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Despite a strong relationship between tinnitus-related distress and depression, the underlying mechanisms represent a long-standing question. By investigating the co-development of tinnitus-related distress and depressiveness throughout therapy, we capture the dynamic interplay of both conditions and uncover underlying common features mediating their link.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Large datasets from two different day clinics in Germany have been analyzed using a regularization method for predictor selection (analysis 1) and latent growth curve modeling (LCM; analysis 2). Tinnitus-related distress was assessed using the Tinnitus Questionnaire (TQ). All patients have been experiencing chronic subjective tinnitus with a minimum mean severity level of TQ grade 2. Treatment at both day clinics involved tinnitus management according to clinical guidelines with minor idiosyncratic differences. Analysis 1 was performed on a dataset of 500 patients who received the Jena Interdisciplinary Treatment for Tinnitus (JITT) for 5 consecutive days between 2013 and 2017. Analysis 2 was performed on a second dataset, which included 1016 patients treated at the Tinnitus Center of the Charit\u00e9 Universit\u00e4tsmedizin Berlin for 7 days between 2011 and 2015.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Here, we show a substantial bidirectional relationship between tinnitus-related distress and depression severity while emphasizing the role of somatic symptoms and perceived stress in the experience and maintenance of tinnitus awareness. The LCM provides adequate model fit (CFI\u2009=\u20090.993, SRMR\u2009=\u20090.016).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results indicate enhanced therapy success in depression when tinnitus-related distress is addressed and vice versa. The combined treatment of tinnitus and depression is proposed for future treatment strategies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s43856-024-00678-6","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T13:44:23Z","timestamp":1732196663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A retrospective two-center cohort study of the bidirectional relationship between depression and tinnitus-related distress"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3773-1025","authenticated-orcid":false,"given":"Cosima F.","family":"Lukas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Mazurek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Brueggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Jungh\u00f6fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas\u2013Lichius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-597X","authenticated-orcid":false,"given":"Christian","family":"Dobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"678_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fnsys.2012.00053","volume":"6","author":"JJ Eggermont","year":"2012","unstructured":"Eggermont, J. 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