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Aberrant expression of the\n                    <jats:italic>MYC<\/jats:italic>\n                    oncogene promotes PDAC progression. Recent reports have established a role for enhancer RNAs (eRNAs), originating from active enhancers, in controlling gene transcription. Here we show that a novel\n                    <jats:italic>MYC<\/jats:italic>\n                    eRNA regulates\n                    <jats:italic>MYC<\/jats:italic>\n                    gene expression during chronic inflammatory conditions in pancreatic cancer cells. A higher amount of\n                    <jats:italic>MYC<\/jats:italic>\n                    eRNA is observed in chronic pancreatitis and in pancreatic cancer patients. We show that\n                    <jats:italic>MYC<\/jats:italic>\n                    eRNA interacts with YEATS2, a histone reader protein of the ATAC-HAT complex, and augments the association of YEATS2-containing ATAC complexes with\n                    <jats:italic>MYC<\/jats:italic>\n                    promoter\/enhancer regions and thus increases\n                    <jats:italic>MYC<\/jats:italic>\n                    gene expression. TNF-\u03b1 induced Tyrosine dephosphorylation of the YEATS domain increases\n                    <jats:italic>MYC<\/jats:italic>\n                    eRNA binding to the YEATS2 protein in pancreatic cancer cells. Our study adds another regulatory layer of\n                    <jats:italic>MYC<\/jats:italic>\n                    gene expression by enhancer-driven transcription.\n                  <\/jats:p>","DOI":"10.1038\/s44319-025-00446-0","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:37:41Z","timestamp":1744357061000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic interaction of MYC enhancer RNA with YEATS2 protein regulates MYC gene transcription in pancreatic cancer"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8715-7534","authenticated-orcid":false,"given":"Jayita","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5061-0630","authenticated-orcid":false,"given":"Aniket","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1105-0687","authenticated-orcid":false,"given":"Shouvik","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhan K","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-6162","authenticated-orcid":false,"given":"Srikanta","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-5010","authenticated-orcid":false,"given":"Anup","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"issue":"7","key":"446_CR1","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3390\/ijms18071338","volume":"18","author":"A Adamska","year":"2017","unstructured":"Adamska A, Domenichini A, Falasca M (2017) Pancreatic ductal adenocarcinoma: current and evolving therapies. 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