{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:14:58Z","timestamp":1788995698454,"version":"build-2803163510"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":113,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82293633,HY2021-7,82270180"],"award-info":[{"award-number":["82293633,HY2021-7,82270180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Med"],"DOI":"10.1038\/s43856-026-01598-3","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:28:41Z","timestamp":1776756521000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chidamide synergizes with cisplatin-etoposide to trigger pyroptosis and anti-tumor immunity in diffuse large B-cell lymphoma"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7383-0734","authenticated-orcid":false,"given":"Jianbo","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9164-7034","authenticated-orcid":false,"given":"Bowen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-9813","authenticated-orcid":false,"given":"Weimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-8493","authenticated-orcid":false,"given":"Dali","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-3095","authenticated-orcid":false,"given":"Huajun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2543-9808","authenticated-orcid":false,"given":"Yingjie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-0271","authenticated-orcid":false,"given":"Yunkun","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-2616","authenticated-orcid":false,"given":"Fan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-0144","authenticated-orcid":false,"given":"Mi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"1598_CR1","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/ajh.27075","volume":"98","author":"M Tavakkoli","year":"2023","unstructured":"Tavakkoli, M. & Barta, S. K. 2024 update: Advances in the risk stratification and management of large B-cell lymphoma. Am. J. Hematol. 98, 1791\u20131805 (2023).","journal-title":"Am. J. Hematol."},{"key":"1598_CR2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1309\/AJCP7YLTQPUSDQ5C","volume":"138","author":"J Sun","year":"2012","unstructured":"Sun, J. et al. Distribution of lymphoid neoplasms in China: Analysis of 4,638 cases according to the World Health Organization Classification. Am. J. Clin. Pathol. 138, 429\u2013434 (2012).","journal-title":"Am. J. Clin. Pathol."},{"key":"1598_CR3","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/ajh.24086","volume":"90","author":"M Al-Hamadani","year":"2015","unstructured":"Al-Hamadani, M. et al. Non-Hodgkin lymphoma subtype distribution, geodemographic patterns, and survival in the US: A longitudinal analysis of the National Cancer Data Base from 1998 to 2011. Am. J. Hematol. 90, 790\u2013795 (2015).","journal-title":"Am. J. Hematol."},{"key":"1598_CR4","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi, L. et al. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25, 486\u2013541 (2018).","journal-title":"Cell Death Differ."},{"key":"1598_CR5","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1109\/TMI.2019.2947628","volume":"39","author":"N Kumar","year":"2020","unstructured":"Kumar, N. et al. A multi-organ nucleus segmentation challenge. IEEE Trans. Med Imaging 39, 1380\u20131391 (2020).","journal-title":"IEEE Trans. Med Imaging"},{"key":"1598_CR6","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.3389\/fimmu.2018.02918","volume":"9","author":"P Ahechu","year":"2018","unstructured":"Ahechu, P. et al. NLRP3 inflammasome: A possible link between obesity-associated low-grade chronic inflammation and colorectal cancer development. Front. Immunol. 9, 2918 (2018).","journal-title":"Front. Immunol."},{"key":"1598_CR7","doi-asserted-by":"crossref","unstructured":"Galluzzi, L. et al. Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol. 17 (2017).","DOI":"10.1038\/nri.2017.48"},{"key":"1598_CR8","doi-asserted-by":"publisher","first-page":"8049","DOI":"10.1021\/acs.nanolett.9b03245","volume":"19","author":"J-X Fan","year":"2019","unstructured":"Fan, J.-X. et al. Epigenetics-based tumor cells pyroptosis for enhancing the immunological effect of chemotherapeutic nanocarriers. Nano Lett. 19, 8049\u20138058 (2019).","journal-title":"Nano Lett."},{"key":"1598_CR9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41568-024-00674-x","volume":"24","author":"P Meier","year":"2024","unstructured":"Meier, P. et al. Immunogenic cell death in cancer: Targeting necroptosis to induce antitumour immunity. Nat. Rev. Cancer 24, 299\u2013315 (2024).","journal-title":"Nat. Rev. Cancer"},{"key":"1598_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","volume":"579","author":"Z Zhang","year":"2020","unstructured":"Zhang, Z. et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 579, 415\u2013420 (2020).","journal-title":"Nature"},{"key":"1598_CR11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41586-020-2079-1","volume":"579","author":"Q Wang","year":"2020","unstructured":"Wang, Q. et al. A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature 579, 421\u2013426 (2020).","journal-title":"Nature"},{"key":"1598_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02344-4","volume":"24","author":"C Huang","year":"2025","unstructured":"Huang, C. et al. Targeting pyroptosis for cancer immunotherapy: Mechanistic insights and clinical perspectives. Mol. Cancer 24, 131 (2025).","journal-title":"Mol. Cancer"},{"key":"1598_CR13","doi-asserted-by":"crossref","unstructured":"Xiao, R. et al., Bendamustine-rituximab elicits dual tumoricidal and immunomodulatory responses via cGAS-STING activation in diffuse large B-cell lymphoma. J Immunother Cancer. 12, e009212 (2024).","DOI":"10.1136\/jitc-2024-009212"},{"key":"1598_CR14","doi-asserted-by":"crossref","unstructured":"Li, Y., & Seto, E. HDACs and HDAC inhibitors in cancer development and therapy. Cold Spring Harb. Perspect. Med. 6, a026831 (2016).","DOI":"10.1101\/cshperspect.a026831"},{"key":"1598_CR15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-025-02280-1","volume":"10","author":"M Tufail","year":"2025","unstructured":"Tufail, M., Jiang, C. H. & Li, N. Immune evasion in cancer: Mechanisms and cutting-edge therapeutic approaches. Signal Transduct. Target Ther. 10, 227 (2025).","journal-title":"Signal Transduct. Target Ther."},{"key":"1598_CR16","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00280-011-1766-x","volume":"69","author":"Z-Q Ning","year":"2012","unstructured":"Ning, Z.-Q. et al. Chidamide (CS055\/HBI-8000): A new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother. Pharmacol. 69, 901\u2013909 (2012).","journal-title":"Cancer Chemother. Pharmacol."},{"key":"1598_CR17","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/hon.3088","volume":"41","author":"HY Cao","year":"2023","unstructured":"Cao, H. Y. et al. Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy. Hematol. Oncol. 41, 301\u2013309 (2023).","journal-title":"Hematol. Oncol."},{"key":"1598_CR18","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s13238-020-00694-x","volume":"11","author":"X Wang","year":"2020","unstructured":"Wang, X. et al. HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma. Protein Cell 11, 472\u2013482 (2020).","journal-title":"Protein Cell"},{"key":"1598_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2210-0","volume":"11","author":"XW Guan","year":"2020","unstructured":"Guan, X. W. et al. Novel HDAC inhibitor chidamide synergizes with rituximab to inhibit diffuse large B-cell lymphoma tumour growth by upregulating CD20. Cell Death Dis. 11, 20 (2020).","journal-title":"Cell Death Dis."},{"key":"1598_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06505-z","volume":"15","author":"W Xu","year":"2024","unstructured":"Xu, W. et al. Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis. Cell Death Dis. 15, 115 (2024).","journal-title":"Cell Death Dis."},{"key":"1598_CR21","doi-asserted-by":"publisher","first-page":"204062072412924","DOI":"10.1177\/20406207241292446","volume":"15","author":"X Chen","year":"2024","unstructured":"Chen, X. et al. Real-world efficacy of chidamide plus R-CHOP in newly diagnosed double-expressor diffuse large B-cell lymphoma. Ther. Adv. Hematol. 15, 20406207241292446 (2024).","journal-title":"Ther. Adv. Hematol."},{"key":"1598_CR22","first-page":"790","volume":"37","author":"LY Ping","year":"2016","unstructured":"Ping, L. Y. et al. Efficacy and survival analysis of DICE regimen for 97 patients with relapsed or refractory Non-Hodgkin\u2019s lymphoma]. Zhonghua Xue Ye Xue Za Zhi 37, 790\u2013794 (2016).","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"1598_CR23","doi-asserted-by":"crossref","unstructured":"Stef\u00e0no, E. et al. An overview of altered pathways associated with sensitivity to platinum-based chemotherapy in neuroendocrine tumors: Strengths and prospects. Int. J. Mol. Sci. 25, 8568 (2024).","DOI":"10.3390\/ijms25168568"},{"key":"1598_CR24","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.7150\/ijbs.60292","volume":"17","author":"H Yan","year":"2021","unstructured":"Yan, H. et al. Cisplatin induces pyroptosis via activation of MEG3\/NLRP3\/caspase-1\/GSDMD pathway in triple-negative breast cancer. Int. J. Biol. Sci. 17, 2606\u20132621 (2021).","journal-title":"Int. J. Biol. Sci."},{"key":"1598_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10495-019-01515-1","volume":"24","author":"CC Zhang","year":"2019","unstructured":"Zhang, C. C. et al. Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3\/GSDME activation. Apoptosis 24, 312\u2013325 (2019).","journal-title":"Apoptosis"},{"key":"1598_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang, Y. et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547, 99\u2013103 (2017).","journal-title":"Nature"},{"key":"1598_CR27","doi-asserted-by":"crossref","unstructured":"wang, X. et al. SO-YOLO based WBC detection with fourier ptychographic microscopy. IEEE Access, 2018. PP: p. 1-1.","DOI":"10.1109\/ACCESS.2018.2865541"},{"key":"1598_CR28","doi-asserted-by":"crossref","unstructured":"Wang, X. et al. The synergistic anti-tumor activity of EZH2 inhibitor SHR2554 and HDAC inhibitor chidamide through ORC1 reduction of DNA replication process in diffuse large B cell lymphoma. Cancers (Basel) 13, 4249 (2021).","DOI":"10.3390\/cancers13174249"},{"key":"1598_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50956-x","volume":"14","author":"C Wu","year":"2024","unstructured":"Wu, C. et al. Targeting HDACs for diffuse large B-cell lymphoma therapy. Sci. Rep. 14, 289 (2024).","journal-title":"Sci. Rep."},{"key":"1598_CR30","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","volume":"7","author":"W Gao","year":"2022","unstructured":"Gao, W. et al. Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct. Target. Ther. 7, 196 (2022).","journal-title":"Signal Transduct. Target. Ther."},{"key":"1598_CR31","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1134\/S0006350924700763","volume":"69","author":"ME Solovieva","year":"2024","unstructured":"Solovieva, M. E., Shatalin, Y. V. & Akatov, V. S. Paraptosis and other types of nonapoptotic regulated cell death. Biophysics 69, 674\u2013691 (2024).","journal-title":"Biophysics"},{"key":"1598_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16361-y","volume":"11","author":"P-C Pao","year":"2020","unstructured":"Pao, P.-C. et al. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer\u2019s disease. Nat. Commun. 11, 2484 (2020).","journal-title":"Nat. Commun."},{"key":"1598_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36614-w","volume":"14","author":"Y Wei","year":"2023","unstructured":"Wei, Y. et al. GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis. Nat. Commun. 14, 929 (2023).","journal-title":"Nat. Commun."},{"key":"1598_CR34","doi-asserted-by":"publisher","first-page":"W171","DOI":"10.1093\/nar\/gkz365","volume":"47","author":"K Labun","year":"2019","unstructured":"Labun, K. et al. CHOPCHOP v3: Expanding the CRISPR web toolbox beyond genome editing. Nucleic Acids Res. 47, W171\u2013w174 (2019).","journal-title":"Nucleic Acids Res."},{"key":"1598_CR35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41420-025-02376-1","volume":"11","author":"W Wang","year":"2025","unstructured":"Wang, W., Li, T. & Wu, K. Cell death in tumor microenvironment: An insight for exploiting novel therapeutic approaches. Cell Death Discov. 11, 93 (2025).","journal-title":"Cell Death Discov."},{"key":"1598_CR36","doi-asserted-by":"publisher","first-page":"216413","DOI":"10.1016\/j.canlet.2023.216413","volume":"575","author":"RN Zhang","year":"2023","unstructured":"Zhang, R. N. et al. Epigenetic regulation of pyroptosis in cancer: Molecular pathogenesis and targeting strategies. Cancer Lett. 575, 216413 (2023).","journal-title":"Cancer Lett."},{"key":"1598_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0479-y","volume":"10","author":"L Croes","year":"2018","unstructured":"Croes, L. et al. Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer. Clin. Epigenetics 10, 51 (2018).","journal-title":"Clin. Epigenetics"},{"key":"1598_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03431-2","volume":"12","author":"W Xia","year":"2021","unstructured":"Xia, W. et al. Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation. Cell Death Dis. 12, 139 (2021).","journal-title":"Cell Death Dis."},{"key":"1598_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05840-x","volume":"14","author":"J Dai","year":"2023","unstructured":"Dai, J. et al. LncRNA LINC00969 promotes acquired gefitinib resistance by epigenetically suppressing of NLRP3 at transcriptional and posttranscriptional levels to inhibit pyroptosis in lung cancer. Cell Death Dis. 14, 312 (2023).","journal-title":"Cell Death Dis."},{"key":"1598_CR40","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1002\/mc.23468","volume":"61","author":"Z Zhang","year":"2022","unstructured":"Zhang, Z. et al. Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression. Mol. Carcinog. 61, 1161\u20131176 (2022).","journal-title":"Mol. Carcinog."},{"key":"1598_CR41","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s11064-022-03766-y","volume":"48","author":"K Luo","year":"2023","unstructured":"Luo, K. et al. HDAC inhibitor SAHA alleviates pyroptosis by up-regulating miR-340 to inhibit NEK7 signaling in subarachnoid hemorrhage. Neurochem Res 48, 458\u2013470 (2023).","journal-title":"Neurochem Res"},{"key":"1598_CR42","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41420-022-00906-9","volume":"8","author":"F Yao","year":"2022","unstructured":"Yao, F. et al. HDAC11 promotes both NLRP3\/caspase-1\/GSDMD and caspase-3\/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells. Cell Death Discov. 8, 112 (2022).","journal-title":"Cell Death Discov."},{"key":"1598_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36550-9","volume":"14","author":"N Wang","year":"2023","unstructured":"Wang, N. et al. A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis. Nat. Commun. 14, 779 (2023).","journal-title":"Nat. Commun."},{"key":"1598_CR44","doi-asserted-by":"crossref","unstructured":"Zhou, Z. et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science 368, eaaz7548 (2020).","DOI":"10.1126\/science.aaz7548"},{"key":"1598_CR45","volume":"8","author":"Y Xiao","year":"2021","unstructured":"Xiao, Y. et al. Microenvironment-responsive prodrug-induced pyroptosis boosts cancer immunotherapy. Adv. Sci. (Weinh., Baden. -Wurtt., Ger.) 8, e2101840 (2021).","journal-title":"Adv. Sci. (Weinh., Baden. -Wurtt., Ger.)"},{"key":"1598_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5581\/1516-8484.20110036","volume":"33","author":"M Bellesso","year":"2011","unstructured":"Bellesso, M. et al. Disease progression after R-CHOP treatment associated with the loss of CD20 antigen expression. Rev. Bras. Hematol. Hemoter. 33, 148\u2013150 (2011).","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"1598_CR47","doi-asserted-by":"publisher","first-page":"e1315486","DOI":"10.1080\/2162402X.2017.1315486","volume":"6","author":"CA Carter","year":"2017","unstructured":"Carter, C. A. et al. No patient left behind: The promise of immune priming with epigenetic agents. Oncoimmunology 6, e1315486 (2017).","journal-title":"Oncoimmunology"},{"key":"1598_CR48","doi-asserted-by":"publisher","first-page":"102537","DOI":"10.1016\/j.xcrm.2025.102537","volume":"7","author":"A Li","year":"2026","unstructured":"Li, A. et al. 5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation. Cell Rep. Med. 7, 102537 (2026).","journal-title":"Cell Rep. Med."}],"container-title":["Communications Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01598-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01598-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01598-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:28:49Z","timestamp":1786523329000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01598-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1598"],"URL":"https:\/\/doi.org\/10.1038\/s43856-026-01598-3","relation":{},"ISSN":["2730-664X"],"issn-type":[{"value":"2730-664X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"9 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"438"}}