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To better understand its role in growth coordination, we induced fat body atrophy by knocking down several key enzymes of the glycolytic pathway in adipose cells. Our results show that impairing the last steps of glycolysis leads to a drastic drop in adipose cell size and lipid droplet content, and downregulation of the mTOR pathway and REPTOR transcriptional activity. Strikingly, fat body atrophy results in the distant disorganization of body wall muscles and the release of muscle-specific proteins in the hemolymph. Furthermore, we showed that REPTOR activity is required for fat body atrophy downstream of glycolysis inhibition, and that the effect of fat body atrophy on muscles depends on the production of TNF-\u03b1\/egr and of the insulin pathway inhibitor ImpL2.\n                  <\/jats:p>","DOI":"10.1038\/s44319-024-00241-3","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:03:30Z","timestamp":1725876210000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-\u03b1\/egr and ImpL2 signaling in Drosophila larvae"],"prefix":"10.1038","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-5031","authenticated-orcid":false,"given":"Miriam","family":"Rodr\u00edguez-V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8932-8656","authenticated-orcid":false,"given":"Jennifer","family":"Falconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-0850","authenticated-orcid":false,"given":"Lisa","family":"Heron-Milhavet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-7843","authenticated-orcid":false,"given":"Patrice","family":"Lassus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-9566","authenticated-orcid":false,"given":"Charles","family":"G\u00e9minard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-2713","authenticated-orcid":false,"given":"Alexandre","family":"Djiane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"241_CR1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2016.03.003","volume":"23","author":"N Agrawal","year":"2016","unstructured":"Agrawal N, Delanoue R, Mauri A, Basco D, Pasco M, Thorens B, L\u00e9opold P (2016) The Drosophila TNF Eiger is an adipokine that acts on insulin-producing cells to mediate nutrient response. 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