","journal-title":"Cell Rep."},{"key":"1120_CR25","doi-asserted-by":"publisher","first-page":"e49860","DOI":"10.1371\/journal.pone.0049860","volume":"7","author":"L Urbani","year":"2012","unstructured":"Urbani, L., Piccoli, M., Franzin, C., Pozzobon, M. & De Coppi, P. Hypoxia increases mouse satellite cell clone proliferation maintaining both in vitro and in vivo heterogeneity and myogenic potential. PLoS ONE 7, e49860 (2012).","journal-title":"PLoS ONE"},{"key":"1120_CR26","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1242\/dev.079665","volume":"139","author":"W Liu","year":"2012","unstructured":"Liu, W. et al. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Development 139, 2857\u20132865 (2012).","journal-title":"Development"},{"key":"1120_CR27","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1172\/JCI96208","volume":"128","author":"L Xie","year":"2018","unstructured":"Xie, L. et al. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J. Clin. Invest. 128, 2339\u20132355 (2018).","journal-title":"J. Clin. Invest."},{"key":"1120_CR28","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41586-020-2857-9","volume":"587","author":"M Shang","year":"2020","unstructured":"Shang, M. et al. Macrophage-derived glutamine boosts satellite cells and muscle regeneration. Nature 587, 626\u2013631 (2020).","journal-title":"Nature"},{"key":"1120_CR29","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1126\/science.1144090","volume":"317","author":"AS Brack","year":"2007","unstructured":"Brack, A. S. et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science317, 807\u2013810 (2007).","journal-title":"Science"},{"key":"1120_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36265-x","volume":"14","author":"F Lazure","year":"2023","unstructured":"Lazure, F. et al. Transcriptional reprogramming of skeletal muscle stem cells by the niche environment. Nat. Commun. 14, 535 (2023).","journal-title":"Nat. Commun."},{"key":"1120_CR31","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.stem.2012.04.002","volume":"10","author":"M Cerletti","year":"2012","unstructured":"Cerletti, M., Jang, Y. C., Finley, L. W., Haigis, M. C. & Wagers, A. J. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell 10, 515\u2013519 (2012).","journal-title":"Cell Stem Cell"},{"key":"1120_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108343","volume":"26","author":"A Kneppers","year":"2023","unstructured":"Kneppers, A. et al. AMPK\u03b12 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion. iScience 26, 108343 (2023).","journal-title":"iScience"},{"key":"1120_CR33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nature16187","volume":"529","author":"L Garc\u00eda-Prat","year":"2016","unstructured":"Garc\u00eda-Prat, L. et al. Autophagy maintains stemness by preventing senescence. Nature 529, 37\u201342 (2016).","journal-title":"Nature"},{"key":"1120_CR34","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/s41556-020-00593-7","volume":"22","author":"L Garc\u00eda-Prat","year":"2020","unstructured":"Garc\u00eda-Prat, L. et al. FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age. Nat. Cell Biol. 22, 1307\u20131318 (2020).","journal-title":"Nat. Cell Biol."},{"key":"1120_CR35","first-page":"921","volume":"40","author":"D Kim","year":"2007","unstructured":"Kim, D., Jitrapakdee, S. & Thompson, M. Differential regulation of the promoter activity of the mouse UCP2 and UCP3 genes by MyoD and myogenin. J. Biochem. Mol. Biol. 40, 921\u2013927 (2007).","journal-title":"J. Biochem. Mol. Biol."},{"key":"1120_CR36","doi-asserted-by":"publisher","first-page":"5362","DOI":"10.1074\/jbc.M807523200","volume":"284","author":"X Chen","year":"2009","unstructured":"Chen, X. et al. In vitro evidence suggests that miR-133a-mediated regulation of uncoupling protein 2 (UCP2) is an indispensable step in myogenic differentiation. J. Biol. Chem. 284, 5362\u20135369 (2009).","journal-title":"J. Biol. Chem."},{"key":"1120_CR37","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/s42003-021-02810-x","volume":"4","author":"DW McKellar","year":"2021","unstructured":"McKellar, D. W. et al. Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration. Commun. Biol. 4, 1280 (2021).","journal-title":"Commun. Biol."},{"key":"1120_CR38","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1038\/nprot.2015.110","volume":"10","author":"L Liu","year":"2015","unstructured":"Liu, L., Cheung, T. H., Charville, G. W. & Rando, T. A. Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting. Nat. Protoc. 10, 1612\u20131624 (2015).","journal-title":"Nat. Protoc."},{"key":"1120_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-1-4939-7283-8_5","volume":"1668","author":"CH Ly","year":"2017","unstructured":"Ly, C. H. & Ryall, J. G. Measuring mitochondrial substrate utilization in skeletal muscle stem cells. Methods Mol. Biol. 1668, 61\u201373 (2017).","journal-title":"Methods Mol. Biol."},{"key":"1120_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110267","volume":"38","author":"F Yue","year":"2022","unstructured":"Yue, F. et al. Lipid droplet dynamics regulate adult muscle stem cell fate. Cell Rep. 38, 110267 (2022).","journal-title":"Cell Rep."},{"key":"1120_CR41","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.cmet.2018.04.015","volume":"27","author":"PJ White","year":"2018","unstructured":"White, P. J. et al. The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase. Cell Metab. 27, 1281\u20131293 (2018).","journal-title":"Cell Metab."},{"key":"1120_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102401","volume":"298","author":"B Yenilmez","year":"2022","unstructured":"Yenilmez, B. et al. Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice. J. Biol. Chem. 298, 102401 (2022).","journal-title":"J. Biol. Chem."},{"key":"1120_CR43","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2337\/dc13-0989","volume":"37","author":"DM Scholtens","year":"2014","unstructured":"Scholtens, D. M. et al. Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care 37, 158\u2013166 (2014).","journal-title":"Diabetes Care"},{"key":"1120_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-017-1303-y","volume":"14","author":"TL Parry","year":"2018","unstructured":"Parry, T. L. et al. Untargeted metabolomics analysis of ischemia-reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats. Metabolomics 14, 8 (2018).","journal-title":"Metabolomics"},{"key":"1120_CR45","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s00125-020-05198-1","volume":"63","author":"Y Liu","year":"2020","unstructured":"Liu, Y. et al. Metabolomic and genetic associations with insulin resistance in pregnancy. Diabetologia 63, 1783\u20131795 (2020).","journal-title":"Diabetologia"},{"key":"1120_CR46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.celrep.2015.08.072","volume":"13","author":"JR Gooding","year":"2015","unstructured":"Gooding, J. R. et al. Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism. Cell Rep. 13, 157\u2013167 (2015).","journal-title":"Cell Rep."},{"key":"1120_CR47","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s42255-020-0184-y","volume":"2","author":"GS Baht","year":"2020","unstructured":"Baht, G. S. et al. Meteorin-like facilitates skeletal muscle repair through a Stat3\/IGF-1 mechanism. Nat. Metab. 2, 278\u2013289 (2020).","journal-title":"Nat. Metab."},{"key":"1120_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35390-3","volume":"13","author":"DE Lee","year":"2022","unstructured":"Lee, D. E. et al. Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro\/adipogenic progenitor signaling. Nat. Commun. 13, 7613 (2022).","journal-title":"Nat. Commun."},{"key":"1120_CR49","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.exger.2019.03.009","volume":"121","author":"DE Lee","year":"2019","unstructured":"Lee, D. E. et al. Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice. Exp. Gerontol. 121, 62\u201370 (2019).","journal-title":"Exp. Gerontol."},{"key":"1120_CR50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/apha.12687","volume":"218","author":"DE Lee","year":"2016","unstructured":"Lee, D. E. et al. Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet-induced obese mice. Acta Physiol. (Oxf.) 218, 167\u2013177 (2016).","journal-title":"Acta Physiol. (Oxf.)"}],"container-title":["Nature Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01120-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01120-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01120-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:02:57Z","timestamp":1779289377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01120-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["1120"],"URL":"https:\/\/doi.org\/10.1038\/s43587-026-01120-3","relation":{},"ISSN":["2662-8465"],"issn-type":[{"value":"2662-8465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"22 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"C.B.N. is a paid consultant for Eli Lilly, Axcella Health, Boehringer Ingelheim and Sigilon, which were not involved and have no competing interest in the research described in this paper. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}