{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:44:29Z","timestamp":1788497069977,"version":"build-2803163510"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TR-SFB 152"],"award-info":[{"award-number":["TR-SFB 152"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1118"],"award-info":[{"award-number":["SFB 1118"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1550"],"award-info":[{"award-number":["SFB 1550"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 894"],"award-info":[{"award-number":["CRC 894"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005690","name":"Universit\u00e4t des Saarlandes","doi-asserted-by":"publisher","award":["Young Investigator Grant"],"award-info":[{"award-number":["Young Investigator Grant"]}],"id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore glucose homeostasis, a response that is impaired in patients with diabetes and its long-term complication hypoglycemia-associated autonomic failure (HAAF). We show that insulin-evoked hypoglycemia is severely aggravated in mice lacking the cation channel proteins TRPC1, TRPC4, TRPC5, and TRPC6, which cannot be explained by alterations in glucagon or glucocorticoid action. By using various TRPC compound knockout mouse lines, we pinpointed the failure in sympathetic counter-regulation to the lack of the TRPC5 channel subtype in adrenal chromaffin cells, which prevents proper adrenaline rise in blood plasma. Using electrophysiological analyses, we delineate a previously unknown signaling pathway in which stimulation of PAC1 or muscarinic receptors activates TRPC5 channels in a phospholipase-C-dependent manner to induce sustained adrenaline secretion as a crucial step in the sympathetic counter response to insulin-induced hypoglycemia. By comparing metabolites in the plasma, we identified reduced taurine levels after hypoglycemia induction as a commonality in TRPC5-deficient mice and HAAF patients.<\/jats:p>","DOI":"10.1038\/s44318-024-00231-0","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:08:05Z","timestamp":1728288485000},"page":"5813-5836","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia"],"prefix":"10.1038","volume":"43","author":[{"given":"Jenny","family":"Br\u00f6ker-Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Rego Terol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Mathar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5465-354X","authenticated-orcid":false,"given":"Ana","family":"Moreno-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8684-4698","authenticated-orcid":false,"given":"Linette Liqi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Makke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-0865","authenticated-orcid":false,"given":"Gernot","family":"Poschet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8545-4698","authenticated-orcid":false,"given":"Julia","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr","family":"Tsvilovskyy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Haberkorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Wartenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Susperreguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-1530","authenticated-orcid":false,"given":"Michael","family":"Berlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2137-6173","authenticated-orcid":false,"given":"Roger","family":"Ottenheijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-2275","authenticated-orcid":false,"given":"Koenraad","family":"Philippaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moya","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-7407","authenticated-orcid":false,"given":"Tobias","family":"Wiedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1019-6341","authenticated-orcid":false,"given":"Anouar","family":"Belkacemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-7543","authenticated-orcid":false,"given":"Rebecca T","family":"Levinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan E","family":"Camacho Londo\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Klebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Dinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-8618","authenticated-orcid":false,"given":"Frank","family":"Zufall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-629X","authenticated-orcid":false,"given":"Peter","family":"Nussbaumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-6907","authenticated-orcid":false,"given":"Ulrich","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-4818","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Hell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-7804","authenticated-orcid":false,"given":"Peter","family":"Nawroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Birnbaumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-362X","authenticated-orcid":false,"given":"Trese","family":"Leinders-Zufall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-9129","authenticated-orcid":false,"given":"Rohini","family":"Kuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Bruns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-2636","authenticated-orcid":false,"given":"Marc","family":"Freichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"issue":"Suppl 5","key":"231_CR1","first-page":"735S","volume":"3","author":"A Adachi","year":"1995","unstructured":"Adachi A, Kobashi M, Funahashi M (1995) Glucose-responsive neurons in the brainstem. Obes Res 3(Suppl 5):735S\u2013740S","journal-title":"Obes Res"},{"key":"231_CR2","doi-asserted-by":"crossref","unstructured":"Ayala JE, Bracy DP, Malabanan C, James FD, Ansari T, Fueger PT, McGuinness OP, Wasserman DH (2011) Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice. J Vis Exp e3188","DOI":"10.3791\/3188-v"},{"key":"231_CR3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1113\/jphysiol.2005.098822","volume":"570","author":"RH Balfour","year":"2006","unstructured":"Balfour RH, Hansen AM, Trapp S (2006) Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem. J Physiol 570:469\u2013484","journal-title":"J Physiol"},{"key":"231_CR4","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.2337\/diabetes.49.9.1543","volume":"49","author":"A Battezzati","year":"2000","unstructured":"Battezzati A, Benedini S, Fattorini A, Piceni Sereni L, Luzi L (2000) Effect of hypoglycemia on amino acid and protein metabolism in healthy humans. Diabetes 49:1543\u20131551","journal-title":"Diabetes"},{"key":"231_CR5","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1039\/D0CB00126K","volume":"1","author":"CC Bauer","year":"2020","unstructured":"Bauer CC, Minard A, Pickles IB, Simmons KJ, Chuntharpursat-Bon E, Burnham MP, Kapur N, Beech DJ, Muench SP, Wright MH et al (2020) Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels. RSC Chem Biol 1:436\u2013448","journal-title":"RSC Chem Biol"},{"key":"231_CR6","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1523\/JNEUROSCI.4201-06.2007","volume":"27","author":"CS Bauer","year":"2007","unstructured":"Bauer CS, Woolley RJ, Teschemacher AG, Seward EP (2007) Potentiation of exocytosis by phospholipase C-coupled G-protein-coupled receptors requires the priming protein Munc13-1. J Neurosci 27:212\u2013219","journal-title":"J Neurosci"},{"key":"231_CR7","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1210\/en.2016-1810","volume":"158","author":"A Beck","year":"2017","unstructured":"Beck A, Gotz V, Qiao S, Weissgerber P, Flockerzi V, Freichel M, Boehm U (2017) Functional characterization of transient receptor potential (TRP) channel C5 in female murine gonadotropes. Endocrinology 158:887\u2013902","journal-title":"Endocrinology"},{"key":"231_CR8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1085\/jgp.200810153","volume":"133","author":"NT Blair","year":"2009","unstructured":"Blair NT, Kaczmarek JS, Clapham DE (2009) Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol 133:525\u2013546","journal-title":"J Gen Physiol"},{"key":"231_CR9","doi-asserted-by":"publisher","first-page":"15236","DOI":"10.1073\/pnas.1905705116","volume":"116","author":"T Blum","year":"2019","unstructured":"Blum T, Moreno-Perez A, Pyrski M, Bufe B, Arifovic A, Weissgerber P, Freichel M, Zufall F, Leinders-Zufall T (2019) Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus. Proc Natl Acad Sci USA 116:15236\u201315243","journal-title":"Proc Natl Acad Sci USA"},{"key":"231_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00424-017-2082-z","volume":"470","author":"R Borges","year":"2018","unstructured":"Borges R, Gandia L, Carbone E (2018) Old and emerging concepts on adrenal chromaffin cell stimulus-secretion coupling. Pflug Arch 470:1\u20136","journal-title":"Pflug Arch"},{"key":"231_CR11","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.15252\/embj.201696369","volume":"36","author":"J Br\u00f6ker-Lai","year":"2017","unstructured":"Br\u00f6ker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weissgerber P et al (2017) Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J 36:2770\u20132789","journal-title":"EMBO J"},{"key":"231_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.ymeth.2004.01.004","volume":"33","author":"D Bruns","year":"2004","unstructured":"Bruns D (2004) Detection of transmitter release with carbon fiber electrodes. Methods 33:312\u2013321","journal-title":"Methods"},{"key":"231_CR13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0896-6273(00)00097-0","volume":"28","author":"D Bruns","year":"2000","unstructured":"Bruns D, Riedel D, Klingauf J, Jahn R (2000) Quantal release of serotonin. Neuron 28:205\u2013220","journal-title":"Neuron"},{"key":"231_CR14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fnana.2017.00098","volume":"11","author":"D Bucci","year":"2017","unstructured":"Bucci D, Busceti CL, Calierno MT, Di Pietro P, Madonna M, Biagioni F, Ryskalin L, Limanaqi F, Nicoletti F, Fornai F (2017) Systematic morphometry of catecholamine nuclei in the brainstem. Front Neuroanat 11:98","journal-title":"Front Neuroanat"},{"key":"231_CR15","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/BF02004704","volume":"11","author":"J Bugajski","year":"1981","unstructured":"Bugajski J, Zacny E (1981) The role of central histamine H1- and H2-receptors in hypothermia induced by histamine in the rat. Agents Actions 11:442\u2013447","journal-title":"Agents Actions"},{"key":"231_CR16","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/jnc.13849","volume":"139","author":"E Calvo-Gallardo","year":"2016","unstructured":"Calvo-Gallardo E, Lopez-Gil A, Mendez-Lopez I, Martinez-Ramirez C, Padin JF, Garcia AG (2016) Faster kinetics of quantal catecholamine release in mouse chromaffin cells stimulated with acetylcholine, compared with other secretagogues. J Neurochem 139:722\u2013736","journal-title":"J Neurochem"},{"key":"231_CR17","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1002\/cphy.c190003","volume":"9","author":"E Carbone","year":"2019","unstructured":"Carbone E, Borges R, Eiden LE, Garcia AG, Hernandez-Cruz A (2019) Chromaffin cells of the adrenal medulla: physiology, pharmacology, and disease. Compr Physiol 9:1443\u20131502","journal-title":"Compr Physiol"},{"key":"231_CR18","doi-asserted-by":"publisher","first-page":"e0127498","DOI":"10.1371\/journal.pone.0127498","volume":"10","author":"C Carson","year":"2015","unstructured":"Carson C, Raman P, Tullai J, Xu L, Henault M, Thomas E, Yeola S, Lao J, McPate M, Verkuyl JM et al (2015) Englerin A agonizes the TRPC4\/C5 cation channels to inhibit tumor cell line proliferation. PLoS ONE 10:e0127498","journal-title":"PLoS ONE"},{"key":"231_CR19","doi-asserted-by":"publisher","first-page":"29634","DOI":"10.18632\/oncotarget.25659","volume":"9","author":"SY Cheung","year":"2018","unstructured":"Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P et al (2018) TRPC4\/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A. Oncotarget 9:29634\u201329643","journal-title":"Oncotarget"},{"key":"231_CR20","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.2337\/diabetes.54.12.3592","volume":"54","author":"PE Cryer","year":"2005","unstructured":"Cryer PE (2005) Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54:3592\u20133601","journal-title":"Diabetes"},{"key":"231_CR21","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1172\/JCI28735","volume":"116","author":"PE Cryer","year":"2006","unstructured":"Cryer PE (2006) Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes. J Clin Investig 116:1470\u20131473","journal-title":"J Clin Investig"},{"key":"231_CR22","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1056\/NEJMra1215228","volume":"369","author":"PE Cryer","year":"2013","unstructured":"Cryer PE (2013) Mechanisms of hypoglycemia-associated autonomic failure in diabetes. N. Engl J Med 369:362\u2013372","journal-title":"N. Engl J Med"},{"key":"231_CR23","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00424-007-0314-3","volume":"455","author":"A Dietrich","year":"2007","unstructured":"Dietrich A, Kalwa H, Storch U, Mederos y Schnitzler M, Salanova B, Pinkenburg O, Dubrovska G, Essin K, Gollasch M, Birnbaumer L et al (2007) Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflug Arch 455:465\u2013477","journal-title":"Pflug Arch"},{"key":"231_CR24","doi-asserted-by":"publisher","first-page":"6980","DOI":"10.1128\/MCB.25.16.6980-6989.2005","volume":"25","author":"A Dietrich","year":"2005","unstructured":"Dietrich A, Mederos YSM, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H et al (2005) Increased vascular smooth muscle contractility in TRPC6-\/- mice. Mol Cell Biol 25:6980\u20136989","journal-title":"Mol Cell Biol"},{"key":"231_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00424-017-2062-3","volume":"470","author":"LE Eiden","year":"2018","unstructured":"Eiden LE, Emery AC, Zhang L, Smith CB (2018) PACAP signaling in stress: insights from the chromaffin cell. Pflug Arch 470:79\u201388","journal-title":"Pflug Arch"},{"key":"231_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/35055019","volume":"3","author":"M Freichel","year":"2001","unstructured":"Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weissgerber P, Biel M, Philipp S, Freise D, Droogmans G et al (2001) Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-\/- mice. Nat Cell Biol 3:121\u2013127","journal-title":"Nat Cell Biol"},{"key":"231_CR27","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.celrep.2016.12.072","volume":"18","author":"Y Gao","year":"2017","unstructured":"Gao Y, Yao T, Deng Z, Sohn JW, Sun J, Huang Y, Kong X, Yu KJ, Wang RT, Chen H et al (2017) TrpC5 mediates acute leptin and serotonin effects via pomc neurons. Cell Rep 18:583\u2013592","journal-title":"Cell Rep"},{"key":"231_CR28","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.2337\/db14-0340","volume":"63","author":"SM Gray","year":"2014","unstructured":"Gray SM, Meijer RI, Barrett EJ (2014) Insulin regulates brain function, but how does it get there? Diabetes 63:3992\u20133997","journal-title":"Diabetes"},{"key":"231_CR29","doi-asserted-by":"publisher","first-page":"e0222771","DOI":"10.1371\/journal.pone.0222771","volume":"14","author":"JB Groener","year":"2019","unstructured":"Groener JB, Valkanou A, Kender Z, Pfeiffenberger J, Kihm L, Fleming T, Nawroth PP, Kopf S (2019) Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes. PLoS ONE 14:e0222771","journal-title":"PLoS ONE"},{"key":"231_CR30","first-page":"1215","volume":"38","author":"U Haberkorn","year":"1997","unstructured":"Haberkorn U, Bellemann ME, Altmann A, Gerlach L, Morr I, Oberdorfer F, Brix G, Doll J, Blatter J, van Kaick G (1997) PET 2-fluoro-2-deoxyglucose uptake in rat prostate adenocarcinoma during chemotherapy with gemcitabine. J Nucl Med 38:1215\u20131221","journal-title":"J Nucl Med"},{"key":"231_CR31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s002590100489","volume":"28","author":"U Haberkorn","year":"2001","unstructured":"Haberkorn U, Bellemann ME, Brix G, Kamencic H, Morr I, Traut U, Altmann A, Doll J, Blatter J, Kinscherf R (2001) Apoptosis and changes in glucose transport early after treatment of Morris hepatoma with gemcitabine. Eur J Nucl Med 28:418\u2013425","journal-title":"Eur J Nucl Med"},{"key":"231_CR32","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1073\/pnas.012608999","volume":"99","author":"C Hamelink","year":"2002","unstructured":"Hamelink C, Tjurmina O, Damadzic R, Young WS, Weihe E, Lee HW, Eiden LE (2002) Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci USA 99:461\u2013466","journal-title":"Proc Natl Acad Sci USA"},{"key":"231_CR33","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1111\/bph.13011","volume":"172","author":"K Harada","year":"2015","unstructured":"Harada K, Matsuoka H, Miyata H, Matsui M, Inoue M (2015) Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic deletion. Br J Pharm 172:1348\u20131359","journal-title":"Br J Pharm"},{"key":"231_CR34","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1079\/NRR19880009","volume":"1","author":"KC Hayes","year":"1988","unstructured":"Hayes KC (1988) Taurine nutrition. Nutr Res Rev 1:99\u2013113","journal-title":"Nutr Res Rev"},{"key":"231_CR35","doi-asserted-by":"publisher","first-page":"42459","DOI":"10.1074\/jbc.M111.289389","volume":"286","author":"J Hill","year":"2011","unstructured":"Hill J, Chan SA, Kuri B, Smith C (2011) Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells. J Biol Chem 286:42459\u201342469","journal-title":"J Biol Chem"},{"key":"231_CR36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00424-017-2047-2","volume":"470","author":"M Inoue","year":"2018","unstructured":"Inoue M, Matsuoka H, Harada K, Kao LS (2018) Muscarinic receptors in adrenal chromaffin cells: physiological role and regulation of ion channels. Pflug Arch 470:29\u201338","journal-title":"Pflug Arch"},{"key":"231_CR37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1085\/jgp.200810075","volume":"133","author":"JB Jensen","year":"2009","unstructured":"Jensen JB, Lyssand JS, Hague C, Hille B (2009) Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7.2\/7.3 K+ channels. J Gen Physiol 133:347\u2013359","journal-title":"J Gen Physiol"},{"key":"231_CR38","doi-asserted-by":"publisher","first-page":"819","DOI":"10.4103\/2230-8210.117219","volume":"17","author":"S Kalra","year":"2013","unstructured":"Kalra S, Mukherjee JJ, Venkataraman S, Bantwal G, Shaikh S, Saboo B, Das AK, Ramachandran A (2013) Hypoglycemia: The neglected complication. Indian J Endocrinol Metab 17:819\u2013834","journal-title":"Indian J Endocrinol Metab"},{"key":"231_CR39","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1016\/j.neuron.2022.09.029","volume":"110","author":"A Kollewe","year":"2022","unstructured":"Kollewe A, Schwarz Y, Oleinikov K, Raza A, Haupt A, Wartenberg P, Wyatt A, Boehm U, Ectors F, Bildl W et al (2022) Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes. Neuron 110:4162\u20134175.e7","journal-title":"Neuron"},{"key":"231_CR40","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1111\/j.1471-4159.2009.06206.x","volume":"110","author":"BA Kuri","year":"2009","unstructured":"Kuri BA, Chan SA, Smith CB (2009) PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway. J Neurochem 110:1214\u20131225","journal-title":"J Neurochem"},{"key":"231_CR41","doi-asserted-by":"publisher","first-page":"E580","DOI":"10.1152\/ajpendo.00237.2014","volume":"307","author":"EF LaGamma","year":"2014","unstructured":"LaGamma EF, Kirtok N, Chan O, Nankova BB (2014) Partial blockade of nicotinic acetylcholine receptors improves the counterregulatory response to hypoglycemia in recurrently hypoglycemic rats. Am J Physiol Endocrinol Metab 307:E580\u2013588","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"231_CR42","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/S0021-9258(19)40153-1","volume":"265","author":"EJ Lewis","year":"1990","unstructured":"Lewis EJ, Allison S, Fader D, Claflin V, Baizer L (1990) Bovine dopamine beta-hydroxylase cDNA. Complete coding sequence and expression in mammalian cells with vaccinia virus vector. J Biol Chem 265:1021\u20131028","journal-title":"J Biol Chem"},{"key":"231_CR43","doi-asserted-by":"publisher","first-page":"E29","DOI":"10.1152\/ajpendo.00168.2004","volume":"288","author":"F Li","year":"2005","unstructured":"Li F, Obrosova IG, Abatan O, Tian D, Larkin D, Stuenkel EL, Stevens MJ (2005) Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. Am J Physiol Endocrinol Metab 288:E29\u201336","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"231_CR44","unstructured":"Lip G, Hall J (2007) Comprehensive hypertension. Mosby 1:1\u20131222"},{"key":"231_CR45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/978-1-59745-526-8_11","volume":"491","author":"JD Lippiat","year":"2008","unstructured":"Lippiat JD (2008) Whole-cell recording using the perforated patch clamp technique. Methods Mol Biol 491:141\u2013149","journal-title":"Methods Mol Biol"},{"key":"231_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14335","volume":"8","author":"CH Liu","year":"2017","unstructured":"Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH et al (2017) Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun 8:14335","journal-title":"Nat Commun"},{"key":"231_CR47","unstructured":"Lowell BB, O\u2019 Foighil D, Yu J (2006) Development and phenotype of ChAT-IRES-Cre mice. MGI Direct Data Submission. MGI Ref ID J:114556"},{"key":"231_CR48","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ceca.2012.01.005","volume":"51","author":"S Mahapatra","year":"2012","unstructured":"Mahapatra S, Calorio C, Vandael DH, Marcantoni A, Carabelli V, Carbone E (2012) Calcium channel types contributing to chromaffin cell excitability, exocytosis and endocytosis. Cell Calcium 51:321\u2013330","journal-title":"Cell Calcium"},{"key":"231_CR49","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.neuroscience.2011.05.007","volume":"189","author":"M Marom","year":"2011","unstructured":"Marom M, Birnbaumer L, Atlas D (2011) Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)-dependent potentiation of catecholamine release. Neuroscience 189:132\u2013145","journal-title":"Neuroscience"},{"key":"231_CR50","doi-asserted-by":"publisher","first-page":"3924","DOI":"10.1111\/bph.14791","volume":"176","author":"A Minard","year":"2019","unstructured":"Minard A, Bauer CC, Chuntharpursat-Bon E, Pickles IB, Wright DJ, Ludlow MJ, Burnham MP, Warriner SL, Beech DJ, Muraki K et al (2019) Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative. Br J Pharm 176:3924\u20133938","journal-title":"Br J Pharm"},{"key":"231_CR51","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/0006-8993(87)90537-3","volume":"422","author":"DA Morilak","year":"1987","unstructured":"Morilak DA, Fornal CA, Jacobs BL (1987) Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. III. Glucoregulatory challenge. Brain Res 422:32\u201339","journal-title":"Brain Res"},{"key":"231_CR52","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1073\/pnas.2535311100","volume":"100","author":"T Munsch","year":"2003","unstructured":"Munsch T, Freichel M, Flockerzi V, Pape HC (2003) Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci USA 100:16065\u201316070","journal-title":"Proc Natl Acad Sci USA"},{"key":"231_CR53","first-page":"R1350","volume":"267","author":"MS Muntzel","year":"1994","unstructured":"Muntzel MS, Morgan DA, Mark AL, Johnson AK (1994) Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity. Am J Physiol 267:R1350\u20131355","journal-title":"Am J Physiol"},{"key":"231_CR54","doi-asserted-by":"publisher","first-page":"8079","DOI":"10.1074\/jbc.M609638200","volume":"282","author":"T Mustafa","year":"2007","unstructured":"Mustafa T, Grimaldi M, Eiden LE (2007) The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion. J Biol Chem 282:8079\u20138091","journal-title":"J Biol Chem"},{"key":"231_CR55","doi-asserted-by":"publisher","first-page":"16172","DOI":"10.1074\/jbc.M111664200","volume":"277","author":"AG Obukhov","year":"2002","unstructured":"Obukhov AG, Nowycky MC (2002) TRPC4 can be activated by G-protein-coupled receptors and provides sufficient Ca(2+) to trigger exocytosis in neuroendocrine cells. J Biol Chem 277:16172\u201316178","journal-title":"J Biol Chem"},{"key":"231_CR56","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1242\/dev.02838","volume":"134","author":"R Parlato","year":"2007","unstructured":"Parlato R, Otto C, Begus Y, Stotz S, Schutz G (2007) Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development 134:1663\u20131670","journal-title":"Development"},{"key":"231_CR57","unstructured":"Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates, 2nd ed. Academic Press"},{"key":"231_CR58","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1124\/mol.112.082271","volume":"83","author":"KD Phelan","year":"2013","unstructured":"Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L et al (2013) Canonical transient receptor channel 5 (TRPC5) and TRPC1\/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharm 83:429\u2013438","journal-title":"Mol Pharm"},{"key":"231_CR59","doi-asserted-by":"crossref","unstructured":"Qiu J, Wagner EJ, Ronnekleiv OK, Kelly MJ (2018) Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels. J Neuroendocrinol 30:e12501","DOI":"10.1111\/jne.12501"},{"key":"231_CR60","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.cmet.2014.03.004","volume":"19","author":"J Qiu","year":"2014","unstructured":"Qiu J, Zhang C, Borgquist A, Nestor CC, Smith AW, Bosch MA, Ku S, Wagner EJ, Ronnekleiv OK, Kelly MJ (2014) Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab 19:682\u2013693","journal-title":"Cell Metab"},{"key":"231_CR61","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.cell.2009.03.039","volume":"137","author":"A Riccio","year":"2009","unstructured":"Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ et al (2009) Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137:761\u2013772","journal-title":"Cell"},{"key":"231_CR62","first-page":"2673","volume":"18","author":"H Ripps","year":"2012","unstructured":"Ripps H, Shen W (2012) Review: taurine: a \u201cvery essential\u201d amino acid. Mol Vis 18:2673\u20132686","journal-title":"Mol Vis"},{"key":"231_CR63","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1210\/en.2010-1458","volume":"152","author":"S Ritter","year":"2011","unstructured":"Ritter S, Li AJ, Wang Q, Dinh TT (2011) Minireview: The value of looking backward: the essential role of the hindbrain in counterregulatory responses to glucose deficit. Endocrinology 152:4019\u20134032","journal-title":"Endocrinology"},{"key":"231_CR64","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cmet.2011.01.010","volume":"13","author":"J Rossi","year":"2011","unstructured":"Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee CE, Choi MJ, Lauzon D, Lowell BB, Elmquist JK (2011) Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 13:195\u2013204","journal-title":"Cell Metab"},{"key":"231_CR65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1210\/TEAM.9781936704200.ch2","volume":"3","author":"VH Routh","year":"2012","unstructured":"Routh VH, Donovan CM, Ritter S (2012) 2. Hypoglycemia detection. Transl Endocrinol Metab 3:47\u201387","journal-title":"Transl Endocrinol Metab"},{"key":"231_CR66","doi-asserted-by":"publisher","first-page":"8158","DOI":"10.1074\/jbc.M116.773556","volume":"292","author":"HN Rubaiy","year":"2017","unstructured":"Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM et al (2017) Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1\/4\/5 channels. J Biol Chem 292:8158\u20138173","journal-title":"J Biol Chem"},{"key":"231_CR67","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.molmet.2018.01.003","volume":"9","author":"R Sachdeva","year":"2018","unstructured":"Sachdeva R, Schlotterer A, Schumacher D, Matka C, Mathar I, Dietrich N, Medert R, Kriebs U, Lin J, Nawroth P et al (2018) TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation. Mol Metab 9:156\u2013167","journal-title":"Mol Metab"},{"key":"231_CR68","doi-asserted-by":"publisher","first-page":"e3000445","DOI":"10.1371\/journal.pbio.3000445","volume":"17","author":"Y Schwarz","year":"2019","unstructured":"Schwarz Y, Oleinikov K, Schindeldecker B, Wyatt A, Weissgerber P, Flockerzi V, Boehm U, Freichel M, Bruns D (2019) TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. PLoS Biol 17:e3000445","journal-title":"PLoS Biol"},{"key":"231_CR69","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12929-017-0370-8","volume":"24","author":"S Seemann","year":"2017","unstructured":"Seemann S, Zohles F, Lupp A (2017) Comprehensive comparison of three different animal models for systemic inflammation. J Biomed Sci 24:60","journal-title":"J Biomed Sci"},{"key":"231_CR70","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9801640","volume":"2016","author":"M Senthilkumaran","year":"2016","unstructured":"Senthilkumaran M, Zhou XF, Bobrovskaya L (2016) Challenges in modelling hypoglycaemia-associated autonomic failure: a review of human and animal studies. Int J Endocrinol 2016:9801640","journal-title":"Int J Endocrinol"},{"key":"231_CR71","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ejphar.2006.05.013","volume":"541","author":"T Shimizu","year":"2006","unstructured":"Shimizu T, Okada S, Yamaguchi N, Sasaki T, Lu L, Yokotani K (2006) Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats. Eur J Pharm 541:152\u2013157","journal-title":"Eur J Pharm"},{"key":"231_CR72","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.dsx.2014.05.001","volume":"9","author":"MM Sirdah","year":"2015","unstructured":"Sirdah MM (2015) Protective and therapeutic effectiveness of taurine in diabetes mellitus: a rationale for antioxidant supplementation. Diab Metab Syndr 9:55\u201364","journal-title":"Diab Metab Syndr"},{"key":"231_CR73","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12031-012-9749-x","volume":"48","author":"CB Smith","year":"2012","unstructured":"Smith CB, Eiden LE (2012) Is PACAP the major neurotransmitter for stress transduction at the adrenomedullary synapse? J Mol Neurosci 48:403\u2013412","journal-title":"J Mol Neurosci"},{"key":"231_CR74","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.neuron.2011.06.012","volume":"71","author":"JW Sohn","year":"2011","unstructured":"Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK (2011) Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 71:488\u2013497","journal-title":"Neuron"},{"key":"231_CR75","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.tem.2015.06.005","volume":"26","author":"L Steinbusch","year":"2015","unstructured":"Steinbusch L, Labouebe G, Thorens B (2015) Brain glucose sensing in homeostatic and hedonic regulation. Trends Endocrinol Metab 26:455\u2013466","journal-title":"Trends Endocrinol Metab"},{"key":"231_CR76","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1074\/jbc.M111.283218","volume":"287","author":"U Storch","year":"2012","unstructured":"Storch U, Forst AL, Philipp M, Gudermann T, Mederos y Schnitzler M (2012) Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J Biol Chem 287:3530\u20133540","journal-title":"J Biol Chem"},{"key":"231_CR77","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1749-6632.2011.05904.x","volume":"1220","author":"N Stroth","year":"2011","unstructured":"Stroth N, Holighaus Y, Ait-Ali D, Eiden LE (2011) PACAP: a master regulator of neuroendocrine stress circuits and the cellular stress response. Ann N Y Acad Sci 1220:49\u201359","journal-title":"Ann N Y Acad Sci"},{"key":"231_CR78","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0896-6273(01)00240-9","volume":"29","author":"C Strubing","year":"2001","unstructured":"Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645\u2013655","journal-title":"Neuron"},{"key":"231_CR79","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.jpba.2007.04.001","volume":"44","author":"S Uran","year":"2007","unstructured":"Uran S, Landmark KE, Hjellum G, Skotland T (2007) Quantification of 13C pyruvate and 13C lactate in dog blood by reversed-phase liquid chromatography-electrospray ionization mass spectrometry after derivatization with 3-nitrophenylhydrazine. J Pharm Biomed Anal 44:947\u2013954","journal-title":"J Pharm Biomed Anal"},{"key":"231_CR80","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fnins.2014.00038","volume":"8","author":"AJ Verberne","year":"2014","unstructured":"Verberne AJ, Sabetghadam A, Korim WS (2014) Neural pathways that control the glucose counterregulatory response. Front Neurosci 8:38","journal-title":"Front Neurosci"},{"key":"231_CR81","doi-asserted-by":"publisher","first-page":"e1006512","DOI":"10.1371\/journal.pgen.1006512","volume":"12","author":"BD Weger","year":"2016","unstructured":"Weger BD, Weger M, Gorling B, Schink A, Gobet C, Keime C, Poschet G, Jost B, Krone N, Hell R et al (2016) Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids. PLoS Genet 12:e1006512","journal-title":"PLoS Genet"},{"key":"231_CR82","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1111\/j.1471-4159.2009.06533.x","volume":"112","author":"PC Wu","year":"2010","unstructured":"Wu PC, Fann MJ, Kao LS (2010) Characterization of Ca2+ signaling pathways in mouse adrenal medullary chromaffin cells. J Neurochem 112:1210\u20131222","journal-title":"J Neurochem"},{"key":"231_CR83","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ceca.2017.05.009","volume":"67","author":"A Wyatt","year":"2017","unstructured":"Wyatt A, Wartenberg P, Candlish M, Krasteva-Christ G, Flockerzi V, Boehm U (2017) Genetic strategies to analyze primary TRP channel-expressing cells in mice. Cell Calcium 67:91\u2013104","journal-title":"Cell Calcium"},{"key":"231_CR84","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nature10567","volume":"479","author":"T Xue","year":"2011","unstructured":"Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P et al (2011) Melanopsin signalling in mammalian iris and retina. Nature 479:67\u201373","journal-title":"Nature"},{"key":"231_CR85","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuron.2017.05.031","volume":"95","author":"Z Zhao","year":"2017","unstructured":"Zhao Z, Wang L, Gao W, Hu F, Zhang J, Ren Y, Lin R, Feng Q, Cheng M, Ju D et al (2017) A central catecholaminergic circuit controls blood glucose levels during stress. Neuron 95:138\u2013152.e135","journal-title":"Neuron"},{"key":"231_CR86","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nrendo.2017.151","volume":"14","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Ley SH, Hu FB (2018) Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 14:88\u201398","journal-title":"Nat Rev Endocrinol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44318-024-00231-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44318-024-00231-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44318-024-00231-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:38:56Z","timestamp":1779237536000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44318-024-00231-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":86,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12,2]]}},"alternative-id":["231"],"URL":"https:\/\/doi.org\/10.1038\/s44318-024-00231-0","relation":{},"ISSN":["1460-2075"],"issn-type":[{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"14 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}]}}