{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:55:20Z","timestamp":1785819320927,"version":"3.56.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL147947"],"award-info":[{"award-number":["R01HL147947"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F31HL163924"],"award-info":[{"award-number":["F31HL163924"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cardiovasc Res"],"DOI":"10.1038\/s44161-024-00562-5","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:07:01Z","timestamp":1732079221000},"page":"1468-1481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intrinsic GATA4 expression sensitizes the aortic root to dilation in a Loeys\u2013Dietz syndrome mouse model"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-9506","authenticated-orcid":false,"given":"Emily E.","family":"Bramel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Espinoza Camejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.","family":"Creamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-3752","authenticated-orcid":false,"given":"Leda","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzna","family":"Saqib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rustam","family":"Bagirzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2244-7256","authenticated-orcid":false,"given":"Anthony","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-9692","authenticated-orcid":false,"given":"Jacob T.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve L.","family":"Stein-O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-5980","authenticated-orcid":false,"given":"Albert J.","family":"Pedroza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Fischbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-0165","authenticated-orcid":false,"given":"Harry C.","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-6842","authenticated-orcid":false,"given":"Elena","family":"Gallo MacFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"562_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41569-022-00763-0","volume":"20","author":"E Chou","year":"2023","unstructured":"Chou, E., Pirruccello, J. P., Ellinor, P. T. & Lindsay, M. E. Genetics and mechanisms of thoracic aortic disease. Nat. Rev. Cardiol. 20, 168\u2013180 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"562_CR2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/gim.2014.11","volume":"16","author":"G MacCarrick","year":"2014","unstructured":"MacCarrick, G. et al. Loeys\u2013Dietz syndrome: a primer for diagnosis and management. Genet. Med. 16, 576\u2013587 (2014).","journal-title":"Genet. Med."},{"key":"562_CR3","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ng1511","volume":"37","author":"BL Loeys","year":"2005","unstructured":"Loeys, B. L. et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat. Genet. 37, 275\u2013281 (2005).","journal-title":"Nat. Genet."},{"key":"562_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/ng.744","volume":"43","author":"IM van de Laar","year":"2011","unstructured":"van de Laar, I. M. et al. Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis. Nat. Genet. 43, 121\u2013126 (2011).","journal-title":"Nat. Genet."},{"key":"562_CR5","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/ng.2349","volume":"44","author":"ME Lindsay","year":"2012","unstructured":"Lindsay, M. E. et al. Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nat. Genet. 44, 922\u2013927 (2012).","journal-title":"Nat. Genet."},{"key":"562_CR6","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jacc.2015.01.040","volume":"65","author":"AM Bertoli-Avella","year":"2015","unstructured":"Bertoli-Avella, A. M. et al. Mutations in a TGF-beta ligand, TGFB3, cause syndromic aortic aneurysms and dissections. J. Am. Coll. Cardiol. 65, 1324\u20131336 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"key":"562_CR7","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/humu.22854","volume":"36","author":"D Micha","year":"2015","unstructured":"Micha, D. et al. SMAD2 mutations are associated with arterial aneurysms and dissections. Hum. Mutat. 36, 1145\u20131149 (2015).","journal-title":"Hum. Mutat."},{"key":"562_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1136\/jmedgenet-2011-100382","volume":"49","author":"IM van de Laar","year":"2012","unstructured":"van de Laar, I. M. et al. Phenotypic spectrum of the SMAD3-related aneurysms-osteoarthritis syndrome. J. Med. Genet. 49, 47\u201357 (2012).","journal-title":"J. Med. Genet."},{"key":"562_CR9","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1172\/JCI69666","volume":"124","author":"EM Gallo","year":"2014","unstructured":"Gallo, E. M. et al. Angiotensin II-dependent TGF-\u03b2 signaling contributes to Loeys\u2013Dietz syndrome vascular pathogenesis. J. Clin. Invest. 124, 448\u2013460 (2014).","journal-title":"J. Clin. Invest."},{"key":"562_CR10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1172\/JCI123547","volume":"129","author":"EG MacFarlane","year":"2019","unstructured":"MacFarlane, E. G. et al. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys\u2013Dietz syndrome. J. Clin. Invest. 129, 659\u2013675 (2019).","journal-title":"J. Clin. Invest."},{"key":"562_CR11","doi-asserted-by":"publisher","first-page":"S757","DOI":"10.1016\/j.athoracsur.2006.10.091","volume":"83","author":"JA Williams","year":"2007","unstructured":"Williams, J. A. et al. Early surgical experience with Loeys\u2013Dietz: a new syndrome of aggressive thoracic aortic aneurysm disease. Ann. Thorac. Surg. 83, S757\u2013S763 (2007).","journal-title":"Ann. Thorac. Surg."},{"key":"562_CR12","first-page":"663","volume":"38","author":"GC Hughes","year":"2011","unstructured":"Hughes, G. C. Aggressive aortic replacement for Loeys\u2013Dietz syndrome. Tex. Heart Inst. J. 38, 663\u2013666 (2011).","journal-title":"Tex. Heart Inst. J."},{"key":"562_CR13","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.athoracsur.2017.01.053","volume":"103","author":"ND Patel","year":"2017","unstructured":"Patel, N. D. et al. Aortic root replacement for children with Loeys\u2013Dietz Syndrome. Ann. Thorac. Surg. 103, 1513\u20131518 (2017).","journal-title":"Ann. Thorac. Surg."},{"key":"562_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s10237-018-1077-9","volume":"18","author":"MR Bersi","year":"2019","unstructured":"Bersi, M. R., Bellini, C., Humphrey, J. D. & Avril, S. Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics. Biomech. Model. Mechanobiol. 18, 203\u2013218 (2019).","journal-title":"Biomech. Model. Mechanobiol."},{"key":"562_CR15","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1161\/ATVBAHA.120.313033","volume":"40","author":"J Gong","year":"2020","unstructured":"Gong, J. et al. In vitro lineage-specific differentiation of vascular smooth muscle cells in response to SMAD3 deficiency: implications for SMAD3-related thoracic aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. 40, 1651\u20131663 (2020).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"562_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1161\/CIRCULATIONAHA.118.038362","volume":"140","author":"AS Kalluri","year":"2019","unstructured":"Kalluri, A. S. et al. Single-cell analysis of the normal mouse aorta reveals functionally distinct endothelial cell populations. Circulation 140, 147\u2013163 (2019).","journal-title":"Circulation"},{"key":"562_CR17","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1093\/cvr\/cvy006","volume":"114","author":"JB Michel","year":"2018","unstructured":"Michel, J. B., Jondeau, G. & Milewicz, D. M. From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta. Cardiovasc. Res. 114, 578\u2013589 (2018).","journal-title":"Cardiovasc. Res."},{"key":"562_CR18","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"562_CR19","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","volume":"25","author":"G Bindea","year":"2009","unstructured":"Bindea, G. et al. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25, 1091\u20131093 (2009).","journal-title":"Bioinformatics"},{"key":"562_CR20","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/CIRCRESAHA.118.313105","volume":"123","author":"Y Yamashiro","year":"2018","unstructured":"Yamashiro, Y. et al. Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm in mouse and humans. Circ. Res. 123, 660\u2013672 (2018).","journal-title":"Circ. Res."},{"key":"562_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1161\/01.RES.88.1.37","volume":"88","author":"TE Bunton","year":"2001","unstructured":"Bunton, T. E. et al. Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan syndrome. Circ. Res. 88, 37\u201343 (2001).","journal-title":"Circ. Res."},{"key":"562_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.826495","volume":"9","author":"EE Bramel","year":"2022","unstructured":"Bramel, E. E. et al. Postnatal Smad3 inactivation in murine smooth muscle cells elicits a temporally and regionally distinct transcriptional response. Front. Cardiovasc. Med. 9, 826495 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"562_CR23","doi-asserted-by":"publisher","first-page":"D882","DOI":"10.1093\/nar\/gkz1062","volume":"48","author":"Y Luo","year":"2020","unstructured":"Luo, Y. et al. New developments on the Encyclopedia of DNA Elements (ENCODE) data portal. Nucleic Acids Res. 48, D882\u2013D889 (2020).","journal-title":"Nucleic Acids Res."},{"key":"562_CR24","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1093\/bioinformatics\/btq466","volume":"26","author":"A Lachmann","year":"2010","unstructured":"Lachmann, A. et al. ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. Bioinformatics 26, 2438\u20132444 (2010).","journal-title":"Bioinformatics"},{"key":"562_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90","volume":"1","author":"Z Xie","year":"2021","unstructured":"Xie, Z. et al. Gene set knowledge discovery with enrichr. Curr. Protoc. 1, e90 (2021).","journal-title":"Curr. Protoc."},{"key":"562_CR26","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1161\/ATVBAHA.112.300614","volume":"33","author":"T Ashino","year":"2013","unstructured":"Ashino, T., Yamamoto, M., Yoshida, T. & Numazawa, S. Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. Arterioscler. Thromb. Vasc. Biol. 33, 760\u2013768 (2013).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"562_CR27","doi-asserted-by":"publisher","first-page":"47658","DOI":"10.1074\/jbc.M108678200","volume":"276","author":"YH Chen","year":"2001","unstructured":"Chen, Y. H., Layne, M. D., Watanabe, M., Yet, S. F. & Perrella, M. A. Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells. J. Biol. Chem. 276, 47658\u201347663 (2001).","journal-title":"J. Biol. Chem."},{"key":"562_CR28","doi-asserted-by":"publisher","first-page":"18425","DOI":"10.1074\/jbc.M500775200","volume":"280","author":"H Sellak","year":"2005","unstructured":"Sellak, H., Choi, C., Browner, N. & Lincoln, T. M. Upstream stimulatory factors (USF-1\/USF-2) regulate human cGMP-dependent protein kinase I gene expression in vascular smooth muscle cells. J. Biol. Chem. 280, 18425\u201318433 (2005).","journal-title":"J. Biol. Chem."},{"key":"562_CR29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.omtm.2021.02.021","volume":"21","author":"Q Wang","year":"2021","unstructured":"Wang, Q. et al. A hierarchical and collaborative BRD4\/CEBPD partnership governs vascular smooth muscle cell inflammation. Mol. Ther. Methods Clin. Dev. 21, 54\u201366 (2021).","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"562_CR30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12929-014-0110-2","volume":"22","author":"CY Ko","year":"2015","unstructured":"Ko, C. Y., Chang, W. C. & Wang, J. M. Biological roles of CCAAT\/enhancer-binding protein delta during inflammation. J. Biomed. Sci. 22, 6 (2015).","journal-title":"J. Biomed. Sci."},{"key":"562_CR31","doi-asserted-by":"publisher","first-page":"7543","DOI":"10.1073\/pnas.94.14.7543","volume":"94","author":"TC Herzig","year":"1997","unstructured":"Herzig, T. C. et al. Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc. Natl Acad. Sci. USA 94, 7543\u20137548 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"562_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.936142","volume":"9","author":"EE Bramel","year":"2022","unstructured":"Bramel, E. E. et al. Distinct contribution of global and regional angiotensin II type 1a receptor inactivation to amelioration of aortopathy in Tgfbr1M318R\/+ mice. Front. Cardiovasc. Med. 9, 936142 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"562_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115938","volume":"169","author":"Q Ren","year":"2023","unstructured":"Ren, Q. et al. C\/EBP\u03b2: the structure, regulation, and its roles in inflammation-related diseases. Biomed. Pharmacother. 169, 115938 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"562_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8743","volume":"6","author":"T Mondal","year":"2015","unstructured":"Mondal, T. et al. MEG3 long noncoding RNA regulates the TGF-\u03b2 pathway genes through formation of RNA\u2013DNA triplex structures. Nat. Commun. 6, 7743 (2015).","journal-title":"Nat. Commun."},{"key":"562_CR35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00018-024-05193-4","volume":"81","author":"S Liu","year":"2024","unstructured":"Liu, S. et al. LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF. Cell. Mol. Life Sci. 81, 175 (2024).","journal-title":"Cell. Mol. Life Sci."},{"key":"562_CR36","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1161\/CIRCULATIONAHA.121.054744","volume":"144","author":"D Zhou","year":"2021","unstructured":"Zhou, D. et al. hiPSC modeling of lineage-specific smooth muscle cell defects caused by TGFBR1A230T variant, and its therapeutic implications for Loeys\u2013Dietz syndrome. Circulation 144, 1145\u20131159 (2021).","journal-title":"Circulation"},{"key":"562_CR37","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1161\/ATVBAHA.122.317381","volume":"42","author":"AJ Pedroza","year":"2022","unstructured":"Pedroza, A. J. et al. Embryologic origin influences smooth muscle cell phenotypic modulation signatures in murine marfan syndrome aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. 42, 1154\u20131168 (2022).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"562_CR38","doi-asserted-by":"publisher","first-page":"e332","DOI":"10.1016\/j.jtcvs.2023.07.023","volume":"166","author":"AJ Pedroza","year":"2023","unstructured":"Pedroza, A. J. et al. Early clinical outcomes and molecular smooth muscle cell phenotyping using a prophylactic aortic arch replacement strategy in Loeys\u2013Dietz syndrome. J. Thorac. Cardiovasc. Surg. 166, e332\u2013e376 (2023).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"562_CR39","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1038\/s41596-023-00892-x","volume":"18","author":"JAI Johnson","year":"2023","unstructured":"Johnson, J. A. I. et al. Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS. Nat. Protoc. 18, 3690\u20133731 (2023).","journal-title":"Nat. Protoc."},{"key":"562_CR40","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.1093\/bioinformatics\/btaa183","volume":"36","author":"G Sharma","year":"2020","unstructured":"Sharma, G., Colantuoni, C., Goff, L. A., Fertig, E. J. & Stein-O\u2019Brien, G. projectR: an R\/Bioconductor package for transfer learning via PCA, NMF, correlation and clustering. Bioinformatics 36, 3592\u20133593 (2020).","journal-title":"Bioinformatics"},{"key":"562_CR41","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2105-14-128","volume":"14","author":"EY Chen","year":"2013","unstructured":"Chen, E. Y. et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinf. 14, 128 (2013).","journal-title":"BMC Bioinf."},{"key":"562_CR42","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov, M. V. et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44, W90\u2013W97 (2016).","journal-title":"Nucleic Acids Res."},{"key":"562_CR43","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon, A. et al. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 1, 417\u2013425 (2015).","journal-title":"Cell Syst."},{"key":"562_CR44","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","volume":"20","author":"AS Castanza","year":"2023","unstructured":"Castanza, A. S. et al. Extending support for mouse data in the Molecular Signatures Database (MSigDB). Nat. Methods 20, 1619\u20131620 (2023).","journal-title":"Nat. Methods"},{"key":"562_CR45","doi-asserted-by":"publisher","unstructured":"Korbecki, J., Maruszewska, A., Bosiacki, M., Chlubek, D. & Baranowska-Bosiacka, I. The potential importance of CXCL1 in the physiological state and in noncancer diseases of the cardiovascular system, respiratory system and skin. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms24010205 (2022).","DOI":"10.3390\/ijms24010205"},{"key":"562_CR46","doi-asserted-by":"publisher","first-page":"933","DOI":"10.18632\/aging.202204","volume":"13","author":"Y Shen","year":"2020","unstructured":"Shen, Y. et al. IRF-1 contributes to the pathological phenotype of VSMCs during atherogenesis by increasing CCL19 transcription. Aging 13, 933\u2013943 (2020).","journal-title":"Aging"},{"key":"562_CR47","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5612","volume":"349","author":"C Kang","year":"2015","unstructured":"Kang, C. et al. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349, aaa5612 (2015).","journal-title":"Science"},{"key":"562_CR48","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1161\/ATVBAHA.121.316600","volume":"41","author":"C Yap","year":"2021","unstructured":"Yap, C., Mieremet, A., de Vries, C. J. M., Micha, D. & de Waard, V. Six shades of vascular smooth muscle cells illuminated by KLF4 (Kruppel-like factor 4). Arterioscler. Thromb. Vasc. Biol. 41, 2693\u20132707 (2021).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"562_CR49","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1161\/CIRCRESAHA.118.314344","volume":"125","author":"K Jeong","year":"2019","unstructured":"Jeong, K. et al. Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription. Circ. Res. 125, 152\u2013166 (2019).","journal-title":"Circ. Res."},{"key":"562_CR50","doi-asserted-by":"publisher","first-page":"12573","DOI":"10.1073\/pnas.0400752101","volume":"101","author":"AJ Watt","year":"2004","unstructured":"Watt, A. J., Battle, M. A., Li, J. & Duncan, S. A. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc. Natl Acad. Sci. USA 101, 12573\u201312578 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"562_CR51","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nm1666","volume":"14","author":"A Wirth","year":"2008","unstructured":"Wirth, A. et al. G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat. Med. 14, 64\u201368 (2008).","journal-title":"Nat. Med."},{"key":"562_CR52","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1152\/physrev.00041.2008","volume":"89","author":"JE Wagenseil","year":"2009","unstructured":"Wagenseil, J. E. & Mecham, R. P. Vascular extracellular matrix and arterial mechanics. Physiol. Rev. 89, 957\u2013989 (2009).","journal-title":"Physiol. Rev."},{"key":"562_CR53","doi-asserted-by":"publisher","unstructured":"van Dorst, D. C. H. et al. Transforming growth factor-\u03b2 and the renin\u2013angiotensin system in syndromic thoracic aortic aneurysms: implications for treatment. Cardiovasc. Drugs Ther. https:\/\/doi.org\/10.1007\/s10557-020-07116-4 (2020).","DOI":"10.1007\/s10557-020-07116-4"},{"key":"562_CR54","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/ATVBAHA.124.318374","volume":"44","author":"A Daugherty","year":"2024","unstructured":"Daugherty, A., Sawada, H., Sheppard, M. B. & Lu, H. S. Angiotensinogen as a therapeutic target for cardiovascular and metabolic diseases. Arterioscler. Thromb. Vasc. Biol. 44, 1021\u20131030 (2024).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"562_CR55","doi-asserted-by":"publisher","unstructured":"Pedroza, A. J. et al. Single-cell transcriptomic profiling of vascular smooth muscle cell phenotype modulation in Marfan syndrome aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. https:\/\/doi.org\/10.1161\/ATVBAHA.120.314670 (2020).","DOI":"10.1161\/ATVBAHA.120.314670"},{"key":"562_CR56","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1161\/ATVBAHA.118.311727","volume":"39","author":"M Clement","year":"2019","unstructured":"Clement, M. et al. Vascular smooth muscle cell plasticity and autophagy in dissecting aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 39, 1149\u20131159 (2019).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"562_CR57","doi-asserted-by":"publisher","first-page":"23807","DOI":"10.1074\/jbc.M302719200","volume":"278","author":"S Pikkarainen","year":"2003","unstructured":"Pikkarainen, S. et al. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. J. Biol. Chem. 278, 23807\u201323816 (2003).","journal-title":"J. Biol. Chem."},{"key":"562_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03394-7","volume":"9","author":"CL Lino Cardenas","year":"2018","unstructured":"Lino Cardenas, C. L. et al. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat. Commun. 9, 1009 (2018).","journal-title":"Nat. Commun."},{"key":"562_CR59","first-page":"343","volume":"156","author":"YQ Wang","year":"2018","unstructured":"Wang, Y. Q., Batool, A., Chen, S. R. & Liu, Y. X. GATA4 is a negative regulator of contractility in mouse testicular peritubular myoid cells. Reproduction 156, 343\u2013351 (2018).","journal-title":"Reproduction"},{"key":"562_CR60","doi-asserted-by":"publisher","unstructured":"Smith, J. D., Chen, J. Z., Phillips, R., Daugherty, A. & Sheppard, M. B. Losartan Increases Survival of the Fbn1mgR\/mgR mouse model of Marfan syndrome in an age-dependent manner. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2021.02.19.429438 (2021).","DOI":"10.1101\/2021.02.19.429438"},{"key":"562_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15481","volume":"8","author":"B Yang","year":"2017","unstructured":"Yang, B. et al. Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat. Commun. 8, 15481 (2017).","journal-title":"Nat. Commun."},{"key":"562_CR62","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature01827","volume":"424","author":"V Garg","year":"2003","unstructured":"Garg, V. et al. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424, 443\u2013447 (2003).","journal-title":"Nature"},{"key":"562_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/srep36776","volume":"6","author":"D Lepage","year":"2016","unstructured":"Lepage, D. et al. Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Sci. Rep. 6, 36776 (2016).","journal-title":"Sci. Rep."},{"key":"562_CR64","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/B978-0-12-387786-4.00005-1","volume":"100","author":"P Zhou","year":"2012","unstructured":"Zhou, P., He, A. & Pu, W. T. Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Curr. Top. Dev. Biol. 100, 143\u2013169 (2012).","journal-title":"Curr. Top. Dev. Biol."},{"key":"562_CR65","doi-asserted-by":"publisher","unstructured":"Bramel, E. E. MERFISH data for thoracic aorta of control and Loeys\u2013Dietz syndrome mice. V1. Harvard Dataverse https:\/\/doi.org\/10.7910\/DVN\/KZWIFX (2024).","DOI":"10.7910\/DVN\/KZWIFX"}],"container-title":["Nature Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00562-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00562-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00562-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:58:58Z","timestamp":1733943538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00562-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":65,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["562"],"URL":"https:\/\/doi.org\/10.1038\/s44161-024-00562-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4420617\/v1","asserted-by":"object"}]},"ISSN":["2731-0590"],"issn-type":[{"value":"2731-0590","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"assertion":[{"value":"14 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}