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Here we present a new technical framework that provides near-real-time guidance on VT ablation targets, inherently incorporating uncertainty in reconstructed scar anatomy. We demonstrate close agreement between simulated ECG \u2018fingerprint\u2019 signatures of VT circuits and clinical recordings in ischemic ablation patients, highlighting the need to account for variations in reconstructed scar anatomy to identify the best-matching simulated circuit. Finally, we introduce a robust method for integrating anatomical information across all viable simulated circuits from different model \u2018instances\u2019 into a simulated ablation target heatmap for practical clinical guidance.<\/jats:p>","DOI":"10.1038\/s44161-026-00856-w","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:02:00Z","timestamp":1786698120000},"page":"807-818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accounting for uncertainty in computational models of ventricular tachycardia improves ablation guidance"],"prefix":"10.1038","volume":"5","author":[{"given":"Abdul Mateen","family":"Qadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5278-6362","authenticated-orcid":false,"given":"Ursula","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando O.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Nazarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0295-7978","authenticated-orcid":false,"given":"Ali-Razak","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Bhagirath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Aldo","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Rajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-4617","authenticated-orcid":false,"given":"Luca","family":"Azzolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel","family":"Neic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-6908","authenticated-orcid":false,"given":"Gernot","family":"Plank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Whitaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-1902","authenticated-orcid":false,"given":"Martin J.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"856_CR1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.jacep.2019.09.015","volume":"5","author":"GS Guandalini","year":"2019","unstructured":"Guandalini, G. 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G.P. is CTO of NumeriCor. A.N. is CEO of NumeriCor. L.A. and M.G. are employees of NumeriCor. The other authors declare no competing interests. The algorithm underlying the VITA technology for finding VT circuits within a computational model is subject to a filed patent, jointly submitted by Medical University of Graz, King\u2019s College London and NumeriCor, currently at Patent Cooperation Treaty stage. The inventors on this patent are G.P., M.J.B., F.O.C. and A.N. (application no. PCT\/EP2022\/072542).","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}