{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:45:18Z","timestamp":1793778318147,"version":"4.6.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["F30 HL158014"],"award-info":[{"award-number":["F30 HL158014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007483"],"award-info":[{"award-number":["T32HL007483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL007150"],"award-info":[{"award-number":["T32 HL007150"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL 142905"],"award-info":[{"award-number":["R01 HL 142905"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK123528"],"award-info":[{"award-number":["R01 DK123528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1009"],"award-info":[{"award-number":["SFB1009"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1348"],"award-info":[{"award-number":["SFB 1348"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cardiovasc Res"],"DOI":"10.1038\/s44161-022-00147-0","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T17:04:15Z","timestamp":1668186255000},"page":"1006-1021","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C\u2013CDH5 inhibition"],"prefix":"10.1038","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-2596","authenticated-orcid":false,"given":"Derek C.","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Mahadevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-900X","authenticated-orcid":false,"given":"Aileen A.","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mericko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiyah","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Jannaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid F.","family":"Nottebaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Vestweber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P.","family":"Scallan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-7086","authenticated-orcid":false,"given":"Mark L.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"147_CR1","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1172\/JCI92823","volume":"127","author":"CT Griffin","year":"2017","unstructured":"Griffin, C. T. & Gao, S. Building discontinuous liver sinusoidal vessels. J. Clin. Invest. 127, 790\u2013792 (2017).","journal-title":"J. Clin. Invest."},{"key":"147_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature17624","volume":"532","author":"T Itkin","year":"2016","unstructured":"Itkin, T. et al. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature 532, 323\u2013328 (2016).","journal-title":"Nature"},{"key":"147_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.stem.2009.01.006","volume":"4","author":"AT Hooper","year":"2009","unstructured":"Hooper, A. T. et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 4, 263\u2013274 (2009).","journal-title":"Cell Stem Cell"},{"key":"147_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature13146","volume":"507","author":"SK Ramasamy","year":"2014","unstructured":"Ramasamy, S. K., Kusumbe, A. P., Wang, L. & Adams, R. H. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature 507, 376\u2013380 (2014).","journal-title":"Nature"},{"key":"147_CR5","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1073\/pnas.92.8.3566","volume":"92","author":"A Kaipainen","year":"1995","unstructured":"Kaipainen, A. et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl Acad. Sci. USA 92, 3566\u20133570 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"147_CR6","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1096\/fj.99-1049com","volume":"14","author":"TA Partanen","year":"2000","unstructured":"Partanen, T. A. et al. VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues. FASEB J. 14, 2087\u20132096 (2000).","journal-title":"FASEB J."},{"key":"147_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/ni1013","volume":"5","author":"MJ Karkkainen","year":"2004","unstructured":"Karkkainen, M. J. et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat. Immunol. 5, 74\u201380 (2004).","journal-title":"Nat. Immunol."},{"key":"147_CR8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/ng.321","volume":"41","author":"BM Hogan","year":"2009","unstructured":"Hogan, B. M. et al. ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nat. Genet. 41, 396\u2013398 (2009).","journal-title":"Nat. Genet."},{"key":"147_CR9","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1038\/ng.484","volume":"41","author":"M Alders","year":"2009","unstructured":"Alders, M. et al. Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans. Nat. Genet. 41, 1272\u20131274 (2009).","journal-title":"Nat. Genet."},{"key":"147_CR10","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1242\/dev.100495","volume":"141","author":"L Le Guen","year":"2014","unstructured":"Le Guen, L. et al. Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development 141, 1239\u20131249 (2014).","journal-title":"Development"},{"key":"147_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1749-6632.2002.tb04871.x","volume":"979","author":"A Saaristo","year":"2002","unstructured":"Saaristo, A., Karkkainen, M. J. & Alitalo, K. Insights into the molecular pathogenesis and targeted treatment of lymphedema. Ann. N. Y. Acad. Sci. 979, 94\u2013110 (2002).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"147_CR12","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1182\/blood-2015-12-687970","volume":"128","author":"S Fang","year":"2016","unstructured":"Fang, S. et al. Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood 128, 710\u2013720 (2016).","journal-title":"Blood"},{"key":"147_CR13","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1182\/blood-2012-10-462689","volume":"121","author":"Z Zou","year":"2013","unstructured":"Zou, Z. et al. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood 121, 3228\u20133236 (2013).","journal-title":"Blood"},{"key":"147_CR14","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1172\/JCI83967","volume":"126","author":"HM Bui","year":"2016","unstructured":"Bui, H. M. et al. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. J. Clin. Invest. 126, 2167\u20132180 (2016).","journal-title":"J. Clin. Invest."},{"key":"147_CR15","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1128\/MCB.01526-13","volume":"34","author":"N Dartsch","year":"2014","unstructured":"Dartsch, N., Schulte, D., Hagerling, R., Kiefer, F. & Vestweber, D. Fusing VE-cadherin to \u03b1-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation. Mol. Cell. Biol. 34, 1634\u20131648 (2014).","journal-title":"Mol. Cell. Biol."},{"key":"147_CR16","doi-asserted-by":"publisher","first-page":"ra72","DOI":"10.1126\/scisignal.aad9256","volume":"9","author":"EJ Gordon","year":"2016","unstructured":"Gordon, E. J. et al. The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci. Signal. 9, ra72 (2016).","journal-title":"Sci. Signal."},{"key":"147_CR17","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/ncb1486","volume":"8","author":"J Gavard","year":"2006","unstructured":"Gavard, J. & Gutkind, J. S. VEGF controls endothelial-cell permeability by promoting the \u03b2-arrestin-dependent endocytosis of VE-cadherin. Nat. Cell Biol. 8, 1223\u20131234 (2006).","journal-title":"Nat. Cell Biol."},{"key":"147_CR18","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1083\/jcb.200602080","volume":"174","author":"MG Lampugnani","year":"2006","unstructured":"Lampugnani, M. G., Orsenigo, F., Gagliani, M. C., Tacchetti, C. & Dejana, E. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J. Cell Biol. 174, 593\u2013604 (2006).","journal-title":"J. Cell Biol."},{"key":"147_CR19","doi-asserted-by":"crossref","unstructured":"Hagerling, R. et al. Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds. EMBO J. 37, e98271 (2018).","DOI":"10.15252\/embj.201798271"},{"key":"147_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.devcel.2010.01.011","volume":"18","author":"K Si-Tayeb","year":"2010","unstructured":"Si-Tayeb, K., Lemaigre, F. P. & Duncan, S. A. Organogenesis and development of the liver. Dev. Cell 18, 175\u2013189 (2010).","journal-title":"Dev. Cell"},{"key":"147_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ncb3476","volume":"19","author":"UH Langen","year":"2017","unstructured":"Langen, U. H. et al. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat. Cell Biol. 19, 189\u2013201 (2017).","journal-title":"Nat. Cell Biol."},{"key":"147_CR22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41586-018-0522-3","volume":"562","author":"L Lorenz","year":"2018","unstructured":"Lorenz, L. et al. Mechanosensing by \u03b21 integrin induces angiocrine signals for liver growth and survival. Nature 562, 128\u2013132 (2018).","journal-title":"Nature"},{"key":"147_CR23","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1242\/jcs.111.13.1853","volume":"111","author":"S Esser","year":"1998","unstructured":"Esser, S., Lampugnani, M. G., Corada, M., Dejana, E. & Risau, W. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J. Cell Sci. 111, 1853\u20131865 (1998).","journal-title":"J. Cell Sci."},{"key":"147_CR24","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1084\/jem.20111343","volume":"209","author":"Z Sun","year":"2012","unstructured":"Sun, Z. et al. VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J. Exp. Med. 209, 1363\u20131377 (2012).","journal-title":"J. Exp. Med."},{"key":"147_CR25","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1083\/jcb.200209019","volume":"161","author":"M Grazia Lampugnani","year":"2003","unstructured":"Grazia Lampugnani, M. et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1\/CD148. J. Cell Biol. 161, 793\u2013804 (2003).","journal-title":"J. Cell Biol."},{"key":"147_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1086\/303019","volume":"67","author":"A Irrthum","year":"2000","unstructured":"Irrthum, A., Karkkainen, M. J., Devriendt, K., Alitalo, K. & Vikkula, M. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. Am. J. Hum. Genet. 67, 295\u2013301 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"147_CR27","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/75997","volume":"25","author":"MJ Karkkainen","year":"2000","unstructured":"Karkkainen, M. J. et al. Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nat. Genet. 25, 153\u2013159 (2000).","journal-title":"Nat. Genet."},{"key":"147_CR28","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1242\/dev.137901","volume":"143","author":"M Shin","year":"2016","unstructured":"Shin, M. et al. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development 143, 3785\u20133795 (2016).","journal-title":"Development"},{"key":"147_CR29","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nature09002","volume":"465","author":"Y Wang","year":"2010","unstructured":"Wang, Y. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465, 483\u2013486 (2010).","journal-title":"Nature"},{"key":"147_CR30","doi-asserted-by":"publisher","first-page":"e39558","DOI":"10.1371\/journal.pone.0039558","volume":"7","author":"S Coso","year":"2012","unstructured":"Coso, S., Zeng, Y., Opeskin, K. & Williams, E. D. Vascular endothelial growth factor receptor-3 directly interacts with phosphatidylinositol 3-kinase to regulate lymphangiogenesis. PLoS ONE 7, e39558 (2012).","journal-title":"PLoS ONE"},{"key":"147_CR31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1161\/ATVBAHA.114.304881","volume":"35","author":"Y Deng","year":"2015","unstructured":"Deng, Y., Zhang, X. & Simons, M. Molecular controls of lymphatic VEGFR3 signaling. Arterioscler. Thromb. Vasc. Biol. 35, 421\u2013429 (2015).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"147_CR32","doi-asserted-by":"publisher","first-page":"e74686","DOI":"10.1371\/journal.pone.0074686","volume":"8","author":"MT Dellinger","year":"2013","unstructured":"Dellinger, M. T., Meadows, S. M., Wynne, K., Cleaver, O. & Brekken, R. A. Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS ONE 8, e74686 (2013).","journal-title":"PLoS ONE"},{"key":"147_CR33","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1161\/CIRCRESAHA.116.310477","volume":"120","author":"K Heinolainen","year":"2017","unstructured":"Heinolainen, K. et al. VEGFR3 modulates vascular permeability by controlling VEGF\/VEGFR2 signaling. Circ. Res. 120, 1414\u20131425 (2017).","journal-title":"Circ. Res."},{"key":"147_CR34","first-page":"213","volume":"27","author":"M Simons","year":"2012","unstructured":"Simons, M. An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda) 27, 213\u2013222 (2012).","journal-title":"Physiology (Bethesda)"},{"key":"147_CR35","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/sj.onc.1209855","volume":"26","author":"Y Wallez","year":"2007","unstructured":"Wallez, Y. et al. Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site. Oncogene 26, 1067\u20131077 (2007).","journal-title":"Oncogene"},{"key":"147_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11017","volume":"7","author":"X Li","year":"2016","unstructured":"Li, X. et al. VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nat. Commun. 7, 11017 (2016).","journal-title":"Nat. Commun."},{"key":"147_CR37","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nature08995","volume":"465","author":"S Sawamiphak","year":"2010","unstructured":"Sawamiphak, S. et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 465, 487\u2013491 (2010).","journal-title":"Nature"},{"key":"147_CR38","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/cr.2010.116","volume":"20","author":"L Zhang","year":"2010","unstructured":"Zhang, L. et al. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 20, 1319\u20131331 (2010).","journal-title":"Cell Res."},{"key":"147_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03692-0","volume":"9","author":"Y Zhang","year":"2018","unstructured":"Zhang, Y. et al. Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms. Nat. Commun. 9, 1296 (2018).","journal-title":"Nat. Commun."},{"key":"147_CR40","doi-asserted-by":"publisher","first-page":"3898","DOI":"10.1093\/emboj\/16.13.3898","volume":"16","author":"V Joukov","year":"1997","unstructured":"Joukov, V. et al. Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J. 16, 3898\u20133911 (1997).","journal-title":"EMBO J."},{"key":"147_CR41","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature09493","volume":"468","author":"BS Ding","year":"2010","unstructured":"Ding, B. S. et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 468, 310\u2013315 (2010).","journal-title":"Nature"},{"key":"147_CR42","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1161\/CIRCRESAHA.121.318852","volume":"130","author":"NR Harris","year":"2022","unstructured":"Harris, N. R. et al. VE-cadherin is required for cardiac lymphatic maintenance and signaling. Circ. Res. 130, 5\u201323 (2022).","journal-title":"Circ. Res."},{"key":"147_CR43","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1038\/ncb2331","volume":"13","author":"T Tammela","year":"2011","unstructured":"Tammela, T. et al. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat. Cell Biol. 13, 1202\u20131213 (2011).","journal-title":"Nat. Cell Biol."},{"key":"147_CR44","doi-asserted-by":"crossref","unstructured":"Karaman, S. et al. Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. J. Exp. Med. 219, e20210565 (2022).","DOI":"10.1084\/jem.20210565"},{"key":"147_CR45","doi-asserted-by":"crossref","unstructured":"Kunnapuu, J. & Jeltsch, M. Outside in and brakes off for lymphatic growth. Sci. Signal. 14, eabj5058 (2021).","DOI":"10.1126\/scisignal.abj5058"},{"key":"147_CR46","unstructured":"Herantis Pharma. Herantis announces inconclusive results from phase II study with lymfactin in breast cancer related lymphedema. https:\/\/herantis.com\/press-releases\/herantis-announces-inconclusive-results-from-phase-ii-study-with-lymfactin-in-breast-cancer-related-lymphedema\/ (2021)."},{"key":"147_CR47","doi-asserted-by":"crossref","unstructured":"Stevenson Keller 4th, T. C. et al. Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction. J. Clin. Invest. 131, e147070 (2021).","DOI":"10.1172\/JCI147070"},{"key":"147_CR48","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1038\/emboj.2011.304","volume":"30","author":"D Schulte","year":"2011","unstructured":"Schulte, D. et al. Stabilizing the VE-cadherin\u2013catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 30, 4157\u20134170 (2011).","journal-title":"EMBO J."},{"key":"147_CR49","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1016\/j.celrep.2019.07.072","volume":"28","author":"Y Yang","year":"2019","unstructured":"Yang, Y., Cha, B., Motawe, Z. Y., Srinivasan, R. S. & Scallan, J. P. VE-cadherin is required for lymphatic valve formation and maintenance. Cell Rep. 28, 2397\u20132412 (2019).","journal-title":"Cell Rep."},{"key":"147_CR50","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41586-020-2536-x","volume":"583","author":"P He","year":"2020","unstructured":"He, P. et al. The changing mouse embryo transcriptome at whole tissue and single-cell resolution. Nature 583, 760\u2013767 (2020).","journal-title":"Nature"},{"key":"147_CR51","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/s41422-020-0378-6","volume":"30","author":"X Wang","year":"2020","unstructured":"Wang, X. et al. Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level. Cell Res. 30, 1109\u20131126 (2020).","journal-title":"Cell Res."},{"key":"147_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28775-x","volume":"13","author":"Y Liu","year":"2022","unstructured":"Liu, Y. et al. A specialized bone marrow microenvironment for fetal haematopoiesis. Nat. Commun. 13, 1327 (2022).","journal-title":"Nat. Commun."},{"key":"147_CR53","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587 (2021).","journal-title":"Cell"},{"key":"147_CR54","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","volume":"180","author":"J Kalucka","year":"2020","unstructured":"Kalucka, J. et al. Single-cell transcriptome atlas of murine endothelial cells. Cell 180, 764\u2013779 (2020).","journal-title":"Cell"}],"container-title":["Nature Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s44161-022-00147-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-022-00147-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-022-00147-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:39:35Z","timestamp":1728347975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s44161-022-00147-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["147"],"URL":"https:\/\/doi.org\/10.1038\/s44161-022-00147-0","relation":{},"ISSN":["2731-0590"],"issn-type":[{"value":"2731-0590","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,11]]},"assertion":[{"value":"6 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}