{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:55:00Z","timestamp":1790852100695,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["TMPGMFU22TT"],"award-info":[{"award-number":["TMPGMFU22TT"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["Idea Grant Program 22"],"award-info":[{"award-number":["Idea Grant Program 22"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["MFAG 2020"],"award-info":[{"award-number":["MFAG 2020"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PNRR-MR1-2022-12376821"],"award-info":[{"award-number":["PNRR-MR1-2022-12376821"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PRIN-2022-PNRR (P2022JLNZ7)"],"award-info":[{"award-number":["PRIN-2022-PNRR (P2022JLNZ7)"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PRIN (20224FL9T5)"],"award-info":[{"award-number":["PRIN (20224FL9T5)"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["259130777-SFB1177"],"award-info":[{"award-number":["259130777-SFB1177"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["259130777-SFB1177"],"award-info":[{"award-number":["259130777-SFB1177"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["259130777 - SFB1177"],"award-info":[{"award-number":["259130777 - SFB1177"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020027","name":"Dr. Rolf M. Schwiete Stiftung","doi-asserted-by":"publisher","award":["13\/2017"],"award-info":[{"award-number":["13\/2017"]}],"id":[{"id":"10.13039\/501100020027","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CRC project on Selective Autophagy"},{"name":"EU\/EFPIA\/OICR\/McGill\/KTH\/Diamond","award":["875510"],"award-info":[{"award-number":["875510"]}]},{"name":"AFM Telethon","award":["23551"],"award-info":[{"award-number":["23551"]}]},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERC","award":["ER-REMODEL"],"award-info":[{"award-number":["ER-REMODEL"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2025,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endoplasmic reticulum (ER) plasticity and ER-phagy are intertwined processes essential for maintaining ER dynamics. We investigated the interplay between two isoforms of the ER-phagy receptor FAM134B in regulating ER remodeling in differentiating myoblasts. During myogenesis, the canonical FAM134B1 is degraded, while its isoform FAM134B2 is transcriptionally upregulated. The switch, favoring FAM134B2, is an important regulator of ER morphology during myogenesis. FAM134B2 partial reticulon homology domain, with its rigid conformational characteristics, enables efficient ER reshaping. FAM134B2 action increases in the active phase of differentiation leading to ER restructuring via ER-phagy, which then reverts to physiological levels when myotubes are mature and the ER is reorganized. Knocking out both FAM134B isoforms in myotubes results in an aberrant proteome landscape and the formation of dilated ER structures, both of which are rescued by FAM134B2 re-expression. Our results underscore how the fine-tuning of FAM134B isoforms and ER-phagy orchestrate the ER dynamics during myogenesis providing insights into the molecular mechanisms governing ER homeostasis in muscle cells.<\/jats:p>","DOI":"10.1038\/s44318-024-00356-2","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T07:46:11Z","timestamp":1736149571000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Two FAM134B isoforms differentially regulate ER dynamics during myogenesis"],"prefix":"10.1038","volume":"44","author":[{"given":"Viviana","family":"Buonomo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-8320","authenticated-orcid":false,"given":"Kateryna","family":"Lohachova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-7502","authenticated-orcid":false,"given":"Alessio","family":"Reggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-4191","authenticated-orcid":false,"given":"Sara","family":"Cano-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-180X","authenticated-orcid":false,"given":"Michele","family":"Cillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-712X","authenticated-orcid":false,"given":"Lucia","family":"Santorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Venditti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Polishchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7222-3033","authenticated-orcid":false,"given":"Lorene","family":"Brunello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Petrosino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malan","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8526-8692","authenticated-orcid":false,"given":"Rossella","family":"De Cegli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Di Bartolomeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-3969","authenticated-orcid":false,"given":"Cesare","family":"Gargioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Swuec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1786-4211","authenticated-orcid":false,"given":"Mirko","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-439X","authenticated-orcid":false,"given":"Alexandra","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-0391","authenticated-orcid":false,"given":"Ramachandra M","family":"Bhaskara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9942-9389","authenticated-orcid":false,"given":"Paolo","family":"Grumati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"356_CR1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.molcel.2019.03.034","volume":"74","author":"H An","year":"2019","unstructured":"An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW (2019) TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress. Mol Cell 74:891\u2013908.e10","journal-title":"Mol Cell"},{"key":"356_CR2","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-44101-5","volume":"14","author":"R Berkane","year":"2023","unstructured":"Berkane R, Ho-Xuan H, Glogger M, Sanz-Martinez P, Brunello L, Glaesner T, Kuncha SK, Holzh\u00fcter K, Cano-Franco S, Buonomo V et al (2023) The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways. Nat Commun 14:8364","journal-title":"Nat Commun"},{"key":"356_CR3","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10345-3","volume":"10","author":"RM Bhaskara","year":"2019","unstructured":"Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G (2019) Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy. Nat Commun 10:2370","journal-title":"Nat Commun"},{"key":"356_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/dmm.010389","volume":"6","author":"P Bonaldo","year":"2013","unstructured":"Bonaldo P, Sandri M (2013) Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech 6:25\u201339","journal-title":"Dis Model Mech"},{"key":"356_CR5","doi-asserted-by":"crossref","DOI":"10.1242\/dev.146506","volume":"145","author":"P Boya","year":"2018","unstructured":"Boya P, Codogno P, Rodriguez-Muela N (2018) Autophagy in stem cells: repair, remodelling and metabolic reprogramming. Development 145:dev146506","journal-title":"Development"},{"key":"356_CR6","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1093\/hmg\/ddr427","volume":"20","author":"V Carmignac","year":"2011","unstructured":"Carmignac V, Svensson M, K\u00f6rner Z, Elowsson L, Matsumura C, Gawlik KI, Allamand V, Durbeej M (2011) Autophagy is increased in laminin \u03b12 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A. Hum Mol Genet 20:4891\u20134902","journal-title":"Hum Mol Genet"},{"key":"356_CR7","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1242\/dev.151035","volume":"144","author":"J Chal","year":"2017","unstructured":"Chal J, Pourqui\u00e9 O (2017) Making muscle: skeletal myogenesis in vivo and in vitro. Development 144:2104\u20132122","journal-title":"Development"},{"key":"356_CR8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.cub.2019.01.041","volume":"29","author":"Q Chen","year":"2019","unstructured":"Chen Q, Xiao Y, Chai P, Zheng P, Teng J, Chen J (2019) ATL3 is a tubular ER-phagy receptor for GABARAP-mediated selective autophagy. Curr Biol 29:846\u2013855.e6","journal-title":"Curr Biol"},{"key":"356_CR9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.molcel.2019.03.033","volume":"74","author":"H Chino","year":"2019","unstructured":"Chino H, Hatta T, Natsume T, Mizushima N (2019) Intrinsically disordered protein TEX264 mediates ER-phagy. Mol Cell 74:909\u2013921.e6","journal-title":"Mol Cell"},{"key":"356_CR10","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105696","volume":"39","author":"L Cinque","year":"2020","unstructured":"Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG, De Cegli R, Di Malta C, Svelto M, Lanzara C et al (2020) MiT\/TFE factors control ER\u2010phagy via transcriptional regulation of FAM134B. EMBO J 39:e105696","journal-title":"EMBO J"},{"key":"356_CR11","doi-asserted-by":"crossref","unstructured":"Cristiani A, Dutta A, Poveda-Cuevas SA, Kern A, Bhaskara RM (2023) Identification of potential selective autophagy receptors from protein-content profiling of autophagosomes. J Cell Biochem 125:e30405","DOI":"10.1002\/jcb.30405"},{"key":"356_CR12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.molcel.2019.05.011","volume":"75","author":"CN Cunningham","year":"2019","unstructured":"Cunningham CN, Williams JM, Knupp J, Arunagiri A, Arvan P, Tsai B (2019) Cells Deploy a two-pronged strategy to rectify misfolded proinsulin aggregates. Mol Cell 75:442\u2013456.e4","journal-title":"Mol Cell"},{"key":"356_CR13","doi-asserted-by":"crossref","DOI":"10.1186\/s12915-018-0603-7","volume":"16","author":"I Dikic","year":"2018","unstructured":"Dikic I (2018) Open questions: why should we care about ER-phagy and ER remodelling? BMC Biol 16:131","journal-title":"BMC Biol"},{"key":"356_CR14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-023-06090-9","volume":"618","author":"H Foronda","year":"2023","unstructured":"Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, Gonz\u00e1lez A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L et al (2023) Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature 618:402\u2013410","journal-title":"Nature"},{"key":"356_CR15","doi-asserted-by":"crossref","first-page":"e99847","DOI":"10.15252\/embj.201899847","volume":"38","author":"A Forrester","year":"2019","unstructured":"Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G et al (2019) A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J 38:e99847","journal-title":"EMBO J"},{"key":"356_CR16","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ncb3423","volume":"18","author":"F Fumagalli","year":"2016","unstructured":"Fumagalli F, Noack J, Bergmann TJ, Cebollero E, Pisoni GB, Fasana E, Fregno I, Galli C, Loi M, Sold\u00e0 T et al (2016) Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Nat Cell Biol 18:1173\u20131184","journal-title":"Nat Cell Biol"},{"key":"356_CR17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41586-023-06089-2","volume":"618","author":"A Gonz\u00e1lez","year":"2023","unstructured":"Gonz\u00e1lez A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Br\u00e4uning B et al (2023) Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum. Nature 618:394\u2013401","journal-title":"Nature"},{"key":"356_CR18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nm.2247","volume":"16","author":"P Grumati","year":"2010","unstructured":"Grumati P, Coletto L, Sabatelli P, Cescon M, Angelin A, Bertaggia E, Blaauw B, Urciuolo A, Tiepolo T, Merlini L et al (2010) Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration. Nat Med 16:1313\u20131320","journal-title":"Nat Med"},{"key":"356_CR19","doi-asserted-by":"crossref","first-page":"jcs217364","DOI":"10.1242\/jcs.217364","volume":"131","author":"P Grumati","year":"2018","unstructured":"Grumati P, Dikic I, Stolz A (2018) ER-phagy at a glance. J Cell Sci 131:jcs217364","journal-title":"J Cell Sci"},{"key":"356_CR20","doi-asserted-by":"crossref","first-page":"e25555","DOI":"10.7554\/eLife.25555","volume":"6","author":"P Grumati","year":"2017","unstructured":"Grumati P, Morozzi G, H\u00f6lper S, Mari M, Harwardt M-LI, Yan R, M\u00fcller S, Reggiori F, Heilemann M, Dikic I (2017) Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. eLife 6:e25555","journal-title":"eLife"},{"key":"356_CR21","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.molcel.2022.02.018","volume":"82","author":"A Gubas","year":"2022","unstructured":"Gubas A, Dikic I (2022) ER remodeling via ER-phagy. Mol Cell 82:1492\u20131500","journal-title":"Mol Cell"},{"key":"356_CR22","doi-asserted-by":"crossref","unstructured":"He X, He H, Hou Z, Wang Z, Shi Q, Zhou T, Wu Y, Qin Y, Wang J, Cai Z et al (2024) ER-phagy restrains inflammatory responses through its receptor UBAC2. EMBO J 43:5057\u20135084","DOI":"10.1038\/s44318-024-00232-z"},{"key":"356_CR23","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41556-024-01356-4","volume":"26","author":"MJ Hoyer","year":"2024","unstructured":"Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F et al (2024) Combinatorial selective ER-phagy remodels the ER during neurogenesis. Nat Cell Biol 26:378\u2013392","journal-title":"Nat Cell Biol"},{"key":"356_CR24","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1093\/brain\/awu287","volume":"137","author":"CA H\u00fcbner","year":"2014","unstructured":"H\u00fcbner CA, Kurth I (2014) Membrane-shaping disorders: a common pathway in axon degeneration. Brain 137:3109\u20133121","journal-title":"Brain"},{"key":"356_CR25","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102608","volume":"39","author":"X Jiang","year":"2020","unstructured":"Jiang X, Wang X, Ding X, Du M, Li B, Weng X, Zhang J, Li L, Tian R, Zhu Q et al (2020) FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER\u2010phagy. EMBO J 39:e102608","journal-title":"EMBO J"},{"key":"356_CR26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.molcel.2016.09.037","volume":"64","author":"T Kaizuka","year":"2016","unstructured":"Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N (2016) An autophagic flux probe that releases an internal control. Mol Cell 64:835\u2013849","journal-title":"Mol Cell"},{"key":"356_CR27","doi-asserted-by":"crossref","first-page":"G733","DOI":"10.1152\/ajpgi.00094.2020","volume":"319","author":"U Keles","year":"2020","unstructured":"Keles U, Iscan E, Yilmaz HE, Karak\u00fclah G, Suner A, Bal E, Tasdemir N, Cavga AD, Ekin U, Mutlu Z et al (2020) Differential expression of full-length and NH2 terminally truncated FAM134B isoforms in normal physiology and cancer. Am J Physiol-Gastrointest Liver Physiol 319:G733\u2013G747","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"356_CR28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature14498","volume":"522","author":"A Khaminets","year":"2015","unstructured":"Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N et al (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 522:354\u2013358","journal-title":"Nature"},{"key":"356_CR29","doi-asserted-by":"crossref","DOI":"10.1186\/2044-5040-1-29","volume":"1","author":"JD Knight","year":"2011","unstructured":"Knight JD, Kothary R (2011) The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis. Skelet Muscle 1:29","journal-title":"Skelet Muscle"},{"key":"356_CR30","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900340","volume":"2","author":"S Kohno","year":"2019","unstructured":"Kohno S, Shiozaki Y, Keenan AL, Miyazaki-Anzai S, Miyazaki M (2019) An N-terminal\u2013truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy. Life Sci Alliance 2:e201900340","journal-title":"Life Sci Alliance"},{"key":"356_CR31","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ng.464","volume":"41","author":"I Kurth","year":"2009","unstructured":"Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK, Rotthier A, Baets J, Senderek J, Topaloglu H, Farrell SA et al (2009) Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. Nat Genet 41:1179\u20131181","journal-title":"Nat Genet"},{"key":"356_CR32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cmet.2009.10.008","volume":"10","author":"E Masiero","year":"2009","unstructured":"Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, Metzger D, Reggiani C, Schiaffino S, Sandri M (2009) Autophagy is required to maintain muscle mass. Cell Metab 10:507\u2013515","journal-title":"Cell Metab"},{"key":"356_CR33","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12397","volume":"7","author":"I Moretti","year":"2016","unstructured":"Moretti I, Ciciliot S, Dyar KA, Abraham R, Murgia M, Agatea L, Akimoto T, Bicciato S, Forcato M, Pierre P et al (2016) MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity. Nat Commun 7:12397","journal-title":"Nat Commun"},{"key":"356_CR34","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1016\/j.molcel.2021.10.001","volume":"81","author":"A Ordureau","year":"2021","unstructured":"Ordureau A, Kraus F, Zhang J, An H, Park S, Ahfeldt T, Paulo JA, Harper JW (2021) Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy. Mol Cell 81:5082\u20135098.e11","journal-title":"Mol Cell"},{"key":"356_CR35","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1242\/dev.111.4.1097","volume":"111","author":"MO Ott","year":"1991","unstructured":"Ott MO, Bober E, Lyons G, Arnold H, Buckingham M (1991) Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo. Development 111:1097\u20131107","journal-title":"Development"},{"key":"356_CR36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/embor.2010.92","volume":"11","author":"SH Park","year":"2010","unstructured":"Park SH, Blackstone C (2010) Further assembly required: construction and dynamics of the endoplasmic reticulum network. EMBO Rep 11:515\u2013521","journal-title":"EMBO Rep"},{"key":"356_CR37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ceb.2011.04.007","volume":"23","author":"D Pendin","year":"2011","unstructured":"Pendin D, McNew JA, Daga A (2011) Balancing ER dynamics: shaping, bending, severing, and mending membranes. Curr Opin Cell Biol 23:435\u2013442","journal-title":"Curr Opin Cell Biol"},{"key":"356_CR38","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202052289","volume":"22","author":"A Reggio","year":"2021","unstructured":"Reggio A, Buonomo V, Berkane R, Bhaskara RM, Tellechea M, Peluso I, Polishchuk E, Di Lorenzo G, Cirillo C, Esposito M et al (2021) Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and collagen quality control. EMBO Rep 22:e52289","journal-title":"EMBO Rep"},{"key":"356_CR39","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00038.2021","volume":"102","author":"F Reggiori","year":"2022","unstructured":"Reggiori F, Molinari M (2022) ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum. Physiol Rev 102:1393\u20131448","journal-title":"Physiol Rev"},{"key":"356_CR40","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/hmg\/ddn046","volume":"17","author":"N Rismanchi","year":"2008","unstructured":"Rismanchi N, Soderblom C, Stadler J, Zhu P-P, Blackstone C (2008) Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. Hum Mol Genet 17:1591\u20131604","journal-title":"Hum Mol Genet"},{"key":"356_CR41","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1600-0854.2008.00717.x","volume":"9","author":"D Rossi","year":"2008","unstructured":"Rossi D, Barone V, Giacomello E, Cusimano V, Sorrentino V (2008) The sarcoplasmic reticulum: an organized patchwork of specialized domains. Traffic 9:1044\u20131049","journal-title":"Traffic"},{"key":"356_CR42","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/biom12040488","volume":"12","author":"D Rossi","year":"2022","unstructured":"Rossi D, Pierantozzi E, Amadsun DO, Buonocore S, Rubino EM, Sorrentino V (2022) The sarcoplasmic reticulum of skeletal muscle cells: a labyrinth of membrane contact sites. Biomolecules 12:488","journal-title":"Biomolecules"},{"key":"356_CR43","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/15548627.2021.1968228","volume":"18","author":"Y Shiozaki","year":"2022","unstructured":"Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M (2022) MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis. Autophagy 18:1049\u20131061","journal-title":"Autophagy"},{"key":"356_CR44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.devcel.2017.11.024","volume":"44","author":"MD Smith","year":"2018","unstructured":"Smith MD, Harley ME, Kemp AJ, Wills J, Lee M, Arends M, von Kriegsheim A, Behrends C, Wilkinson S (2018) CCPG1 is a non-canonical autophagy cargo receptor essential for ER-phagy and pancreatic ER proteostasis. Dev Cell 44:217\u2013232.e11","journal-title":"Dev Cell"},{"key":"356_CR45","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1134\/S000629792209005X","volume":"87","author":"E Turishcheva","year":"2022","unstructured":"Turishcheva E, Vildanova M, Onishchenko G, Smirnova E (2022) The role of endoplasmic reticulum stress in differentiation of cells of mesenchymal origin. Biochem Mosc 87:916\u2013931","journal-title":"Biochem Mosc"},{"key":"356_CR46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cell.2005.11.047","volume":"124","author":"GK Voeltz","year":"2006","unstructured":"Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA (2006) A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 124:573\u2013586","journal-title":"Cell"},{"key":"356_CR47","volume":"222","author":"X Wang","year":"2023","unstructured":"Wang X, Jiang X, Li B, Zheng J, Guo J, Gao L, Du M, Weng X, Li L, Chen S et al (2023) A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy. J Cell Biol 222:e202201068","journal-title":"J Cell Biol"},{"key":"356_CR48","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev-biochem-072711-163501","volume":"84","author":"LM Westrate","year":"2015","unstructured":"Westrate LM, Lee JE, Prinz WA, Voeltz GK (2015) Form follows function: the importance of endoplasmic reticulum shape. Annu Rev Biochem 84:791\u2013811","journal-title":"Annu Rev Biochem"},{"key":"356_CR49","volume":"1","author":"Z Xie","year":"2021","unstructured":"Xie Z, Bailey A, Kuleshov MV, Clarke DJB, Evangelista JE, Jenkins SL, Lachmann A, Wojciechowicz ML, Kropiwnicki E, Jagodnik KM et al (2021) Gene set knowledge discovery with Enrichr. Curr Protoc 1:e90","journal-title":"Curr Protoc"},{"key":"356_CR50","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.tcb.2016.06.002","volume":"26","author":"H Zhang","year":"2016","unstructured":"Zhang H, Hu J (2016) Shaping the endoplasmic reticulum into a social network. Trends Cell Biol 26:934\u2013943","journal-title":"Trends Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44318-024-00356-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44318-024-00356-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44318-024-00356-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:06:46Z","timestamp":1786039606000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44318-024-00356-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,17]]}},"alternative-id":["356"],"URL":"https:\/\/doi.org\/10.1038\/s44318-024-00356-2","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"9 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}],"article-number":"4"}}