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Here we show that cytotoxic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes accumulate in the bone marrow of mice during aging and induce myelopoiesis, increasing the neutrophil-to-lymphocyte ratio. T cell receptor-dependent induction of mitochondrial stress and activation of STING upregulates the chemokine CCL5 in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes. During aging, hematopoietic stem cells and downstream myeloid progenitors upregulate CCR5, the primary receptor for CCL5. Genetic ablation of\n                    <jats:italic>Ccr5<\/jats:italic>\n                    in hematopoietic progenitors mitigates T cell-induced myeloid skewing and neutrophil expansion. Pharmacological blockade of CCR5 using the Food and Drug Administration-approved drug maraviroc normalizes myelopoiesis, reduces circulating and tissue-infiltrating neutrophils, and improves multiple aging-related biomarkers and functional outcomes in aged mice. Together, these findings demonstrate a T cell\u2013bone marrow axis that exacerbates age-associated decline and highlight CCR5 inhibition as a potential geroprotective strategy.\n                  <\/jats:p>","DOI":"10.1038\/s43587-026-01209-9","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:02:47Z","timestamp":1787734967000},"page":"2110-2125","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5\u2013CCR5 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