{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:45:25Z","timestamp":1785843925673,"version":"3.56.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brain and Spine Research Institute, Weill Cornell Medicine\/New York Presbyterian hospital"},{"DOI":"10.13039\/100015109","name":"Glut1 Deficiency Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS089817"],"award-info":[{"award-number":["R01NS089817"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS105477"],"award-info":[{"award-number":["R01NS105477"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS126209"],"award-info":[{"award-number":["R01NS126209"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P30NS062691"],"award-info":[{"award-number":["P30NS062691"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA941434"],"award-info":[{"award-number":["AHA941434"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015591","name":"Rose Hills Foundation","doi-asserted-by":"publisher","award":["EDUC4-12753"],"award-info":[{"award-number":["EDUC4-12753"]}],"id":[{"id":"10.13039\/100015591","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TG2-01169"],"award-info":[{"award-number":["TG2-01169"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["R00GM132518"],"award-info":[{"award-number":["R00GM132518"]}]},{"name":"NIH\/NCI","award":["P30CA015704"],"award-info":[{"award-number":["P30CA015704"]}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54HD087101"],"award-info":[{"award-number":["U54HD087101"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50HD103557"],"award-info":[{"award-number":["P50HD103557"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCLA Broad Stem Cell Research Center"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neural progenitor cells within the cerebral cortex undergo a characteristic switch between symmetric self-renewing cell divisions early in development and asymmetric neurogenic divisions later. Yet, the mechanisms controlling this transition remain unclear. Previous work has shown that early but not late neural progenitor cells (NPCs) endogenously express the autism-linked transcription factor Foxp1, and both loss and gain of Foxp1 function can alter NPC activity and fate choices. Here, we show that premature loss of Foxp1 upregulates transcriptional programs regulating angiogenesis, glycolysis, and cellular responses to hypoxia. These changes coincide with a premature destabilization of HIF-1\u03b1, an elevation in HIF-1\u03b1 target genes, including Vegfa in NPCs, and precocious vascular network development. In vitro experiments demonstrate that stabilization of HIF-1\u03b1 in Foxp1-deficient NPCs rescues the premature differentiation phenotype and restores NPC maintenance. Our data indicate that the endogenous decline in Foxp1 expression activates the HIF-1\u03b1 transcriptional program leading to changes in the tissue environment adjacent to NPCs, which, in turn, might alter their self-renewal and neurogenic capacities.<\/jats:p>","DOI":"10.1038\/s44319-024-00131-8","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T09:01:57Z","timestamp":1712739717000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance"],"prefix":"10.1038","volume":"25","author":[{"given":"Jessie E","family":"Buth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E","family":"Dyevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-395X","authenticated-orcid":false,"given":"Chengbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-4774","authenticated-orcid":false,"given":"Lei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael RM","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-3270","authenticated-orcid":false,"given":"Jennifer H","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-8089","authenticated-orcid":false,"given":"M Elizabeth","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2696-3708","authenticated-orcid":false,"given":"Bennett G","family":"Novitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-7865","authenticated-orcid":false,"given":"Caroline Alayne","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"issue":"2","key":"131_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W (2015) HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics 31(2):166\u2013169","journal-title":"Bioinformatics"},{"key":"131_CR2","doi-asserted-by":"publisher","unstructured":"Andrews MG, Pearson CA (2024) Toward an understanding of glucose metabolism in radial glial biology and brain development. Life Sci Alliance 7. https:\/\/doi.org\/10.26508\/lsa.202302193","DOI":"10.26508\/lsa.202302193"},{"key":"131_CR3","unstructured":"Andrews S (2010) FastQC: a quality control tool for high throughput sequence data. Preprint at http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc"},{"issue":"4","key":"131_CR4","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s10803-015-2672-6","volume":"46","author":"EC Azmitia","year":"2016","unstructured":"Azmitia EC, Saccomano ZT, Alzoobaee MF, Boldrini M, Whitaker-Azmitia PM (2016) Persistent angiogenesis in the autism brain: an immunocytochemical study of postmortem cortex, brainstem and cerebellum. J Autism Dev Disord 46(4):1307\u20131318","journal-title":"J Autism Dev Disord"},{"issue":"9","key":"131_CR5","doi-asserted-by":"publisher","first-page":"5549","DOI":"10.1074\/jbc.M113.500405","volume":"289","author":"J Bagnall","year":"2014","unstructured":"Bagnall J, Leedale J, Taylor SE, Spiller DG, White MRH, Sharkey KJ, Bearon RN, S\u00e9e V (2014) Tight control of hypoxia-inducible factor-\u03b1 transient dynamics is essential for cell survival in hypoxia. J Biol Chem 289(9):5549\u20135564","journal-title":"J Biol Chem"},{"key":"131_CR6","doi-asserted-by":"publisher","unstructured":"Baruah J, Vasudevan A (2019) The vessels shaping mental health or illness. Open Neurol J 13. https:\/\/doi.org\/10.2174\/1874205X01913010001","DOI":"10.2174\/1874205X01913010001"},{"issue":"24","key":"131_CR7","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1002\/1873-3468.12906","volume":"591","author":"R Beattie","year":"2017","unstructured":"Beattie R, Hippenmeyer S (2017) Mechanisms of radial glia progenitor cell lineage progression. FEBS Lett 591(24):3993\u20134008","journal-title":"FEBS Lett"},{"issue":"5","key":"131_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1124\/mol.113.089623","volume":"85","author":"J Brocato","year":"2014","unstructured":"Brocato J, Chervona Y, Costa M (2014) Molecular responses to hypoxia-inducible factor 1\u03b1 and beyond. Mol Pharmacol 85(5):651\u2013657","journal-title":"Mol Pharmacol"},{"key":"131_CR9","doi-asserted-by":"publisher","unstructured":"Corrado C, Fontana S (2020) Hypoxia and HIF signaling: one axis with divergent effects. Int J Mol Sci 21(16). https:\/\/doi.org\/10.3390\/ijms21165611","DOI":"10.3390\/ijms21165611"},{"issue":"10","key":"131_CR10","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1523\/JNEUROSCI.3441-12.2013","volume":"33","author":"CL Cunningham","year":"2013","unstructured":"Cunningham CL, Mart\u00ednez-Cerde\u00f1o V, Noctor SC (2013) Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci 33(10):4216\u20134233","journal-title":"J Neurosci"},{"issue":"2","key":"131_CR11","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1073\/pnas.0805165106","volume":"106","author":"R Daneman","year":"2009","unstructured":"Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA (2009) Wnt\/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci USA 106(2):641\u2013646","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"131_CR12","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1242\/dev.127.13.2863","volume":"127","author":"AR Desai","year":"2000","unstructured":"Desai AR, McConnell SK (2000) Progressive restriction in fate potential by neural progenitors during cerebral cortical development. Development 127(13):2863\u20132872","journal-title":"Development"},{"issue":"1","key":"131_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29(1):15\u201321","journal-title":"Bioinformatics"},{"issue":"7","key":"131_CR14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/s41593-022-01093-7","volume":"25","author":"X Dong","year":"2022","unstructured":"Dong X, Zhang Q, Yu X, Wang D, Ma J, Ma J, Shi S-H (2022) Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex. Nat Neurosci 25(7):865\u2013875","journal-title":"Nat Neurosci"},{"issue":"1","key":"131_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nprot.2011.429","volume":"7","author":"M Eiraku","year":"2011","unstructured":"Eiraku M, Sasai Y (2011) Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues. Nat Protoc 7(1):69\u201379","journal-title":"Nat Protoc"},{"issue":"19","key":"131_CR16","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","volume":"32","author":"P Ewels","year":"2016","unstructured":"Ewels P, Magnusson M, Lundin S, K\u00e4ller M (2016) MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics 32(19):3047\u20133048","journal-title":"Bioinformatics"},{"issue":"3","key":"131_CR17","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1182\/blood-2009-07-232694","volume":"115","author":"X Feng","year":"2010","unstructured":"Feng X, Ippolito GC, Tian L, Wiehagen K, Oh S, Sambandam A, Willen J, Bunte RM, Maika SD, Harriss JV et al (2010) Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood 115(3):510\u2013518","journal-title":"Blood"},{"key":"131_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13312","volume":"7","author":"J Frost","year":"2016","unstructured":"Frost J, Galdeano C, Soares P, Gadd MS, Grzes KM, Ellis L, Epemolu O, Shimamura S, Bantscheff M, Grandi P et al (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-\u03b1 hydroxylation via VHL inhibition. Nat Commun 7:13312","journal-title":"Nat Commun"},{"issue":"6","key":"131_CR19","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1083\/jcb.200302047","volume":"161","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D et al (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 161(6):1163\u20131177","journal-title":"J Cell Biol"},{"issue":"5","key":"131_CR20","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1158\/0008-5472.CAN-13-2117","volume":"74","author":"GG Gomez","year":"2014","unstructured":"Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK (2014) Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Res 74(5):1429\u20131439","journal-title":"Cancer Res"},{"issue":"9","key":"131_CR21","doi-asserted-by":"publisher","first-page":"e70873","DOI":"10.1371\/journal.pone.0070873","volume":"8","author":"S Grundmann","year":"2013","unstructured":"Grundmann S, Lindmayer C, Hans FP, Hoefer I, Helbing T, Pasterkamp G, Bode C, de Kleijn D, Moser M (2013) FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells. PLoS ONE 8(9):e70873","journal-title":"PLoS ONE"},{"issue":"2","key":"131_CR22","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0012-1606(03)00356-7","volume":"262","author":"JJ Haigh","year":"2003","unstructured":"Haigh JJ, Morelli PI, Gerhardt H, Haigh K, Tsien J, Damert A, Miquerol L, Muhlner U, Klein R, Ferrara N et al (2003) Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 262(2):225\u2013241","journal-title":"Dev Biol"},{"issue":"32","key":"131_CR23","doi-asserted-by":"publisher","first-page":"E3325","DOI":"10.1073\/pnas.1412840111","volume":"111","author":"ME Hubbi","year":"2014","unstructured":"Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL (2014) Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1\u03b1 to promote cell-cycle progression. Proc Natl Acad Sci USA 111(32):E3325\u201334","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"131_CR24","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/gene.20009","volume":"38","author":"T Iwasato","year":"2004","unstructured":"Iwasato T, Nomura R, Ando R, Ikeda T, Tanaka M, Itohara S (2004) Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis 38(3):130\u2013138","journal-title":"Genesis"},{"issue":"3","key":"131_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41419-019-1438-z","volume":"10","author":"S Ji","year":"2019","unstructured":"Ji S, Zhou W, Li X, Liu S, Wang F, Li X, Zhao T, Ji G, Du J, Hao A (2019) Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in C57BL\/6J mice. Cell Death Dis 10(3):211","journal-title":"Cell Death Dis"},{"key":"131_CR26","doi-asserted-by":"publisher","DOI":"10.1177\/1744806917711612","volume":"13","author":"J Jiang","year":"2017","unstructured":"Jiang J, Hu Y, Zhang B, Shi Y, Zhang J, Wu X, Yao P (2017) MicroRNA-9 regulates mammalian axon regeneration in peripheral nerve injury. Mol Pain 13:1744806917711612","journal-title":"Mol Pain"},{"issue":"5","key":"131_CR27","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.celrep.2019.09.048","volume":"29","author":"M Komabayashi-Suzuki","year":"2019","unstructured":"Komabayashi-Suzuki M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, Ajioka I, Matsushita J, Kidoya H, Takakura N et al (2019) Spatiotemporally dependent vascularization is differently utilized among neural progenitor subtypes during neocortical development. Cell Rep 29(5):1113\u20131129.e5","journal-title":"Cell Rep"},{"issue":"9","key":"131_CR28","doi-asserted-by":"publisher","first-page":"924","DOI":"10.15252\/embj.201592372","volume":"35","author":"C Lange","year":"2016","unstructured":"Lange C, Turrero Garcia M, Decimo I, Bifari F, Eelen G, Quaegebeur A, Boon R, Zhao H, Boeckx B, Chang J et al (2016) Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO Jl 35(9):924\u2013941","journal-title":"EMBO Jl"},{"issue":"11","key":"131_CR29","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1038\/onc.2013.76","volume":"33","author":"SH Lee","year":"2014","unstructured":"Lee SH, Bae SC, Kim KW, Lee YM (2014) RUNX3 inhibits hypoxia-inducible factor-1\u03b1 protein stability by interacting with prolyl hydroxylases in gastric cancer cells. Oncogene 33(11):1458\u20131467","journal-title":"Oncogene"},{"issue":"18","key":"131_CR30","doi-asserted-by":"publisher","first-page":"14760","DOI":"10.1074\/jbc.M112.340232","volume":"287","author":"S-H Lee","year":"2012","unstructured":"Lee S-H, Che X, Jeong J-H, Choi J-Y, Lee Y-J, Lee Y-H, Bae S-C, Lee Y-M (2012) Runx2 protein stabilizes hypoxia-inducible factor-1\u03b1 through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J Biol Chem 287(18):14760\u201314771","journal-title":"J Biol Chem"},{"issue":"7","key":"131_CR31","doi-asserted-by":"publisher","first-page":"12433","DOI":"10.18632\/oncotarget.14015","volume":"8","author":"C Li","year":"2017","unstructured":"Li C, Zhang K, Chen J, Chen L, Wang R, Chu X (2017) MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers. Oncotarget 8(7):12433\u201312450","journal-title":"Oncotarget"},{"issue":"16","key":"131_CR32","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R (2009) The sequence alignment\/Map format and SAMtools. Bioinformatics 25(16):2078\u20132079","journal-title":"Bioinformatics"},{"issue":"12","key":"131_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550","journal-title":"Genome Biol"},{"issue":"7","key":"131_CR34","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.celrep.2017.07.051","volume":"20","author":"R Madelaine","year":"2017","unstructured":"Madelaine R, Sloan SA, Huber N, Notwell JH, Leung LC, Skariah G, Halluin C, Pa\u015fca SP, Bejerano G, Krasnow et al (2017) MicroRNA-9 couples brain neurogenesis and angiogenesis. Cell Rep 20(7):1533\u20131542","journal-title":"Cell Rep"},{"issue":"Pt 6","key":"131_CR35","first-page":"1454","volume":"126","author":"LK Nguyen","year":"2013","unstructured":"Nguyen LK, Cavadas MAS, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT et al (2013) A dynamic model of the hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) network. J Cell Sci 126(Pt 6):1454\u20131463","journal-title":"J Cell Sci"},{"issue":"3","key":"131_CR36","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1523\/JNEUROSCI.4330-10.2011","volume":"31","author":"G Otaegi","year":"2011","unstructured":"Otaegi G, Pollock A, Hong J, Sun T (2011) MicroRNA miR-9 modifies motor neuron columns by a tuning regulation of FoxP1 levels in developing spinal cords. J Neurosci 31(3):809\u2013818","journal-title":"J Neurosci"},{"key":"131_CR37","doi-asserted-by":"publisher","first-page":"749026","DOI":"10.3389\/fnagi.2021.749026","volume":"13","author":"J Ouellette","year":"2021","unstructured":"Ouellette J, Lacoste B (2021) From neurodevelopmental to neurodegenerative disorders: the vascular continuum. Front Aging Neurosci 13:749026","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"131_CR38","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1016\/j.celrep.2020.01.034","volume":"30","author":"CA Pearson","year":"2020","unstructured":"Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelaj\u00e1uregui A, Novitch BG (2020) Foxp1 regulates neural stem cell self-renewal and bias toward deep layer cortical fates. Cell Rep 30(6):1964\u20131981.e3","journal-title":"Cell Rep"},{"issue":"12","key":"131_CR39","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1242\/dev.062794","volume":"138","author":"CA Pearson","year":"2011","unstructured":"Pearson CA, Ohyama K, Manning L, Aghamohammadzadeh S, Sang H, Placzek M (2011) FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development. Development 138(12):2613\u20132624","journal-title":"Development"},{"issue":"6","key":"131_CR40","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/sj.onc.1210676","volume":"27","author":"ZG Peng","year":"2008","unstructured":"Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ (2008) Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1alpha. Oncogene 27(6):839\u2013847","journal-title":"Oncogene"},{"issue":"4","key":"131_CR41","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1093\/cercor\/bhaa351","volume":"31","author":"E Penna","year":"2021","unstructured":"Penna E, Mangum JM, Shepherd H, Mart\u00ednez-Cerde\u00f1o V, Noctor SC (2021) Development of the neuro-immune-vascular plexus in the ventricular zone of the prenatal rat neocortex. Cereb Cortex 31(4):2139\u20132155","journal-title":"Cereb Cortex"},{"key":"131_CR42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4137\/JEN.S32843","volume":"10","author":"B Radhakrishnan","year":"2016","unstructured":"Radhakrishnan B, Alwin Prem Anand A (2016) Role of miRNA-9 in brain development. J Exp Neurosci 10:101\u2013120","journal-title":"J Exp Neurosci"},{"issue":"2","key":"131_CR43","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuron.2012.02.024","volume":"74","author":"DL Rousso","year":"2012","unstructured":"Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG (2012) Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron 74(2):314\u2013330","journal-title":"Neuron"},{"issue":"18","key":"131_CR44","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1128\/MCB.05089-11","volume":"31","author":"T Sengupta","year":"2011","unstructured":"Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC (2011) Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol 31(18):3885\u20133895","journal-title":"Mol Cell Biol"},{"issue":"6","key":"131_CR45","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/nn1694","volume":"9","author":"Q Shen","year":"2006","unstructured":"Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, Temple S (2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci 9(6):743\u2013751","journal-title":"Nat Neurosci"},{"key":"131_CR46","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1146\/annurev-cellbio-101011-155801","volume":"30","author":"E Taverna","year":"2014","unstructured":"Taverna E, G\u00f6tz M, Huttner WB (2014) The cell biology of neurogenesis: toward an understanding of the development and evolution of the neocortex. Ann Rev Cell Dev Biol 30:465\u2013502","journal-title":"Ann Rev Cell Dev Biol"},{"issue":"6440","key":"131_CR47","doi-asserted-by":"publisher","first-page":"eaav2522","DOI":"10.1126\/science.aav2522","volume":"364","author":"L Telley","year":"2019","unstructured":"Telley L, Agirman G, Prados J, Amberg N, Fi\u00e8vre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer et al (2019) Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science 364(6440):eaav2522","journal-title":"Science"},{"issue":"4","key":"131_CR48","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nn2074","volume":"11","author":"A Vasudevan","year":"2008","unstructured":"Vasudevan A, Long JE, Crandall JE, Rubenstein JLR, Bhide PG (2008) Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nat Neurosci 11(4):429\u2013439","journal-title":"Nat Neurosci"},{"issue":"3","key":"131_CR49","doi-asserted-by":"publisher","first-page":"112237","DOI":"10.1016\/j.celrep.2023.112237","volume":"42","author":"J Zhang","year":"2023","unstructured":"Zhang J, Roberts JM, Chang F, Schwakopf J, Vetter ML (2023) Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1. Cell Rep 42(3):112237","journal-title":"Cell Rep"},{"issue":"16","key":"131_CR50","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1101\/gad.1929210","volume":"24","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Li S, Yuan L, Tian Y, Weidenfeld J, Yang J, Liu F, Chokas AL, Morrisey EE (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev 24(16):1746\u20131757","journal-title":"Genes Dev"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44319-024-00131-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44319-024-00131-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44319-024-00131-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:07:14Z","timestamp":1785841634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44319-024-00131-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,14]]}},"alternative-id":["131"],"URL":"https:\/\/doi.org\/10.1038\/s44319-024-00131-8","relation":{},"ISSN":["1469-3178"],"issn-type":[{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"5 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}],"article-number":"9"}}