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(Houston, TX), L.L. (Houston, TX)\/Houston Methodist Hospital (Houston, TX); publication number 20250114337; status, application pending; specific aspect of this study covered in the patent application: the invention is a therapeutic approach for modulating cellular transdifferentiation and potentially angiogenesis by modulating O-GlcNAcylation (GlcNAc) of proteins to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo. The projected use includes (1) wound or fracture healing and treating vascularization (ischemic tissues, coronary, cerebral and peripheral arterial disease) by enhancing the O-GlcNAcylation pathway, potentially enhancing angiogenesis and (2) treating tumor neovascularization or excess vascularization (age-related macular degeneration, diabetic retinopathy, telangiectasias, AV malformations) by inhibiting the GlcNAcylation pathway, potentially inhibiting angiogenesis). The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}