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We have recently reported that m\n                    <jats:sup>6<\/jats:sup>\n                    A is involved in the postnatal control of \u03b2-cell function in physiological states and in type 1 and 2 diabetes. However, the precise mechanisms by which m\n                    <jats:sup>6<\/jats:sup>\n                    A acts to regulate the development of human and mouse pancreas are unexplored. Here, we show that the m\n                    <jats:sup>6<\/jats:sup>\n                    A landscape is dynamic during human pancreas development, and that METTL14, one of the m\n                    <jats:sup>6<\/jats:sup>\n                    A writer complex proteins, is essential for the early differentiation of both human and mouse pancreatic cells.\n                  <\/jats:p>","DOI":"10.1038\/s44318-024-00213-2","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:51:09Z","timestamp":1727283069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation"],"prefix":"10.1038","volume":"43","author":[{"given":"Sevim","family":"Kahraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8826-9095","authenticated-orcid":false,"given":"Dario F","family":"De Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-0135","authenticated-orcid":false,"given":"Natalie K","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-6066","authenticated-orcid":false,"given":"Mehdi","family":"Pirouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-7424","authenticated-orcid":false,"given":"Chuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-6119","authenticated-orcid":false,"given":"Rohit N","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"213_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/ng.1035","volume":"44","author":"HL Allen","year":"2012","unstructured":"Allen HL, Flanagan SE, Shaw-Smith C, De Franco E, Akerman I, Caswell R, Ferrer J, Hattersley AT, Ellard S (2012) GATA6 haploinsufficiency causes pancreatic agenesis in humans. 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RNK is on the Scientific Advisory Board of Novo Nordisk, Biomea and Inversago Therapeutics. CH is a scientific founder, a member of the scientific advisory board and equity holder of Aferna Bio, Inc. and AccuaDX Inc., a scientific co-founder and equity holder of Accent Therapeutics, Inc., and a member of the scientific advisory board of Rona Therapeutics. RIG is a co-founder, scientific advisory board member, and equity holder of Redona Therapeutics. The Gregory lab receives or has received research funding from Sanofi, Astellas, and Ono. The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}],"article-number":"8"}}