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These genes underwent bioanalysis, including gene ontology enrichment, protein-protein interaction and cell-type enrichment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here we show that multiple neuroinflammatory transcripts are overexpressed in the Huntington\u2019s disease midcingulate cortex, such as those linked to classical complement, toll-like receptor signaling and AQP4 activity. However, related processes, such as chemokine activity, are downregulated, implying that a complex combination of gain and loss of neuroinflammatory function is occurring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, neuroinflammation-related transcripts are overrepresented in Huntington\u2019s disease cases with motor symptoms compared to mood and mixed. These findings suggest a potentially unique role for the midcingulate cortex in motor-specific neuroinflammatory pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s43856-026-01526-5","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:03:54Z","timestamp":1780563834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploration of the genetic neuroinflammatory environment in the human midcingulate cortex in Huntington\u2019s disease"],"prefix":"10.1038","volume":"6","author":[{"given":"Mackenzie W.","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6917-8638","authenticated-orcid":false,"given":"Shelley","family":"Scheepers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thulani","family":"Palpagama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvindar","family":"Singh-Bains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-8953","authenticated-orcid":false,"given":"Aod\u00e1n","family":"Laighneach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-570X","authenticated-orcid":false,"given":"Derek W.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Tippett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Waldvogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L. 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