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This study sought to investigate the pathogenicity of rodent-adapted MARV in ferrets. Challenge with guinea pig-adapted (GPA)-MARV resulted in uniform lethality among ferrets, whereas challenge with mouse-adapted (MA)-MARV resulted in partial lethality. Ferrets challenged with GPA-MARV manifested clinical signs of filovirus disease, including a petechial rash. These animals supported high levels of viral replication and exhibited coagulation abnormalities exemplified by thrombocytopenia, a feature absent among ferrets challenged with GPA-EBOV. A dysregulated immune response and hematological perturbations were also observed among GPA-MARV-challenged ferrets. Lastly, several genome mutations appeared in GPA-MARV following ferret challenge. This study provides insight into the pathogenesis of MARV and represents the first report and characterization of a lethal Marburg virus ferret model.<\/jats:p>","DOI":"10.1038\/s44298-025-00147-4","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T17:23:12Z","timestamp":1757352192000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rodent adapted marburg viruses are lethal in ferrets"],"prefix":"10.1038","volume":"3","author":[{"given":"Zachary","family":"Schiffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Garnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylie N.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Audet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Azaransky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Banadyga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"147_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/ilar\/ilab011","volume":"61","author":"Z Schiffman","year":"2020","unstructured":"Schiffman, Z. et al. 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