{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:22:38Z","timestamp":1791015758564,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370472"],"award-info":[{"award-number":["82370472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070482"],"award-info":[{"award-number":["82070482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51927805"],"award-info":[{"award-number":["51927805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2017SHZDZX01"],"award-info":[{"award-number":["2017SHZDZX01"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cardiovasc Res"],"DOI":"10.1038\/s44161-024-00606-w","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T10:03:38Z","timestamp":1737540218000},"page":"275-292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0099-1008","authenticated-orcid":false,"given":"Jingjing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoquan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieradilijiang","family":"Abudupataer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-9335","authenticated-orcid":false,"given":"Fa-Xing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-2489","authenticated-orcid":false,"given":"Cuiping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-4193","authenticated-orcid":false,"given":"Kai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-0416","authenticated-orcid":false,"given":"Weijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"606_CR1","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1016\/j.jacc.2020.03.018","volume":"75","author":"J Barallobre-Barreiro","year":"2020","unstructured":"Barallobre-Barreiro, J. et al. Extracellular matrix in vascular disease, part 2\/4: JACC Focus Seminar. J. Am. Coll. Cardiol. 75, 2189\u20132203 (2020).","journal-title":"J. Am. Coll. Cardiol."},{"key":"606_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","volume":"18","author":"E Bossone","year":"2021","unstructured":"Bossone, E. & Eagle, K. A. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes. Nat. Rev. Cardiol. 18, 331\u2013348 (2021).","journal-title":"Nat. Rev. Cardiol."},{"key":"606_CR3","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41569-022-00763-0","volume":"20","author":"E Chou","year":"2023","unstructured":"Chou, E., Pirruccello, J. P., Ellinor, P. T. & Lindsay, M. E. Genetics and mechanisms of thoracic aortic disease. Nat. Rev. Cardiol. 20, 168\u2013180 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"606_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-med-100415-022956","volume":"68","author":"DM Milewicz","year":"2017","unstructured":"Milewicz, D. M., Prakash, S. K. & Ramirez, F. Therapeutics targeting drivers of thoracic aortic aneurysms and acute aortic dissections: insights from predisposing genes and mouse models. Annu. Rev. Med. 68, 51\u201367 (2017).","journal-title":"Annu. Rev. Med."},{"key":"606_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrcardio.2016.211","volume":"14","author":"A Verstraeten","year":"2017","unstructured":"Verstraeten, A., Luyckx, I. & Loeys, B. Aetiology and management of hereditary aortopathy. Nat. Rev. Cardiol. 14, 197\u2013208 (2017).","journal-title":"Nat. Rev. Cardiol."},{"key":"606_CR6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1161\/CIRCRESAHA.118.312439","volume":"124","author":"JH Lindeman","year":"2019","unstructured":"Lindeman, J. H. & Matsumura, J. S. Pharmacologic management of aneurysms. Circ. Res. 124, 631\u2013646 (2019).","journal-title":"Circ. Res."},{"key":"606_CR7","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","volume":"124","author":"RA Quintana","year":"2019","unstructured":"Quintana, R. A. & Taylor, W. R. Cellular mechanisms of aortic aneurysm formation. Circ. Res. 124, 607\u2013618 (2019).","journal-title":"Circ. Res."},{"key":"606_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/science.1124287","volume":"312","author":"JP Habashi","year":"2006","unstructured":"Habashi, J. P. et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312, 117\u2013121 (2006).","journal-title":"Science"},{"key":"606_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ng.3723","volume":"49","author":"A Granata","year":"2017","unstructured":"Granata, A. et al. An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Nat. Genet. 49, 97\u2013109 (2017).","journal-title":"Nat. Genet."},{"key":"606_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11389-1","volume":"10","author":"GK Schwaerzer","year":"2019","unstructured":"Schwaerzer, G. K. et al. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat. Commun. 10, 3533 (2019).","journal-title":"Nat. Commun."},{"key":"606_CR11","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1038\/s41588-023-01510-y","volume":"55","author":"T Roychowdhury","year":"2023","unstructured":"Roychowdhury, T. et al. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nat. Genet. 55, 1831\u20131842 (2023).","journal-title":"Nat. Genet."},{"key":"606_CR12","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41588-023-01420-z","volume":"55","author":"D Klarin","year":"2023","unstructured":"Klarin, D. et al. Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. Nat. Genet. 55, 1106\u20131115 (2023).","journal-title":"Nat. Genet."},{"key":"606_CR13","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1177\/096721099400200412","volume":"2","author":"PB Dobrin","year":"1994","unstructured":"Dobrin, P. B. & Mrkvicka, R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation. Cardiovasc. Surg. 2, 484\u2013488 (1994).","journal-title":"Cardiovasc. Surg."},{"key":"606_CR14","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.jbiomech.2011.11.021","volume":"45","author":"JD Humphrey","year":"2012","unstructured":"Humphrey, J. D. & Holzapfel, G. A. Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms. J. Biomech. 45, 805\u2013814 (2012).","journal-title":"J. Biomech."},{"key":"606_CR15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1161\/CIRCRESAHA.118.312436","volume":"124","author":"A Pinard","year":"2019","unstructured":"Pinard, A., Jones, G. T. & Milewicz, D. M. Genetics of thoracic and abdominal aortic diseases. Circ. Res. 124, 588\u2013606 (2019).","journal-title":"Circ. Res."},{"key":"606_CR16","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jacc.2018.04.089","volume":"72","author":"M Renard","year":"2018","unstructured":"Renard, M. et al. Clinical validity of genes for heritable thoracic aortic aneurysm and dissection. J. Am. Coll. Cardiol. 72, 605\u2013615 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"606_CR17","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.ajhg.2021.06.016","volume":"108","author":"T Roychowdhury","year":"2021","unstructured":"Roychowdhury, T. et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am. J. Hum. Genet. 108, 1578\u20131589 (2021).","journal-title":"Am. J. Hum. Genet."},{"key":"606_CR18","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s41588-022-01070-7","volume":"54","author":"C Tcheandjieu","year":"2022","unstructured":"Tcheandjieu, C. et al. High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease. Nat. Genet. 54, 772\u2013782 (2022).","journal-title":"Nat. Genet."},{"key":"606_CR19","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08648","volume":"4","author":"JJ Doyle","year":"2015","unstructured":"Doyle, J. J. et al. A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. eLife 4, e08648 (2015).","journal-title":"eLife"},{"key":"606_CR20","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41586-020-2741-7","volume":"588","author":"TS Luongo","year":"2020","unstructured":"Luongo, T. S. et al. SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature 588, 174\u2013179 (2020).","journal-title":"Nature"},{"key":"606_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19871-x","volume":"11","author":"E Girardi","year":"2020","unstructured":"Girardi, E. et al. Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Nat. Commun. 11, 6145 (2020).","journal-title":"Nat. Commun."},{"key":"606_CR22","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe5310","volume":"6","author":"N Kory","year":"2020","unstructured":"Kory, N. et al. MCART1\/SLC25A51 is required for mitochondrial NAD transport. Sci. Adv. 6, eabe5310 (2020).","journal-title":"Sci. Adv."},{"key":"606_CR23","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.jacc.2011.06.012","volume":"58","author":"A Redheuil","year":"2011","unstructured":"Redheuil, A. et al. Age-related changes in aortic arch geometry: relationship with proximal aortic function and left ventricular mass and remodeling. J. Am. Coll. Cardiol. 58, 1262\u20131270 (2011).","journal-title":"J. Am. Coll. Cardiol."},{"key":"606_CR24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/cvr\/cvy009","volume":"114","author":"P Lacolley","year":"2018","unstructured":"Lacolley, P., Regnault, V. & Avolio, A. P. Smooth muscle cell and arterial aging: basic and clinical aspects. Cardiovasc. Res. 114, 513\u2013528 (2018).","journal-title":"Cardiovasc. Res."},{"key":"606_CR25","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1161\/ATVBAHA.118.310956","volume":"39","author":"DM Milewicz","year":"2019","unstructured":"Milewicz, D. M. & Ramirez, F. Therapies for thoracic aortic aneurysms and acute aortic dissections. Arterioscler. Thromb. Vasc. Biol. 39, 126\u2013136 (2019).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"606_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1161\/ATVBAHA.116.307211","volume":"36","author":"B Trachet","year":"2016","unstructured":"Trachet, B. et al. Ascending aortic aneurysm in angiotensin II-infused mice. Arterioscler. Thromb. Vasc. Biol. 36, 673\u2013681 (2016).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"606_CR27","doi-asserted-by":"publisher","first-page":"e33246","DOI":"10.7554\/eLife.33246","volume":"7","author":"A Davila","year":"2018","unstructured":"Davila, A. et al. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. eLife 7, e33246 (2018).","journal-title":"eLife"},{"key":"606_CR28","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1161\/CIRCULATIONAHA.121.058173","volume":"145","author":"H Sawada","year":"2022","unstructured":"Sawada, H. et al. Second heart field-derived cells contribute to angiotensin II-mediated ascending aortopathies. Circulation 145, 987\u20131001 (2022).","journal-title":"Circulation"},{"key":"606_CR29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1126\/science.1192152","volume":"332","author":"JP Habashi","year":"2011","unstructured":"Habashi, J. P. et al. Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science 332, 361\u2013365 (2011).","journal-title":"Science"},{"key":"606_CR30","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1126\/science.abd5491","volume":"372","author":"J Zhu","year":"2021","unstructured":"Zhu, J. et al. Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science 372, 968\u2013972 (2021).","journal-title":"Science"},{"key":"606_CR31","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.3945\/jn.117.256404","volume":"147","author":"VL Albaugh","year":"2017","unstructured":"Albaugh, V. L., Mukherjee, K. & Barbul, A. Proline precursors and collagen synthesis: biochemical challenges of nutrient supplementation and wound healing. J. Nutr. 147, 2011\u20132017 (2017).","journal-title":"J. Nutr."},{"key":"606_CR32","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s42255-021-00374-y","volume":"3","author":"DH Tran","year":"2021","unstructured":"Tran, D. H. et al. Mitochondrial NADP+ is essential for proline biosynthesis during cell growth. Nat. Metab. 3, 571\u2013585 (2021).","journal-title":"Nat. Metab."},{"key":"606_CR33","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1161\/ATVBAHA.122.318135","volume":"43","author":"C Zhang","year":"2023","unstructured":"Zhang, C. et al. Aortic stress activates an adaptive program in thoracic aortic smooth muscle cells that maintains aortic strength and protects against aneurysm and dissection in mice. Arterioscler. Thromb. Vasc. Biol. 43, 234\u2013252 (2023).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"606_CR34","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1073\/pnas.94.5.1852","volume":"94","author":"X Liu","year":"1997","unstructured":"Liu, X., Wu, H., Byrne, M., Krane, S. & Jaenisch, R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc. Natl Acad. Sci. USA 94, 1852\u20131856 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"606_CR35","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.matbio.2018.03.008","volume":"70","author":"S D\u2019hondt","year":"2018","unstructured":"D\u2019hondt, S. et al. Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model. Matrix Biol. 70, 72\u201383 (2018).","journal-title":"Matrix Biol."},{"key":"606_CR36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1165\/rcmb.2019-0008OC","volume":"61","author":"RB Hamanaka","year":"2019","unstructured":"Hamanaka, R. B. et al. Glutamine metabolism is required for collagen protein synthesis in lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 61, 597\u2013606 (2019).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"606_CR37","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1161\/CIRCRESAHA.116.310022","volume":"120","author":"A Watson","year":"2017","unstructured":"Watson, A. et al. Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease. Circ. Res. 120, 1889\u20131902 (2017).","journal-title":"Circ. Res."},{"key":"606_CR38","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1016\/j.cmet.2021.10.016","volume":"33","author":"DG Le Couteur","year":"2021","unstructured":"Le Couteur, D. G. et al. Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell Metab. 33, 2367\u20132379 (2021).","journal-title":"Cell Metab."},{"key":"606_CR39","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000145167","volume":"106","author":"T Toda","year":"1980","unstructured":"Toda, T., Tsuda, N., Nishimori, I., Leszczynski, D. & Kummerow, F. A. Morphometrical analysis of the aging process in human arteries and aorta. Acta Anat. 106, 35\u201344 (1980).","journal-title":"Acta Anat."},{"key":"606_CR40","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1073\/pnas.0910312107","volume":"107","author":"JH Lindeman","year":"2010","unstructured":"Lindeman, J. H. et al. Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome. Proc. Natl Acad. Sci. USA 107, 862\u2013865 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"606_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.800730","volume":"8","author":"C Cavinato","year":"2021","unstructured":"Cavinato, C. et al. Progressive microstructural deterioration dictates evolving biomechanical dysfunction in the Marfan aorta. Front. Cardiovasc. Med. 8, 800730 (2021).","journal-title":"Front. Cardiovasc. Med."},{"key":"606_CR42","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nature10145","volume":"473","author":"ME Lindsay","year":"2011","unstructured":"Lindsay, M. E. & Dietz, H. C. Lessons on the pathogenesis of aneurysm from heritable conditions. Nature 473, 308\u2013316 (2011).","journal-title":"Nature"},{"key":"606_CR43","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1172\/JCI130730","volume":"130","author":"CJ Bowen","year":"2020","unstructured":"Bowen, C. J. et al. Targetable cellular signaling events mediate vascular pathology in vascular Ehlers\u2013Danlos syndrome. J. Clin. Invest. 130, 686\u2013698 (2020).","journal-title":"J. Clin. Invest."},{"key":"606_CR44","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.matbio.2019.10.001","volume":"85","author":"C Wang","year":"2020","unstructured":"Wang, C. et al. Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus. Matrix Biol. 85, 47\u201367 (2020).","journal-title":"Matrix Biol."},{"key":"606_CR45","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1159\/000051092","volume":"38","author":"P Sansilvestri-Morel","year":"2001","unstructured":"Sansilvestri-Morel, P. et al. Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins. J. Vasc. Res. 38, 560\u2013568 (2001).","journal-title":"J. Vasc. Res."},{"key":"606_CR46","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/joim.13034","volume":"287","author":"S Holm Nielsen","year":"2020","unstructured":"Holm Nielsen, S. et al. Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome. J. Intern. Med. 287, 493\u2013513 (2020).","journal-title":"J. Intern. Med."},{"key":"606_CR47","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0304-4165(92)90095-C","volume":"1156","author":"GJ Rucklidge","year":"1992","unstructured":"Rucklidge, G. J., Milne, G., McGaw, B. A., Milne, E. & Robins, S. P. Turnover rates of different collagen types measured by isotope ratio mass spectrometry. Biochim. Biophys. Acta 1156, 57\u201361 (1992).","journal-title":"Biochim. Biophys. Acta"},{"key":"606_CR48","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103334","volume":"39","author":"S Schw\u00f6rer","year":"2020","unstructured":"Schw\u00f6rer, S. et al. Proline biosynthesis is a vent for TGF\u03b2-induced mitochondrial redox stress. EMBO J. 39, e103334 (2020).","journal-title":"EMBO J."},{"key":"606_CR49","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s10545-011-9319-3","volume":"34","author":"R Kretz","year":"2011","unstructured":"Kretz, R. et al. Defect in proline synthesis: pyrroline-5-carboxylate reductase 1 deficiency leads to a complex clinical phenotype with collagen and elastin abnormalities. J. Inherit. Metab. Dis. 34, 731\u2013739 (2011).","journal-title":"J. Inherit. Metab. Dis."},{"key":"606_CR50","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ymgme.2014.05.003","volume":"112","author":"B Fischer","year":"2014","unstructured":"Fischer, B. et al. Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1. Mol. Genet. Metab. 112, 310\u2013316 (2014).","journal-title":"Mol. Genet. Metab."},{"key":"606_CR51","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1002\/ajmg.a.34326","volume":"155","author":"DS Lin","year":"2011","unstructured":"Lin, D. S. et al. Compound heterozygous mutations in PYCR1 further expand the phenotypic spectrum of De Barsy syndrome. Am. J. Med. Genet. A 155, 3095\u20133099 (2011).","journal-title":"Am. J. Med. Genet. A"},{"key":"606_CR52","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1002\/ajmg.a.34057","volume":"155","author":"DL Skidmore","year":"2011","unstructured":"Skidmore, D. L. et al. Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding \u03941-pyrroline-5-carboxylate synthase (P5CS). Am. J. Med. Genet. A 155, 1848\u20131856 (2011).","journal-title":"Am. J. Med. Genet. A"},{"key":"606_CR53","doi-asserted-by":"publisher","first-page":"H1786","DOI":"10.1152\/ajpheart.00229.2020","volume":"320","author":"BO Aicher","year":"2021","unstructured":"Aicher, B. O. et al. Moderate aerobic exercise prevents matrix degradation and death in a mouse model of aortic dissection and aneurysm. Am. J. Physiol. Heart Circ. Physiol. 320, H1786\u2013H1801 (2021).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"606_CR54","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/japplphysiol.00132.2017","volume":"123","author":"C Gibson","year":"2017","unstructured":"Gibson, C. et al. Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm. J. Appl. Physiol. 123, 147\u2013160 (2017).","journal-title":"J. Appl. Physiol."},{"key":"606_CR55","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1093\/cvr\/cvz303","volume":"116","author":"T Horimatsu","year":"2020","unstructured":"Horimatsu, T. et al. Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+\/nicotinamide. Cardiovasc. Res. 116, 2226\u20132238 (2020).","journal-title":"Cardiovasc. Res."},{"key":"606_CR56","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.120.051171","volume":"143","author":"J Oller","year":"2021","unstructured":"Oller, J. et al. Extracellular tuning of mitochondrial respiration leads to aortic aneurysm. Circulation 143, 2091\u20132109 (2021).","journal-title":"Circulation"},{"key":"606_CR57","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","volume":"22","author":"AJ Covarrubias","year":"2021","unstructured":"Covarrubias, A. J., Perrone, R., Grozio, A. & Verdin, E. NAD+ metabolism and its roles in cellular processes during ageing. Nat. Rev. Mol. Cell Biol. 22, 119\u2013141 (2021).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"606_CR58","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41588-021-00962-4","volume":"54","author":"JP Pirruccello","year":"2022","unstructured":"Pirruccello, J. P. et al. Deep learning enables genetic analysis of the human thoracic aorta. Nat. Genet. 54, 40\u201351 (2022).","journal-title":"Nat. Genet."},{"key":"606_CR59","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","volume":"48","author":"A Gusev","year":"2016","unstructured":"Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245\u2013252 (2016).","journal-title":"Nat. Genet."}],"container-title":["Nature Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00606-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00606-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00606-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T14:22:24Z","timestamp":1742221344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s44161-024-00606-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["606"],"URL":"https:\/\/doi.org\/10.1038\/s44161-024-00606-w","relation":{},"ISSN":["2731-0590"],"issn-type":[{"value":"2731-0590","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"13 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}