{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:10:08Z","timestamp":1742962208156,"version":"3.40.3"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Med"],"DOI":"10.1038\/s43856-025-00810-0","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T03:36:05Z","timestamp":1742960165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Individualized cerebellar damage predicts the presence of behavioral disorders in children with brainstem tumors"],"prefix":"10.1038","volume":"5","author":[{"given":"Heyuan","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaikai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guocan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiying","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congying","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuntao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4813-621X","authenticated-orcid":false,"given":"Lingzhong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-3765","authenticated-orcid":false,"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"810_CR1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1193474","volume":"11","author":"RG Boukaka","year":"2023","unstructured":"Boukaka, R. G. et al. Brainstem tumors in children: a monocentric series in the light of genetic and bio-molecular progress in pediatric neuro-oncology. Front Pediatr. 11, 1193474 (2023).","journal-title":"Front Pediatr."},{"key":"810_CR2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.apmr.2004.09.005","volume":"86","author":"PW New","year":"2005","unstructured":"New, P. W. & Thomas, S. J. Cognitive impairments in the locked-in syndrome: A case report. Archives of Physical Medicine and Rehabilitation. 86, 338\u2013343 (2005).","journal-title":"Archives of Physical Medicine and Rehabilitation."},{"key":"810_CR3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/13554790802001403","volume":"13","author":"R Omar","year":"2007","unstructured":"Omar, R. et al. The neuro-behavioural syndrome of brainstem disease. Neurocase. 13, 452\u2013465 (2007).","journal-title":"Neurocase."},{"key":"810_CR4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/pbc.21084","volume":"49","author":"C Wolfe-Christensen","year":"2007","unstructured":"Wolfe-Christensen, C., Mullins, L. L., Scott, J. G. & McNall-Knapp, R. Y. Persistent psychosocial problems in children who develop posterior fossa syndrome after medulloblastoma resection. Pediatr Blood Cancer. 49, 723\u2013726 (2007).","journal-title":"Pediatr Blood Cancer."},{"key":"810_CR5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11060-022-04161-x","volume":"160","author":"H Jia","year":"2022","unstructured":"Jia, H. et al. Brainstem tumors may increase the impairment of behavioral emotional cognition in children. J Neurooncol. 160, 423\u2013432 (2022).","journal-title":"J Neurooncol."},{"key":"810_CR6","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1037\/a0016106","volume":"23","author":"HJ De Smet","year":"2009","unstructured":"De Smet, H. J. et al. Long-term cognitive deficits following posterior fossa tumor resection: a neuropsychological and functional neuroimaging follow-up study. Neuropsychology. 23, 694\u2013704 (2009).","journal-title":"Neuropsychology."},{"key":"810_CR7","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/brain\/123.5.1051","volume":"123","author":"D Riva","year":"2000","unstructured":"Riva, D. & Giorgi, C. The cerebellum contributes to higher functions during development - Evidence from a series of children surgically treated for posterior fossa tumours. Brain. 123, 1051\u20131054 (2000).","journal-title":"Brain."},{"key":"810_CR8","doi-asserted-by":"crossref","first-page":"e826","DOI":"10.1016\/j.wneu.2019.11.016","volume":"134","author":"A Shah","year":"2020","unstructured":"Shah, A., Jhawar, S. S., Nunez, M., Goel, A. & Goel, A. Brainstem anatomy: A study on the basis of the pattern of fiber organization. World Neurosurg. 134, e826\u2013e846 (2020).","journal-title":"World Neurosurg."},{"key":"810_CR9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4103\/0366-6999.226890","volume":"131","author":"ZY Zhang","year":"2018","unstructured":"Zhang, Z. Y., Liu, Z. Q., Qin, W., Chen, Y. W. & Liu, Z. J. Clinical and radiological features of Wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction. China Med J (Engl). 131, 665\u2013671 (2018).","journal-title":"China Med J (Engl)."},{"key":"810_CR10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0074-7742(08)60363-3","volume":"41","author":"JD Schmahmann","year":"1997","unstructured":"Schmahmann, J. D. & Sherman, J. C. Cerebellar cognitive affective syndrome. Int Rev Neurobiol. 41, 433\u2013440 (1997).","journal-title":"Int Rev Neurobiol."},{"key":"810_CR11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jnr.490020204","volume":"2","author":"RS Snider","year":"1976","unstructured":"Snider, R. S. & Maiti, A. Cerebellar contributions to the Papez circuit. J. Neurosci. Res. 2, 133\u2013146 (1976).","journal-title":"J. Neurosci. Res."},{"key":"810_CR12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.siny.2016.04.010","volume":"21","author":"CJ Stoodley","year":"2016","unstructured":"Stoodley, C. J. & Limperopoulos, C. Structure-function relationships in the developing cerebellum: Evidence from early-life cerebellar injury and neurodevelopmental disorders. Seminars in Fetal and Neonatal Medicine. 21, 356\u2013364 (2016).","journal-title":"Seminars in Fetal and Neonatal Medicine."},{"key":"810_CR13","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1038\/s41593-024-01787-0","volume":"27","author":"JY Hansen","year":"2024","unstructured":"Hansen, J. Y. et al. Integrating Brainstem and Cortical Functional Architectures. Nature Neuroscience. 27, 2500\u20132511 (2024).","journal-title":"Nature Neuroscience."},{"key":"810_CR14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00062-015-0495-7","volume":"27","author":"S Zhang","year":"2017","unstructured":"Zhang, S., Ai, L., Chen, X. Z. & Wang, K. Radiological evaluation of infratentorial gangliogliomas in various anatomic locations of the cerebellum and brainstem. Clin. Neuroradiol. 27, 319\u2013327 (2017).","journal-title":"Clin. Neuroradiol."},{"key":"810_CR15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/cne.903260202","volume":"326","author":"JD Schmahmann","year":"1992","unstructured":"Schmahmann, J. D. & Pandya, D. N. Course of the fiber pathways to pons from parasensory association areas in the rhesus monkey. J Comp Neurol. 326, 159\u2013179 (1992).","journal-title":"J Comp Neurol."},{"key":"810_CR16","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1097\/00001756-200108080-00039","volume":"12","author":"KO Bushara","year":"2001","unstructured":"Bushara, K. O. et al. Multiple tactile maps in the human cerebellum. Neuroreport. 12, 2483\u20132486 (2001).","journal-title":"Neuroreport."},{"key":"810_CR17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuroimage.2018.01.082","volume":"172","author":"X Guell","year":"2018","unstructured":"Guell, X., Gabrieli, J. D. E. & Schmahmann, J. D. Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort. Neuroimage. 172, 437\u2013449 (2018).","journal-title":"Neuroimage."},{"key":"810_CR18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12311-014-0626-8","volume":"14","author":"T D\u2019aes","year":"2014","unstructured":"D\u2019aes, T. & Mari\u00ebn, P. Cognitive and Affective Disturbances Following Focal Brainstem Lesions: A Review and Report of Three Cases. The Cerebellum. 14, 317\u2013340 (2014).","journal-title":"The Cerebellum."},{"key":"810_CR19","volume":"1","author":"XN Zuo","year":"2014","unstructured":"Zuo, X. N. et al. An open science resource for establishing reliability and reproducibility in functional connectomics. Scientific data. 1, 140049 (2014).","journal-title":"Scientific data."},{"key":"810_CR20","doi-asserted-by":"publisher","unstructured":"Xi-Nian, Z. & Consortium, C. developing Chinese Color Nest Project (devCCNP) Lite. https:\/\/doi.org\/10.57760\/sciencedb.07860 (2024).","DOI":"10.57760\/sciencedb.07860"},{"key":"810_CR21","volume":"218","author":"S Han","year":"2020","unstructured":"Han, S., Carass, A., He, Y. & Prince, J. L. Automatic Cerebellum Anatomical Parcellation Using U - Net with Locally Constrained Optimization. Neuroimage. 218, 116819 (2020).","journal-title":"Neuroimage."},{"key":"810_CR22","volume":"109","author":"WS Neo","year":"2021","unstructured":"Neo, W. S., Suzuki, T. & Kelleher, B. L. Structural validity of the Child Behavior Checklist (CBCL) for preschoolers with neurogenetic syndromes. Res Dev Disabil. 109, 103834 (2021).","journal-title":"Res Dev Disabil."},{"key":"810_CR23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","volume":"8","author":"WE Johnson","year":"2007","unstructured":"Johnson, W. E., Li, C. & Rabinovic, A. Adjusting Batch Effects in Microarray Expression Data Using Empirical Bayes Methods. Biostatistics. 8, 118\u2013127 (2007).","journal-title":"Biostatistics."},{"key":"810_CR24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.biopsych.2015.12.023","volume":"80","author":"AF Marquand","year":"2016","unstructured":"Marquand, A. F., Rezek, I., Buitelaar, J. & Beckmann, C. F. Understanding heterogeneity in clinical cohorts using normative models: beyond case-control studies. Biol Psychiatry. 80, 552\u2013561 (2016).","journal-title":"Biol Psychiatry."},{"key":"810_CR25","doi-asserted-by":"crossref","first-page":"e2442","DOI":"10.1212\/WNL.0000000000207298","volume":"100","author":"S Verdi","year":"2023","unstructured":"Verdi, S. et al. Revealing individual neuroanatomical heterogeneity in alzheimer disease using neuroanatomical normative modeling. Neurology. 100, e2442\u2013e2453 (2023).","journal-title":"Neurology."},{"key":"810_CR26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.biopsych.2022.05.014","volume":"92","author":"Z Cui","year":"2022","unstructured":"Cui, Z. et al. Linking individual differences in personalized functional network topography to psychopathology in youth. Biol Psychiatry. 92, 973\u2013983 (2022).","journal-title":"Biol Psychiatry."},{"key":"810_CR27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/01616412.2021.2018122","volume":"44","author":"Y Wei","year":"2022","unstructured":"Wei, Y. et al. Longitudinal gray matter atrophy and accompanied functional connectivity alterations in patients with pontine infarction. Neurol Res. 44, 667\u2013676 (2022).","journal-title":"Neurol Res."},{"key":"810_CR28","doi-asserted-by":"crossref","unstructured":"Re, T. J. et al. High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults. Brain Behav. 7, e00589 (2017).","DOI":"10.1002\/brb3.589"},{"key":"810_CR29","first-page":"537","volume":"28","author":"GK Spanos","year":"2007","unstructured":"Spanos, G. K. et al. cerebellar atrophy after moderate-to-severe pediatric traumatic brain injury. Am. J. Neuroradiol. 28, 537\u2013542 (2007).","journal-title":"Am. J. Neuroradiol."},{"key":"810_CR30","unstructured":"Larysz, D. et al. 271-274 (Springer Vienna)."},{"key":"810_CR31","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/STROKEAHA.111.000744","volume":"44","author":"S Mah","year":"2013","unstructured":"Mah, S., deVeber, G., Wei, X. C., Liapounova, N. & Kirton, A. Cerebellar atrophy in childhood arterial ischemic stroke: acute diffusion MRI biomarkers. Stroke. 44, 2468\u20132474 (2013).","journal-title":"Stroke."},{"key":"810_CR32","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.neuroimage.2013.09.033","volume":"86","author":"F Van Overwalle","year":"2014","unstructured":"Van Overwalle, F., Baetens, K., Marien, P. & Vandekerckhove, M. Social cognition and the cerebellum: a meta-analysis of over 350 fMRI studies. Neuroimage. 86, 554\u2013572 (2014).","journal-title":"Neuroimage."},{"key":"810_CR33","doi-asserted-by":"crossref","DOI":"10.1016\/j.dcn.2023.101238","volume":"60","author":"IR Olson","year":"2023","unstructured":"Olson, I. R., Hoffman, L. J., Jobson, K. R., Popal, H. S. & Wang, Y. Little brain, little minds: The big role of the cerebellum in social development. Dev. Cogn. Neurosci. 60, 101238 (2023).","journal-title":"Dev. Cogn. Neurosci."},{"key":"810_CR34","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s12311-021-01246-7","volume":"20","author":"OY Chao","year":"2021","unstructured":"Chao, O. Y., Zhang, H., Pathak, S. S., Huston, J. P. & Yang, Y. M. Functional Convergence of Motor and Social Processes in Lobule IV\/V of the Mouse Cerebellum. Cerebellum. 20, 836\u2013852 (2021).","journal-title":"Cerebellum."},{"key":"810_CR35","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1542\/peds.2007-1041","volume":"120","author":"C Limperopoulos","year":"2007","unstructured":"Limperopoulos, C. et al. Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics. 120, 584\u2013593 (2007).","journal-title":"Pediatrics."},{"key":"810_CR36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev-neuro-070918-050258","volume":"42","author":"JD Schmahmann","year":"2019","unstructured":"Schmahmann, J. D., Guell, X., Stoodley, C. J. & Halko, M. A. The theory and neuroscience of cerebellar cognition. Annu Rev Neurosci. 42, 337\u2013364 (2019).","journal-title":"Annu Rev Neurosci."},{"key":"810_CR37","doi-asserted-by":"crossref","unstructured":"Carta, I., Chen, C. H., Schott, A. L., Dorizan, S. & Khodakhah, K. Cerebellar modulation of the reward circuitry and social behavior. Science. 363, eaav0581 (2019).","DOI":"10.1126\/science.aav0581"},{"key":"810_CR38","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3171\/2013.8.PEDS13168","volume":"12","author":"M Pitsika","year":"2013","unstructured":"Pitsika, M. & Tsitouras, V. Cerebellar mutism. J Neurosurg-Pediatr. 12, 604\u2013614 (2013).","journal-title":"J Neurosurg-Pediatr."},{"key":"810_CR39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neubiorev.2020.06.030","volume":"116","author":"KGO Ike","year":"2020","unstructured":"Ike, K. G. O., de Boer, S. F., Buwalda, B. & Kas, M. J. H. Social Withdrawal: An Initially Adaptive Behavior That Becomes Maladaptive When Expressed Excessively. Neurosci. Biobehav. Rev. 116, 251\u2013267 (2020).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"810_CR40","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1002\/cne.22735","volume":"519","author":"LA O\u2019Connell","year":"2011","unstructured":"O\u2019Connell, L. A. & Hofmann, H. A. The vertebrate mesolimbic reward system and social behavior network: a comparative synthesis. J Comp Neurol. 519, 3599\u20133639 (2011).","journal-title":"J Comp Neurol."},{"key":"810_CR41","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/scan\/nsac042","volume":"17","author":"MR Frazier","year":"2022","unstructured":"Frazier, M. R. et al. A Missing Link in Affect Regulation: The Cerebellum. Social Cognitive Affective Neuroscience. 17, 1068\u20131081 (2022).","journal-title":"Social Cognitive Affective Neuroscience."},{"key":"810_CR42","doi-asserted-by":"publisher","unstructured":"Jia, H. Cerebellum analysis (Zenodo, 2025) https:\/\/doi.org\/10.5281\/zenodo.15023957.","DOI":"10.5281\/zenodo.15023957"}],"container-title":["Communications Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43856-025-00810-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-025-00810-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-025-00810-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T03:37:13Z","timestamp":1742960233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43856-025-00810-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["810"],"URL":"https:\/\/doi.org\/10.1038\/s43856-025-00810-0","relation":{},"ISSN":["2730-664X"],"issn-type":[{"value":"2730-664X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"5 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Consent obtained directly from patients\u2019 parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"91"}}