{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:00:47Z","timestamp":1790290847915,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":106,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI116471"],"award-info":[{"award-number":["R01AI116471"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Med"],"DOI":"10.1038\/s43856-026-01649-9","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:23:39Z","timestamp":1781213019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Foodborne sources of antimicrobial-resistant Escherichia coli in community-acquired urinary tract infections in Bangladesh"],"prefix":"10.1038","volume":"6","author":[{"given":"Mohammed Badrul","family":"Amin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Flatgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Injamamul","family":"Hoque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwana","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-6180","authenticated-orcid":false,"given":"Md. Rayhanul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdia","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5107-5289","authenticated-orcid":false,"given":"Mohammad Aminul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"1649_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89240-5","volume":"15","author":"Y He","year":"2025","unstructured":"He, Y. et al. Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021. Sci. Rep. 15, 4702 (2025).","journal-title":"Sci. Rep."},{"key":"1649_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fmicb.2013.00029","volume":"4","author":"L Nordstrom","year":"2013","unstructured":"Nordstrom, L., Liu, C. M. & Price, L. B. Foodborne urinary tract infections: a new paradigm for antimicrobial-resistant foodborne illness. Front. Microbiol. 4, 29 (2013).","journal-title":"Front. Microbiol."},{"key":"1649_CR3","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1056\/NEJMcp1104429","volume":"366","author":"TM Hooton","year":"2012","unstructured":"Hooton, T. M. Uncomplicated urinary tract infection. N. Engl. J. Med. 366, 1028\u20131037 (2012).","journal-title":"N. Engl. J. Med."},{"key":"1649_CR4","doi-asserted-by":"publisher","first-page":"e0274423","DOI":"10.1371\/journal.pone.0274423","volume":"17","author":"MA Islam","year":"2022","unstructured":"Islam, M. A. et al. Prevalence, etiology and antibiotic resistance patterns of community-acquired urinary tract infections in Dhaka, Bangladesh. PloS ONE 17, e0274423 (2022).","journal-title":"PloS ONE"},{"key":"1649_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1128\/CMR.4.1.80","volume":"4","author":"JR Johnson","year":"1991","unstructured":"Johnson, J. R. Virulence factors in Escherichia coli urinary tract infection. Clin. Microbiol. Rev. 4, 80\u2013128 (1991).","journal-title":"Clin. Microbiol. Rev."},{"key":"1649_CR6","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1086\/315418","volume":"181","author":"TA Russo","year":"2000","unstructured":"Russo, T. A. & Johnson, J. R. Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC.  J. Infect. Dis. 181, 1753\u20131754 (2000).","journal-title":"J. Infect. Dis."},{"key":"1649_CR7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1086\/527386","volume":"46","author":"SP Smith","year":"2008","unstructured":"Smith, S. P., Manges, A. R. & Riley, L. W. Temporal changes in the prevalence of community-acquired antimicrobial-resistant urinary tract infection affected by Escherichia coli clonal group composition. Clin. Infect. Dis. 46, 689\u2013695 (2008).","journal-title":"Clin. Infect. Dis."},{"key":"1649_CR8","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1128\/AAC.00297-09","volume":"53","author":"JR Johnson","year":"2009","unstructured":"Johnson, J. R. et al. Epidemic clonal groups of Escherichia coli as a cause of antimicrobial-resistant urinary tract infections in Canada, 2002 to 2004. Antimicrob. Agents Chemother. 53, 2733\u20132739 (2009).","journal-title":"Antimicrob. Agents Chemother."},{"key":"1649_CR9","first-page":"415","volume":"52","author":"J Bahadin","year":"2011","unstructured":"Bahadin, J., Teo, S. & Mathew, S. Aetiology of community-acquired urinary tract infection and antimicrobial susceptibility patterns of uropathogens isolated. Singap. Med. J. 52, 415 (2011).","journal-title":"Singap. Med. J."},{"key":"1649_CR10","doi-asserted-by":"publisher","first-page":"328","DOI":"10.7196\/SAMJ.4346","volume":"101","author":"FJ Bosch","year":"2011","unstructured":"Bosch, F. J., Van Vuuren, C. & Joubert, G. Antimicrobial resistance patterns in outpatient urinary tract infections-the constant need to revise prescribing habits. South Afr. Med. J. 101, 328\u2013331 (2011).","journal-title":"South Afr. Med. J."},{"key":"1649_CR11","unstructured":"Okesola, A. O. & Aroundegbe, T. I. Antibiotic resistance pattern of uropathogenic Escherichia coli in South West Nigeria. Afr. J. Med. Med. Sci. 40, 235\u2013238 (2011)."},{"key":"1649_CR12","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1111\/j.1464-410X.2011.10528.x","volume":"109","author":"IM Cullen","year":"2012","unstructured":"Cullen, I. M. et al. The changing pattern of antimicrobial resistance within 42 033 Escherichia coli isolates from nosocomial, community and urology patient-specific urinary tract infections, Dublin, 1999\u20132009. BJU Int. 109, 1198\u20131206 (2012).","journal-title":"BJU Int."},{"key":"1649_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3201\/eid1601.091118","volume":"16","author":"C Vincent","year":"2010","unstructured":"Vincent, C. et al. Food reservoir for Escherichia coli causing urinary tract infections. Emerg. Infect. Dis. 16, 88 (2010).","journal-title":"Emerg. Infect. Dis."},{"key":"1649_CR14","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1086\/428451","volume":"191","author":"JR Johnson","year":"2005","unstructured":"Johnson, J. R., Kuskowski, M. A., Smith, K., O\u2019Bryan, T. T. & Tatini, S. Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods.  J. Infect. Dis. 191, 1040\u20131049 (2005).","journal-title":"J. Infect. Dis."},{"key":"1649_CR15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1089\/fpd.2009.0409","volume":"7","author":"L Jakobsen","year":"2010","unstructured":"Jakobsen, L. et al. Escherichia coli isolates from broiler chicken meat, broiler chickens, pork, and pigs share phylogroups and antimicrobial resistance with community-dwelling humans and patients with urinary tract infection. Foodborne Pathog. Dis. 7, 537\u2013547 (2010).","journal-title":"Foodborne Pathog. Dis."},{"key":"1649_CR16","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/cid\/cis502","volume":"55","author":"AR Manges","year":"2012","unstructured":"Manges, A. R. & Johnson, J. R. Food-borne origins of Escherichia coli causing extraintestinal infections. Clin. Infect. Dis. 55, 712\u2013719 (2012).","journal-title":"Clin. Infect. Dis."},{"key":"1649_CR17","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03415-23","volume":"12","author":"M Aziz","year":"2024","unstructured":"Aziz, M. et al. Pediatric urinary tract infections caused by poultry-associated Escherichia coli. Microbiol. Spectr. 12, e0341523 (2024).","journal-title":"Microbiol. Spectr."},{"key":"1649_CR18","doi-asserted-by":"publisher","first-page":"100526","DOI":"10.1016\/j.onehlt.2023.100526","volume":"16","author":"MS Islam","year":"2023","unstructured":"Islam, M. S., Rahman, A. T., Hassan, J. & Rahman, M. T. Extended-spectrum beta-lactamase in Escherichia coli isolated from humans, animals, and environments in Bangladesh: a one health perspective systematic review and meta-analysis. One Health 16, 100526 (2023).","journal-title":"One Health"},{"key":"1649_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2024.110717","volume":"418","author":"MB Amin","year":"2024","unstructured":"Amin, M. B. et al. Prevalence and antimicrobial resistance of major foodborne pathogens isolated from pangas and tilapia fish sold in retail markets of Dhaka city, Bangladesh. Int. J. Food Microbiol. 418, 110717 (2024).","journal-title":"Int. J. Food Microbiol."},{"key":"1649_CR20","doi-asserted-by":"crossref","unstructured":"Nicolle, L. E. et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin. Infect. Dis. 40, 643\u2013654 (2005).","DOI":"10.1086\/427507"},{"key":"1649_CR21","doi-asserted-by":"crossref","unstructured":"Mebkhout, F. et al. Evaluation of bacterial contamination of laying hen eggshells by using a classic and fast method: first report in Algeria. Agric. Sci. Technol. 14, 49\u201356 (2022).","DOI":"10.15547\/ast.2022.04.049"},{"key":"1649_CR22","doi-asserted-by":"publisher","first-page":"e01203","DOI":"10.1128\/AEM.01203-18","volume":"84","author":"RA Canales","year":"2018","unstructured":"Canales, R. A., Wilson, A. M., Pearce-Walker, J. I., Verhougstraete, M. P. & Reynolds, K. A. Methods for handling left-censored data in quantitative microbial risk assessment. Appl. Environ. Microbiol. 84, e01203\u2013e01218 (2018).","journal-title":"Appl. Environ. Microbiol."},{"key":"1649_CR23","unstructured":"CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 27th edn. CLSI supplement M100 (Clinical and Laboratory Standards Institute, 2017)."},{"key":"1649_CR24","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos, A. P. et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol. Infect. 18, 268\u2013281 (2012).","journal-title":"Clin. Microbiol. Infect."},{"key":"1649_CR25","doi-asserted-by":"crossref","unstructured":"Islam, M. A., et al. Fecal colonization with multidrug-resistant E. coli among healthy infants in rural Bangladesh. Front. Microbiol. 10, 640 (2019).","DOI":"10.3389\/fmicb.2019.00640"},{"key":"1649_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.803043","volume":"13","author":"MB Amin","year":"2022","unstructured":"Amin, M. B. et al. Identifying the sources of intestinal colonization with extended-spectrum \u03b2-lactamase-producing Escherichia coli in healthy infants in the community. Front. Microbiol. 13, 803043 (2022).","journal-title":"Front. Microbiol."},{"key":"1649_CR27","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","volume":"19","author":"A Bankevich","year":"2012","unstructured":"Bankevich, A. et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J. Comput Biol. 19, 455\u2013477 (2012).","journal-title":"J. Comput Biol."},{"key":"1649_CR28","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","volume":"30","author":"T Seemann","year":"2014","unstructured":"Seemann, T. Prokka: rapid prokaryotic genome annotation. Bioinformatics 30, 2068\u20132069 (2014).","journal-title":"Bioinformatics"},{"key":"1649_CR29","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1093\/bioinformatics\/btv421","volume":"31","author":"AJ Page","year":"2015","unstructured":"Page, A. J. et al. Roary: rapid large-scale prokaryote pan genome analysis. Bioinformatics 31, 3691\u20133693 (2015).","journal-title":"Bioinformatics"},{"key":"1649_CR30","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1128\/JCM.00008-15","volume":"53","author":"G Joensen Katrine","year":"2015","unstructured":"Joensen Katrine, G., Tetzschner Anna, M. M., Iguchi, A., Aarestrup Frank, M. & Scheutz, F. Rapid and easy in silico serotyping of Escherichia coli isolates by use of whole-genome sequencing data. J. Clin. Microbiol. 53, 2410\u20132426 (2015).","journal-title":"J. Clin. Microbiol."},{"key":"1649_CR31","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/molbev\/msu300","volume":"32","author":"LT Nguyen","year":"2015","unstructured":"Nguyen, L. T., Schmidt, H. A., von Haeseler, A. & Minh, B. Q. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol. Biol. Evol. 32, 268\u2013274 (2015).","journal-title":"Mol. Biol. Evol."},{"key":"1649_CR32","doi-asserted-by":"publisher","first-page":"W293","DOI":"10.1093\/nar\/gkab301","volume":"49","author":"I Letunic","year":"2021","unstructured":"Letunic, I. & Bork, P. Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Nucleic Acids Res. 49, W293\u2013W296 (2021).","journal-title":"Nucleic Acids Res."},{"key":"1649_CR33","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.chom.2020.09.015","volume":"28","author":"MG Durrant","year":"2020","unstructured":"Durrant, M. G., Li, M. M., Siranosian, B. A., Montgomery, S. B. & Bhatt, A. S. A bioinformatic analysis of integrative mobile genetic elements highlights their role in bacterial adaptation. Cell Host Microbe 28, 767 (2020).","journal-title":"Cell Host Microbe"},{"key":"1649_CR34","doi-asserted-by":"crossref","unstructured":"Robertson, J., Bessonov, K., Schonfeld, J. & Nash, J. H. E. Universal whole-sequence-based plasmid typing and its utility to prediction of host range and epidemiological surveillance. Microb. Genom. 6, mgen000435 (2020).","DOI":"10.1099\/mgen.0.000435"},{"key":"1649_CR35","doi-asserted-by":"crossref","unstructured":"Robertson, J. & Nash, J. H. E. MOB-suite: software tools for clustering, reconstruction and typing of plasmids from draft assemblies. Microb. Genom. 4, e000206 (2018).","DOI":"10.1099\/mgen.0.000206"},{"key":"1649_CR36","doi-asserted-by":"crossref","unstructured":"Gu, Z., Gu, L., Eils, R., Schlesner, M. & Brors, B. \u201c Circlize\u201d implements and enhances circular visualization in R. Bioinformatics 30, 2811\u20132 (2014).","DOI":"10.1093\/bioinformatics\/btu393"},{"key":"1649_CR37","unstructured":"Hadley, W. Ggplot2 Elegant Graphics for Data Analysis (Springer-Verlag New York, 2016) https:\/\/ggplot2.tidyverse.org."},{"key":"1649_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2336-6","volume":"19","author":"P Clausen","year":"2018","unstructured":"Clausen, P., Aarestrup, F. M. & Lund, O. Rapid and precise alignment of raw reads against redundant databases with KMA. BMC Bioinform. 19, 307 (2018).","journal-title":"BMC Bioinform."},{"key":"1649_CR39","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1093\/jac\/dkaa345","volume":"75","author":"V Bortolaia","year":"2020","unstructured":"Bortolaia, V. et al. ResFinder 4.0 for predictions of phenotypes from genotypes. J. Antimicrob. Chemother. 75, 3491\u20133500 (2020).","journal-title":"J. Antimicrob. Chemother."},{"key":"1649_CR40","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1093\/jac\/dkx217","volume":"72","author":"E Zankari","year":"2017","unstructured":"Zankari, E. et al. PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens. J. Antimicrob. Chemother. 72, 2764\u20132768 (2017).","journal-title":"J. Antimicrob. Chemother."},{"key":"1649_CR41","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/cid\/ciu785","volume":"60","author":"B Lazarus","year":"2014","unstructured":"Lazarus, B., Paterson, D. L., Mollinger, J. L. & Rogers, B. A. Do human extraintestinal Escherichia coli infections resistant to expanded-spectrum cephalosporins originate from food-producing animals? A systematic review. Clin. Infect. Dis. 60, 439\u2013452 (2014).","journal-title":"Clin. Infect. Dis."},{"key":"1649_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2023.100558","volume":"16","author":"V Garc\u00eda","year":"2023","unstructured":"Garc\u00eda, V. et al. Genomics, biofilm formation and infection of bladder epithelial cells in potentially uropathogenic Escherichia coli (UPEC) from animal sources and human urinary tract infections (UTIs) further support food-borne transmission. One Health 16, 100558 (2023).","journal-title":"One Health"},{"key":"1649_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2023.100518","volume":"16","author":"CM Liu","year":"2023","unstructured":"Liu, C. M. et al. Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections. One Health 16, 100518 (2023).","journal-title":"One Health"},{"key":"1649_CR44","doi-asserted-by":"publisher","first-page":"e03956","DOI":"10.1128\/spectrum.03956-23","volume":"12","author":"BM Flatgard","year":"2024","unstructured":"Flatgard, B. M. et al. Tracking antimicrobial resistance transmission in urban and rural communities in Bangladesh: a One Health study of genomic diversity of ESBL-producing and carbapenem-resistant Escherichia coli. Microbiol. Spectr. 12, e03956\u201303923 (2024).","journal-title":"Microbiol. Spectr."},{"key":"1649_CR45","doi-asserted-by":"publisher","first-page":"e00582","DOI":"10.1128\/spectrum.00582-22","volume":"10","author":"A Kremer","year":"2022","unstructured":"Kremer, A. et al. ESBL Escherichia coli isolates have enhanced gut colonization capacity compared to non-ESBL strains in neonatal mice. Microbiol. Spectr. 10, e00582\u201300522 (2022).","journal-title":"Microbiol. Spectr."},{"key":"1649_CR46","doi-asserted-by":"publisher","first-page":"E238","DOI":"10.1111\/1469-0691.12128","volume":"19","author":"M Accogli","year":"2013","unstructured":"Accogli, M. et al. IncI1 plasmids associated with the spread of CMY-2, CTX-M-1 and SHV-12 in Escherichia coli of animal and human origin. Clin. Microbiol. Infect. 19, E238\u2013E240 (2013).","journal-title":"Clin. Microbiol. Infect."},{"key":"1649_CR47","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fmicb.2013.00188","volume":"4","author":"J Wang","year":"2013","unstructured":"Wang, J. et al. Molecular characterization of bla ESBL\u2013harboring conjugative plasmids identified in multi-drug resistant Escherichia coli isolated from food-producing animals and healthy humans. Front. Microbiol. 4, 188 (2013).","journal-title":"Front. Microbiol."},{"key":"1649_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58006-6","volume":"10","author":"Y-C Chen","year":"2020","unstructured":"Chen, Y.-C., Chang, C.-C., Chiu, T. H. T., Lin, M.-N. & Lin, C.-L. The risk of urinary tract infection in vegetarians and non-vegetarians: a prospective study. Sci. Rep. 10, 906 (2020).","journal-title":"Sci. Rep."},{"key":"1649_CR49","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1089\/fpd.2007.0026","volume":"4","author":"AR Manges","year":"2007","unstructured":"Manges, A. R. et al. Retail meat consumption and the acquisition of antimicrobial resistant Escherichia coli causing urinary tract infections: a case\u2013Control study. Foodborne Pathog. Dis. 4, 419\u2013431 (2007).","journal-title":"Foodborne Pathog. Dis."}],"container-title":["Communications Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01649-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01649-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01649-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:52:53Z","timestamp":1790290373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43856-026-01649-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1649"],"URL":"https:\/\/doi.org\/10.1038\/s43856-026-01649-9","relation":{},"ISSN":["2730-664X"],"issn-type":[{"value":"2730-664X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"28 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"498"}}