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In recent years, we have gained extensive knowledge about their structure, biogenesis, and function from single cells, cell\u2013cell interactions to tissue homeostasis, including their role in human diseases. Centrosome abnormalities are linked to, among others primary microcephaly, birth defects, ciliopathies, and tumorigenesis. Centrosome amplification, a state where two or more centrosomes are present in the G1 phase of the cell cycle, correlates in cancer with karyotype alterations, clinical aggressiveness, and lymph node metastasis. However, amplified centrosomes also appear in healthy tissues and, independent of their established role, in multi-ciliation. One example is the liver where hepatocytes carry amplified centrosomes owing to whole-genome duplication events during organogenesis. More recently, amplified centrosomes have been found in neuronal progenitors and several cell types of hematopoietic origin in which they enhance cellular effector functions. These findings suggest that extra centrosomes do not necessarily pose a risk for genome integrity and are harnessed for physiological processes. Here, we compare established and emerging \u2018non-canonical functions\u2019 of amplified centrosomes in cancerous and somatic cells and discuss their role in cellular physiology.<\/jats:p>","DOI":"10.1038\/s44319-024-00260-0","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:02:32Z","timestamp":1726470152000},"page":"4153-4167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Amplified centrosomes\u2014more than just a threat"],"prefix":"10.1038","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-5738","authenticated-orcid":false,"given":"Eva","family":"Kiermaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-1409","authenticated-orcid":false,"given":"Isabel","family":"St\u00f6tzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-9615","authenticated-orcid":false,"given":"Marina A","family":"Schapfl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-4153","authenticated-orcid":false,"given":"Andreas","family":"Villunger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"260_CR1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/j.cub.2021.01.028","volume":"31","author":"SD Adams","year":"2021","unstructured":"Adams SD, Csere J, D\u2019angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G et al (2021) Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. 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