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We conducted a randomized controlled trial to evaluate the efficacy of a cognitive-behavioral digital therapeutic, <jats:italic>reclarit<\/jats:italic>, on psychosocial outcomes in adult RA patients with impaired health-related quality of life. Participants were randomized to <jats:italic>reclarit<\/jats:italic> plus treatment as usual (TAU) or TAU plus educational and informational material (active control). The primary outcome was SF-36 mental (MCS) and physical (PCS) component summary scores at 3 months, with additional assessments at 6 months. <jats:italic>reclarit<\/jats:italic> significantly improved SF-36 MCS scores compared to control (mean difference 3.3 [95% CI 0.7, 5.9]; p\u2009=\u20090.014), with high user satisfaction and sustained improvements at 6 months. Depression, anxiety, fatigue, and social\/work functioning also improved significantly, while SF-36 PCS, pain, and disability scores did not differ. In conclusion, <jats:italic>reclarit<\/jats:italic> offers immediate, effective, evidence-based and personalized psychological support for RA patients.<\/jats:p>","DOI":"10.1038\/s44184-024-00085-8","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T19:04:11Z","timestamp":1725390251000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of a cognitive-behavioral digital therapeutic on psychosocial outcomes in rheumatoid arthritis: randomized controlled trial"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-4069","authenticated-orcid":false,"given":"Linda T.","family":"Betz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitta A.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-0657","authenticated-orcid":false,"given":"Johannes","family":"Knitza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-5574","authenticated-orcid":false,"given":"Michaela","family":"Koehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-7186","authenticated-orcid":false,"given":"Frank","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"85_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3899\/jrheum.200367","volume":"48","author":"KB Almutairi","year":"2021","unstructured":"Almutairi, K. 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J.K. has received grants, contracts, consulting fees, travel support, and\/or speakers fees from ABATON, Abbvie, AstraZeneca, the German Federal Ministry of Education and Research (BMBF), BMS, Boehringer Ingelheim, Chugai, the German Research Foundation (DFG), the Germany Society of Internal Medicine (DGIM), EIT Health, Galapagos, Gilead, GSK, Janssen, Lilly, Medac, Novartis, Pfizer, Rheumaakademie, Rheumatology Network, Sanofi, Thermo Fisher, UCB, Vila Health, and Werfen, has served on Data Safety Monitoring or Advisory Boards for ABATON, AbbVie, Boehringer Ingelheim, Chugai, Galapagos, Gilead, GSK, Lilly, Medac, Novartis, Pfizer, UCB, Vila Health, and Werthen, and has a leadership or fiduciary role in the Deutsche Gesellschaft f\u00fcr Innere Medizin, Deutsche Gesellschaft f\u00fcr Rheumatologie, and the Digital Rheumatology Network. M.K. and F.B. have no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}