{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:06:51Z","timestamp":1784311611694,"version":"3.55.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cardiovasc Res"],"DOI":"10.1038\/s44161-024-00530-z","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:02:59Z","timestamp":1724824979000},"page":"1140-1157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5492-5650","authenticated-orcid":false,"given":"Lucie","family":"Boulgakoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sturny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Olejnickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sedmera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-5914","authenticated-orcid":false,"given":"Lucile","family":"Miquerol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"530_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo, S. E. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433\u2013436 (2013).","journal-title":"Nature"},{"key":"530_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrcardio.2015.193","volume":"13","author":"M Haissaguerre","year":"2016","unstructured":"Haissaguerre, M., Vigmond, E., Stuyvers, B., Hocini, M. & Bernus, O. Ventricular arrhythmias and the His-Purkinje system. Nat. Rev. Cardiol. 13, 155\u2013166 (2016).","journal-title":"Nat. Rev. Cardiol."},{"key":"530_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1161\/CIRCRESAHA.110.218156","volume":"107","author":"L Miquerol","year":"2010","unstructured":"Miquerol, L. et al. Biphasic development of the mammalian ventricular conduction system. Circ. Res. 107, 153\u2013161 (2010).","journal-title":"Circ. Res."},{"key":"530_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cardiores.2004.03.007","volume":"63","author":"L Miquerol","year":"2004","unstructured":"Miquerol, L. et al. Architectural and functional asymmetry of the His-Purkinje system of the murine heart. Cardiovasc. Res. 63, 77\u201386 (2004).","journal-title":"Cardiovasc. Res."},{"key":"530_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19150-9","volume":"11","author":"C Choquet","year":"2020","unstructured":"Choquet, C., Kelly, R. G. & Miquerol, L. Nkx2-5 defines distinct scaffold and recruitment phases during formation of the murine cardiac Purkinje fiber network. Nat. Commun. 11, 5300 (2020).","journal-title":"Nat. Commun."},{"key":"530_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/aja.1002040403","volume":"204","author":"B Delorme","year":"1995","unstructured":"Delorme, B. et al. Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev. Dyn. 204, 358\u2013371 (1995).","journal-title":"Dev. Dyn."},{"key":"530_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00118-1","volume":"8","author":"X Tian","year":"2017","unstructured":"Tian, X. et al. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat. Commun. 8, 87 (2017).","journal-title":"Nat. Commun."},{"key":"530_CR8","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1126\/science.1077857","volume":"298","author":"KD Poss","year":"2002","unstructured":"Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Science 298, 2188\u20132190 (2002).","journal-title":"Science"},{"key":"530_CR9","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/bies.950180714","volume":"18","author":"D Sedmera","year":"1996","unstructured":"Sedmera, D. & Thomas, P. S. Trabeculation in the embryonic heart. BioEssays 18, 607\u2013607 (1996).","journal-title":"BioEssays"},{"key":"530_CR10","doi-asserted-by":"publisher","first-page":"966","DOI":"10.18632\/aging.100526","volume":"4","author":"BJ Haubner","year":"2012","unstructured":"Haubner, B. J. et al. Complete cardiac regeneration in a mouse model of myocardial infarction. Aging 4, 966\u2013977 (2012).","journal-title":"Aging"},{"key":"530_CR11","first-page":"315","volume":"58","author":"B Emde","year":"2014","unstructured":"Emde, B., Heinen, A., G\u00f6decke, A. & Bottermann, K. Wheat germ agglutinin staining as a suitable method for detection and quantification of fibrosis in cardiac tissue after myocardial infarction. Eur. J. Histochem. 58, 315\u2013319 (2014).","journal-title":"Eur. J. Histochem."},{"key":"530_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1073\/pnas.1208863110","volume":"110","author":"ER Porrello","year":"2013","unstructured":"Porrello, E. R. et al. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc. Natl Acad. Sci. USA 110, 187\u2013192 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"530_CR13","doi-asserted-by":"publisher","first-page":"18455","DOI":"10.1073\/pnas.1905824116","volume":"116","author":"Z Wang","year":"2019","unstructured":"Wang, Z. et al. Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling. Proc. Natl Acad. Sci. USA 116, 18455\u201318465 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"530_CR14","doi-asserted-by":"publisher","first-page":"E12245","DOI":"10.1073\/pnas.1805829115","volume":"115","author":"K Kretzschmar","year":"2018","unstructured":"Kretzschmar, K. et al. Profiling proliferative cells and their progeny in damaged murine hearts. Proc. Natl Acad. Sci. USA 115, E12245\u2013E12254 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"530_CR15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1161\/CIRCEP.109.928820","volume":"3","author":"BA Pallante","year":"2010","unstructured":"Pallante, B. A. et al. Contactin-2 expression in the cardiac Purkinje fiber network. Circ. Arrhythmia Electrophysiol. 3, 186\u2013194 (2010).","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"530_CR16","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1161\/01.RES.74.5.839","volume":"74","author":"D Gros","year":"1994","unstructured":"Gros, D. et al. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Circ. Res. 74, 839\u2013851 (1994).","journal-title":"Circ. Res."},{"key":"530_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ydbio.2021.07.005","volume":"478","author":"PC Kahr","year":"2021","unstructured":"Kahr, P. C. et al. A novel transgenic Cre allele to label mouse cardiac conduction system: cardiac conduction system mouse model. Dev. Biol. 478, 163\u2013172 (2021).","journal-title":"Dev. Biol."},{"key":"530_CR18","doi-asserted-by":"publisher","first-page":"4444","DOI":"10.1172\/JCI87968","volume":"126","author":"A Shekhar","year":"2016","unstructured":"Shekhar, A. et al. Transcription factor ETV1 is essential for rapid conduction in the heart. J. Clin. Invest. 126, 4444\u20134459 (2016).","journal-title":"J. Clin. Invest."},{"key":"530_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"KH Kim","year":"2016","unstructured":"Kim, K. H. et al. Irx3 is required for postnatal maturation of the mouse ventricular conduction system. Sci. Rep. 6, 1\u201314 (2016).","journal-title":"Sci. Rep."},{"key":"530_CR20","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1161\/CIRCRESAHA.118.314578","volume":"125","author":"WR Goodyer","year":"2019","unstructured":"Goodyer, W. R. et al. Transcriptomic profiling of the developing cardiac conduction system at single-cell resolution. Circ. Res. 125, 379\u2013397 (2019).","journal-title":"Circ. Res."},{"key":"530_CR21","doi-asserted-by":"publisher","first-page":"dev199431","DOI":"10.1242\/dev.199431","volume":"148","author":"C Delgado","year":"2021","unstructured":"Delgado, C. et al. Neural cell adhesion molecule is required for ventricular conduction system development. Dev. 148, dev199431 (2021).","journal-title":"Dev."},{"key":"530_CR22","first-page":"11509","volume":"1867","author":"VWW van Eif","year":"2020","unstructured":"van Eif, V. W. W., Stefanovic, S., Mohan, R. A. & Christoffels, V. M. Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression. Biochim. Biophys. Acta Mol. Cell Res. 1867, 11509 (2020).","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"530_CR23","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1161\/CIRCRESAHA.113.301588","volume":"113","author":"X Liang","year":"2013","unstructured":"Liang, X. et al. HCN4 dynamically marks the first heart field and conduction system precursors. Circ. Res. 113, 399\u2013407 (2013).","journal-title":"Circ. Res."},{"key":"530_CR24","first-page":"1","volume":"8","author":"Y Li","year":"2018","unstructured":"Li, Y. et al. Genetic targeting of Purkinje fibres by Sema3a-CreERT2. Sci Rep. 8, 1\u20139 (2018).","journal-title":"Sci Rep."},{"key":"530_CR25","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.ydbio.2006.12.044","volume":"303","author":"S Meysen","year":"2007","unstructured":"Meysen, S. et al. Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system. Dev. Biol. 303, 740\u2013753 (2007).","journal-title":"Dev. Biol."},{"key":"530_CR26","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1172\/JCI19846","volume":"113","author":"PY Jay","year":"2004","unstructured":"Jay, P. Y. et al. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J. Clin. Invest. 113, 1130\u20131137 (2004).","journal-title":"J. Clin. Invest."},{"key":"530_CR27","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1002\/dvdy.22650","volume":"240","author":"D Sedmera","year":"2011","unstructured":"Sedmera, D. & Thompson, R. P. Myocyte proliferation in the developing heart. Dev. Dyn. 240, 1322\u20131334 (2011).","journal-title":"Dev. Dyn."},{"key":"530_CR28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ydbio.2012.05.001","volume":"368","author":"BA de Boer","year":"2012","unstructured":"de Boer, B. A., van den Berg, G., de Boer, P. A. J., Moorman, A. F. M. & Ruijter, J. M. Growth of the developing mouse heart: An interactive qualitative and quantitative 3D atlas. Dev. Biol. 368, 203\u2013213 (2012).","journal-title":"Dev. Biol."},{"key":"530_CR29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0040-8166(74)90037-8","volume":"6","author":"CE Challice","year":"1973","unstructured":"Challice, C. E. & Vir\u00e1gh, S. The architectural development of the early mammalian heart. Tissue Cell 6, 447\u2013462 (1973).","journal-title":"Tissue Cell"},{"key":"530_CR30","doi-asserted-by":"publisher","unstructured":"Liu, X. et al. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle. Nature https:\/\/doi.org\/10.1038\/s41467-021-25933-5 (2021).","DOI":"10.1038\/s41467-021-25933-5"},{"key":"530_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02650-6","volume":"9","author":"H S\u00e1nchez-Iranzo","year":"2018","unstructured":"S\u00e1nchez-Iranzo, H. et al. Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nat. Commun. 9, 428 (2018).","journal-title":"Nat. Commun."},{"key":"530_CR32","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.devcel.2020.02.019","volume":"53","author":"M Cui","year":"2020","unstructured":"Cui, M. et al. Dynamic transcriptional responses to injury of regenerative and non-regenerative cardiomyocytes revealed by single-nucleus RNA sequencing. Dev. Cell 53, 102\u2013116.e8 (2020).","journal-title":"Dev. Cell"},{"key":"530_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-25653-w","volume":"12","author":"M Cui","year":"2021","unstructured":"Cui, M. et al. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nat. Commun. 12, 1\u201315 (2021).","journal-title":"Nat. Commun."},{"key":"530_CR34","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1242\/dev.147827","volume":"144","author":"Q Xiao","year":"2017","unstructured":"Xiao, Q. et al. A p53-based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration. Dev. 144, 580\u2013589 (2017).","journal-title":"Dev."},{"key":"530_CR35","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature14582","volume":"523","author":"W Kimura","year":"2015","unstructured":"Kimura, W. et al. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature 523, 226\u2013230 (2015).","journal-title":"Nature"},{"key":"530_CR36","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/ncb3149","volume":"17","author":"GD Uva","year":"2015","unstructured":"Uva, G. D. et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat. Cell Biol. 17, 627\u2013638 (2015).","journal-title":"Nat. Cell Biol."},{"key":"530_CR37","doi-asserted-by":"publisher","first-page":"e001320","DOI":"10.1161\/JAHA.114.001320","volume":"4","author":"T Konfino","year":"2015","unstructured":"Konfino, T., Landa, N., Ben-Mordechai, T. & Leor, J. The type of injury dictates the mode of repair in neonatal and adult heart. J. Am. Heart Assoc. 4, e001320 (2015).","journal-title":"J. Am. Heart Assoc."},{"key":"530_CR38","first-page":"1","volume":"2015","author":"M Gemberling","year":"2015","unstructured":"Gemberling, M., Karra, R., Dickson, A. L. & Poss, K. D. Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. eLife 2015, 1\u201317 (2015).","journal-title":"eLife"},{"key":"530_CR39","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1073\/pnas.1311705111","volume":"111","author":"L Zhao","year":"2014","unstructured":"Zhao, L. et al. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc. Natl Acad. Sci. USA 111, 1403\u20131408 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"530_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.50163","volume":"8","author":"H Honkoop","year":"2019","unstructured":"Honkoop, H. et al. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLife 8, 1\u201327 (2019).","journal-title":"eLife"},{"key":"530_CR41","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","volume":"138","author":"K Bersell","year":"2009","unstructured":"Bersell, K., Arab, S., Haring, B. & K\u00fchn, B. Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138, 257\u2013270 (2009).","journal-title":"Cell"},{"key":"530_CR42","doi-asserted-by":"publisher","first-page":"dev200654","DOI":"10.1242\/dev.200654","volume":"149","author":"P DeBenedittis","year":"2022","unstructured":"DeBenedittis, P. et al. Coupled myovascular expansion directs cardiac growth and regeneration. Development 149, dev200654 (2022).","journal-title":"Development"},{"key":"530_CR43","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nature08804","volume":"464","author":"K Kikuchi","year":"2010","unstructured":"Kikuchi, K. et al. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature 464, 601\u2013605 (2010).","journal-title":"Nature"},{"key":"530_CR44","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1161\/CIRCULATIONAHA.118.038944","volume":"140","author":"K van Duijvenboden","year":"2019","unstructured":"van Duijvenboden, K. et al. Conserved NPPB+ border zone switches from MEF2- to AP-1-driven gene program. Circulation 140, 864\u2013879 (2019).","journal-title":"Circulation"},{"key":"530_CR45","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/cvr\/cvt228","volume":"101","author":"IA Sergeeva","year":"2014","unstructured":"Sergeeva, I. A. et al. A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease. Cardiovasc. Res. 101, 78\u201386 (2014).","journal-title":"Cardiovasc. Res."},{"key":"530_CR46","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1161\/01.RES.33.5.597","volume":"33","author":"PL Friedman","year":"1973","unstructured":"Friedman, P. L., Stewart, J. R., Fenoglio, J. J. & Wit, A. L. Survival of subendocardial Purkinje fibers after extensive myocardial infarction in dogs. In vitro and in vivo correlations. Circ. Res. 33, 597\u2013611 (1973).","journal-title":"Circ. Res."},{"key":"530_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0212096","volume":"14","author":"V Garcia-Bustos","year":"2019","unstructured":"Garcia-Bustos, V. et al. Changes in the spatial distribution of the Purkinje network after acute myocardial infarction in the pig. PLoS ONE 14, 1\u201317 (2019).","journal-title":"PLoS ONE"},{"key":"530_CR48","first-page":"1","volume":"9","author":"H Wang","year":"2022","unstructured":"Wang, H. et al. Electrophysiologic conservation of epicardial conduction dynamics after myocardial infarction and natural heart regeneration in newborn piglets. Front. Cardiovasc. Med. 9, 1\u201310 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"530_CR49","first-page":"161","volume":"10","author":"H Watanabe","year":"2023","unstructured":"Watanabe, H. et al. Purkinje cardiomyocytes of the adult ventricular conduction system are highly diploid but not uniquely regenerative. J. Cardiovasc. Dev. Dis. 10, 161 (2023).","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"530_CR50","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCULATIONAHA.112.103390","volume":"126","author":"S Rentschler","year":"2012","unstructured":"Rentschler, S. et al. Myocardial notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation 126, 1058\u20131066 (2012).","journal-title":"Circulation"},{"key":"530_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ydbio.2014.12.018","volume":"399","author":"A Darehzereshki","year":"2015","unstructured":"Darehzereshki, A. et al. Differential regenerative capacity of neonatal mouse hearts after cryoinjury. Dev. Biol. 399, 91\u201399 (2015).","journal-title":"Dev. Biol."},{"key":"530_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-016-0580-3","volume":"111","author":"BJ Haubner","year":"2016","unstructured":"Haubner, B. J., Schuetz, T. & Penninger, J. M. A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Res. Cardiol. 111, 1\u201310 (2016).","journal-title":"Basic Res. Cardiol."},{"key":"530_CR53","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello, E. R. et al. Transient regeneration potential of the neonatal mouse heart. Science 331, 1078\u20131080 (2011).","journal-title":"Science"},{"key":"530_CR54","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s002469900133","volume":"18","author":"DM Saker","year":"1997","unstructured":"Saker, D. M., Walsh-Sukys, M., Spector, M. & Zahka, K. G. Cardiac recovery and survival after neonatal myocardial infarction. Pediatr. Cardiol. 18, 139\u2013142 (1997).","journal-title":"Pediatr. Cardiol."},{"key":"530_CR55","first-page":"194","volume":"10","author":"C Choquet","year":"2023","unstructured":"Choquet, C. et al. Nkx2-5 loss of function in the His-Purkinje system hampers its maturation and leads to mechanical dysfunction. J Cardiovasc. Dev. Dis. 10, 194 (2023).","journal-title":"J Cardiovasc. Dev. Dis."},{"key":"530_CR56","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1016\/j.jacc.2016.08.064","volume":"68","author":"P Maury","year":"2016","unstructured":"Maury, P. et al. Cardiac phenotype and long-term follow-up of patients with mutations in NKX2-5 gene. J. Am. Coll. Cardiol. 68, 2389\u20132390 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"key":"530_CR57","first-page":"E007505","volume":"14","author":"SJRJ Logantha","year":"2021","unstructured":"Logantha, S. J. R. J. et al. Remodeling of the Purkinje network in congestive heart failure in the rabbit. Circ. Hear. Fail. 14, E007505 (2021).","journal-title":"Circ. Hear. Fail."},{"key":"530_CR58","doi-asserted-by":"publisher","first-page":"H1712","DOI":"10.1152\/ajpheart.00621.2011","volume":"302","author":"BS Harris","year":"2012","unstructured":"Harris, B. S. et al. Remodeling of the peripheral cardiac conduction system in response to pressure overload. AJP Hear. Circ. Physiol. 302, H1712\u2013H1725 (2012).","journal-title":"AJP Hear. Circ. Physiol."},{"key":"530_CR59","first-page":"1","volume":"2016","author":"JN Blom","year":"2016","unstructured":"Blom, J. N., Lu, X., Arnold, P. & Feng, Q. Myocardial infarction in neonatal mice, a model of cardiac regeneration. J. Vis. Exp. 2016, 1\u201312 (2016).","journal-title":"J. Vis. Exp."},{"key":"530_CR60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/dvg.20687","volume":"49","author":"S Beyer","year":"2011","unstructured":"Beyer, S., Kelly, R. G. & Miquerol, L. Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells. Genesis 49, 83\u201391 (2011).","journal-title":"Genesis"},{"key":"530_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-213X-1-4","volume":"1","author":"S Srinivas","year":"2001","unstructured":"Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 1\u20138 (2001).","journal-title":"BMC Dev. Biol"},{"key":"530_CR62","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nn.2467","volume":"13","author":"L Madisen","year":"2010","unstructured":"Madisen, L. et al. A robust and high-throughput Cre reporting and characterization. Nat. Neurosci. 13, 133\u2013140 (2010).","journal-title":"Nat. Neurosci."},{"key":"530_CR63","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cell.2010.09.016","volume":"143","author":"HJ Snippert","year":"2010","unstructured":"Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134\u2013144 (2010).","journal-title":"Cell"},{"key":"530_CR64","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1242\/dev.126.15.3437","volume":"126","author":"Y Saga","year":"1999","unstructured":"Saga, Y. et al. MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development 126, 3437\u20133447 (1999).","journal-title":"Development"},{"key":"530_CR65","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1242\/dev.126.6.1269","volume":"126","author":"M Tanaka","year":"1999","unstructured":"Tanaka, M., Chen, Z., Bartunkova, S., Yamasaki, N. & Izumo, S. The cardiac homeobox gene Csx\/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126, 1269\u20131280 (1999).","journal-title":"Development"},{"key":"530_CR66","doi-asserted-by":"publisher","first-page":"D766","DOI":"10.1093\/nar\/gky955","volume":"47","author":"A Frankish","year":"2019","unstructured":"Frankish, A. et al. GENCODE reference annotation for the human and mouse genomes. Nucleic Acids Res. 47, D766\u2013D773 (2019).","journal-title":"Nucleic Acids Res."},{"key":"530_CR67","doi-asserted-by":"crossref","first-page":"D682","DOI":"10.1093\/nar\/gkz1138","volume":"48","author":"AD Yates","year":"2020","unstructured":"Yates, A. D. et al. Ensembl 2020. Nucleic Acids Res. 48, D682\u2013D688 (2020).","journal-title":"Nucleic Acids Res."},{"key":"530_CR68","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1093\/bioinformatics\/btr011","volume":"27","author":"G Mar\u00e7ais","year":"2011","unstructured":"Mar\u00e7ais, G. & Kingsford, C. A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Bioinformatics 27, 764\u2013770 (2011).","journal-title":"Bioinformatics"},{"key":"530_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn301","volume":"36","author":"JD Gans","year":"2008","unstructured":"Gans, J. D. & Wolinsky, M. Improved assay-dependent searching of nucleic acid sequence databases. Nucleic Acids Res. 36, 1\u20135 (2008).","journal-title":"Nucleic Acids Res."},{"key":"530_CR70","doi-asserted-by":"publisher","first-page":"D213","DOI":"10.1093\/nar\/gkx997","volume":"46","author":"JM Rodriguez","year":"2018","unstructured":"Rodriguez, J. M. et al. APPRIS 2017: principal isoforms for multiple gene sets. Nucleic Acids Res. 46, D213\u2013D217 (2018).","journal-title":"Nucleic Acids Res."},{"key":"530_CR71","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/s41592-023-01938-4","volume":"20","author":"C Bravo Gonz\u00e1lez-Blas","year":"2023","unstructured":"Bravo Gonz\u00e1lez-Blas, C. et al. SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks. Nat. Methods 20, 1355\u20131367 (2023).","journal-title":"Nat. Methods"},{"key":"530_CR72","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/cvr\/cvt076","volume":"98","author":"AJ De La Rosa","year":"2013","unstructured":"De La Rosa, A. J. et al. Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis. Cardiovasc. Res. 98, 504\u2013514 (2013).","journal-title":"Cardiovasc. Res."},{"key":"530_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.isci.2021.102387","volume":"24","author":"H Kolesov\u00e1","year":"2021","unstructured":"Kolesov\u00e1, H., Olejn\u00ed\u010dkov\u00e1, V., Kvasilov\u00e1, A., Gregorovi\u010dov\u00e1, M. & Sedmera, D. Tissue clearing and imaging methods for cardiovascular development. iScience 24, 1\u201325 (2021).","journal-title":"iScience"},{"key":"530_CR74","doi-asserted-by":"publisher","unstructured":"Boulgakoff, L. & Miquerol, L. Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells. Zenodo https:\/\/doi.org\/10.5281\/zenodo.12773891 (2024).","DOI":"10.5281\/zenodo.12773891"}],"updated-by":[{"DOI":"10.1038\/s44161-024-00548-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000}}],"container-title":["Nature Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00530-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00530-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00530-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:05:37Z","timestamp":1730811937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00530-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":74,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["530"],"URL":"https:\/\/doi.org\/10.1038\/s44161-024-00530-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3615267\/v1","asserted-by":"object"}]},"ISSN":["2731-0590"],"issn-type":[{"value":"2731-0590","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"15 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s44161-024-00548-3","URL":"https:\/\/doi.org\/10.1038\/s44161-024-00548-3","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}