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Even after weight restoration, core symptoms such as body dissatisfaction, intense fear of eating, and preoccupation with body shape and weight often persist, contributing to a high risk of relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study evaluated the feasibility and safety of a weight-maintaining ketogenic dietary therapy administered over 14 weeks in adults with anorexia nervosa who were either mildly underweight or weight-restored. The study also examined whether ketogenic therapy could reduce eating disorder symptoms. Twenty-two individuals participated, and eighteen (82%) completed the trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Repeated-measures MANCOVA (intent-to-treat; comorbidity and medication included in the model) reveals significant overall treatment effects (Wilk\u2019s \u03bb\u2009=\u20090.165, F\u2009=\u20092.383,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and symptom score\u00a0decreases over time on the Eating Disorder Examination Questionnaire (EDE-Q) subscales\u00a0Restraint, Eating Concern, Shape Concern, and\u00a0Weight Concern,\u00a0as well as for depression scores. At study completion, 72% of participants show EDE-Q and depression scores within the normal range. At three-month follow-up, 39% of completers continue ketogenic dietary therapy, of whom 28% show an increase in EDE-Q Global scores, while among those not maintaining ketogenic therapy, 64% present with an elevation in EDE-Q scores. Ketogenic dietary therapy does not precipitate worsening of symptoms or clinically significant weight loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ketogenic dietary therapy is well-tolerated and demonstrates potential efficacy in reducing core symptoms of AN among adults who are mildly underweight or weight-restored. These findings support the further investigation of ketogenic dietary therapy as a potential intervention for this population. ClinicalTrials.gov ID: NCT06000774; Registration Date August 14, 2023.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s43856-026-01644-0","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:04:45Z","timestamp":1780477485000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Symptom impact and safety of ketogenic therapy in adults with anorexia nervosa: a feasibility trial"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-3441","authenticated-orcid":false,"given":"Guido K. 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