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L.S.E. is now an employee of Celgene\/Bristol Myers Squibb. Celgene\/Bristol Myers Squibb had no role in the funding, design, conduct or interpretation of this study. N.O.S. has received research funding from Regeneron Pharmaceuticals, unrelated to this work. K.A.V.-M. is an employee at Illumina. R.W.K. is an employee at Psomagen. R. Mehran reports institutional research grants from Abbott Laboratories, Abiomed, Applied Therapeutics, AstraZeneca, Bayer, Beth Israel Deaconess, Bristol Myers Squibb, CERC, Chiesi, Concept Medical, CSL Behring, DSI, Medtronic, Novartis Pharmaceuticals and OrbusNeich; consultant fees from Abbott Laboratories, Boston Scientific, CardiaWave, Chiesi, Janssen Scientific Affairs, Medscape\/WebMD, Medtelligence (Janssen Scientific Affairs), Roivant Sciences, Sanofi and Siemens Medical Solutions; consultant fees paid to the institution from Abbott Laboratories and Bristol Myers Squibb; advisory board fees paid to the institution from Spectranetics\/Philips\/Volcano Corp.; consultant fees (spouse) from Abiomed, The Medicines Company and Merck; equity <1% from Claret Medical and Elixir Medical; DSMB membership fees paid to the institution from Watermark Research Partners; consulting (no fee) from Idorsia Pharmaceuticals and Regeneron Pharmaceuticals; and Associate Editor for American College of Cardiology (ACC) and American Medical Association (AMA). R. Malhotra is a consultant for MyoKardia (now owned by Bristol Myers Squibb), Epizon Pharma, Renovacor and Third Pole; is a co-founder of Patch and Angea Biotherapeutics; and has received research funding from Angea Biotherapeutics, Bayer Pharmaceuticals and Amgen. A.M.S. receives funding from Seven Bridges Genomics to develop tools for the NHLBI BioData Catalyst consortium. P.N. reports grants from Amgen, Apple, Boston Scientific, AstraZeneca, Allelica, Novartis and Genentech; consulting income from GV, Blackstone Life Sciences, Foresite Labs, Apple, AstraZeneca, Allelica, Novartis, HeartFlow and Genentech; being a scientific advisor to Esperion Therapeutics, Preciseli and TenSixteen Bio; being a scientific co-founder of TenSixteen Bio; and spousal employment at Vertex, all unrelated to the present work. C.L.M. received a research grant from AstraZeneca for an unrelated project. The remaining authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}