{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:34:39Z","timestamp":1780378479615,"version":"3.54.1"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G092518N"],"award-info":[{"award-number":["G092518N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0C6820N"],"award-info":[{"award-number":["G0C6820N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["PhD fellowship 11E7920N"],"award-info":[{"award-number":["PhD fellowship 11E7920N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["MSCA SoE postdoctoral fellowship 673343\/12ZZE23N"],"award-info":[{"award-number":["MSCA SoE postdoctoral fellowship 673343\/12ZZE23N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202004910440"],"award-info":[{"award-number":["202004910440"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["Internal Funds C14\/21\/117"],"award-info":[{"award-number":["Internal Funds C14\/21\/117"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["postdoctoral mandate PDMT2\/23\/083"],"award-info":[{"award-number":["postdoctoral mandate PDMT2\/23\/083"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000092","name":"HHS | NIH | U.S. National Library of Medicine","doi-asserted-by":"publisher","award":["R01 grant HD100535"],"award-info":[{"award-number":["R01 grant HD100535"]}],"id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Precision Environmental Health pilot award P30ES030285"],"award-info":[{"award-number":["Precision Environmental Health pilot award P30ES030285"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Folic acid (FA) is well known to prevent neural tube defects (NTDs), but we do not know why many human NTD cases still remain refractory to FA supplementation. Here, we investigate how the DNA demethylase TET1 interacts with maternal FA status to regulate mouse embryonic brain development. We determined that cranial NTDs display higher penetrance in non-inbred than in inbred\n                    <jats:italic>Tet1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    embryos and are resistant to FA supplementation across strains. Maternal diets that are either too rich or deficient in FA are linked to an increased incidence of cranial deformities in wild type and\n                    <jats:italic>Tet1<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    offspring and to altered DNA hypermethylation in\n                    <jats:italic>Tet1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    embryos, primarily at neurodevelopmental loci. Excess FA in\n                    <jats:italic>Tet1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    embryos results in phospholipid metabolite loss and reduced expression of multiple membrane solute carriers, including a FA transporter gene that exhibits increased promoter DNA methylation and thereby mimics FA deficiency. Moreover, FA deficiency reveals that\n                    <jats:italic>Tet1<\/jats:italic>\n                    haploinsufficiency can contribute to DNA hypermethylation and susceptibility to NTDs. Overall, our study suggests that epigenetic dysregulation may underlie NTD development despite FA supplementation.\n                  <\/jats:p>","DOI":"10.1038\/s44319-024-00316-1","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T09:29:10Z","timestamp":1732267750000},"page":"175-199","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2722-0745","authenticated-orcid":false,"given":"Lehua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-7529","authenticated-orcid":false,"given":"Bernard K","family":"van der Veer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-3959","authenticated-orcid":false,"given":"Qiuying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Champeris Tsaniras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannes","family":"Brangers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm H M","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2089-4315","authenticated-orcid":false,"given":"Rita","family":"Khoueiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-2338","authenticated-orcid":false,"given":"Steven S","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-8754","authenticated-orcid":false,"given":"Richard H","family":"Finnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-5175","authenticated-orcid":false,"given":"Kian Peng","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"316_CR1","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2012-13-10-r87","volume":"13","author":"A Akalin","year":"2012","unstructured":"Akalin A, Kormaksson M, Li S, Garrett-Bakelman FE, Figueroa ME, Melnick A, Mason CE (2012) methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol 13:R87","journal-title":"Genome Biol"},{"key":"316_CR2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.seizure.2015.02.030","volume":"27","author":"AA Asadi-Pooya","year":"2015","unstructured":"Asadi-Pooya AA (2015) High dose folic acid supplementation in women with epilepsy: are we sure it is safe? Seizure 27:51\u201353","journal-title":"Seizure"},{"key":"316_CR3","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.celrep.2020.01.065","volume":"30","author":"M Bartoccetti","year":"2020","unstructured":"Bartoccetti M, van der Veer BK, Luo X, Khoueiry R, She P, Bajaj M, Xu J, Janiszewski A, Thienpont B, Pasque V et al (2020) Regulatory dynamics of Tet1 and Oct4 resolve stages of global DNA demethylation and transcriptomic changes in reprogramming. Cell Rep. 30:2150\u20132169.e2159","journal-title":"Cell Rep."},{"key":"316_CR4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12031-015-0673-8","volume":"58","author":"S Barua","year":"2016","unstructured":"Barua S, Kuizon S, Brown WT, Junaid MA (2016) High gestational folic acid supplementation alters expression of imprinted and candidate autism susceptibility genes in a sex-specific manner in mouse offspring. J Mol Neurosci 58:277\u2013286","journal-title":"J Mol Neurosci"},{"key":"316_CR5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature12362","volume":"500","author":"K Blaschke","year":"2013","unstructured":"Blaschke K, Ebata KT, Karimi MM, Zepeda-Martinez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A et al (2013) Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature 500:222\u2013226","journal-title":"Nature"},{"key":"316_CR6","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1093\/hmg\/ddn262","volume":"17","author":"KA Burren","year":"2008","unstructured":"Burren KA, Savery D, Massa V, Kok RM, Scott JM, Blom HJ, Copp AJ, Greene ND (2008) Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet 17:3675\u20133685","journal-title":"Hum Mol Genet"},{"key":"316_CR7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41421-022-00512-0","volume":"9","author":"X Cao","year":"2023","unstructured":"Cao X, Xu J, Lin YL, Cabrera RM, Chen Q, Zhang C, Steele JW, Han X, Gross SS, Wlodarczyk BJ et al (2023) Excess folic acid intake increases DNA de novo point mutations. Cell Discov 9:22","journal-title":"Cell Discov"},{"key":"316_CR8","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jnutbio.2010.10.003","volume":"22","author":"H Chang","year":"2011","unstructured":"Chang H, Zhang T, Zhang Z, Bao R, Fu C, Wang Z, Bao Y, Li Y, Wu L, Zheng X et al (2011) Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects. J Nutr Biochem 22:1172\u20131177","journal-title":"J Nutr Biochem"},{"key":"316_CR9","doi-asserted-by":"crossref","unstructured":"Chang S, Jing J, Shangguan S, Li B, Yao X, Liu X, Zhang T, Wu J, Wang L (2021) The effect of folic acid deficiency on Mest\/Peg1 in neural tube defects. Int J Neurosci: 131:468\u2013477","DOI":"10.1080\/00207454.2020.1750386"},{"key":"316_CR10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3945\/ajcn.114.086603","volume":"101","author":"KE Christensen","year":"2015","unstructured":"Christensen KE, Mikael LG, Leung KY, Levesque N, Deng L, Wu Q, Malysheva OV, Best A, Caudill MA, Greene ND et al (2015) High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. Am J Clin Nutr 101:646\u2013658","journal-title":"Am J Clin Nutr"},{"key":"316_CR11","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1093\/nar\/gkac089","volume":"50","author":"S Chrysanthou","year":"2022","unstructured":"Chrysanthou S, Tang Q, Lee J, Taylor SJ, Zhao Y, Steidl U, Zheng D, Dawlaty MM (2022) The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity. Nucleic Acids Res 50:3169\u20133189","journal-title":"Nucleic Acids Res"},{"key":"316_CR12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.2643","volume":"220","author":"AJ Copp","year":"2010","unstructured":"Copp AJ, Greene ND (2010) Genetics and development of neural tube defects. J Pathol 220:217\u2013230","journal-title":"J Pathol"},{"key":"316_CR13","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3390\/nu12061716","volume":"12","author":"M Cosin-Tomas","year":"2020","unstructured":"Cosin-Tomas M, Luan Y, Leclerc D, Malysheva OV, Lauzon N, Bahous RH, Christensen KE, Caudill MA, Rozen R (2020) Moderate folic acid supplementation in pregnant mice results in behavioral alterations in offspring with sex-specific changes in methyl metabolism. Nutrients 12:1716","journal-title":"Nutrients"},{"key":"316_CR14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-nutr-043020-091647","volume":"42","author":"KS Crider","year":"2022","unstructured":"Crider KS, Qi YP, Yeung LF, Mai CT, Head Zauche L, Wang A, Daniels K, Williams JL (2022) Folic acid and the prevention of birth defects: 30 years of opportunity and controversies. Annu Rev Nutr 42:423\u2013452","journal-title":"Annu Rev Nutr"},{"key":"316_CR15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","volume":"3","author":"KS Crider","year":"2012","unstructured":"Crider KS, Yang TP, Berry RJ, Bailey LB (2012) Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate\u2019s role. Adv Nutr 3:21\u201338","journal-title":"Adv Nutr"},{"key":"316_CR16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/biof.1154","volume":"40","author":"RP da Silva","year":"2014","unstructured":"da Silva RP, Kelly KB, Al Rajabi A, Jacobs RL (2014) Novel insights on interactions between folate and lipid metabolism. Biofactors 40:277\u2013283","journal-title":"Biofactors"},{"key":"316_CR17","doi-asserted-by":"crossref","first-page":"eabd0875","DOI":"10.1126\/science.abd0875","volume":"372","author":"G Dixon","year":"2021","unstructured":"Dixon G, Pan H, Yang D, Rosen BP, Jashari T, Verma N, Pulecio J, Caspi I, Lee K, Stransky S et al (2021) QSER1 protects DNA methylation valleys from de novo methylation. Science 372:eabd0875","journal-title":"Science"},{"key":"316_CR18","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.3390\/nu15214699","volume":"15","author":"AM Fardous","year":"2023","unstructured":"Fardous AM, Heydari AR (2023) Uncovering the hidden dangers and molecular mechanisms of excess folate: a narrative review. Nutrients 15:4699","journal-title":"Nutrients"},{"key":"316_CR19","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.659612","volume":"12","author":"RH Finnell","year":"2021","unstructured":"Finnell RH, Caiaffa CD, Kim SE, Lei Y, Steele J, Cao X, Tukeman G, Lin YL, Cabrera RM, Wlodarczyk BJ (2021) Gene environment interactions in the etiology of neural tube defects. Front Genet 12:659612","journal-title":"Front Genet"},{"key":"316_CR20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/dmm.024109","volume":"9","author":"KS Fong","year":"2016","unstructured":"Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S (2016) A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech 9:585\u2013596","journal-title":"Dis Model Mech"},{"key":"316_CR21","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.2023.20452","volume":"330","author":"MJ Barry","year":"2023","unstructured":"Force USPST, Barry MJ, Nicholson WK, Silverstein M, Chelmow D, Coker TR, Davis EM, Donahue KE, Jaen CR, Li L et al (2023) Folic acid supplementation to prevent neural tube defects: US Preventive Services Task Force reaffirmation recommendation statement. JAMA 330:454\u2013459","journal-title":"JAMA"},{"key":"316_CR22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bbrc.2008.09.074","volume":"376","author":"N Gonen","year":"2008","unstructured":"Gonen N, Bram EE, Assaraf YG (2008) PCFT\/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells. Biochem Biophys Res Commun 376:787\u2013792","journal-title":"Biochem Biophys Res Commun"},{"key":"316_CR23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/bdra.20542","volume":"85","author":"JD Gray","year":"2009","unstructured":"Gray JD, Ross ME (2009) Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice. Birth Defects Res A Clin Mol Teratol 85:314\u2013321","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"316_CR24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","volume":"338","author":"Group MVSR","year":"1991","unstructured":"Group MVSR (1991) Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet 338:131\u2013137","journal-title":"Lancet"},{"key":"316_CR25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3945\/ajcn.112.042572","volume":"97","author":"P Haggarty","year":"2013","unstructured":"Haggarty P, Hoad G, Campbell DM, Horgan GW, Piyathilake C, McNeill G (2013) Folate in pregnancy and imprinted gene and repeat element methylation in the offspring. Am J Clin Nutr 97:94\u201399","journal-title":"Am J Clin Nutr"},{"key":"316_CR26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/cercor\/bhaa248","volume":"31","author":"A Harlan De Crescenzo","year":"2021","unstructured":"Harlan De Crescenzo A, Panoutsopoulos AA, Tat L, Schaaf Z, Racherla S, Henderson L, Leung KY, Greene NDE, Green R, Zarbalis KS (2021) Deficient or excess folic acid supply during pregnancy alter cortical neurodevelopment in mouse offspring. Cereb Cortex 31:635\u2013649","journal-title":"Cereb Cortex"},{"key":"316_CR27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/bdra.20676","volume":"88","author":"MJ Harris","year":"2010","unstructured":"Harris MJ, Juriloff DM (2010) An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth Defects Res A Clin Mol Teratol 88:653\u2013669","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"316_CR28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41586-020-2119-x","volume":"583","author":"Y He","year":"2020","unstructured":"He Y, Hariharan M, Gorkin DU, Dickel DE, Luo C, Castanon RG, Nery JR, Lee AY, Zhao Y, Huang H et al (2020) Spatiotemporal DNA methylome dynamics of the developing mouse fetus. Nature 583:752\u2013759","journal-title":"Nature"},{"key":"316_CR29","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.1210944","volume":"333","author":"YF He","year":"2011","unstructured":"He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L et al (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333:1303\u20131307","journal-title":"Science"},{"key":"316_CR30","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2217\/epi-2016-0003","volume":"8","author":"RE Irwin","year":"2016","unstructured":"Irwin RE, Pentieva K, Cassidy T, Lees-Murdock DJ, McLaughlin M, Prasad G, McNulty H, Walsh CP (2016) The interplay between DNA methylation, folate and neurocognitive development. Epigenomics 8:863\u2013879","journal-title":"Epigenomics"},{"key":"316_CR31","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","volume":"333","author":"S Ito","year":"2011","unstructured":"Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333:1300\u20131303","journal-title":"Science"},{"key":"316_CR32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3389\/fnins.2018.00562","volume":"12","author":"F Jie","year":"2018","unstructured":"Jie F, Yin G, Yang W, Yang M, Gao S, Lv J, Li B (2018) Stress in regulation of GABA amygdala system and relevance to neuropsychiatric diseases. Front Neurosci 12:562","journal-title":"Front Neurosci"},{"key":"316_CR33","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10577","volume":"7","author":"BR Joubert","year":"2016","unstructured":"Joubert BR, den Dekker HT, Felix JF, Bohlin J, Ligthart S, Beckett E, Tiemeier H, van Meurs JB, Uitterlinden AG, Hofman A et al (2016) Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nat Commun 7:10577","journal-title":"Nat Commun"},{"key":"316_CR34","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/jdb6030022","volume":"6","author":"DM Juriloff","year":"2018","unstructured":"Juriloff DM, Harris MJ (2018) Insights into the etiology of mammalian neural tube closure defects from developmental, genetic and evolutionary studies. J Dev Biol 6:22","journal-title":"J Dev Biol"},{"key":"316_CR35","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.3390\/ijms21207534","volume":"21","author":"RA Keuls","year":"2020","unstructured":"Keuls RA, Kojima K, Lozzi B, Steele JW, Chen Q, Gross SS, Finnell RH, Parchem RJ (2020) MiR-302 regulates glycolysis to control cell-cycle during neural tube closure. Int J Mol Sci 21:7534","journal-title":"Int J Mol Sci"},{"key":"316_CR36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ng.3868","volume":"49","author":"R Khoueiry","year":"2017","unstructured":"Khoueiry R, Sohni A, Thienpont B, Luo X, Velde JV, Bartoccetti M, Boeckx B, Zwijsen A, Rao A, Lambrechts D et al (2017) Lineage-specific functions of TET1 in the postimplantation mouse embryo. Nat Genet 49:1061\u20131072","journal-title":"Nat Genet"},{"key":"316_CR37","doi-asserted-by":"crossref","unstructured":"Khoueiry R, Sohni A, Thienpont B, Luo X, Velde JV, Bartoccetti M, Boeckx B, Zwijsen A, Rao A, Lambrechts D et al (2017) Lineage-specific functions of TET1 in the postimplantation mouse embryo. Gene Expression Omnibus GSE71744 (https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE71744) [DATASET]","DOI":"10.1038\/ng.3868"},{"key":"316_CR38","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1073\/pnas.1800138115","volume":"115","author":"J Kim","year":"2018","unstructured":"Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A et al (2018) Formate rescues neural tube defects caused by mutations in Slc25a32. Proc Natl Acad Sci USA 115:4690\u20134695","journal-title":"Proc Natl Acad Sci USA"},{"key":"316_CR39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/bioinformatics\/btr709","volume":"28","author":"R Kolde","year":"2012","unstructured":"Kolde R, Laur S, Adler P, Vilo J (2012) Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics 28:573\u2013580","journal-title":"Bioinformatics"},{"key":"316_CR40","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","volume":"27","author":"F Krueger","year":"2011","unstructured":"Krueger F, Andrews SR (2011) Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Bioinformatics 27:1571\u20131572","journal-title":"Bioinformatics"},{"key":"316_CR41","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/bdra.23554","volume":"109","author":"RY Leduc","year":"2017","unstructured":"Leduc RY, Singh P, McDermid HE (2017) Genetic backgrounds and modifier genes of NTD mouse models: an opportunity for greater understanding of the multifactorial etiology of neural tube defects. Birth Defects Res 109:140\u2013152","journal-title":"Birth Defects Res"},{"key":"316_CR42","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.celrep.2017.10.072","volume":"21","author":"KY Leung","year":"2017","unstructured":"Leung KY, Pai YJ, Chen QY, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ et al (2017) Partitioning of one-carbon units in folate and methionine metabolism is essential for neural tube closure. Cell Rep 21:1795\u20131808","journal-title":"Cell Rep"},{"key":"316_CR43","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","volume":"49","author":"Z Li","year":"2008","unstructured":"Li Z, Vance DE (2008) Phosphatidylcholine and choline homeostasis. J Lipid Res 49:1187\u20131194","journal-title":"J Lipid Res"},{"key":"316_CR44","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ng.3258","volume":"47","author":"J Liao","year":"2015","unstructured":"Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C et al (2015) Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet 47:469\u2013478","journal-title":"Nat Genet"},{"key":"316_CR45","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550","journal-title":"Genome Biol"},{"key":"316_CR46","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41390-021-01908-6","volume":"92","author":"X Lu","year":"2022","unstructured":"Lu X, Yang S, Jie M, Wang S, Sun C, Wu L, Chang S, Pei P, Wang S, Zhang T et al (2022) Folate deficiency disturbs PEG10 methylation modifications in human spina bifida. Pediatr Res 92:987\u2013994","journal-title":"Pediatr Res"},{"key":"316_CR47","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1101\/gad.329474.119","volume":"34","author":"X Luo","year":"2020","unstructured":"Luo X, van der Veer BK, Sun L, Bartoccetti M, Boretto M, Vankelecom H, Khoueiry R, Koh KP (2020) Coordination of germ layer lineage choice by TET1 during primed pluripotency. Genes Dev 34:598\u2013618","journal-title":"Genes Dev"},{"key":"316_CR48","volume":"6","author":"L Ly","year":"2020","unstructured":"Ly L, Chan D, Landry M, Angle C, Martel J, Trasler J (2020) Impact of mothers\u2019 early life exposure to low or high folate on progeny outcome and DNA methylation patterns. Environ Epigenet 6:dvaa018","journal-title":"Environ Epigenet"},{"key":"316_CR49","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1093\/hmg\/ddr289","volume":"20","author":"A Marean","year":"2011","unstructured":"Marean A, Graf A, Zhang Y, Niswander L (2011) Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet 20:3678\u20133683","journal-title":"Hum Mol Genet"},{"key":"316_CR50","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature07107","volume":"454","author":"A Meissner","year":"2008","unstructured":"Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB et al (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454:766\u2013770","journal-title":"Nature"},{"key":"316_CR51","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1042\/BST0371328","volume":"37","author":"H Mohler","year":"2009","unstructured":"Mohler H (2009) Role of GABAA receptors in cognition. Biochem Soc Trans 37:1328\u20131333","journal-title":"Biochem Soc Trans"},{"key":"316_CR52","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1073\/pnas.1211199110","volume":"110","author":"J Momb","year":"2013","unstructured":"Momb J, Lewandowski JP, Bryant JD, Fitch R, Surman DR, Vokes SA, Appling DR (2013) Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Proc Natl Acad Sci USA 110:549\u2013554","journal-title":"Proc Natl Acad Sci USA"},{"key":"316_CR88","doi-asserted-by":"crossref","unstructured":"Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yigit M, Gluck IM, Trummer C, Qin W, Bartoschek MD, Traube FR et al (2020) Author Correction: Recent evolution of a TET-controlled and DPPA3\/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun 11:6443","DOI":"10.1038\/s41467-020-20453-0"},{"key":"316_CR53","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/nutrit\/nuy025","volume":"76","author":"LK Murray","year":"2018","unstructured":"Murray LK, Smith MJ, Jadavji NM (2018) Maternal oversupplementation with folic acid and its impact on neurodevelopment of offspring. Nutr Rev 76:708\u2013721","journal-title":"Nutr Rev"},{"key":"316_CR54","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1242\/dev.145904","volume":"144","author":"E Nikolopoulou","year":"2017","unstructured":"Nikolopoulou E, Galea GL, Rolo A, Greene ND, Copp AJ (2017) Neural tube closure: cellular, molecular and biomechanical mechanisms. Development 144:552\u2013566","journal-title":"Development"},{"key":"316_CR55","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","volume":"99","author":"M Okano","year":"1999","unstructured":"Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247\u2013257","journal-title":"Cell"},{"key":"316_CR56","volume":"6","author":"YJ Pai","year":"2015","unstructured":"Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND (2015) Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nat Commun 6:6388","journal-title":"Nat Commun"},{"key":"316_CR57","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.3945\/jn.117.247445","volume":"147","author":"C Paniz","year":"2017","unstructured":"Paniz C, Bertinato JF, Lucena MR, De Carli E, Amorim PMD, Gomes GW, Palchetti CZ, Figueiredo MS, Pfeiffer CM, Fazili Z et al (2017) A daily dose of 5 mg folic acid for 90 days is associated with increased serum unmetabolized folic acid and reduced natural killer cell cytotoxicity in healthy brazilian adults. J Nutr 147:1684\u20131692","journal-title":"J Nutr"},{"key":"316_CR58","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/jim-2019-001025","volume":"67","author":"C Paniz","year":"2019","unstructured":"Paniz C, Lucena MR, Bertinato JF, Louren\u00e7o FR, Barros BCA, Gomes GW, Figueiredo MS, Can\u00e7ado RD, Blaia-D Avila VLN, Pfeiffer CM et al (2019) Daily supplementation with 5 mg of folic acid in Brazilian patients with hereditary spherocytosis. J Invest Med 67:1110\u20131117","journal-title":"J Invest Med"},{"key":"316_CR59","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","volume":"14","author":"R Patro","year":"2017","unstructured":"Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C (2017) Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods 14:417\u2013419","journal-title":"Nat Methods"},{"key":"316_CR60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/bdra.20754","volume":"91","author":"L Pickell","year":"2011","unstructured":"Pickell L, Brown K, Li D, Wang XL, Deng L, Wu Q, Selhub J, Luo L, Jerome-Majewska L, Rozen R (2011) High intake of folic acid disrupts embryonic development in mice. Birth Defects Res A Clin Mol Teratol 91:8\u201319","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"316_CR61","volume":"11","author":"S Rai","year":"2023","unstructured":"Rai S, Leydier L, Sharma S, Katwala J, Sahu A (2023) A quest for genetic causes underlying signaling pathways associated with neural tube defects. Front Pediatr 11:1126209","journal-title":"Front Pediatr"},{"key":"316_CR62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12987-022-00391-3","volume":"19","author":"V Sangha","year":"2022","unstructured":"Sangha V, Hoque MT, Henderson JT, Bendayan R (2022) Novel localization of folate transport systems in the murine central nervous system. Fluids Barriers CNS 19:92","journal-title":"Fluids Barriers CNS"},{"key":"316_CR63","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gr.209601.116","volume":"27","author":"T Smith","year":"2017","unstructured":"Smith T, Heger A, Sudbery I (2017) UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy. Genome Res 27:491\u2013499","journal-title":"Genome Res"},{"key":"316_CR64","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/MCB.01172-14","volume":"35","author":"A Sohni","year":"2015","unstructured":"Sohni A, Bartoccetti M, Khoueiry R, Spans L, Vande Velde J, De Troyer L, Pulakanti K, Claessens F, Rao S, Koh KP (2015) Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation. Mol Cell Biol 35:1026\u20131042","journal-title":"Mol Cell Biol"},{"key":"316_CR65","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1523-1755.2005.00076.x","volume":"67","author":"F Stam","year":"2005","unstructured":"Stam F, van Guldener C, Ter Wee PM, Jakobs C, de Meer K, Stehouwer CD (2005) Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease. Kidney Int 67:259\u2013264","journal-title":"Kidney Int"},{"key":"316_CR66","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/ajcn\/83.1.5","volume":"83","author":"LM Stead","year":"2006","unstructured":"Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL (2006) Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 83:5\u201310","journal-title":"Am J Clin Nutr"},{"key":"316_CR67","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.832492","volume":"10","author":"JW Steele","year":"2022","unstructured":"Steele JW, Lin YL, Chen N, Wlodarczyk BJ, Chen Q, Attarwala N, Venkatesalu M, Cabrera RM, Gross SS, Finnell RH (2022) Embryonic hypotaurine levels contribute to strain-dependent susceptibility in mouse models of valproate-induced neural tube defects. Front Cell Dev Biol 10:832492","journal-title":"Front Cell Dev Biol"},{"key":"316_CR68","first-page":"275","volume":"18","author":"M Stephens","year":"2017","unstructured":"Stephens M (2017) False discovery rates: a new deal. Biostatistics 18:275\u2013294","journal-title":"Biostatistics"},{"key":"316_CR69","volume":"10","author":"ZX Sun","year":"2019","unstructured":"Sun ZX, Xu XG, He JL, Murray A, Sun MA, Wei XR, Wang X, McCoig E, Xie E, Jiang X et al (2019) EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity. Nat Commun 10:3892","journal-title":"Nat Commun"},{"key":"316_CR70","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","volume":"324","author":"M Tahiliani","year":"2009","unstructured":"Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L et al (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:930\u2013935","journal-title":"Science"},{"key":"316_CR71","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1096\/fj.201601214RR","volume":"31","author":"A Tserga","year":"2017","unstructured":"Tserga A, Binder AM, Michels KB (2017) Impact of folic acid intake during pregnancy on genomic imprinting of IGF2\/H19 and 1-carbon metabolism. FASEB J 31:5149\u20135158","journal-title":"FASEB J"},{"key":"316_CR72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-010-9088-4","volume":"34","author":"PM Ueland","year":"2011","unstructured":"Ueland PM (2011) Choline and betaine in health and disease. J Inherit Metab Dis 34:3\u201315","journal-title":"J Inherit Metab Dis"},{"key":"316_CR73","unstructured":"van der Veer BK, Chen L, Custers C, Athanasouli P, Schroiff M, Cornelis R, Chui JS, Finnell RH, Lluis F, Koh KP (2023) Gene Expression Omnibus GSE214845 (https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE214845) [DATASET]"},{"key":"316_CR74","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1093\/nar\/gkad231","volume":"51","author":"BK van der Veer","year":"2023","unstructured":"van der Veer BK, Chen L, Custers C, Athanasouli P, Schroiff M, Cornelis R, Chui JS, Finnell RH, Lluis F, Koh KP (2023) Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation. Nucleic Acids Res 51:5469\u20135498","journal-title":"Nucleic Acids Res"},{"key":"316_CR89","doi-asserted-by":"publisher","unstructured":"van der Veer BK, Chen L, Tsaniras SC, Brangers W, Chen Q, Schroiff M, Custers C, Kwak HHM, Khoueiry R, Cabrera R et al. 2024. Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations. bioRxiv. https:\/\/doi.org\/10.1101\/2024.02.21.581196","DOI":"10.1101\/2024.02.21.581196"},{"key":"316_CR75","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.2023.9864","volume":"330","author":"M Viswanathan","year":"2023","unstructured":"Viswanathan M, Urrutia RP, Hudson KN, Middleton JC, Kahwati LC (2023) Folic acid supplementation to prevent neural tube defects: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 330:460\u2013466","journal-title":"JAMA"},{"key":"316_CR76","doi-asserted-by":"crossref","DOI":"10.1126\/science.1222002","volume":"339","author":"JB Wallingford","year":"2013","unstructured":"Wallingford JB, Niswander LA, Shaw GM, Finnell RH (2013) The continuing challenge of understanding, preventing, and treating neural tube defects. Science 339:1222002","journal-title":"Science"},{"key":"316_CR77","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1597\/15-170","volume":"53","author":"H Wang","year":"2016","unstructured":"Wang H, Chen W (2016) Dose-dependent antiteratogenic effects of folic acid on all-trans retinoic acid-induced cleft palate in fetal mice. Cleft Palate Craniofac J 53:720\u2013726","journal-title":"Cleft Palate Craniofac J"},{"key":"316_CR78","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1111\/jcmm.13228","volume":"21","author":"L Wang","year":"2017","unstructured":"Wang L, Shangguan S, Xin Y, Chang S, Wang Z, Lu X, Wu L, Niu B, Zhang T (2017) Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects. J Cell Mol Med 21:3244\u20133253","journal-title":"J Cell Mol Med"},{"key":"316_CR79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12263-020-00681-1","volume":"16","author":"X Wang","year":"2021","unstructured":"Wang X, Li Z, Zhu Y, Yan J, Liu H, Huang G, Li W (2021) Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning\/memory abilities. Genes Nutr 16:1","journal-title":"Genes Nutr"},{"key":"316_CR80","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1990","volume":"39","author":"M Weber","year":"2007","unstructured":"Weber M, Hellmann I, Stadler MB, Ramos L, Paabo S, Rebhan M, Schubeler D (2007) Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 39:457\u2013466","journal-title":"Nat Genet"},{"key":"316_CR81","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-genet-120213-092208","volume":"48","author":"JJ Wilde","year":"2014","unstructured":"Wilde JJ, Petersen JR, Niswander L (2014) Genetic, epigenetic, and environmental contributions to neural tube closure. Annu Rev Genet 48:583\u2013611","journal-title":"Annu Rev Genet"},{"key":"316_CR82","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrg.2017.33","volume":"18","author":"X Wu","year":"2017","unstructured":"Wu X, Zhang Y (2017) TET-mediated active DNA demethylation: mechanism, function and beyond. Nat Rev Genet 18:517\u2013534","journal-title":"Nat Rev Genet"},{"key":"316_CR83","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature12805","volume":"504","author":"S Yamaguchi","year":"2013","unstructured":"Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y (2013) Role of Tet1 in erasure of genomic imprinting. Nature 504:460\u2013464","journal-title":"Nature"},{"key":"316_CR84","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1007\/s00018-012-1227-7","volume":"70","author":"Y Yamaguchi","year":"2013","unstructured":"Yamaguchi Y, Miura M (2013) How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals. Cell Mol Life Sci 70:3171\u20133186","journal-title":"Cell Mol Life Sci"},{"key":"316_CR85","doi-asserted-by":"crossref","first-page":"e0151586","DOI":"10.1371\/journal.pone.0151586","volume":"11","author":"I Zaganjor","year":"2016","unstructured":"Zaganjor I, Sekkarie A, Tsang BL, Williams J, Razzaghi H, Mulinare J, Sniezek JE, Cannon MJ, Rosenthal J (2016) Describing the prevalence of neural tube defects worldwide: a systematic literature review. PLoS ONE 11:e0151586","journal-title":"PLoS ONE"},{"key":"316_CR86","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.stem.2013.05.006","volume":"13","author":"RR Zhang","year":"2013","unstructured":"Zhang RR, Cui QY, Murai K, Lim YC, Smith ZD, Jin S, Ye P, Rosa L, Lee YK, Wu HP et al (2013) Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell 13:237\u2013245","journal-title":"Cell Stem Cell"},{"key":"316_CR87","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.molcel.2016.10.030","volume":"64","author":"W Zhang","year":"2016","unstructured":"Zhang W, Xia W, Wang Q, Towers AJ, Chen J, Gao R, Zhang Y, Yen CA, Lee AY, Li Y et al (2016) Isoform switch of TET1 regulates DNA demethylation and mouse development. Mol Cell 64:1062\u20131073","journal-title":"Mol Cell"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44319-024-00316-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/s44319-024-00316-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/s44319-024-00316-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:46:48Z","timestamp":1779122808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/s44319-024-00316-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,10]]}},"alternative-id":["316"],"URL":"https:\/\/doi.org\/10.1038\/s44319-024-00316-1","relation":{},"ISSN":["1469-3178"],"issn-type":[{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,22]]},"assertion":[{"value":"15 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}}]}}