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The radiation-free guidance of endovascular interventions with MPI is especially promising. Here, we present a safety study on the heating of metallic medical implants during MPI measurements under realistic conditions in an extracorporeally-perfused cadaver model. The measurements were conducted by fiberoptic thermometers and showed no detectable heating of the tested endovascular devices in the cadaver model. A temperature increase of no more than 0.11\u2009K was observed on the surface of the investigated proximal femoral nail. The in vitro testing of orthopedic prostheses (knee and hip) revealed a slight heating effect of 0.45\u2009K. The dependence of heating on the applied excitation frequency was measured. Overall, the tested repertoire of implants did not heat by a clinically-relevant amount in a human-sized MPI-scanner under realistic conditions, indicating their safe usage in future clinical applications.<\/jats:p>","DOI":"10.1038\/s44172-025-00561-9","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T19:14:38Z","timestamp":1764616478000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Towards clinical magnetic particle imaging: safety measurements of medical implants in a human cadaver model"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-3428","authenticated-orcid":false,"given":"Franz","family":"Wegner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-4245","authenticated-orcid":false,"given":"Thomas","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7865-8712","authenticated-orcid":false,"given":"Patrick Naoki","family":"Elfers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kleefeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-8111","authenticated-orcid":false,"given":"Philipp","family":"Gruschwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-117X","authenticated-orcid":false,"given":"Teresa","family":"Reichl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-9024","authenticated-orcid":false,"given":"Johanna","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-0184","authenticated-orcid":false,"given":"Thomas","family":"Kampf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-5231","authenticated-orcid":false,"given":"Martin A.","family":"R\u00fcckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-3388","authenticated-orcid":false,"given":"Volker C.","family":"Behr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten M.","family":"Buzug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-4792","authenticated-orcid":false,"given":"Roman","family":"Kloeckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8937-1198","authenticated-orcid":false,"given":"J\u00f6rg","family":"Barkhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten A.","family":"Bley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"561_CR1","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/nature03808","volume":"435","author":"B Gleich","year":"2005","unstructured":"Gleich, B. & Weizenecker, J. 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