{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:18:29Z","timestamp":1785928709150,"version":"3.56.0"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN159697"],"award-info":[{"award-number":["FRN159697"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN191807"],"award-info":[{"award-number":["FRN191807"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Mitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix in mitral valve leaflets. Large-scale genome-wide association study (GWAS) underlined that MVP is heritable. The molecular underpinnings of the disease remain largely unknown.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We interrogated cross-modality data totaling more than 500,000 subjects including GWAS, 4809 molecules of the blood proteome, and genome-wide expression of mitral valves to identify candidate drivers of MVP. Data were investigated through Mendelian randomization, network analysis, ligand-receptor inference and digital cell quantification.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In this study, Mendelian randomization identify that 33 blood proteins, enriched in networks for immunity, are associated with the risk of MVP. MVP- associated blood proteins are enriched in ligands for which their cognate receptors are differentially expressed in mitral valve leaflets during MVP and enriched in cardiac endothelial cells and macrophages. MVP-associated blood proteins are involved in the renewal-polarization of macrophages and regulation of adaptive immune response. Cytokine activity profiling and digital cell quantification show in MVP a shift toward cytokine signature promoting M2 macrophage polarization. Assessment of druggability identify CSF1R, CX3CR1, CCR6, IL33, MMP8, ENPEP and angiotensin receptors as actionable targets in MVP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Hence, integrative analysis identifies networks of candidate molecules and cells involved in immune control and remodeling of the extracellular matrix, which drive the risk of MVP.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s43856-024-00530-x","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:03:18Z","timestamp":1717675398000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse"],"prefix":"10.1038","volume":"4","author":[{"given":"Louis-Hippolyte","family":"Minvielle Moncla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-1436","authenticated-orcid":false,"given":"Mewen","family":"Briend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mame","family":"Sokhna Sylla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rufiange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-3711","authenticated-orcid":false,"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-2004","authenticated-orcid":false,"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"530_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nrcardio.2015.161","volume":"12","author":"RA Levine","year":"2015","unstructured":"Levine, R. A. et al. Mitral valve disease-morphology and mechanisms. Nat. Rev. Cardiol. 12, 689\u2013710 (2015).","journal-title":"Nat. Rev. Cardiol."},{"key":"530_CR2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.path.2012.03.001","volume":"5","author":"JP Veinot","year":"2012","unstructured":"Veinot, J. P. Native cardiac valve pathology. Surg. Pathol. Clin. 5, 327\u2013352 (2012).","journal-title":"Surg. Pathol. Clin."},{"key":"530_CR3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020919","volume":"10","author":"JE Morningstar","year":"2021","unstructured":"Morningstar, J. E. et al. Mitral valve prolapse and its motley crew-syndromic prevalence, pathophysiology, and progression of a common heart condition. J. Am. Heart Assoc. 10, e020919 (2021).","journal-title":"J. Am. Heart Assoc."},{"key":"530_CR4","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1093\/eurheartj\/ehx505","volume":"39","author":"T Le Tourneau","year":"2018","unstructured":"Le Tourneau, T. et al. New insights into mitral valve dystrophy: a Filamin-a genotype-phenotype and outcome study. Eur. Heart J. 39, 1269\u20131277 (2018).","journal-title":"Eur. Heart J."},{"key":"530_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature14670","volume":"525","author":"R Durst","year":"2015","unstructured":"Durst, R. et al. Mutations in DCHS1 cause mitral valve prolapse. Nature 525, 109\u2013113 (2015).","journal-title":"Nature"},{"key":"530_CR6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/mgg3.347","volume":"6","author":"A Clemenceau","year":"2018","unstructured":"Clemenceau, A. et al. Deleterious variants in DCHS1 are prevalent in sporadic cases of mitral valve prolapse. Mol. Genet Genom. Med. 6, 114\u2013120 (2018).","journal-title":"Mol. Genet Genom. Med."},{"key":"530_CR7","doi-asserted-by":"publisher","first-page":"eaax0290","DOI":"10.1126\/scitranslmed.aax0290","volume":"11","author":"KA Toomer","year":"2019","unstructured":"Toomer, K. A. et al. Primary cilia defects causing mitral valve prolapse. Sci. Transl. Med. 11, eaax0290 (2019).","journal-title":"Sci. Transl. Med."},{"key":"530_CR8","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/ng.3383","volume":"47","author":"C Dina","year":"2015","unstructured":"Dina, C. et al. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat. Genet. 47, 1206\u20131211 (2015).","journal-title":"Nat. Genet."},{"key":"530_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.gene.2016.07.033","volume":"591","author":"LY Sakai","year":"2016","unstructured":"Sakai, L. Y., Keene, D. R., Renard, M. & De Backer, J. FBN1: the disease-causing gene for Marfan syndrome and other genetic disorders. Gene 591, 279\u2013291 (2016).","journal-title":"Gene"},{"key":"530_CR10","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1172\/JCI23701","volume":"114","author":"AE Weyman","year":"2004","unstructured":"Weyman, A. E. & Scherrer-Crosbie, M. Marfan syndrome and mitral valve prolapse. J. Clin. Investig. 114, 1543\u20131546 (2004).","journal-title":"J. Clin. Investig."},{"key":"530_CR11","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1093\/eurheartj\/ehac049","volume":"43","author":"C Roselli","year":"2022","unstructured":"Roselli, C. et al. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur. Heart J. 43, 1668\u20131680 (2022).","journal-title":"Eur. Heart J."},{"key":"530_CR12","doi-asserted-by":"publisher","first-page":"S189","DOI":"10.1161\/CIRCULATIONAHA.111.082610","volume":"126","author":"A Geirsson","year":"2012","unstructured":"Geirsson, A. et al. Modulation of transforming growth factor-\u03b2 signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers. Circulation 126, S189\u2013S197 (2012).","journal-title":"Circulation"},{"key":"530_CR13","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1161\/CIRCGENETICS.114.000921","volume":"8","author":"NM Thalji","year":"2015","unstructured":"Thalji, N. M. et al. Nonbiased molecular screening identifies novel molecular regulators of fibrogenic and proliferative signaling in myxomatous mitral valve disease. Circ. Cardiovasc. Genet. 8, 516\u2013528 (2015).","journal-title":"Circ. Cardiovasc. Genet."},{"key":"530_CR14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1161\/ATVBAHA.117.310667","volume":"38","author":"A Hulin","year":"2018","unstructured":"Hulin, A. et al. Macrophage transitions in heart valve development and myxomatous valve disease. Arterioscler Thromb. Vasc. Biol. 38, 636\u2013644 (2018).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"530_CR15","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/cvr\/cvw229","volume":"113","author":"A Hulin","year":"2017","unstructured":"Hulin, A., Moore, V., James, J. M. & Yutzey, K. E. Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease. Cardiovasc. Res. 113, 40\u201351 (2017).","journal-title":"Cardiovasc. Res."},{"key":"530_CR16","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3389\/fimmu.2019.00941","volume":"10","author":"T Kolitz","year":"2019","unstructured":"Kolitz, T., Shiber, S., Sharabi, I., Winder, A. & Zandman-Goddard, G. Cardiac manifestations of antiphospholipid syndrome with focus on its primary form. Front. Immunol. 10, 941 (2019).","journal-title":"Front. Immunol."},{"key":"530_CR17","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.rdc.2006.05.008","volume":"32","author":"F Tenedios","year":"2006","unstructured":"Tenedios, F., Erkan, D. & Lockshin, M. D. Cardiac manifestations in the antiphospholipid syndrome. Rheum. Dis. Clin. North Am. 32, 491\u2013507 (2006).","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"530_CR18","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1177\/0961203308098598","volume":"18","author":"ME Evangelopoulos","year":"2009","unstructured":"Evangelopoulos, M. E. et al. Mitral valve prolapse in young healthy individuals. An early index of autoimmunity? Lupus 18, 436\u2013440 (2009).","journal-title":"Lupus"},{"key":"530_CR19","doi-asserted-by":"publisher","unstructured":"Delwarde, C. et al. Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model. Cardiovasc. Res. cvac136 https:\/\/doi.org\/10.1093\/cvr\/cvac136 (2022).","DOI":"10.1093\/cvr\/cvac136"},{"key":"530_CR20","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/j.1740-8261.2009.01559.x","volume":"50","author":"E Terzo","year":"2009","unstructured":"Terzo, E. et al. Echocardiographic assessment of 537 dogs with mitral valve prolapse and leaflet involvement. Vet. Radio. Ultrasound 50, 416\u2013422 (2009).","journal-title":"Vet. Radio. Ultrasound"},{"key":"530_CR21","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3390\/vetsci9070326","volume":"9","author":"D Piantedosi","year":"2022","unstructured":"Piantedosi, D. et al. Pro-inflammatory and immunological profile of dogs with myxomatous mitral valve disease. Vet. Sci. 9, 326 (2022).","journal-title":"Vet. Sci."},{"key":"530_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrg.2018.4","volume":"19","author":"KJ Karczewski","year":"2018","unstructured":"Karczewski, K. J. & Snyder, M. P. Integrative omics for health and disease. Nat. Rev. Genet. 19, 299\u2013310 (2018).","journal-title":"Nat. Rev. Genet."},{"key":"530_CR23","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.3389\/fimmu.2020.01683","volume":"11","author":"BK Dhillon","year":"2020","unstructured":"Dhillon, B. K., Smith, M., Baghela, A., Lee, A. H. Y. & Hancock, R. E. W. Systems biology approaches to understanding the human immune system. Front. Immunol. 11, 1683 (2020).","journal-title":"Front. Immunol."},{"key":"530_CR24","doi-asserted-by":"publisher","unstructured":"Jiang, P. et al. Big data in basic and translational cancer research. Nat. Rev. Cancer 1\u201315 https:\/\/doi.org\/10.1038\/s41568-022-00502-0 (2022).","DOI":"10.1038\/s41568-022-00502-0"},{"key":"530_CR25","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nbt.3870","volume":"35","author":"ND Price","year":"2017","unstructured":"Price, N. D. et al. A wellness study of 108 individuals using personal, dense, dynamic data clouds. Nat. Biotechnol. 35, 747\u2013756 (2017).","journal-title":"Nat. Biotechnol."},{"key":"530_CR26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.120.003196","volume":"14","author":"V Bon-Baret","year":"2021","unstructured":"Bon-Baret, V. et al. System genetics including causal inference identify immune targets for coronary artery disease and the lifespan. Circ. Genom. Precis. Med. 14, e003196 (2021).","journal-title":"Circ. Genom. Precis. Med."},{"key":"530_CR27","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1136\/jmedgenet-2021-107696","volume":"58","author":"L Wang","year":"2021","unstructured":"Wang, L. et al. Methodology in phenome-wide association studies: a systematic review. J. Med. Genet. 58, 720\u2013728 (2021).","journal-title":"J. Med. Genet."},{"key":"530_CR28","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s42255-020-00287-2","volume":"2","author":"L Folkersen","year":"2020","unstructured":"Folkersen, L. et al. Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. Nat. Metab. 2, 1135\u20131148 (2020).","journal-title":"Nat. Metab."},{"key":"530_CR29","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad, E. et al. Large-scale integration of the plasma proteome with genetics and disease. Nat. Genet. 53, 1712\u20131721 (2021).","journal-title":"Nat. Genet."},{"key":"530_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08811-2","volume":"23","author":"L-HM Moncla","year":"2022","unstructured":"Moncla, L.-H. M. et al. Mendelian randomization of circulating proteome identifies actionable targets in heart failure. BMC Genom. 23, 588 (2022).","journal-title":"BMC Genom."},{"key":"530_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-022-00381-4","volume":"16","author":"A Chignon","year":"2022","unstructured":"Chignon, A. et al. Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease. Hum. Genom. 16, 8 (2022).","journal-title":"Hum. Genom."},{"key":"530_CR32","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1177\/0962280215597579","volume":"26","author":"S Burgess","year":"2017","unstructured":"Burgess, S., Small, D. S. & Thompson, S. G. A review of instrumental variable estimators for Mendelian randomization. Stat. Methods Med. Res. 26, 2333\u20132355 (2017).","journal-title":"Stat. Methods Med. Res."},{"key":"530_CR33","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","volume":"23","author":"G Davey Smith","year":"2014","unstructured":"Davey Smith, G. & Hemani, G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum. Mol. Genet. 23, R89\u2013R98 (2014).","journal-title":"Hum. Mol. Genet."},{"key":"530_CR34","first-page":"1370","volume":"19","author":"J Yan","year":"2018","unstructured":"Yan, J., Risacher, S. L., Shen, L. & Saykin, A. J. Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data. Brief. Bioinform. 19, 1370\u20131381 (2018).","journal-title":"Brief. Bioinform."},{"key":"530_CR35","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s42003-020-0937-x","volume":"3","author":"A Chignon","year":"2020","unstructured":"Chignon, A. et al. Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases. Commun. Biol. 3, 206 (2020).","journal-title":"Commun. Biol."},{"key":"530_CR36","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden, J., Davey Smith, G., Haycock, P. C. & Burgess, S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet. Epidemiol. 40, 304\u2013314 (2016).","journal-title":"Genet. Epidemiol."},{"key":"530_CR37","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/sim.3034","volume":"27","author":"DA Lawlor","year":"2008","unstructured":"Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N. & Davey Smith, G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat. Med. 27, 1133\u20131163 (2008).","journal-title":"Stat. Med."},{"key":"530_CR38","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani, G., Tilling, K. & Davey Smith, G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 13, e1007081 (2017).","journal-title":"PLoS Genet."},{"key":"530_CR39","doi-asserted-by":"publisher","first-page":"D1228","DOI":"10.1093\/nar\/gks1147","volume":"41","author":"K Breuer","year":"2013","unstructured":"Breuer, K. et al. InnateDB: systems biology of innate immunity and beyond\u2014recent updates and continuing curation. Nucleic Acids Res. 41, D1228\u2013D1233 (2013).","journal-title":"Nucleic Acids Res."},{"key":"530_CR40","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n, M. et al. Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015).","journal-title":"Science"},{"key":"530_CR41","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa269","volume":"22","author":"X Shao","year":"2021","unstructured":"Shao, X. et al. CellTalkDB: a manually curated database of ligand-receptor interactions in humans and mice. Brief. Bioinform. 22, bbaa269 (2021).","journal-title":"Brief. Bioinform."},{"key":"530_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1182\/blood-2005-03-1312","volume":"107","author":"JC Qi","year":"2006","unstructured":"Qi, J. C. et al. Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood 107, 135\u2013142 (2006).","journal-title":"Blood"},{"key":"530_CR43","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.cyto.2018.05.038","volume":"111","author":"DJ Blake","year":"2018","unstructured":"Blake, D. J., Martiszus, J. D., Lone, T. H. & Fenster, S. D. Ablation of the CD9 receptor in human lung cancer cells using CRISPR\/Cas alters migration to chemoattractants including IL-16. Cytokine 111, 567\u2013570 (2018).","journal-title":"Cytokine"},{"key":"530_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128","volume":"14","author":"EY Chen","year":"2013","unstructured":"Chen, E. Y. et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform. 14, 128 (2013).","journal-title":"BMC Bioinform."},{"key":"530_CR45","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"530_CR46","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva, N. T., Morris, J. H., Gorodkin, J. & Jensen, L. J. Cytoscape StringApp: network analysis and visualization of proteomics data. J. Proteome Res. 18, 623\u2013632 (2019).","journal-title":"J. Proteome Res."},{"key":"530_CR47","doi-asserted-by":"publisher","first-page":"147","DOI":"10.12688\/f1000research.4460.1","volume":"3","author":"JH Morris","year":"2014","unstructured":"Morris, J. H., Kuchinsky, A., Ferrin, T. E. & Pico, A. R. enhancedGraphics: a Cytoscape app for enhanced node graphics. F1000Research 3, 147 (2014).","journal-title":"F1000Research"},{"key":"530_CR48","doi-asserted-by":"publisher","first-page":"W234","DOI":"10.1093\/nar\/gkz240","volume":"47","author":"G Zhou","year":"2019","unstructured":"Zhou, G. et al. NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis. Nucleic Acids Res. 47, W234\u2013W241 (2019).","journal-title":"Nucleic Acids Res."},{"key":"530_CR49","doi-asserted-by":"crossref","unstructured":"Bb, N. et al. The Gene Expression Deconvolution Interactive Tool (GEDIT): accurate cell type quantification from gene expression data. GigaScience 10, 1\u201315 (2021).","DOI":"10.1093\/gigascience\/giab002"},{"key":"530_CR50","doi-asserted-by":"publisher","first-page":"W199","DOI":"10.1093\/nar\/gkz401","volume":"47","author":"Y Liao","year":"2019","unstructured":"Liao, Y., Wang, J., Jaehnig, E. J., Shi, Z. & Zhang, B. WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs. Nucleic Acids Res. 47, W199\u2013W205 (2019).","journal-title":"Nucleic Acids Res."},{"key":"530_CR51","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s41592-021-01274-5","volume":"18","author":"P Jiang","year":"2021","unstructured":"Jiang, P. et al. Systematic investigation of cytokine signaling activity at the tissue and single-cell levels. Nat. Methods 18, 1181\u20131191 (2021).","journal-title":"Nat. Methods"},{"key":"530_CR52","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","volume":"49","author":"SL Freshour","year":"2021","unstructured":"Freshour, S. L. et al. Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 49, D1144\u2013D1151 (2021).","journal-title":"Nucleic Acids Res."},{"key":"530_CR53","doi-asserted-by":"publisher","first-page":"e72584","DOI":"10.1371\/journal.pone.0072584","volume":"8","author":"P Gautam","year":"2013","unstructured":"Gautam, P., Nair, S. C., Ramamoorthy, K., Swamy, C. V. B. & Nagaraj, R. Analysis of human blood plasma proteome from ten healthy volunteers from Indian population. PLOS One 8, e72584 (2013).","journal-title":"PLOS One"},{"key":"530_CR54","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0960-0760(03)00195-X","volume":"85","author":"GL Hammond","year":"2003","unstructured":"Hammond, G. L., Avvakumov, G. V. & Muller, Y. A. Structure\/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity. J. Steroid Biochem. Mol. Biol. 85, 195\u2013200 (2003).","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"530_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/srep27823","volume":"6","author":"J-X Zhang","year":"2016","unstructured":"Zhang, J.-X., Chen, D.-B., Dong, Q. & Zhao, Z.-D. Identifying a set of influential spreaders in complex networks. Sci. Rep. 6, 27823 (2016).","journal-title":"Sci. Rep."},{"key":"530_CR56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41576-020-0268-2","volume":"22","author":"K Suhre","year":"2021","unstructured":"Suhre, K., McCarthy, M. I. & Schwenk, J. M. Genetics meets proteomics: perspectives for large population-based studies. Nat. Rev. Genet. 22, 19\u201337 (2021).","journal-title":"Nat. Rev. Genet."},{"key":"530_CR57","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/S1471-4906(01)01941-X","volume":"22","author":"A Mantovani","year":"2001","unstructured":"Mantovani, A., Locati, M., Vecchi, A., Sozzani, S. & Allavena, P. Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol. 22, 328\u2013336 (2001).","journal-title":"Trends Immunol."},{"key":"530_CR58","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S1074-7613(04)00003-2","volume":"20","author":"S Rose-John","year":"2004","unstructured":"Rose-John, S. & Neurath, M. F. IL-6 trans-signaling: the heat is on. Immunity 20, 2\u20134 (2004).","journal-title":"Immunity"},{"key":"530_CR59","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/pro.3307","volume":"27","author":"PJ Thul","year":"2018","unstructured":"Thul, P. J. & Lindskog, C. The human protein atlas: a spatial map of the human proteome. Protein Sci. 27, 233\u2013244 (2018).","journal-title":"Protein Sci."},{"key":"530_CR60","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.yjmcc.2017.12.014","volume":"115","author":"KH Driesbaugh","year":"2018","unstructured":"Driesbaugh, K. H. et al. Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation. J. Mol. Cell Cardiol. 115, 94\u2013103 (2018).","journal-title":"J. Mol. Cell Cardiol."},{"key":"530_CR61","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.4049\/jimmunol.173.9.5343","volume":"173","author":"SJ Levine","year":"2004","unstructured":"Levine, S. J. Mechanisms of soluble cytokine receptor generation. J. Immunol. 173, 5343\u20135348 (2004).","journal-title":"J. Immunol."},{"key":"530_CR62","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41573-020-0078-4","volume":"19","author":"MM Attwood","year":"2020","unstructured":"Attwood, M. M., Jonsson, J., Rask-Andersen, M. & Schi\u00f6th, H. B. Soluble ligands as drug targets. Nat. Rev. Drug Discov. 19, 695\u2013710 (2020).","journal-title":"Nat. Rev. Drug Discov."},{"key":"530_CR63","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1210\/jc.2013-4475","volume":"99","author":"K Bozaoglu","year":"2014","unstructured":"Bozaoglu, K. et al. Plasma levels of soluble interleukin 1 receptor accessory protein are reduced in obesity. J. Clin. Endocrinol. Metab. 99, 3435\u20133443 (2014).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"530_CR64","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.4049\/jimmunol.0901575","volume":"183","author":"M Kurowska-Stolarska","year":"2009","unstructured":"Kurowska-Stolarska, M. et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol. 183, 6469\u20136477 (2009).","journal-title":"J. Immunol."},{"key":"530_CR65","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.it.2012.01.008","volume":"33","author":"H Takamatsu","year":"2012","unstructured":"Takamatsu, H. & Kumanogoh, A. Diverse roles for semaphorin-plexin signaling in the immune system. Trends Immunol. 33, 127\u2013135 (2012).","journal-title":"Trends Immunol."},{"key":"530_CR66","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/nri3545","volume":"13","author":"A Kumanogoh","year":"2013","unstructured":"Kumanogoh, A. & Kikutani, H. Immunological functions of the neuropilins and plexins as receptors for semaphorins. Nat. Rev. Immunol. 13, 802\u2013814 (2013).","journal-title":"Nat. Rev. Immunol."},{"key":"530_CR67","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/msb.134947","volume":"10","author":"Z Altboum","year":"2014","unstructured":"Altboum, Z. et al. Digital cell quantification identifies global immune cell dynamics during influenza infection. Mol. Syst. Biol. 10, 720 (2014).","journal-title":"Mol. Syst. Biol."},{"key":"530_CR68","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","volume":"1711","author":"B Chen","year":"2018","unstructured":"Chen, B., Khodadoust, M. S., Liu, C. L., Newman, A. M. & Alizadeh, A. A. Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol. Biol. 1711, 243\u2013259 (2018).","journal-title":"Methods Mol. Biol."},{"key":"530_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/948098","volume":"2012","author":"N-B Hao","year":"2012","unstructured":"Hao, N.-B. et al. Macrophages in tumor microenvironments and the progression of tumors. Clin. Dev. Immunol. 2012, 948098 (2012).","journal-title":"Clin. Dev. Immunol."},{"key":"530_CR70","doi-asserted-by":"publisher","first-page":"921366","DOI":"10.3389\/fimmu.2022.921366","volume":"13","author":"F Li","year":"2022","unstructured":"Li, F., Long, Y., Yu, X., Tong, Y. & Gong, L. Different immunoregulation roles of activin A compared with TGF-\u03b2. Front. Immunol. 13, 921366 (2022).","journal-title":"Front. Immunol."},{"key":"530_CR71","doi-asserted-by":"publisher","first-page":"6787","DOI":"10.4049\/jimmunol.177.10.6787","volume":"177","author":"K Ogawa","year":"2006","unstructured":"Ogawa, K., Funaba, M., Chen, Y. & Tsujimoto, M. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol. 177, 6787\u20136794 (2006).","journal-title":"J. Immunol."},{"key":"530_CR72","doi-asserted-by":"publisher","first-page":"52294","DOI":"10.18632\/oncotarget.10561","volume":"7","author":"F Zhang","year":"2016","unstructured":"Zhang, F. et al. TGF-\u03b2 induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget 7, 52294\u201352306 (2016).","journal-title":"Oncotarget"},{"key":"530_CR73","doi-asserted-by":"publisher","first-page":"928134","DOI":"10.3389\/fimmu.2022.928134","volume":"13","author":"C Liu","year":"2022","unstructured":"Liu, C., Xiao, K. & Xie, L. Advances in the regulation of macrophage polarization by mesenchymal stem cells and implications for ALI\/ARDS treatment. Front. Immunol. 13, 928134 (2022).","journal-title":"Front. Immunol."},{"key":"530_CR74","doi-asserted-by":"publisher","first-page":"7388","DOI":"10.1158\/1078-0432.CCR-17-1004","volume":"23","author":"VG Mart\u00ednez","year":"2017","unstructured":"Mart\u00ednez, V. G. et al. BMP4 induces M2 macrophage polarization and favors tumor progression in bladder cancer. Clin. Cancer Res. 23, 7388\u20137399 (2017).","journal-title":"Clin. Cancer Res."},{"key":"530_CR75","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1164\/rccm.201707-1475OC","volume":"197","author":"A B\u00e9nard","year":"2018","unstructured":"B\u00e9nard, A. et al. B cells producing type I IFN modulate macrophage polarization in tuberculosis. Am. J. Respir. Crit. Care Med. 197, 801\u2013813 (2018).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"530_CR76","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13075-016-0989-y","volume":"18","author":"G Olmes","year":"2016","unstructured":"Olmes, G. et al. CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis. Arthritis Res. Ther. 18, 90 (2016).","journal-title":"Arthritis Res. Ther."},{"key":"530_CR77","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1631\/jzus.B2100930","volume":"23","author":"P Li","year":"2022","unstructured":"Li, P. et al. Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells. J. Zhejiang Univ. Sci. B 23, 407\u2013422 (2022).","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"530_CR78","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1089\/ars.2017.7420","volume":"30","author":"F De Santa","year":"2019","unstructured":"De Santa, F., Vitiello, L., Torcinaro, A. & Ferraro, E. The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration. Antioxid. Redox Signal 30, 1553\u20131598 (2019).","journal-title":"Antioxid. Redox Signal"},{"key":"530_CR79","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S0140-6736(19)30764-0","volume":"394","author":"WD Tap","year":"2019","unstructured":"Tap, W. D. et al. Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. Lancet 394, 478\u2013487 (2019).","journal-title":"Lancet"},{"key":"530_CR80","first-page":"1373","volume":"45","author":"G Chen","year":"2020","unstructured":"Chen, G. et al. A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis. Int. J. Mol. Med. 45, 1373\u20131384 (2020).","journal-title":"Int. J. Mol. Med."},{"key":"530_CR81","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1016\/j.bmcl.2018.07.042","volume":"28","author":"T Tawaraishi","year":"2018","unstructured":"Tawaraishi, T. et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg. Med. Chem. Lett. 28, 3067\u20133072 (2018).","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"530_CR82","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1126\/science.286.5439.525","volume":"286","author":"D Yang","year":"1999","unstructured":"Yang, D. et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286, 525\u2013528 (1999).","journal-title":"Science"},{"key":"530_CR83","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.2147\/JIR.S320287","volume":"14","author":"AJ Okragly","year":"2021","unstructured":"Okragly, A. J. et al. Generation and characterization of torudokimab (LY3375880): a monoclonal antibody that neutralizes interleukin-33. J. Inflamm. Res. 14, 3823\u20133835 (2021).","journal-title":"J. Inflamm. Res."},{"key":"530_CR84","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/1529-0131(199906)42:6<1140::AID-ANR10>3.0.CO;2-7","volume":"42","author":"GN Smith","year":"1999","unstructured":"Smith, G. N., Mickler, E. A., Hasty, K. A. & Brandt, K. D. Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme. Arthritis Rheum. 42, 1140\u20131146 (1999).","journal-title":"Arthritis Rheum."},{"key":"530_CR85","first-page":"2","volume":"8","author":"RS Holmes","year":"2017","unstructured":"Holmes, R. S., Spradling-Reeves, K. D. & Cox, L. A. Mammalian glutamyl aminopeptidase genes (ENPEP) and proteins: comparative studies of a major contributor to arterial hypertension. J. Data Min. Genom. Proteom. 8, 2 (2017).","journal-title":"J. Data Min. Genom. Proteom."},{"key":"530_CR86","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1161\/HYPERTENSIONAHA.112.190942","volume":"60","author":"Y Marc","year":"2012","unstructured":"Marc, Y. et al. Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats. Hypertension 60, 411\u2013418 (2012).","journal-title":"Hypertension"},{"key":"530_CR87","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s40264-014-0239-7","volume":"38","author":"HMA Abraham","year":"2015","unstructured":"Abraham, H. M. A., White, C. M. & White, W. B. The comparative efficacy and safety of the angiotensin receptor blockers in the management of hypertension and other cardiovascular diseases. Drug Saf. 38, 33\u201354 (2015).","journal-title":"Drug Saf."},{"key":"530_CR88","first-page":"23","volume":"377","author":"A Biancotto","year":"2014","unstructured":"Biancotto, A. & McCoy, J. P. Studying the human immunome: the complexity of comprehensive leukocyte immunophenotyping. Curr. Top. Microbiol. Immunol. 377, 23\u201360 (2014).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"530_CR89","doi-asserted-by":"publisher","first-page":"669400","DOI":"10.3389\/fimmu.2021.669400","volume":"12","author":"A Devaprasad","year":"2021","unstructured":"Devaprasad, A., Radstake, T. R. D. J. & Pandit, A. Integration of immunome with disease-gene network reveals common cellular mechanisms between imids and drug repurposing strategies. Front. Immunol. 12, 669400 (2021).","journal-title":"Front. Immunol."},{"key":"530_CR90","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jaut.2011.11.006","volume":"38","author":"B Broux","year":"2012","unstructured":"Broux, B. et al. CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients. J. Autoimmun. 38, 10\u201319 (2012).","journal-title":"J. Autoimmun."},{"key":"530_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36882-3","volume":"9","author":"A Balogh","year":"2019","unstructured":"Balogh, A. et al. Sex hormone-binding globulin provides a novel entry pathway for estradiol and influences subsequent signaling in lymphocytes via membrane receptor. Sci. Rep. 9, 4 (2019).","journal-title":"Sci. Rep."},{"key":"530_CR92","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1161\/CIRCULATIONAHA.121.057301","volume":"145","author":"LSA Passos","year":"2022","unstructured":"Passos, L. S. A. et al. Prothymosin alpha: a novel contributor to estradiol receptor alpha-mediated CD8+ T-cell pathogenic responses and recognition of type 1 collagen in rheumatic heart valve disease. Circulation 145, 531\u2013548 (2022).","journal-title":"Circulation"},{"key":"530_CR93","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1046\/j.1365-2567.1999.00693.x","volume":"96","author":"H Ogasawara","year":"1999","unstructured":"Ogasawara, H. et al. Inhibitory effect of interleukin-16 on interleukin-2 production by CD4+ T cells. Immunology 96, 215\u2013219 (1999).","journal-title":"Immunology"},{"key":"530_CR94","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.4049\/jimmunol.162.7.4293","volume":"162","author":"PA Klimiuk","year":"1999","unstructured":"Klimiuk, P. A., Goronzy, J. J. & Weyand, C. M. IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis. J. Immunol. 162, 4293\u20134299 (1999).","journal-title":"J. Immunol."},{"key":"530_CR95","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","volume":"518","author":"E Gomez Perdiguero","year":"2015","unstructured":"Gomez Perdiguero, E. et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547\u2013551 (2015).","journal-title":"Nature"},{"key":"530_CR96","doi-asserted-by":"publisher","first-page":"5460","DOI":"10.1182\/bloodadvances.2020002683","volume":"4","author":"K Hamidzadeh","year":"2020","unstructured":"Hamidzadeh, K., Belew, A. T., El-Sayed, N. M. & Mosser, D. M. The transition of M-CSF-derived human macrophages to a growth-promoting phenotype. Blood Adv. 4, 5460\u20135472 (2020).","journal-title":"Blood Adv."},{"key":"530_CR97","doi-asserted-by":"publisher","first-page":"249","DOI":"10.4161\/org.25676","volume":"9","author":"CV Jones","year":"2013","unstructured":"Jones, C. V. & Ricardo, S. D. Macrophages and CSF-1: implications for development and beyond. Organogenesis 9, 249\u2013260 (2013).","journal-title":"Organogenesis"},{"key":"530_CR98","first-page":"194","volume":"7","author":"Y Wang","year":"2014","unstructured":"Wang, Y. et al. The M2 polarization of macrophage induced by fractalkine in the endometriotic milieu enhances invasiveness of endometrial stromal cells. Int. J. Clin. Exp. Pathol. 7, 194\u2013203 (2014).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"530_CR99","doi-asserted-by":"publisher","first-page":"e36814","DOI":"10.1371\/journal.pone.0036814","volume":"7","author":"AR Pinto","year":"2012","unstructured":"Pinto, A. R. et al. An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile. PLoS One 7, e36814 (2012).","journal-title":"PLoS One"},{"key":"530_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2018.12.027","volume":"107","author":"Y Huang","year":"2019","unstructured":"Huang, Y. et al. IL-16 regulates macrophage polarization as a target gene of mir-145-3p. Mol. Immunol. 107, 1\u20139 (2019).","journal-title":"Mol. Immunol."},{"key":"530_CR101","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1083\/jcb.201301081","volume":"202","author":"DH Madsen","year":"2013","unstructured":"Madsen, D. H. et al. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J. Cell Biol. 202, 951\u2013966 (2013).","journal-title":"J. Cell Biol."},{"key":"530_CR102","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","volume":"44","author":"TA Wynn","year":"2016","unstructured":"Wynn, T. A. & Vannella, K. M. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44, 450\u2013462 (2016).","journal-title":"Immunity"},{"key":"530_CR103","first-page":"290","volume":"5","author":"A Shiraki","year":"2016","unstructured":"Shiraki, A. et al. Pentraxin-3 regulates the inflammatory activity of macrophages. Biochem. Biophys. Rep. 5, 290\u2013295 (2016).","journal-title":"Biochem. Biophys. Rep."},{"key":"530_CR104","doi-asserted-by":"publisher","first-page":"e0124347","DOI":"10.1371\/journal.pone.0124347","volume":"10","author":"C Y\u0131ld\u0131r\u0131m","year":"2015","unstructured":"Y\u0131ld\u0131r\u0131m, C. et al. Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages. PLoS One 10, e0124347 (2015).","journal-title":"PLoS One"},{"key":"530_CR105","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1161\/CIRCULATIONAHA.119.042391","volume":"141","author":"AJ Kim","year":"2020","unstructured":"Kim, A. J. et al. Deficiency of circulating monocytes ameliorates the progression of myxomatous valve degeneration in marfan syndrome. Circulation 141, 132\u2013146 (2020).","journal-title":"Circulation"},{"key":"530_CR106","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/FJC.0000000000000638","volume":"73","author":"FHH Leenen","year":"2019","unstructured":"Leenen, F. H. H., Ahmad, M., Marc, Y. & Llorens-Cortes, C. Specific inhibition of brain angiotensin iii formation as a new strategy for prevention of heart failure after myocardial infarction. J. Cardiovasc. Pharm. 73, 82\u201391 (2019).","journal-title":"J. Cardiovasc. Pharm."},{"key":"530_CR107","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck, M., Chen, C.-Y., Neale, B. & Do, R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat. Genet. 50, 693\u2013698 (2018).","journal-title":"Nat. Genet."},{"key":"530_CR108","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0034-x","volume":"15","author":"E Kulinskaya","year":"2015","unstructured":"Kulinskaya, E. & Dollinger, M. B. An accurate test for homogeneity of odds ratios based on Cochran\u2019s Q-statistic. BMC Med. Res. Methodol. 15, 49 (2015).","journal-title":"BMC Med. Res. Methodol."},{"key":"530_CR109","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/ije\/dyw252","volume":"45","author":"J Bowden","year":"2016","unstructured":"Bowden, J. et al. Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int. J. Epidemiol. 45, 1961\u20131974 (2016).","journal-title":"Int. J. Epidemiol."},{"key":"530_CR110","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/JLB.1MIR0420-076R","volume":"108","author":"LE Padgett","year":"2020","unstructured":"Padgett, L. E., Araujo, D. J., Hedrick, C. C. & Olingy, C. E. Functional crosstalk between T cells and monocytes in cancer and atherosclerosis. J. Leukoc. Biol. 108, 297\u2013308 (2020).","journal-title":"J. Leukoc. Biol."},{"key":"530_CR111","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19397-w","volume":"12","author":"N Kaneko","year":"2022","unstructured":"Kaneko, N. et al. Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sj\u00f6gren\u2019s syndrome. Sci. Rep. 12, 15427 (2022).","journal-title":"Sci. Rep."},{"key":"530_CR112","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1242\/dev.01056","volume":"131","author":"A Salustri","year":"2004","unstructured":"Salustri, A. et al. PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization. Development 131, 1577\u20131586 (2004).","journal-title":"Development"},{"key":"530_CR113","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1189\/jlb.0608345","volume":"86","author":"V Maina","year":"2009","unstructured":"Maina, V. et al. Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6. J. Leukoc. Biol. 86, 123\u2013132 (2009).","journal-title":"J. Leukoc. Biol."},{"key":"530_CR114","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1083\/jcb.140.2.419","volume":"140","author":"TR Kyriakides","year":"1998","unstructured":"Kyriakides, T. R. et al. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J. Cell Biol. 140, 419\u2013430 (1998).","journal-title":"J. Cell Biol."}],"container-title":["Communications Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43856-024-00530-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-024-00530-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-024-00530-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T13:09:38Z","timestamp":1717679378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43856-024-00530-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":114,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["530"],"URL":"https:\/\/doi.org\/10.1038\/s43856-024-00530-x","relation":{},"ISSN":["2730-664X"],"issn-type":[{"value":"2730-664X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]},"assertion":[{"value":"17 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"108"}}