{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:13:35Z","timestamp":1791598415312,"version":"4.3.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Multiple Sclerosis Scientific and Research Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We aimed to assess the interrelationship between diet, the gut microbiota, and MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case-control study including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food frequency questionnaire \u226421-years of age, and 59 also provided a stool sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here we show that a 1-point increase in a Mediterranean diet score is associated with 37% reduced MS odds (95%CI: 10%\u201353%). Higher fiber and iron intakes are also associated with reduced MS odds. Diet, not MS, explains inter-individual gut microbiota variation. Several gut microbes abundances are associated with both the Mediterranean diet score and having MS, and these microbes are potential mediators of the protective associations of a healthier diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s43856-024-00565-0","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T13:01:24Z","timestamp":1721394084000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Mediterranean diet and associations with the gut microbiota and pediatric-onset multiple sclerosis using trivariate analysis"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-4624","authenticated-orcid":false,"given":"Ali I.","family":"Mirza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Knox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda J.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-5932","authenticated-orcid":false,"given":"Alison","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Van Domselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3574","authenticated-orcid":false,"given":"Charles N.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Ann","family":"Marrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janace","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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The funding source was not involved in the study design, the collection, analysis, and interpretation of the data, or in the decision to submit this article for publication. A.I.M. is funded through the MS Society of Canada endMS Doctoral Studentship (EGID: 3246) and The Multiple Sclerosis Scientific and Research Foundation (PI: Tremlett, EGID: 2636). F.Z. and Y.Z. were funded through research grants held by H.T., including The Multiple Sclerosis Scientific and Research Foundation (PI: H.T., EGID: 2636). L.B. and A.D. are supported by Multiple Sclerosis Society of Western Australia (MSWA). L.B. is also supported by an MS Australia Postdoctoral Research Fellowship. D.L.A. is funded by the Canadian MS Society, the International Progressive MS Alliance, the Canadian Institutes of Health Research and the US Department of Defense. He has received personal compensation for serving as a Consultant for Alexion, Biogen, Celgene, Frequency Therapeutics, GENeuro, Genentech, Merck\/EMD Serono, Novartis, Roche, and Sanofi. D.L.A. has an ownership interest in NeuroRx. A.B.-O. is funded by the NIH, ITN, NMSS and MSSOC. A.B.-O. has participated as a speaker in meetings sponsored by and received consulting fees and\/or grant support from: Janssen\/Actelion; Atara Biotherapeutics, Biogen Idec, Celgene\/Receptos, Roche\/Genentech, Medimmune, Merck\/EMD Serono, Novartis, Sanofi-Genzyme. C.Be. is supported in part by the Bingham Chair in Gastroenterology. He has consulted to or served on advisory boards for Abbvie Canada, Amgen Canada, Bristol Myers Squibb Canada, JAMP Pharmaceuticals, Janssen Canada, Pfizer Canada, Sandoz Canada, Takeda, and has received unrestricted educational grants from Abbvie Canada, Janssen Canada, Pfizer Canada, Bristol Myers Squibb Canada, and Takeda Canada. He has been on the speaker\u2019s bureau of Abbvie Canada, Janssen Canada, Pfizer Canada and Takeda Canada. He has received research grants from Abbvie Canada, Amgen Canada, Pfizer Canada, and Sandoz Canada and contract grants from Janssen. R.A.M. receives research funding from: CIHR, Research Manitoba, Multiple Sclerosis Society of Canada, Multiple Sclerosis Scientific Foundation, Crohn\u2019s and Colitis Canada, National Multiple Sclerosis Society, the CMSC, the Arthritis Society and US Department of Defense. She is a co-investigator on a study funded in part by Biogen Idec and Roche Canada. She is supported by the Waugh Family Chair in Multiple Sclerosis. J.O. receives research funding from: Multiple Sclerosis Society of Canada, Multiple Sclerosis Scientific Foundation, and CMSC. G.V.D. is the Chief Bioinformatics Scientist with the National Microbiology Laboratory \u2013 Public Health Agency of Canada and has received research support in the last three years from the National MS Society, the Canadian Institute of Health Research, and Genome Canada. E.A.Y. has received research support in the last 3 years from the National MS Society, Canadian Institutes of Health Research, National Institutes of Health, Ontario Institute of Regenerative Medicine, Stem Cell Network, SickKids Foundation, Peterson Foundation, MS Society of Canada, and the MS Scientific Research Foundation. She has received funding for investigator-initiated research from Biogen and has served on scientific advisory boards for Biogen, Alexion and Hoffman-LaRoche. B.B. serves as a consultant to Novartis, UCB, and Roche. B.B. provides non-remunerated advice on clinical trial design to Novartis, Biogen, Teva Neuroscience. B.B. is funded by the NMSS, NIH, and Canadian MS Society. E.W. is funded by the NMSS, NIH, PCORI, DoD and Race to Erase MS. E.W. has received consulting honoraria from Emerald Pharmaceutical, and speaking honoraria from Yoga moves MS, Advanced Curriculum and NeurologyLive. She is a site PI for several pharmaceutical clinical trials (Biogen, Roche, Alexion). H.T. has, in the last five years, received research support from the Canada Research Chair Program, the National Multiple Sclerosis Society, the Canadian Institutes of Health Research, the Multiple Sclerosis Society of Canada, the Multiple Sclerosis Scientific Research Foundation and the EDMUS Foundation (\u2018Fondation EDMUS contre la scl\u00e9rose en plaques\u2019). In addition, in the last five years, has had travel expenses or registration fees prepaid or reimbursed to present at CME conferences from the Consortium of MS Centers (2018), National MS Society (2018), ECTRIMS\/ ACTRIMS (2017-2022), American Academy of Neurology (2019). Speaker honoraria are either declined or donated to an MS charity or to an unrestricted grant for use by H.T.\u2019s research group. All other authors declare no potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"148"}}