{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:03:44Z","timestamp":1790960624157,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32300074"],"award-info":[{"award-number":["32300074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2101039"],"award-info":[{"award-number":["2101039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32161133015"],"award-info":[{"award-number":["32161133015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20240813143001003"],"award-info":[{"award-number":["JCYJ20240813143001003"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20240813143701003"],"award-info":[{"award-number":["JCYJ20240813143701003"]}]},{"name":"Shenzhen Science and Technology Program","award":["RCBS20231211090516017"],"award-info":[{"award-number":["RCBS20231211090516017"]}]},{"name":"Shenzhen Science and Technology Program","award":["KQTD20240729102249044"],"award-info":[{"award-number":["KQTD20240729102249044"]}]},{"name":"Medical Scientific Research Foundation of Guagndong Province","award":["A2024342"],"award-info":[{"award-number":["A2024342"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["32101039"],"award-info":[{"award-number":["32101039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["32300074"],"award-info":[{"award-number":["32300074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["32161133015"],"award-info":[{"award-number":["32161133015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752102"],"award-info":[{"award-number":["2024M752102"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SZU Top Ranking Project","award":["860\/00000210"],"award-info":[{"award-number":["860\/00000210"]}]},{"name":"SZU Top Ranking Project \"B&RsacFMS\"","award":["868\/0000080208"],"award-info":[{"award-number":["868\/0000080208"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1\/2 is necessary for Sororin recruitment, it is by itself not sufficient. Here, we demonstrate that DNA replication-coupled Poly(ADP-Ribose) Polymerase (PARP) activity is an additional prerequisite in human cells. During normal S-phase, PARP1 PARylates a microprotein encoded by the alternative ORF\n                    <jats:italic>C11ORF98<\/jats:italic>\n                    , which we designate RSMC (28S rRNA\/ribosome and Sororin micro-cofactor). This PARylation strengthens the interaction of RSMC with Sororin, enhancing both chromatin recruitment and anti-Wapl activity of Sororin in concert with SMC3 acetylation. Notably, overexpression of RSMC is able to rescue cohesion defects induced by the PARP inhibitor olaparib. These findings highlight understudied microproteins as critical regulators of fundamental cellular processes, such as sister chromatid cohesion.\n                  <\/jats:p>","DOI":"10.1038\/s44318-025-00641-8","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T16:55:32Z","timestamp":1763571332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion"],"prefix":"10.1038","volume":"45","author":[{"given":"Meiqian","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-4161","authenticated-orcid":false,"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-7397","authenticated-orcid":false,"given":"Li-Lin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-2082","authenticated-orcid":false,"given":"Xingzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alibek","family":"Ydyrys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2055-3513","authenticated-orcid":false,"given":"Qinhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-6186","authenticated-orcid":false,"given":"Huiqiang","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-3552","authenticated-orcid":false,"given":"Wenya","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"641_CR1","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1073\/pnas.1708291114","volume":"114","author":"RM Alomer","year":"2017","unstructured":"Alomer RM, da Silva EML, Chen J, Piekarz KM, McDonald K, Sansam CG, Sansam CL, Rankin S (2017) Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. Proc Natl Acad Sci USA 114:9906\u20139911","journal-title":"Proc Natl Acad Sci USA"},{"key":"641_CR2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1101\/gad.334730.119","volume":"34","author":"K Azarm","year":"2020","unstructured":"Azarm K, Smith S (2020) Nuclear PARPs and genome integrity. Genes Dev 34:285\u2013301","journal-title":"Genes Dev"},{"key":"641_CR3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/dvdy.24510","volume":"246","author":"R Banerji","year":"2017","unstructured":"Banerji R, Skibbens RV, Iovine MK (2017) How many roads lead to cohesinopathies?. Dev Dyn 246:881\u2013888","journal-title":"Dev Dyn"},{"key":"641_CR4","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1002\/j.1460-2075.1991.tb05013.x","volume":"10","author":"WC Burhans","year":"1991","unstructured":"Burhans WC, Vassilev LT, Wu J, Sogo JM, Nallaseth FS, DePamphilis ML (1991) Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation. EMBO J 10:4351\u20134360","journal-title":"EMBO J"},{"key":"641_CR5","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cell.2012.07.028","volume":"150","author":"KL Chan","year":"2012","unstructured":"Chan KL, Roig MB, Hu B, Beckouet F, Metson J, Nasmyth K (2012) Cohesin\u2019s DNA exit gate is distinct from its entrance gate and is regulated by acetylation. Cell 150:961\u2013974","journal-title":"Cell"},{"key":"641_CR6","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1021\/acs.biochem.7b00265","volume":"56","author":"Q Chu","year":"2017","unstructured":"Chu Q, Rathore A, Diedrich JK, Donaldson CJ, Yates 3rdJR, Saghatelian A (2017) Identification of microprotein-protein interactions via APEX tagging. Biochemistry 56:3299\u20133306","journal-title":"Biochemistry"},{"key":"641_CR7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1097-2765(00)80420-7","volume":"5","author":"R Ciosk","year":"2000","unstructured":"Ciosk R, Shirayama M, Shevchenko A, Tanaka T, Toth A, Shevchenko A, Nasmyth K (2000) Cohesin\u2019s binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell 5:243\u2013254","journal-title":"Mol Cell"},{"key":"641_CR8","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.molcel.2021.07.015","volume":"81","author":"K Cong","year":"2021","unstructured":"Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J et al (2021) Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency. Mol Cell 81:3227","journal-title":"Mol Cell"},{"key":"641_CR9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.sbi.2020.06.009","volume":"65","author":"S Datta","year":"2020","unstructured":"Datta S, Lecomte L, Haering CH (2020) Structural insights into DNA loop extrusion by SMC protein complexes. Curr Opin Struct Biol 65:102\u2013109","journal-title":"Curr Opin Struct Biol"},{"key":"641_CR10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41580-021-00349-7","volume":"22","author":"IF Davidson","year":"2021","unstructured":"Davidson IF, Peters JM (2021) Genome folding through loop extrusion by SMC complexes. Nat Rev Mol Cell Biol 22:445\u2013464","journal-title":"Nat Rev Mol Cell Biol"},{"key":"641_CR11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/excr.1996.0259","volume":"227","author":"S Desnoyers","year":"1996","unstructured":"Desnoyers S, Kaufmann SH, Poirier GG (1996) Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors. Exp Cell Res 227:146\u2013153","journal-title":"Exp Cell Res"},{"key":"641_CR12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0014-4827(88)90289-3","volume":"179","author":"S Fakan","year":"1988","unstructured":"Fakan S, Leduc Y, Lamarre D, Brunet G, Poirier GG (1988) Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus. Exp Cell Res 179:517\u2013526","journal-title":"Exp Cell Res"},{"key":"641_CR13","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.cub.2006.10.061","volume":"16","author":"R Gandhi","year":"2006","unstructured":"Gandhi R, Gillespie PJ, Hirano T (2006) Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol 16:2406\u20132417","journal-title":"Curr Biol"},{"key":"641_CR14","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cub.2017.02.066","volume":"27","author":"Y Goto","year":"2017","unstructured":"Goto Y, Yamagishi Y, Shintomi-Kawamura M, Abe M, Tanno Y, Watanabe Y (2017) Pds5 regulates sister-chromatid cohesion and chromosome bi-orientation through a conserved protein interaction module. Curr Biol 27:1005\u20131012","journal-title":"Curr Biol"},{"key":"641_CR15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.tig.2019.03.008","volume":"35","author":"H Hanzlikova","year":"2019","unstructured":"Hanzlikova H, Caldecott KW (2019) Perspectives on PARPs in S phase. Trends Genet 35:412\u2013422","journal-title":"Trends Genet"},{"key":"641_CR16","first-page":"2546","volume":"45","author":"H Hanzlikova","year":"2017","unstructured":"Hanzlikova H, Gittens W, Krejcikova K, Zeng ZH, Caldecott KW (2017) Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin. Nucleic Acids Res 45:2546\u20132557","journal-title":"Nucleic Acids Res"},{"key":"641_CR17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.molcel.2018.06.004","volume":"71","author":"H Hanzlikova","year":"2018","unstructured":"Hanzlikova H, Kalasova I, Demin AA, Pennicott LE, Cihlarova Z, Caldecott KW (2018) The importance of poly(ADP-ribose) polymerase as a sensor of unligated Okazaki fragments during DNA replication. Mol cell 71:319\u2013331.e313","journal-title":"Mol cell"},{"key":"641_CR18","doi-asserted-by":"crossref","first-page":"R1266","DOI":"10.1016\/j.cub.2018.08.034","volume":"28","author":"M Hassler","year":"2018","unstructured":"Hassler M, Shaltiel IA, Haering CH (2018) Towards a unified model of SMC complex function. Curr Biol 28:R1266\u2013R1281","journal-title":"Curr Biol"},{"key":"641_CR19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10409238.2022.2027336","volume":"57","author":"W Hou","year":"2022","unstructured":"Hou W, Li Y, Zhang J, Xia Y, Wang X, Chen H, Lou H (2022) Cohesin in DNA damage response and double-strand break repair. Crit Rev Biochem Mol Biol 57:333\u2013350","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"641_CR20","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.molcel.2022.02.021","volume":"82","author":"D Huang","year":"2022","unstructured":"Huang D, Kraus WL (2022) The expanding universe of PARP1-mediated molecular and therapeutic mechanisms. Mol cell 82:2315\u20132334","journal-title":"Mol cell"},{"issue":"(15)","key":"641_CR21","volume":"37","author":"MP Ivanov","year":"2018","unstructured":"Ivanov MP, Ladurner R, Poser I, Beveridge R, Rampler E, Hudecz O, Novatchkova M, Heriche JK, Wutz G, van der Lelij P et al (2018) The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion. EMBO J 37:e97150","journal-title":"EMBO J"},{"key":"641_CR22","doi-asserted-by":"crossref","unstructured":"Jiang M, Lou H, Hou W (2021) Microproteins: from behind the scenes to the spotlight. GIAD 2:225\u2013239","DOI":"10.1007\/s42764-021-00040-3"},{"key":"641_CR23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.molcel.2013.08.026","volume":"52","author":"S Jungmichel","year":"2013","unstructured":"Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML (2013) Proteome-wide identification of Poly(ADP-ribosyl)ation targets in different genotoxic stress responses. Mol Cell 52:272\u2013285","journal-title":"Mol Cell"},{"issue":"12","key":"641_CR24","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3390\/cells8121625","volume":"8","author":"T Kamaletdinova","year":"2019","unstructured":"Kamaletdinova T, Fanaei-Kahrani Z, Wang ZQ (2019) The enigmatic function of PARP1: from PARylation activity to PAR readers. Cells 8(12):1625","journal-title":"Cells"},{"key":"641_CR25","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.15252\/embj.201695756","volume":"35","author":"M Kanke","year":"2016","unstructured":"Kanke M, Tahara E, Huis In\u2019t Veld PJ, Nishiyama T (2016) Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO J 35:2686\u20132698","journal-title":"EMBO J"},{"key":"641_CR26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1101\/gad.334433.119","volume":"34","author":"DS Kim","year":"2020","unstructured":"Kim DS, Challa S, Jones A, Kraus WL (2020) PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis. Genes Dev 34:302\u2013320","journal-title":"Genes Dev"},{"key":"641_CR27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.09.040","volume":"127","author":"S Kueng","year":"2006","unstructured":"Kueng S, Hegemann B, Peters BH, Lipp JJ, Schleiffer A, Mechtler K, Peters JM (2006) Wapl controls the dynamic association of cohesin with chromatin. Cell 127:955\u2013967","journal-title":"Cell"},{"key":"641_CR28","doi-asserted-by":"crossref","first-page":"103931","DOI":"10.18632\/oncotarget.21879","volume":"8","author":"E Kukolj","year":"2017","unstructured":"Kukolj E, Kaufmann T, Dick AE, Zeillinger R, Gerlich DW, Slade D (2017) PARP inhibition causes premature loss of cohesion in cancer cells. Oncotarget 8:103931\u2013103951","journal-title":"Oncotarget"},{"key":"641_CR29","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1093\/nar\/gkab269","volume":"49","author":"S Kumamoto","year":"2021","unstructured":"Kumamoto S, Nishiyama A, Chiba Y, Miyashita R, Konishi C, Azuma Y, Nakanishi M (2021) HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation. Nucleic Acids Res 49:5003\u20135016","journal-title":"Nucleic Acids Res"},{"key":"641_CR30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41587-022-01316-z","volume":"40","author":"G Kustatscher","year":"2022","unstructured":"Kustatscher G, Collins T, Gingras AC, Guo T, Hermjakob H, Ideker T, Lilley KS, Lundberg E, Marcotte EM, Ralser M et al (2022a) An open invitation to the understudied proteins initiative. Nat Biotechnol 40:815\u2013817","journal-title":"Nat Biotechnol"},{"key":"641_CR31","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41592-022-01454-x","volume":"19","author":"G Kustatscher","year":"2022","unstructured":"Kustatscher G, Collins T, Gingras AC, Guo T, Hermjakob H, Ideker T, Lilley KS, Lundberg E, Marcotte EM, Ralser M et al (2022b) Understudied proteins: opportunities and challenges for functional proteomics. Nat Methods 19:774\u2013779","journal-title":"Nat Methods"},{"key":"641_CR32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.15252\/embj.201592532","volume":"35","author":"R Ladurner","year":"2016","unstructured":"Ladurner R, Kreidl E, Ivanov MP, Ekker H, Idarraga-Amado MH, Busslinger GA, Wutz G, Cisneros DA, Peters JM (2016) Sororin actively maintains sister chromatid cohesion. EMBO J 35:635\u2013653","journal-title":"EMBO J"},{"key":"641_CR33","doi-asserted-by":"crossref","first-page":"20364","DOI":"10.1073\/pnas.1011069107","volume":"107","author":"AL Lafont","year":"2010","unstructured":"Lafont AL, Song J, Rankin S (2010) Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion. Proc Natl Acad Sci USA 107:20364\u201320369","journal-title":"Proc Natl Acad Sci USA"},{"key":"641_CR34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.15252\/embr.201744737","volume":"19","author":"C Liang","year":"2018","unstructured":"Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S et al (2018) A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion. EMBO Rep 19:43\u201356","journal-title":"EMBO Rep"},{"key":"641_CR35","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1172\/JCI98727","volume":"128","author":"YH Liu","year":"2018","unstructured":"Liu YH, Xu HC, Van der Jeught K, Li YJ, Liu S, Zhang L, Fang YZ, Zhang XN, Radovich M, Schneider BP et al (2018) Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. J Clin Invest 128:2951\u20132965","journal-title":"J Clin Invest"},{"key":"641_CR36","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1093\/bioinformatics\/bty159","volume":"34","author":"M Lo Monte","year":"2018","unstructured":"Lo Monte M, Manelfi C, Gemei M, Corda D, Beccari AR (2018) ADPredict: ADP-ribosylation site prediction based on physicochemical and structural descriptors. Bioinformatics 34:2566\u20132574","journal-title":"Bioinformatics"},{"key":"641_CR37","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.15252\/embj.201797090","volume":"36","author":"AL Marston","year":"2017","unstructured":"Marston AL (2017) Dalmatian: spotting the difference in cohesin protectors. EMBO J 36:1468\u20131470","journal-title":"EMBO J"},{"key":"641_CR38","doi-asserted-by":"crossref","first-page":"e1002574","DOI":"10.1371\/journal.pgen.1002574","volume":"8","author":"JL McLellan","year":"2012","unstructured":"McLellan JL, O\u2019Neil NJ, Barrett I, Ferree E, van Pel DM, Ushey K, Sipahimalani P, Bryan J, Rose AM, Hieter P (2012) Synthetic lethality of cohesins with PARPs and replication fork mediators. PLoS Genet 8:e1002574","journal-title":"PLoS Genet"},{"key":"641_CR39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2022.12.044","volume":"186","author":"M Minamino","year":"2023","unstructured":"Minamino M, Bouchoux C, Canal B, Diffley JFX, Uhlmann F (2023) A replication fork determinant for the establishment of sister chromatid cohesion. Cell 186:837\u2013849.e811","journal-title":"Cell"},{"key":"641_CR40","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.cub.2015.05.017","volume":"25","author":"M Minamino","year":"2015","unstructured":"Minamino M, Ishibashi M, Nakato R, Akiyama K, Tanaka H, Kato Y, Negishi L, Hirota T, Sutani T, Bando M, Shirahige K (2015) Esco1 acetylates cohesin via a mechanism different from that of Esco2. Curr Biol 25:1694\u20131706","journal-title":"Curr Biol"},{"key":"641_CR41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/14728222.2019.1609943","volume":"23","author":"K Mintzas","year":"2019","unstructured":"Mintzas K, Heuser M (2019) Emerging strategies to target the dysfunctional cohesin complex in cancer. Expert Opin Ther Targets 23:525\u2013537","journal-title":"Expert Opin Ther Targets"},{"key":"641_CR42","volume":"10","author":"G Mondal","year":"2019","unstructured":"Mondal G, Stevers M, Goode B, Ashworth A, Solomon DA (2019) A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. Nat Commun 10:1686","journal-title":"Nat Commun"},{"key":"641_CR43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ceb.2018.01.010","volume":"52","author":"C Morales","year":"2018","unstructured":"Morales C, Losada A (2018) Establishing and dissolving cohesion during the vertebrate cell cycle. Curr Opin Cell Biol 52:51\u201357","journal-title":"Curr Opin Cell Biol"},{"key":"641_CR44","doi-asserted-by":"crossref","first-page":"11600","DOI":"10.1093\/nar\/gkac948","volume":"50","author":"T Mosler","year":"2022","unstructured":"Mosler T, Baymaz HI, Graf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A et al (2022) PARP1 proximity proteomics reveals interaction partners at stressed replication forks. Nucleic Acids Res 50:11600\u201311618","journal-title":"Nucleic Acids Res"},{"key":"641_CR45","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/ncb3353","volume":"18","author":"K Nagasaka","year":"2016","unstructured":"Nagasaka K, Hossain MJ, Roberti MJ, Ellenberg J, Hirota T (2016) Sister chromatid resolution is an intrinsic part of chromosome organization in prophase. Nat Cell Biol 18:692\u2013699","journal-title":"Nat Cell Biol"},{"key":"641_CR46","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev-genet-102108-134233","volume":"43","author":"K Nasmyth","year":"2009","unstructured":"Nasmyth K, Haering CH (2009) Cohesin: its roles and mechanisms. Annu Rev Genet 43:525\u2013558","journal-title":"Annu Rev Genet"},{"key":"641_CR47","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.288.5470.1379","volume":"288","author":"K Nasmyth","year":"2000","unstructured":"Nasmyth K, Peters JM, Uhlmann F (2000) Splitting the chromosome: cutting the ties that bind sister chromatids. Science 288:1379\u20131385","journal-title":"Science"},{"key":"641_CR48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2018.11.006","volume":"58","author":"T Nishiyama","year":"2019","unstructured":"Nishiyama T (2019) Cohesion and cohesin-dependent chromatin organization. Curr Opin Cell Biol 58:8\u201314","journal-title":"Curr Opin Cell Biol"},{"key":"641_CR49","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2010.10.031","volume":"143","author":"T Nishiyama","year":"2010","unstructured":"Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A, Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K et al (2010) Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell 143:737\u2013749","journal-title":"Cell"},{"key":"641_CR50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tig.2012.12.004","volume":"29","author":"NJ O\u2019Neil","year":"2013","unstructured":"O\u2019Neil NJ, van Pel DM, Hieter P (2013) Synthetic lethality and cancer: cohesin and PARP at the replication fork. Trends Genet 29:290","journal-title":"Trends Genet"},{"key":"641_CR51","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/nar\/gkz734","volume":"48","author":"MW Orr","year":"2020","unstructured":"Orr MW, Mao Y, Storz G, Qian SB (2020) Alternative ORFs and small ORFs: shedding light on the dark proteome. Nucleic Acids Res 48:1029\u20131042","journal-title":"Nucleic Acids Res"},{"key":"641_CR52","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.molcel.2016.02.033","volume":"62","author":"Z Ouyang","year":"2016","unstructured":"Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H (2016) Structural basis and IP6 requirement for Pds5-dependent cohesin dynamics. Mol cell 62:248\u2013259","journal-title":"Mol cell"},{"issue":"(1)","key":"641_CR53","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-022-01228-0","volume":"15","author":"A Padella","year":"2022","unstructured":"Padella A, Di Ror\u00e0 AGL, Marconi G, Ghetti M, Martinelli G, Simonetti G (2022) Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies. J Hematol Oncol 15:10","journal-title":"J Hematol Oncol"},{"key":"641_CR54","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1093\/nar\/gkab584","volume":"49","author":"B Peng","year":"2021","unstructured":"Peng B, Shi RF, Bian J, Li YW, Wang PP, Wang HL, Liao J, Zhu WG, Xu XZ (2021) PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair. Nucleic Acids Res 49:7554\u20137570","journal-title":"Nucleic Acids Res"},{"key":"641_CR55","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.tcb.2021.03.005","volume":"31","author":"C Perea-Resa","year":"2021","unstructured":"Perea-Resa C, Wattendorf L, Marzouk S, Blower MD (2021) Cohesin: behind dynamic genome topology and gene expression reprogramming. Trends Cell Biol 31:760\u2013773","journal-title":"Trends Cell Biol"},{"issue":"11","key":"641_CR56","doi-asserted-by":"crossref","first-page":"a011130","DOI":"10.1101\/cshperspect.a011130","volume":"4","author":"JM Peters","year":"2012","unstructured":"Peters JM, Nishiyama T (2012) Sister chromatid cohesion. Cold Spring Harb Perspect Biol 4(11):a011130","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"641_CR57","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41556-021-00783-x","volume":"23","author":"A Piazza","year":"2021","unstructured":"Piazza A, Bordelet H, Dumont A, Thierry A, Savocco J, Girard F, Koszul R (2021) Cohesin regulates homology search during recombinational DNA repair. Nat Cell Biol 23:1176\u20131186","journal-title":"Nat Cell Biol"},{"key":"641_CR58","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1080\/15384101.2019.1658476","volume":"18","author":"J Piche","year":"2019","unstructured":"Piche J, Van Vliet PP, Puceat M, Andelfinger G (2019) The expanding phenotypes of cohesinopathies: one ring to rule them all!. Cell Cycle 18:2828\u20132848","journal-title":"Cell Cycle"},{"key":"641_CR59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2005.03.017","volume":"18","author":"S Rankin","year":"2005","unstructured":"Rankin S, Ayad NG, Kirschner MW (2005) Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell 18:185\u2013200","journal-title":"Mol Cell"},{"key":"641_CR60","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1126\/science.1157774","volume":"321","author":"T Rolef Ben-Shahar","year":"2008","unstructured":"Rolef Ben-Shahar T, Heeger S, Lehane C, East P, Flynn H, Skehel M, Uhlmann F (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321:563\u2013566","journal-title":"Science"},{"key":"641_CR61","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03159-2","volume":"9","author":"GE Ronson","year":"2018","unstructured":"Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND (2018) PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation. Nat Commun 9:746","journal-title":"Nat Commun"},{"key":"641_CR62","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.molcel.2009.02.028","volume":"33","author":"BD Rowland","year":"2009","unstructured":"Rowland BD, Roig MB, Nishino T, Kurze A, Uluocak P, Mishra A, Beckouet F, Underwood P, Metson J, Imre R et al (2009) Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity. Mol Cell 33:763\u2013774","journal-title":"Mol Cell"},{"key":"641_CR63","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cub.2007.02.029","volume":"17","author":"J Schmitz","year":"2007","unstructured":"Schmitz J, Watrin E, Lenart P, Mechtler K, Peters JM (2007) Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol 17:630\u2013636","journal-title":"Curr Biol"},{"key":"641_CR64","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/ncb2280","volume":"13","author":"L Schockel","year":"2011","unstructured":"Schockel L, Mockel M, Mayer B, Boos D, Stemmann O (2011) Cleavage of cohesin rings coordinates the separation of centrioles and chromatids. Nat Cell Biol 13:966\u2013972","journal-title":"Nat Cell Biol"},{"key":"641_CR65","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ymeth.2021.09.008","volume":"203","author":"Y Sha","year":"2022","unstructured":"Sha Y, Ma C, Wei X, Liu Y, Chen Y, Li L (2022) DeepSADPr: a hybrid-learning architecture for serine ADP-ribosylation site prediction. Methods 203:575\u2013583","journal-title":"Methods"},{"key":"641_CR66","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1101\/gad.1976710","volume":"24","author":"R Sherwood","year":"2010","unstructured":"Sherwood R, Takahashi TS, Jallepalli PV (2010) Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev 24:2723\u20132731","journal-title":"Genes Dev"},{"key":"641_CR67","doi-asserted-by":"crossref","first-page":"R1126","DOI":"10.1016\/j.cub.2009.10.067","volume":"19","author":"RV Skibbens","year":"2009","unstructured":"Skibbens RV (2009) Establishment of sister chromatid cohesion. Curr Biol 19:R1126\u2013R1132","journal-title":"Curr Biol"},{"key":"641_CR68","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1101\/gad.13.3.307","volume":"13","author":"RV Skibbens","year":"1999","unstructured":"Skibbens RV, Corson LB, Koshland D, Hieter P (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13:307\u2013319","journal-title":"Genes Dev"},{"key":"641_CR69","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1083\/jcb.201801157","volume":"217","author":"R Stanyte","year":"2018","unstructured":"Stanyte R, Nuebler J, Blaukopf C, Hoefler R, Stocsits R, Peters JM, Gerlich DW (2018) Dynamics of sister chromatid resolution during cell cycle progression. J Cell Biol 217:1985\u20132004","journal-title":"J Cell Biol"},{"key":"641_CR70","doi-asserted-by":"crossref","first-page":"e1007685","DOI":"10.1371\/journal.pgen.1007685","volume":"15","author":"H Sun","year":"2019","unstructured":"Sun H, Zhang J, Xin S, Jiang M, Zhang J, Li Z, Cao Q, Lou H (2019) Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. PLoS Genet 15:e1007685","journal-title":"PLoS Genet"},{"key":"641_CR71","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cub.2009.01.062","volume":"19","author":"T Sutani","year":"2009","unstructured":"Sutani T, Kawaguchi T, Kanno R, Itoh T, Shirahige K (2009) Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction. Curr Biol 19:492\u2013497","journal-title":"Curr Biol"},{"key":"641_CR72","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ng1363","volume":"36","author":"ET Tonkin","year":"2004","unstructured":"Tonkin ET, Wang TJ, Lisgo S, Bamshad MJ, Strachan T (2004) NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome. Nat Genet 36:636\u2013641","journal-title":"Nat Genet"},{"issue":"(3)","key":"641_CR73","volume":"6","author":"Z Tothova","year":"2021","unstructured":"Tothova Z, Valton AL, Gorelov RA, Vallurupalli M, Krill-Burger JM, Holmes A, Landers CC, Haydu JE, Malolepsza E, Hartigan C et al (2021) Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS\/AML. JCI Insight 6:e142149","journal-title":"JCI Insight"},{"key":"641_CR74","doi-asserted-by":"crossref","first-page":"W310","DOI":"10.1093\/nar\/gkl206","volume":"34","author":"A Tovchigrechko","year":"2006","unstructured":"Tovchigrechko A, Vakser IA (2006) GRAMM-X public web server for protein-protein docking. Nucleic Acids Res 34:W310\u2013W314","journal-title":"Nucleic Acids Res"},{"key":"641_CR75","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrm.2016.30","volume":"17","author":"F Uhlmann","year":"2016","unstructured":"Uhlmann F (2016) SMC complexes: from DNA to chromosomes. Nat Rev Mol Cell Biol 17:399\u2013412","journal-title":"Nat Rev Mol Cell Biol"},{"key":"641_CR76","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1126\/science.1157880","volume":"321","author":"E Unal","year":"2008","unstructured":"Unal E, Heidinger-Pauli JM, Kim W, Guacci V, Onn I, Gygi SP, Koshland DE (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321:566\u2013569","journal-title":"Science"},{"key":"641_CR77","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ceb.2020.12.001","volume":"70","author":"MS van Ruiten","year":"2021","unstructured":"van Ruiten MS, Rowland BD (2021) On the choreography of genome folding: a grand pas de deux of cohesin and CTCF. Curr Opin Cell Biol 70:84\u201390","journal-title":"Curr Opin Cell Biol"},{"key":"641_CR78","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41568-020-0270-1","volume":"20","author":"T Waldman","year":"2020","unstructured":"Waldman T (2020) Emerging themes in cohesin cancer biology. Nat Rev Cancer 20:504\u2013515","journal-title":"Nat Rev Cancer"},{"key":"641_CR79","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cub.2006.03.049","volume":"16","author":"E Watrin","year":"2006","unstructured":"Watrin E, Schleiffer A, Tanaka K, Eisenhaber F, Nasmyth K, Peters JM (2006) Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol 16:863\u2013874","journal-title":"Curr Biol"},{"key":"641_CR80","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.gpb.2016.05.001","volume":"14","author":"H Wei","year":"2016","unstructured":"Wei H, Yu X (2016) Functions of PARylation in DNA damage repair pathways. Genomics Proteom Bioinforma 14:131\u2013139","journal-title":"Genomics Proteom Bioinforma"},{"key":"641_CR81","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1093","volume":"1","author":"CJ Wienken","year":"2010","unstructured":"Wienken CJ, Baaske P, Rothbauer U, Braun D, Duhr S (2010) Protein-binding assays in biological liquids using microscale thermophoresis. Nat Commun 1:100","journal-title":"Nat Commun"},{"key":"641_CR82","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/s41588-023-01458-z","volume":"55","author":"JC Wu","year":"2023","unstructured":"Wu JC, Liu Y, Zhangding Z, Liu XH, Ai C, Gan TT, Liang HX, Guo YF, Chen M, Liu YY et al (2023) Cohesin maintains replication timing to suppress DNA damage on cancer genes. Nat Genet 55:1347\u20131358","journal-title":"Nat Genet"},{"key":"641_CR83","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1093\/nar\/gkaa906","volume":"48","author":"H Xu","year":"2020","unstructured":"Xu H, Wang J, Liang Y, Fu Y, Li S, Huang J, Xu H, Zou W, Chen B (2020) TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells. Nucleic Acids Res 48:e127","journal-title":"Nucleic Acids Res"},{"key":"641_CR84","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.15252\/embj.201695607","volume":"36","author":"T Yamada","year":"2017","unstructured":"Yamada T, Tahara E, Kanke M, Kuwata K, Nishiyama T (2017) Drosophila Dalmatian combines Sororin and shugoshin roles in establishment and protection of cohesion. EMBO J 36:1513\u20131527","journal-title":"EMBO J"},{"key":"641_CR85","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/jnci\/djx166","volume":"110","author":"Y Yang","year":"2018","unstructured":"Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H et al (2018) Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst 110:304\u2013315","journal-title":"J Natl Cancer Inst"},{"key":"641_CR86","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-genet-112618-043633","volume":"53","author":"S Yatskevich","year":"2019","unstructured":"Yatskevich S, Rhodes J, Nasmyth K (2019) Organization of chromosomal DNA by SMC complexes. Annu Rev Genet 53:445\u2013482","journal-title":"Annu Rev Genet"},{"key":"641_CR87","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145584","volume":"784","author":"A Yoshimura","year":"2021","unstructured":"Yoshimura A, Sutani T, Shirahige K (2021) Functional control of Eco1 through the MCM complex in sister chromatid cohesion. Gene 784:145584","journal-title":"Gene"},{"key":"641_CR88","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1093\/nar\/gkad146","volume":"51","author":"J Zhang","year":"2023","unstructured":"Zhang J, Li L, Miao Y, Liu X, Sun H, Jiang M, Li X, Li Z, Liu C, Liu B et al (2023a) Symmetric control of sister chromatid cohesion establishment. Nucleic Acids Res 51:4760\u20134773","journal-title":"Nucleic Acids Res"},{"key":"641_CR89","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.15252\/embr.201643807","volume":"18","author":"J Zhang","year":"2017","unstructured":"Zhang J, Shi D, Li X, Ding L, Tang J, Liu C, Shirahige K, Cao Q, Lou H (2017) Rtt101-Mms1-Mms22 coordinates replication-coupled sister chromatid cohesion and nucleosome assembly. EMBO Rep 18:1294\u20131305","journal-title":"EMBO Rep"},{"key":"641_CR90","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molcel.2008.06.006","volume":"31","author":"J Zhang","year":"2008","unstructured":"Zhang J, Shi X, Li Y, Kim BJ, Jia J, Huang Z, Yang T, Fu X, Jung SY, Wang Y et al (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31:143\u2013151","journal-title":"Mol Cell"},{"key":"641_CR91","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/s41388-017-0019-9","volume":"37","author":"M Zhang","year":"2018","unstructured":"Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H et al (2018a) A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Oncogene 37:1805\u20131814","journal-title":"Oncogene"},{"key":"641_CR92","volume":"9","author":"M Zhang","year":"2018","unstructured":"Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H et al (2018b) A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun 9:4475","journal-title":"Nat Commun"},{"issue":"11","key":"641_CR93","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41422-023-00853-9","volume":"33","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Liang X, Luo S, Chen Y, Li Y, Ma C, Li N, Gao N (2023b) Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles. Cell Res 33(11):867\u2013878","journal-title":"Cell Res"},{"key":"641_CR94","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s11427-015-4956-7","volume":"58","author":"G Zheng","year":"2015","unstructured":"Zheng G, Yu H (2015) Regulation of sister chromatid cohesion during the mitotic cell cycle. Sci China Life Sci 58:1089\u20131098","journal-title":"Sci China Life Sci"},{"key":"641_CR95","volume":"7","author":"C Zhou","year":"2021","unstructured":"Zhou C, Zhang X, Miao Y, Zhang Y, Li Y, Xiong B (2021) The cohesin stabilizer Sororin drives G(2)-M transition and spindle assembly in mammalian oocytes. Sci Adv 7:eabg9335","journal-title":"Sci Adv"},{"issue":"(36)","key":"641_CR96","volume":"10","author":"J Zhou","year":"2023","unstructured":"Zhou J, Nie RC, He ZP, Cai XX, Chen JW, Lin WP, Yin YX, Xiang ZC, Zhu TC, Xie JJ et al (2023) STAG2 regulates homologous recombination repair and sensitivity to ATM inhibition. Adv Sci 10:2302494","journal-title":"Adv Sci"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44318-025-00641-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44318-025-00641-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44318-025-00641-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:28Z","timestamp":1786977568000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44318-025-00641-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["641"],"URL":"https:\/\/doi.org\/10.1038\/s44318-025-00641-8","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"10 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}],"article-number":"12"}}